RESEARCH

Tumor Suppressive Role of Actin Filament

∙ Upregulation of oncogenic signaling by actin filament defects

∙ Dissection of the role of nuclear filament actin in tumorigenesis

∙ Control of protein trafficking via nuclear filament actin

∙ Therapeutic Target Examination

Chromosomal Instability in Human Disease

∙ Chromosomal instability in cancer

∙ Storage disorder progression by chromosomal instability

∙ Other genetic abnormality-related diseases

Lysosomal Protein Degradation via Vesicular Acidification

∙ Tumor suppressor degradation via vesicular acidification

∙ Positive regulator of vesicular acidification

∙ Screening of acidification inhibitors

∙ Lysosomal disorder through defects in vesicular acidification

Aging-Induced Disease

∙ Molecular mechanism of aging-involved metabolic disease progression

∙ Genomic instability-induced diseases by aging

∙ Amelioration of adult stem cell exhaustion

∙ Regulation of cancer stem cell-like cell