研究發表與專利 

Publications

1. Gao WY, Chen PY, Hsu HJ, Liou JW, Wu CL, Wu MJ, Yen JH*. (2024) Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXRα/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models. Biomedicine & Pharmacotherapy 174, 116598. 

2.  Chen PY, Lin CY, Wu CL, Keak PY, Liou JW,  Gao WY, Lin LI, Yen JH*. (2023) Pinostrobin modulates FOXO3 expression, nuclear localization, and exerts antileukemic effects in AML cells and zebrafish xenografts. Chemico-Biological Interaction 2023, 358: 110729.

3.  Wu PS, Wang CY, Hsu HJ, Yen JH, Wu MJ* (2023). 8-Hydroxydaidzein Induces Apoptosis and Inhibits AML-Associated Gene Expression in U-937 Cells: Potential Phytochemical for AML Treatment. Biomolecules, 13, 1575. (10/2023). 

4.  Chang PR, Liou JW, Chen PY, Gao WY, Wu CL, Wu MJ, Yen JH*. (2023) The Neuroprotective Effects of Flavonoid Fisetin against Corticosterone-Induced Cell Death throughModulation of ERK, p38, and PI3K/Akt/FOXO3a-Dependent Pathways in PC12 Cells. Pharmaceutics 2023, 15, 2376 (9/2023).

5.  Mani H, Chang CC, Hsu HJ, Yang CH, Yen JH, Liou JW*. (2023) Comparison, Analysis, and Molecular Dynamics Simulations of  Structures of a Viral Protein Modeled Using Various Computational Tools. Bioengineering 2023, 10, 1004 (8/2023).

6.  Lin CY, Chen PY, Hsu HJ, Gao WY, Wu MJ, Yen JH*. (2022) The Citrus Flavonoid Nobiletin Downregulates Angiopoietin-like Protein 3 (ANGPTL3) Expression and Exhibits Lipid-Modulating Effects in Hepatic Cells and Adult Zebrafish Models International Journal of Molecular Sciences 23: 12485 (10/2022).

7.  Yen JH, Chu SY, Chen YJ, Su YC, Chien CC, Weng CY, Chen PY*. (2022) A Maternally Inherited Rare Case with Chromoanagenesis-Related Complex Chromosomal Rearrangements and De Novo Microdeletions. Diagnostics 12: 1900 (8/2022).

8.  Chen PY, Wang CY, Tsao EC, Chen YT, Wu MJ, Ho CT, Yen JH*. (2022) 5-Demethylnobiletin Inhibits Cell Proliferation, Downregulates ID1 Expression, Modulates the NF-κB/TNF-α Pathway and Exerts Antileukemic Effects in AML Cells. International Journal of Molecular Sciences 23: 7392 (7/2022).

9.  Liou JW, Mani H, Yen JH* (2022). Viral Hepatitis, Cholesterol Metabolism, and Cholesterol-Lowering Natural Compounds. International Journal of Molecular Sciences 23: 3897 (3/2022).

10.  Wu PS, Wang CY, Chen PS, Hung JH, Yen JH, Wu MJ* (2021). 8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells. Biomedicines, 9, 1907. (12/2021).

11.  Chen PY, Chao TY, Hsu HJ, Wang CY, Lin CY, Gao WY, Wu MJ, Yen JH*. (2021) The Lipid-Modulating Effect of Tangeretin on the Inhibition of Angiopoietin-like 3 (ANGPTL3) Gene Expression through Regulation of LXRα Activation in Hepatic Cells. International Journal of Molecular Sciences 22: 9853 (9/2021).

12.  Chen PY, Gao WY, Liou JW, Lin CY, Wu MJ, Yen JH*. (2021) Angiopoietin-Like Protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia. International Journal of Molecular Sciences 22: 7310 (7/2021). 

13.  Mani H#, Yen JH#, Hsu HJ, Chang CC, Liou JW*. (2021) Effects by hepatitis C virus core protein on host immunity and inflammatory responses. Tzu Chi Medical Journal 34(2):139-147 (9/2021).

14.  Gao WY#, Chen PY#, Hsu HJ, Lin CY, Wu MJ, Yen JH*. (2021) Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells. Biomedicines 9: 326 (3/2021). 

15.  Wu PS#, Yen JH#, Wang, CY, Chen PY, Hung JH, Wu MJ* (2020) 8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells. Biomedicines 8(11): 506. 

16.  Wu PS, Jeng J, Yang JJ, Kao V, Yen JH, Wu MJ* (2020) Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation. J Ethnopharmacology 262:113155. 

17.  Yen JH, Lin CY, Chuang CH, Chin HK, Wu MJ, Chen PY* (2020) Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells. Cells 2020, 9(4):877.

18.  Thang SK, Chen PY, Gao WY, Wu MJ, Pan MH, Yen JH* (2019) Xanthohumol Suppresses NPC1L1 Gene Expression through Downregulation of HNF-4α and Inhibits Cholesterol Uptake in Caco-2 Cells Journal of Agricultural and Food Chemistry. 67(40):11119-11128.

19.  Chang HY, Wu JR, Gao WY, Lin HR, Chen PY, Chen CI, Wu MJ, Yen JH*. (2019) The Cholesterol-Modulating Effect of Methanol Extract of Pigeon Pea (Cajanus cajan (L.) Millsp.) Leaves on Regulating LDLR and PCSK9 Expression in HepG2 Cells. Molecules. 24(3). pii: E493.

20.  Chen PY, Chen YT, Gao WY, Wu MJ, Yen JH*. (2018) Nobiletin Down-Regulates c-KIT Gene Expression and Exerts Antileukemic Effects on Human Acute Myeloid Leukemia Cells. Journal of Agricultural and Food Chemistry. 66(51):13423-13434.

21.  Yang CH, Chen YC, Peng SY, Tsai AP, Lee TJ, Yen JH, Liou JW*. (2018) An engineered arginine-rich α-helical antimicrobial peptide exhibits broad-spectrum bactericidal activity against pathogenic bacteria and reduces bacterial infections in mice. Sci Rep. 2018 8(1):14602.

22.  Gao WY, Chen PY, Chen SF, Wu MJ, Chang HY, Yen JH*. (2018) Pinostrobin inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) gene expression through the modulation of FoxO3a protein in HepG2 cells. Journal of Agricultural and Food Chemistry. 66(24):6083-6093. 

23.  Wu PS, Ding HY, Yen JH, Chen SF, Lee KH, Wu MJ*. (2018) Anti-inflammatory activity of 8-hydroxydaidzein in LPS-stimulated BV2 microglial cells via activation of Nrf2-antioxidant and attenuation of Akt/NF-kappaB-inflammatory signaling pathways, as well as inhibition of COX-2 activity. Journal of Agricultural and Food Chemistry. 66(23):5790-5801.

24.  Chen PY, Tien HJ, Chen SF, Tang HL, Jung HL, Wu MJ, Yen JH*. (2018) Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein. International Journal of Molecular Sciences. 2018;19(4).

25.  Chang CC, Hsu HJ, Yen JH, Lo SY, Liou JW*. (2017) A Sequence in the loop domain of hepatitis C virus E2 protein identified in silico as crucial for the selective binding to human CD81. PLoS One 12(5):e0177383.

26.  Chen SF, Chen PY, Hsu HJ, Wu MJ, Yen JH*. (2017) Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells. Journal of Agricultural and Food Chemistry. 65(36):7908-7918.

27.  Yen JH, Wu P-S, Chen S-F, Wu MJ*. (2017) Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells. International Journal of Molecular Sciences. 18(4): 852.

28.  Chen PY, Yen JH, Cheng CF, Chen PC, Li YS, Li TY, Yeh CN, Fang JS* (2016) Prenatal diagnosis of the maternal derivative chromosome der(15)t(Y;15)(q12;p13) in a dizygotic twin pregnancy. Tzu Chi Medical Journal.12:176-179

29.  Chen HC, Chen PY, Wu MJ, Tai MH, Yen JH* (2016) Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells. PLoS One. 11(9):e0162414.

30.  Huang SL, Chen PY, Wu MJ, Tai MH, Ho CT, Yen JH* (2015) Curcuminoids Modulate the PKCδ/NADPH oxidase/ROS Signaling Pathway and Suppress Matrix Invasion during Monocytes-Macrophages Differentiation. Journal of Agricultural and Food Chemistry 63 (40):8838-48.

31.  Wu PS, Yen JH, Kou MC, Wu MJ*. (2015) Luteolin and apigenin attenuate 4-hydroxy-2-nonenal-mediated cell death through modulation of UPR, Nrf2-ARE and MAPK pathways in PC12 cells. PLoS One 10(6):e0130599.

32.  Chen PY, Wu MJ, Chang HY, Tai MH, Ho CT, Yen JH*. (2015) Up-regulation of miR-34a expression in response to the luteolin-induced neurite outgrowth of PC12 cells. Journal of Agricultural and Food Chemistry 63(16):4148-4159.

33.  Chen PY, Ho YR, Wu MJ, Huang SP, Chen PK, Tai MH, Ho CT, Yen JH* (2015) Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells. Food & Function 6(1):287-96.

34.  Tai MH, Chen PK, Chen PY, Wu MJ, Ho CT, Yen JH* (2014) Curcumin enhances cell-surface LDLR level and promotes LDL uptake through down-regulation of PCSK9 gene expression in HepG2 cells. Molecular Nutrition & Food Research 58(11):2133-45.

35.  Hu LW, Yen JH, Shen YT, Wu KY, Wu MJ* (2014) Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells. PLoS One 9(5):e97880.

36.  Lin MH, Yen JH, Weng CY, Wang L, Ha CL, Wu MJ* (2014) Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: roles of ROS and MAPK pathways. Toxicology 315:24-37.

37.  Lieu CL, Yen JH, Lieu AB, Liu IY* (2013) Sex differences in the effective warfarin dosage in Han and aboriginal Taiwanese patients with the VKORC1-1639AA genotype. Tzu Chi Medical Journal ,25:213-217.

38.  Chiu SP, Wu MJ, Chen PY, Ho YR, Tai MH, Ho CT, Yen JH* (2013) Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. Journal of Agricultural and Food Chemistry 61:9453-63.

39.  Kou MC, Fu SH, Yen JH, Weng CY, Li S, Ho CT and Wu MJ*. (2013) Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3’,4’-hexamethoxyflavone and 3,5,6,7,8,3’,4’-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor. Food & Function 2013, 4 (4), 602 – 609.

40.  Lin LF, Chiu SP, Wu MJ, Chen PY, Yen JH*. (2012) Luteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 Cells. PLoS One 7(8): e43304. 

41.  Liao KK, Wu MJ, Chen PY, Huang SW, Chiu SJ, Ho CT, Yen JH*. (2012) Curcuminoids Promote Neurite Outgrowth in PC12 Cells through MAPK/ERK- and PKC-Dependent Pathways. Journal of Agricultural and Food Chemistry 60: 433−443.

42.  Su JD, Yen JH, Li S, Weng CY, Lin MH, Ho CT, Wu MJ* (2012) 3',4'-didemethylnobiletin induces Phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells. Free Radical Biology & Medicine 52(1):126-141.

43.  Lai HC, Wu MJ, Chen PY, Sheu TT, Chiu SP, Lin MH, Ho CT, Yen JH* (2011). Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells. PLoS One 6(11):e28280. 

44.  Yen JH, Weng CY, Li S, Lo YH, Pan MH, Fu SH, Ho CT, Wu MJ* (2011) Citrus flavonoid, 5-demethylnobiletin, suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells. Molecular Nutrition & Food Research 55(5):733-48. 

45.  Chen WS, Lee YJ, Yu YC, Hsaio CH, Yen JH, Yu SH, Tsai YJ, Chiu SJ*. (2010) Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin. Int J Radiat Oncol Biol Phys. 1;77(5):1527-35.

46.  Lin CW, Wu MJ, Liu IYC, Su JD, Yen JH* (2010) Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression. Journal of Agricultural and Food Chemistry 58: 4477-86.

47.  Lo YH, Pan MH, Li S, Yen JH, Kou MC, Ho CT, Wu MJ*(2010) Nobiletin metabolite, 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells. Biochimica et Biophysica Acta-Molecular and Cell biology of Lipids 1801:114–126.

48.  Hong JT, Yen JH, Wang L, Lo YH, Chen ZT, Wu MJ*(2009) Regulation of Heme Oxygenase-1 Expression and MAPK Pathways in Response to Kaempferol and Rhamnocitrin in PC12 Cells. Toxicology and Applied Pharmacology 37: 59-68.

49.  Kuo MC, Yen JH, Hong JT, Wang CL, Lin CW, Wu MJ* (2009) Cyphomandra betacea Sendt. phenolics protect LDL from oxidation and PC12 cells from oxidative stress. LWT- Food Science and Technology 42:458–463.

50.  Yen JH, Chen WC, Tzeng CC, Fang JS, Chu SY* (2008) Molecular Screening of fragile X Syndrome in Children with Mental Retardation in Hualien. Tzu Chi Medical Journal ,20:309-313.

51.  Tu YC, Lian TW, Yen JH, Chen ZT, Wu MJ* (2007) Antiatherogenic effects of kaempferol and rhamnocitrin. Journal of Agricultural and Food Chemistry 55(24): 9969-9976.

52.  Wang L, Tu Y-C, Lian T-W , Hung J-H, Yen JH, Wu MJ* (2006) Distinctive Antioxidant and Anti-Inflammatory Effects of Flavonols. Journal of Agricultural and Food Chemistry 54: 9798-9804.

53.  Lin YS, Lin CF, Fang YT, Kuo YM, Liao PC, Yeh TM, Hwa KY, Shieh CC, Yen JH, Wang HJ, Su IJ, Lei HY. (2005) Antibody to severe acute respiratory syndrome (SARS)-associated coronavirus spike protein domain 2 cross-reacts with lung epithelial cells and causes cytotoxicity. Clin Exp Immunol. 141(3):500-8.

54.  Wu MJ*, Wang L. Ding HY, Weng CY, Yen JH (2004) Glossogyne tenuifolia Acts to Inhibit Inflammatory Mediator Production in a Macrophage Cell Line by Down-Regulating LPS-Induced NF-B. Journal of Biomedical Science11:186-199. 

55.  Wu MJ*, Yen JH, Wang L, Weng CY (2004) Antioxidant Activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.). American Journal of Chinese Medicine 32, 681-693. 

56.  Wu MJ*, Wang L, Weng CY, Yen JH (2003) Antioxidant activity of methanol extract of the lotus leaf (Nelumbo nucifera Gertn.) American Journal of Chinese Medicine 31:687-698.

57.  Wang L, Liang H-L, Yen JH, Wu MJ* (2003) Antioxidant effect of methanol extracts lotus plumule and blossom (Nelumbo nucifera Gertn.) Journal of Food and Drug Analysis 11: 60-66. 

58.  Yen JH, Chang SC, Hu CR, Chu SC, Lin SS, Hsieh YS, Chang MF. (1995) TCellular proteins specifically bind to the 5'-noncoding region of hepatitis C virus RNA. Virology 20;208(2):723-32.  

59.  Chang SC#, Yen JH#, Kang HY, Jang MH, Chang MF. (1994) Nuclear localization signals in the core protein of hepatitis C virus. Biochem Biophys Res Commun 15;205(2):1284-90.

專利 Patents

1. Monoclonal antibody with the capability of neutralizing enterovirus type 71. (2010) US7718775.

2. 球松素用於製備降低LDL膽固醇之組合物之用途 (2019) 中華民國【發明專利I674895號】

研討會 Posters (International Conference) :     

1.    Lin YX, Yen JH, Wu CL, Lin LI, Chen PY (2023, Sep). Targeting Cytarabine-Resistant Polyploid Giant Cancer Cells (PGCCs) in AML with Shikonin. Pan Pacific Symposium on stem cells and cancer research 2023, Hualien, Taiwan.

2.    Chen PY, Keak PY, Wu CL, Yen JH (2023, Jun). The Anti-Leukemic Activity of Shikonin in Core Binding Factor (CBF) AML: in vitro and in vivo biological studies. European Human Genetics Conference 2023, Glasgow, UK.

3.    Yen JH, Su YC, Lee YS, Chien CC, Weng CY, Chu SY, Chen PY (2022, Jun). A maternal inherited rare case with chromoanagenesis-related complex chromosomal rearrangements and de novo microdeletions. European Human Genetics Conference 2022, Vienna, Austria.

4.    Yen JH, Chen ZA, Lin LI, Chen PY (2020, Jun). Molecular studies for gain of cytarabine-resistance in AML cells with FLT3-ITD mutations. European Human Genetics Virtual Conference 2020, Vienna, Austria.

5.    Chen PY, Chen HJ, Yen JH (2019, Sep). Shikonin exhibits anti-proliferative effects and down-regulates RUNX1-ETO expression in AML Kasumi-1 cells. The 78th Annual Meeting of the Japanese Cancer Association, Kyoto, Japan.

6.    Yen JH, Chen ZA, Lin LI, Chen PY (2019, Jun). Characterization of genomic alterations of cytarabine-resistant AML cells with FLT3-ITD mutation. European Human Genetics Conference 2019, Gothenburg, Sweden.

7.    Chung CH, Gao WY, Chen PY, Yen JH (2018, Sep). Nobiletin and 5-demethylnobiletin promote cell differentiation and exert anti-leukemic effects on human CML cells. The 77th Annual Meeting of the Japanese Cancer Association, Osaka, Japan.

8.    Thang SK, Chen PY, Yen JH (2017, Nov). Xanthohumol Modulates Intestival Cholesterol Absorption via down-regulation of Niemann-Pick C1 like 1 (NPC1L1) Gene Expression. ACS The 1st Asia-Pacific International Conference. Busan, South Korea.

9.    Chen PY, Chen YT, Kao RH, Wu MJ, Tai MH, Ho CT, Yen JH (2016, Oct). Nobiletin and 5-demethylnobiletin suppress c-KIT expression via ERK pathway and inhibit cell proliferation in AML cells. The 75th Annual Meeting of the Japanese Cancer Association. Yokohama, Japan.

10.  Chen YT, Tai1 MH, Wu MJ, Ho CT, Yen JH, Chen PY (2015, Oct). Citrus polymethoxyflavone nobiletin down-regulates c-KIT expression in human leukemia cells. The 74th Annual Meeting of the Japanese Cancer Association. Nagoya, Japan.

11.  Chen HC, Wu MJ, Chen PY, Chen YC, Tai MH, Yen JH (2015, Aug). Tanshinone IIA modulates cell-surface LDLR level and LDL uptake via suppression of PCSK9 gene expression in HepG2 cells. 250th American Chemical Society National Meeting & Exposition, Boston, USA.

12.  Tien HJ, Chen PY, Chen JH, Wu MJ, Yen JH (2015, Aug). Luteolin-mediated apoptosis in leukemia cells involves PTTG1 oncoprotein and differential responses. 250th American Chemical Society National Meeting & Exposition, Boston, USA.

13.  Chen PY, Chen PK, Tai MH, Chen JH, Ｙen JH(2014, Oct). Nobiletin suppresses oncogene PTTG1 expression in THP1 leukemia cells. The 73rd Annual Meeting of the Japanese Cancer Association. Yokohama, Japan.

14.  Tai MH, Chen PK, Chen PY, Wu MJ, Ho CT, Yen JH (2013, Apr). Curcumin decreases PCSK9 gene expression via regulation of hepatocyte nuclear factor 1α (HNF1α) in HepG2 cells. Pharma-Nutrition, 2013, Apr.15-17. Singapore.