@ E413實驗室研究成果 (2024/09)
中藥草紫草活性植化素紫草素(shikonin)在急性骨髓性白血病細胞株與斑馬魚系統有效抑制癌細胞生長之抗癌功效與分子機轉 ，研究成果發表於SCI雜誌 Biomedicine & Pharmacotherapy (2024, IF 6.9, Q1: 4.7%)
Yen JH, Keak PY, Wu CL, Chen HJ, Gao WY, Liou Jw, Chen YR, Lin LI, Chen PY. (2024) Shikonin, a natural naphthoquinone phytochemical, exerts anti-leukemia effects in human CBF-AML cell lines and zebrafish xenograft models. Biomedicine & Pharmacotherapy 179, 117395.
@ E413實驗室發表 綜論文章 (2024/09)
綜論文章(Review Article)探討膽固醇調節基因PCSK9與降膽固醇植化素之應用，發表於SCI雜誌Tzu Chi Medical Journal (2024, IF 1.4, Q2)
Liou JW, Chen PY, Gao WY, Yen JH*. (2024) Natural phytochemicals as small‑molecule proprotein convertase subtilisin/kexin type 9 inhibitors. Tzu Chi Medical Journal 36 (4): 360‑369.
** 恭賀~分子生物暨人類遺傳學系 顏瑞鴻教授 榮任113學年度 慈濟大學特聘教授 **
@ E413實驗室發表 綜論文章 (2024/07)
綜論文章(Review Article)探討癌症中CXCR4訊息路徑與抗癌藥物之應用，發表於SCI雜誌 Tzu Chi Medical Journal (2024, IF 1.4, Q2)
Yen JH, Chang CC, Hsu HJ, Yang CH, Mani H, Liou JW. (2024) C-X-C motif chemokine ligand 12―C-X-C chemokine receptor type 4 signaling axis in cancer and the development of chemotherapeutic molecules. Tzu Chi Medical Journal 36(3):231-239.
@ E413實驗室研究成果 2024/04
忽布花(啤酒花, Hops)類黃酮黃腐醇(Xanthohumol)在肝細胞與斑馬魚高脂質血症系統調節ANGPTL3與脂質代謝之功效 研究成果發表於SCI雜誌 Biomedicine & Pharmacotherapy (2024, IF 7.5, Q1)
Gao WY, Chen PY, Hsu HJ, Liou JW, Wu CL, Wu MJ, Yen JH*. (2024) Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXRα/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models. Biomedicine & Pharmacotherapy 174, 116598.
@ E413實驗室研究成果 2023/11
類黃酮球松素在急性骨髓性白血病細胞株與斑馬魚系統有效抑制癌細胞生長之抗癌功效與分子機轉 研究成果發表於SCI雜誌 Chemico-Biological Interactions (2023, IF 5.1 , Q1)
Chen PY, Lin CY, Wu CL, Keak PY, Liou JW, Gao WY, Lin LI, Yen JH*. (2023) Pinostrobin modulates FOXO3 expression, nuclear localization, and exerts antileukemic effects in AML cells and zebrafish xenografts. (In Press) https://doi.org/10.1016/j.cbi.2023.110729.
@ E413實驗室研究成果 2023/10
蔬果類黃酮木樨草素有效降低因壓力所誘導過度產生皮質類固醇之神經細胞傷害 研究成果發表於SCI雜誌 Pharmaceutics (2023, IF 5.4 , Q1)
Chang PR, Liou JW, Chen PY, Gao WY, Wu CL, Wu MJ, Yen JH*. (2023) The Neuroprotective Effects of Flavonoid Fisetin against Corticosterone-Induced Cell Death throughModulation of ERK, p38, and PI3K/Akt/FOXO3a-Dependent Pathways in PC12 Cells. Pharmaceutics 2023, 15, 2376 (9/2023).
@ E413實驗室研究成果 2022/11
柑橘類黃酮川陳皮素在肝細胞與斑馬魚高脂質血症系統調節脂質代謝之功效 研究成果發表於SCI雜誌 International Journal of Molecular Sciences (2022, IF 6.208, Q1)
Lin CY, Chen PY, Hsu HJ, Gao WY, Wu MJ, Yen JH*. (2022) The Citrus Flavonoid Nobiletin Downregulates Angiopoietin-like Protein 3 (ANGPTL3) Expression and Exhibits Lipid-Modulating Effects in Hepatic Cells and Adult Zebrafish Models. International Journal of Molecular Sciences 23: 12485 (10/2022).