Our aim is to develop bioactive small molecules for biomedical research. Protein regulation by small molecules is a key to understand its role in cell. Our goal is designing small molecules for every protein inside cells to explore biological space. We are particularly interested in de novo molecular design using Artifical Intelligence(AI). Moreover, we are working to elaborate the small molecules toward drug candidates through medicinal chemistry approach.

Identification of small molecule binding protein is essential to understand its mode of action (MOA). Our group is looking for target proteins of natural products using photoaffinity based approach. Identification of natural products, particularly in herbal plants is main topic of our group. We expect to elaborate those therapeutic effect by understanding MOA of natural products.

Extracellular Vesicle(EV)s are nano sized vesicles secreted for cells with their informations. Therefore, analysis of EVs could give their mother cell information. In our body, EVs from all type of cells are secreted into biofluids such as blood and urine. So EVs analysis of body fluids can be used for disease diagnosis. We are developing new tools for EV Analysis for efficient and effective disease diagnosis.

Proteins are essential component for cells. 400,000 different proteins with distinct functions are working together for cell survivals. Elucidation of each protein functions are like drawing a blue print to understand how the cells work. Our group is interested in fluorescence bioprobe development to understand protein functions. We are interested in a specific protein reactive heterocycles for bioprobe development.