Research & Projects

The correct formation of the central nervous system is fundamental for the response to stimuli, which allows for complex behaviors. I am interested in the connection between body plan formation and cell-cell signaling, and exploring the specification of the nerve cord in the segmented worm Capitella teleta can unveil the interplay/uncoupling of axis specification and fate decisions.

Fate decision happens very early during development, and the correct segregation of mRNA, proteins and other molecules during the first divisions is fundamental for the correct formation of cell types. Segmented worms are placed within a clade called Spiralia, which is characterized by the presence of a conserved pattern of cell division where cells position themselves in an angle respect to each other, ressembling a spiral. SPILE genes were discovered a few years back, and hypothesized to specify cell date based on other spiralians. I am interested in the evolution of this gene family within annelids, and its connection to the life history of these animals.