Publications

Publications 

2026

2025

103.  Bo-Rim Song, Sung Kyu Yoon, Chang Hyung Lee, Md Badrul Alam, Chi-Yeol Yoo, Kyu-Shik Jeong, Dong-Sun Lee*, Sang-Han Lee*. Procyanidin A2, a polyphenol autophagy-enhancer, ameliorates hyperglycemia through multifaceted insulin-related mechanisms. Scientific Reports 13(1): 41248 (2025/11/21), DOI: 10.1038/s41598-025-25111-3, *Equal Corresponding author

102. Ko SY, Kim Y, Chung JS, Kim YB, Kim SL, Lee DS, Chun KH, Choi HS. (2025) Auranofin, an antirheumatic drug, shows anticancer stem cell potential via suppression of the Stat3 signal. BMB Reports 58(7): 293-299 (2025/07/), DOI: 10.5483/BMBRep.2025-0037

101. Muhammad Awais Farooqi, Sehui Kim, Sungmin Bae, Sungeun Bae, Farzana Kausar, Hafiz Muhammad Umer Farooqi, Dong-Sun Lee*, Taeyoung Kang*, Chul Ung Kang* (2025) Biogenic synthesis of bioactive zinc nanoparticles from Saccharum officinarum (Jaggery) for biomedical applications. Journal of Materials Research (2025/05/28), DOI: 10.1557/s43578-025-01593-9, *Equal Corresponding author 

100. Muhammad Awais Farooqi, Ji-Hyang Kim, Sehui Kim, Kyeoung Cheol Kim, Hafiz Muhammad Umer Farooqi, Dong-Sun Lee*, Chul Ung Kang* (2025) Cytotoxic and Cellular Response of Doped Nb-NTO Nanoparticles Functionalized with Mentha arvensis and Mucuna pruriens Extracts on MDA-MB-231 Breast Cancer Cells. Applied Biochemistry and Biotechnology (2025/04/03), DOI: 10.1007/s12010-025-05227-y, *Equal Corresponding author 

99. Kyeoung Cheol Kim, Thiruni Dananjana Perera, Su-Lim Kim, Seungtae Kang, Jin Kyu Woo, Hiruni Sandunika Kumarasinghe, Ji-Hyang Kim, Dong-Sun Lee (2025) Development of simple sequence repeat (SSR) markers from a genome survey of a Cymbidium kanran population in Jeju Island, Republic of Korea. J. Microbiol. Biotechnol. 35(1): e2501013 (2025/03/28),  DOI: 10.4014/jmb.2501.01013

98. Kyeoung Cheol Kim, Ji-Hyang Kim, Ju Sung Kim, Dong-Sun Lee (2025) Optimization of ultrasonic‑assisted extraction of anthocyanins from Prunus yedoensis fruit and evaluation of antioxidant and anti‑inflammatory activity. Food Science and Biotechnology (2025/03/17), DOI: 10.1007/s10068-025-01843-w

2024

98. Su-Lim Kim, Won-Kyung Hong, Hack Sun Choi, Dong-Sun Lee (2025) Sertaconazole, an Imidazole Antifungal Agent, Suppresses the Stemness of Breast Cancer Cells by Inhibiting Stat3 Signaling. in vivo 39(1): 190-200 (2025/01/02) doi: 10.21873/invivo.13817

97. Kumarasinghe Hiruni Sandunika, Ji-Hyang Kim, Su-Lim Kim, Kyeoung Cheol Kim, Rambukkana Maggonage Thiruni Dananjana Perera, Seong-Cheol Kim, Dong-Sun Lee (2024) Bioactive constituents from Carica papaya fruit: Implications for drug discovery and pharmacological applications. Applied Biological Chemistry 67(103) (2024/12/12), doi: 10.1186/s13765-024-00962-y

96. Makoto Muroi, Dong-Sun Lee (2024) Inhibitory effects of cryptotanshinone and dihydrotanshinone I on intracellular trafficking of viral glycoproteins. J. Microbiol. Biotechnol. 34(12): 2460 (2024/10/25) doi: 10.4014/jmb.2409.09050

95. Meraj Ansari, Mrinmoy Ghosh, Dong-Sun Lee*, Youngok Son* (2024) Senolytic therapeutics: An emerging treatment modality for osteoarthritis.  Ageing Research Reviews 96; 102275 (2024/03/15), (IF=13.1)  doi: 10.1016/j.arr.2024.102275,  *Equal Corresponding author 

94.  Godagama Gamaarachchige Dinesh Suminda, Yunhui Min, Min Woo Ha, Mrinmoy Ghosh, Dong-Sun Lee*, Young-Ok So* (2024) In vitro and in vivo investigations on arsenic-induced cartilage degeneration in osteoarthritis. Journal of Hazardous Materials 461; 132570 (2024/01/05), (IF=13.6)  doi: 10.1016/j.jhazmat.2023.132570, *Equal Corresponding author 

 2023

93. Jae-Hyun Park, Naito Ishimoto, Kouki Kawakami, Tatsuya Ikuta, Mio Ohki, Toru Ekimoto, Mitsunori Ikeguchi, Dong-Sun Lee, Young-Ho Lee, Jeremy R.H. Tame, Asuka Inoue, Sam-Yong Park (2023)  Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.  Nature Communications 14(1); 7150 (2023/11/03),  (IF=16.6)  doi: 10.1038/s41467-023-42764-8 

92. Su-Lim Kim, Hack Sun Choi, Yu-Chan Ko, and Dong-Sun Lee   (2023) BRD4/nuclear PD-L1/RelB circuit is involved in the stemness of breast cancer cells.  Cell Communication and Signaling 21(1); 315 (2023/11/03),  (IF=8.4)  doi: 10.1186/s12964-023-01319-6 

91. Yu-Chan Ko, Hack Sun Choi, Su-Lim Kim, Dong-Sun Lee   (2023) 13-Oxo-9Z,11E-octadecadienoic Acid Down-regulates c-Myc and Attenuates Breast Cancer Cell Stemness.  in vivo 37(3) 1085-1092  (2023/05/01),  doi: 10.21873/invivo.13183

90. Yu-Chan Ko, Hack Sun Choi, Su-Lim Kim, Dong-Sun Lee  (2023) Isophysalin A inhibits the stemness of breast cancer cells possibly via Stat3 and IL-6 signaling.  Anticancer Research 43(3): 1091-1101 (2023/03/01),  doi: 10.21873/anticanres.16254

89. Andrew Wange Bugenyi, Ma-Ro Lee, Yeon-Jae Choi, Ki-Duk Song, Hak-Kyo Lee, Young-Ok Son, Dong-Sun Lee, Sang-Chul Lee, Young-June Son, Jaeyoung Heo (2023)  Oropharyngeal, proximal colonic, and vaginal microbiomes of healthy Korean native black pig gilts.  BMC Microbiol 23(1); 3 (2023/01/05),  doi: 10.1186/s12866-022-02743-3

 2022

88. Jia-Bin Yu, Dong-Sun Lee, Babu J. Padanilam, Jinu Kim  (2022) Repeated Administration of Cisplatin Transforms Kidney Fibroblasts through G2/M arrest and cellular senescence.  Cells 11(21); 3472 (2022/11/02),  (IF=7.666)  doi: 10.3390/cells11213472

 87. Jaehoon Jung, Andrew W. Bugeyi, Ma-Ro Lee, Yeon-Jae Choi, Ki-Duk Song, Hak-Kyo Lee, Young-Ok Son, Dong-Sun Lee, Sang-Chul Lee, Jaeyoung Heo (2022)   High-Quality Metagenome-Assembled Genomes from Proximal Colonic Microbiomes of Synbiotic-Treated Korean Native Black Pigs Reveal Changes in Functional Capacity.  Scientific Reports 12(1); 14595 (2022/09/15),  doi: 10.1038/s41598-022-18503-2

86. Yu-Chan Ko, Ren Liu, Hu-Nan Sun, Bong-Sik Yun, Hack Sun Choi, Dong-Sun Lee (2022)  Dihydroconiferyl ferulate isolated from Dendropanax morbiferus suppresses stemness of breast cancer cells via nuclear EGFR/Stat3/c-Myc signaling.  Pharmaceuticals 15(6); 664-681 (2022/05/26), (IF-5.215)  doi: 10.3390/ph15060664

85. Dahye Kim, Yunhui Min, Godagama Gamaarachchige Dinesh Sumindac, Chang-Gi Hur, Sang-Chul Lee, Hak-Kyo Lee, Ki-Duk Song, Jaeyoung Heo, Young-Ok Son, Dong-Sun Lee (2022)  Bacillus-supplemented diet improves growth performance in Jeju native pigs by modulating myogenesis and adipogenesis.  Animal Biotechnology 34(5): 1763-1775 (2022/03/21),  doi: 10.1080/10495398.2022.2047996

84. Yu-Chan Ko, Hack Sun Choi, Su-Lim Kim, Bong-Sik Yun, Dong-Sun Lee (2022)  Anti-Inflammatory Effects of (9Z,11E)-13-Oxooctadeca-9,11-dienoic Acid (13-KODE) Derived from Salicornia herbacea L. on Lipopolysaccharide-Stimulated Murine Macrophage via NF-kB and MAPK Inhibition and Nrf2/HO-1 Signaling Activation.  Antioxidants 11(2); 180-194 (2022/01/18),  (IF=7.0)  doi: 10.3390/antiox11020180

 2021

83. Ji-Hyang Kim, Hack Sun Choi, Dong-Sun Lee  (2021)  Primaquine inhibits the endosomal trafficking and nuclear localization of EGFR and induces the apoptosis of breast cancer cells by nuclear EGFR/Stat3-mediated c-Myc downregulation.  International Journal of Molecular Sciences 22(23); 12961-12974 (2021/11/30),  (IF=6.208)  doi: 10.3390/ijms222312961

82. Ren Liu, Hack Sun Choi, Yu-Chan Ko, Bong-Sik Yun, Dong-Sun Lee (2021)  5-Desmethylsinensetin isolated from Artemisia princeps suppresses the stemness of breast cancer cells via Stat3/IL-6 and Stat3/YAP1 signaling.  Life Sciences 280; 119729 (2021/09/01),  (IF=6.1)  doi: 10.1016/j.lfs.2021.119729

81. Su-Lim Kim, Hack Sun Choi, Yu-Chan Ko, Bong-Sik Yun, Dong-Sun Lee (2021)  5-Hydroxymaltol Derived from Beetroot Juice through Lactobacillus Fermentation Suppresses Inflammatory Effect and Oxidant Stress via Regulating NF-kB, MAPKs pathway and NRF2/HO-1 Expression.  Antioxidants 10(8); 1324 (2021/08/23),  (IF=7.0)  doi: 10.3390/antiox10081324

80. Yu-Chan Ko, Hack Sun Choi, Ren Liu, Dong-Sun Lee (2021)  Physalin A, 13,14-seco-16, 24-cyclo-steroid, Inhibits Stemness of Breast Cancer Cells by Regulation of Hedgehog Signaling Pathway and Yes-associated Protein 1 (YAP1).  International Journal of Molecular Sciences 22(16); 8718 (2021/08/13),  (IF=6.208)  doi: 10.3390/ijms22168718

79. Dahye Kim, Yunhui Min, Jiwon Yang, Yunji Heo, Mangeun Kim, Chang-Gi Hur, Sang-Chul Lee, Hak-Kyo Lee, Ki-Duk Song, Jaeyoung Heo, Young-Ok Son, Dong-Sun Lee (2021)  Multi-probiotic Lactobacillus supplementation improves liver function and reduces cholesterol levels in Jeju native pigs.  Animals 11(8); 2309 (2021/08/05),  doi: 10.3390/ani11082309

 2020

78. Su-Lim Kim, Hack Sun Choi, Ji-Hyang Kim, Dong-Sun Lee (2020)  The Antiasthma Medication Ciclesonide Suppresses Breast Cancer Stem Cells through Inhibition of the Glucocorticoid Receptor Signaling-dependent YAP Pathway.  Molecules 25(24); 6028 (2020/12/19),  doi: 10.3390/molecules25246028

77. Hack Sun Choi, Su-Lim Kim, Ji-Hyang Kim, Yu-Chan Ko, Dong-Sun Lee (2020)  Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal.  Antioxidants 9(11); 1119 (2020/11/13),  (IF=7.0) doi: 10.3390/antiox9111119

76. Yu-Chan Ko, Hack Sun Choi, Ji-Hyang Kim, Su-Lim Kim, Bong-Sik Yun, Dong-Sun Lee (2020)  Coriolic Acid (13-(S)-Hydroxy-9Z, 11E-octadecadienoic Acid) from Glasswort (Salicornia herbacea L.) Suppresses Breast Cancer Stem Cell through the Regulation of c-Myc.  Molecules 25(21); 4950 (2020/10/26),  doi: 10.3390/molecules25214950

75. Ren Liu, Hack Sun Choi, Su-Lim Kim, Ji-Hyang Kim, Bong-Sik Yun, Dong-Sun Lee (2020)  6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling.  Molecules 25(19); 4374 (2020/09/23),  doi: 10.3390/molecules25194374

74. Ren Liu, Hack Sun Choi, Xing Zhen, Su-Lim Kim, Ji-Hyang Kim, Yu-Chan Ko, Bong-Sik Yun, Dong-Sun Lee (2020)  Betavulgarin Isolated from Sugar Beet (Beta vulgaris) Suppresses Breast Cancer Stem Cells through Stat3 Signaling.  Molecules 25(13); 2999 (2020/06/30),  doi: 10.3390/molecules25132999

73. Xing Zhen, Hack Sun Choi, Ji-Hyang Kim, Su-Lim Kim, Ren Liu, Yu-Chan Ko, Bong-Sik Yun, Dong-Sun Lee (2020)  Caudatin Isolated from Cynanchum auriculatum Inhibits Breast Cancer Stem Cell Formation via a GR/YAP Signaling.  Biomolecules 10(6): 925 (2020/06/18),  doi: 10.3390/biom10060925

72. Yu-Chan Ko, Hack Sun Choi, Ren Liu, Ji-Hyang Kim, Su-Lim Kim, Bong-Sik Yun, Dong-Sun Lee (2020)  Inhibitory Effects of Tangeretin, A Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation Through Suppression of Stat3 Signaling.  Molecules 25(11): 2599 (2020/06/03),  doi: 10.3390/molecules25112599

71. Hyebin Koh, Hu-Nan Sun, Xing Zhen, Ren Liu, Nisansala Chandimali, Tae Ho Kwon, Dong-Sun Lee (2020)  Wogonin Influences Osteosarcoma Stem Cell Stemness Through ROS-dependent Signaling.  In Vivo 34(3): 1077-1084 (2020/05/01),  doi: 10.21873/invivo.11878

70. Xing Zhen, Hack Sun Choi, Ji-Hyang Kim, Su-Lim Kim, Ren Liu, Bong-Sik Yun, Dong-Sun Lee (2020)  Machilin D, a Lignin Derived from Saururus chinensis, Suppresses Breast Cancer Stem Cells and Inhibits NF-κB Signaling.  Biomolecules 10(2): 245 (2020/02/05),  (IF=5.5)  DOI: 10.3390/biom10020245 (IF; 4.879)

69. Hack Sun Choi, Su-Lim Kim, Ji-Hyang Kim, Dong-Sun Lee (2020)  The FDA-Approved Anti-Asthma Medicine Ciclesonide Inhibits Lung Cancer Stem Cells through Hedgehog Signaling-Mediated SOX2 Regulation.  International Journal of Molecular Sciences 21(3): 1014 (2020/02/04),  (IF=6.208)  doi: 10.3390/ijms21031014

68. Xing Zhen, Hu-Nan Sun, Ren Liu, Hack Sun Choi, Dong-Sun Lee (2020)  Non-thermal Plasma-activated Medium Induces Apoptosis of Aspc1 Cells Through the ROS-dependent Autophagy Pathway.  In Vivo 34(1): 143-153 (2020/01/02),  doi: 10.21873/invivo.11755

 2019

67. Nisansala Chandimali, Hu-Nan Sun, Ling-Zu Kong, Xing Zhen, Ren Liu, Tae Ho Kwon, Dong-Sun Lee  (2019) Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression.  Anticancer Research 39(11): 6115-6123 (2019) (2019/11/11),  doi: 10.21873/anticanres.13819

66. Ji-Hyang Kim, Hack Sun Choi, Su-Lim Kim, Dong-Sun Lee (2019)  The PAK1-Stat3 Signaling Pathway Activates IL-6 Gene Transcription and Human Breast Cancer Stem Cell Formation.  Cancers 11(10): 1527 (2019/10/10),  (IF=5.2)  doi: 10.3390/cancers11101527

65. Hack Sun Choi, Ji-Hyang Kim, Su-Lim Kim, Dong-Sun Lee (2019) Disruption of the NF-κB/IL-8 Signaling Axis by Sulconazole Inhibits Human Breast Cancer Stem Cell Formation.  Cells 8(9): 1007 (2019) (2019/08/30),  (IF=6.0)  doi: 10.3390/cells8091007

64. Liu Y, Kwon T, Kim JS, Chandimali N, Jin YH, Gong YX, Xie DP, Han YH, Jin MH, Shen GN, Jeong DK, Lee DS*, Cui YD*, Sun HN* (2019) Peroxiredoxin V Reduces β-Lapachone-induced Apoptosis of Colon Cancer Cells.  Anticancer Research 39(7): 3677-3686 (2019/07/03),  doi: 10.21873/anticanres.13516,  *Equal Corresponding author

63. Ling-Zu Kong, Nisansala Chandimali, Ying-Hao Han, Dong-Ho Lee, Ji-Su Kim, Sun-Uk Kim, Tae-Don Kim, Dong Kee Jeong, Hu-Nan Sun*, Dong-Sun Lee*, Taeho Kwon* (2019)  Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.  International Journal of Molecular Sciences 20(11):2712 (2019/06/02),  (IF=6.208)  doi: 10.3390/ijms20112712,  *Equal Corresponding author

62. Su-Lim Kim, Hack Sun Choi, Ji-Hyang Kim, Dong Kee Jeong, Ki-Seok Kim, Dong-Sun Lee (2019)  Dihydrotanshinone-induced NOX5 Activation Inhibits Breast Cancer Stem Cell through the ROS/Stat3 Signaling Pathway.  Oxid Med Cell Longev. 2019: (2019/03/24),  (IF=7.31)  doi: 10.1155/2019/9296439

 2018

61. Doseung Lee, Taesun Min, Dong-Sun Lee (2018)  Antiviral activity of methanol extract from Rhus chinensis gall (오배자 추출물의 항바이러스 활성).  J. Appl. Biol. Chem. 61(4): 379-382 (2018/12/31),  doi:10.3839/jabc.2018.053

60. Hack Sun Choi, Su-Lim Kim, Ji-Hyang Kim, Hong-Yuan Deng, Bong-Sik Yun, Dong-Sun Lee (2018)  Triterpene Acid (3-Op-Coumaroyltormentic Acid) Isolated From Aronia Extracts Inhibits Breast Cancer Stem Cell Formation through Downregulation of c-Myc Protein.  International Journal of Molecular Sciences 19(9): 2528 (2018/08/26),  doi: 10.3390/ijms19092528

59. Hack Sun Choi, Ji-Hyang Kim, Su-Lim Kim, Hong-Yuan Deng, Doseung Lee, ChangSook Kim, Bong-Sik Yun, Dong-Sun Lee (2018)  Catechol derived from aronia juice through lactic acid bacteria fermentation inhibits breast cancer stem cell formation via modulation Stat3/IL-6 signaling pathway.  Molecular Carcinogenesis 57(11): 1467-1479 (2018/07/02),  doi: 10.1002/mc.22870

2009-2017 (58 publications)

Foreign Patents

•  COMPOSITION COMPRISING CICLESONIDE FOR INHIBITING GROWTH OF CANCER STEM CELL

        China Patent ; CN110072529B, (Date 2022/11/22)

•  COMPOSITION FOR INHIBITING A GROWTH OF CANCER STEM CELLS COMPRISING CICLESONIDE

 USA Patent ; US 11,191,746 (Date 2021/12/07)

• COMPOSITION FOR INHIBITING GROWTH OF BREAST CANCER STEM CELLS CONTAINING PHENYLACETALDEHYDE

USA Patent ; US 11,324,706 (Data 2022/05/10)