Histone variants with diverse roles in gene expression and DNA damage responses.

Ÿ Investigating the interplay between chromatin, DNA repair and nuclear dysfunction

Ÿ Histone variants, macroH2A1.2 as a splicing-modulated caretaker of genome integrity and tumor growth

Ÿ Interested in DNA double-strand break repair via homologous recombination and its impact on the cellular response to replication stress - a major source of endogenous DNA damage associated with cellular senescence and cancer susceptibility

Chromatin dynamics during development and cancer initiation/progression.

Ÿ Histone variants maintain nuclear organization and euchromatin or heterochromatin architecture

Ÿ The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human genomes in space and time with the goal of gaining deeper mechanistic understanding of how the nucleus is organized and functions during development and cancer progression.

The role of N⁶-methyladenosine (m⁶A) RNA modification in Age-related diseases including cancer.

Ÿ m⁶A-mediated regulation of stability of R-loop (RNA:DNA hybrid) formation in human cancers

Ÿ m⁶A and Cancer: Targeting m6A modifications and their regulatory proteins for treatment strategies