Epi-Thera Laboratory

PUBLICATIONS

1. Baek H, Park SU, Kim J. Emerging role for R-loop formation in hepatocellular carcinoma. Genes Genomics. 2023 Jan 12. doi: 10.1007/s13258-022-01360-8.

2. Lee IG, Joo YH, Jeon H, Jeong R, Kim EH, Chung H, Eyun SI, Kim J*, Seo YJ*, Hong SH*. Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4+ T-cell responses. J Leukoc Biol. 2023 Jan 1;113:71-83. doi: 10.1093/jleuko/qiac008. *Corresponding author.

3. An MJ, Lee HM, Kim CH, Shin GS, Jo AR, Kim JY, Kim MJ, Kim J, Park J, Hwangbo Y, Kim J, Kim JW. c-Jun N-terminal kinase 1 (JNK1) phosphorylates OTX2 transcription factor that regulates early retinal development. Genes Genomics. 2022 Nov 24. doi: 10.1007/s13258-022-01342-w.

4. Jeon H, Lim Y, Lee IG, Kim DI, Kim KP, Hong SH*, Kim J*, Jung YS*, Seo YJ*. Inhibition of KIF20A suppresses the replication of influenza A virus by inhibiting viral entry. J Microbiol. 2022 Nov;60(11):1113-1121. doi: 10.1007/s12275-022-2436-x. Epub 2022 Nov 1. *Corresponding author.

5. Ha YS, Kim TK, Park KS, Hwang S, Kim J*, Kim SJ*. Inhibitory effects of Rocaglamide-A on PPARγ-driven adipogenesis through regulation of mitotic clonal expansion involving the JAK2/STAT3 pathway. BBA-Mol Cell Biol Lipids. 2022 Mar 3;159148. doi: 10.1016/j.bbalip.2022.159148. *Corresponding author.

6. JH Yoon, JW Eun, H Ashktorab, D. T. Smoot, JK Kim, SW Nam, WS Park. Depletion of NK6 Homeobox 3 (NKX6.3) causes gastric carcinogenesis through copy number alterations by inducing impairment of DNA replication and repair regulation. Oncogenesis. 2021 Dec 10;10(12):85. doi: 10.1038/s41389-021-00365-4.

7. Kim HG, Cho JH, Kim J*, Kim SJ*. The Role of Epigenetic Changes in the Progression of Alcoholic Steatohepatitis. Front Physiol. 2021 Jul;12:691738. *Corresponding author.

8. Kim J, Sun C, Tran AD, Chin P, Ruiz PD, Wang K, Gibbons RJ, Gamble MJ, Liu Y, Oberdoerffer P. The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening. Nature Structural & Molecular Biology. 2019 Mar;26(3):213-219.

9. Kim J, Khurana S, Oberdoerffer P. The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth. Mol cell Oncol. 2018 Apr 4;5(3):e1441629.

10. Kim J, Sturgill D, Sebastian R, Khurana S, Tran AD, Kruswick A, Burkett S, Nayer Z, Weyemi U, Bonner W, Oberdoerffer P. Replication stress shapes a protective chromatin environment across fragile genomic regions. Mol Cell. 2018 Jan 4;69(1):36-47.e7. Cover.

11. Kim J, Sturgill D, Tran AD, Sinclair DA, Oberdoerffer P. Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability. Nucleic Acids Res. 2016 Apr 20;44(7):e64.

12. Khurana S, Kruhlak MJ, Kim J, Tran AD, Liu J, Nyswaner K, Shi L, Jailwala P, Sung MH, Hakim O, Oberdoerffer P. A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance. Cell Rep. 2014 Aug 21;8(4)1049-62.

13. Park SJ, Kim JK, Bae HJ, Eun JW, Shen Q, Kim HS, Shin WC, Yang HD, Lee EK, You JS, Park WS, Lee JY, Nam SW. HDAC6 sustains growth stimulation by prolonging the activation of EGF receptor through the inhibition of rabaptin-5-mediated early endosome fusion in gastric cancer. Cancer Lett. 2014 Nov 1;354(1):97-106.

14. Liu J, Kim J, Oberdoerffer P. Metabolic modulation of chromatin: implications for DNA repair and genomic integrity. Front Genet. 2013 Sep 14;4,182, Review.

15. Kim JK, Eun JW, Bae HJ, Shen Q, Park SJ, Kim HS, Park S, Ahn YM, Park WS, Lee JY, Nam SW. Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver. Biomarkers. 2013 Dec;18(8):706-15.

16. Bae HJ, Noh JH, Kim JK, Eun JW, Jung KH, Kim MG, Chang YG, Shen Q, Kim SJ, Park WS, Lee JY, Nam SW. MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. Oncogene. 2013 Jun 3. doi: 10.1038/onc.2013.216. [Epub ahead of print]

17. Noh JH, Chang YG, Kim MG, Jung KH, Kim JK, Bae HJ, Eun JW, Shen Q, Kim SJ, Kwon SH, Park WS, Lee JY, Nam SW. MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer. Cancer Lett. 2013 Jul 28;335(2):455-62.

18. Kim JK, Noh JH, Eun JW, Jung KH, Bae HJ, Shen Q, Kim MG, Chang YG, Kim SJ, Park WS, Lee JY, Borlak J, Nam SW. Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer. Mol Cancer Res, 2013 Jan;11(1):62-73.

19. Jung KH, Kim JK, Noh JH, Eun JW, Bae HJ, Kim MG, Chang YG, Shen Q, Kim SJ, Kwon SH, Park WS, Lee JY, Nam SW. Characteristic molecular signature for the early detection and prediction of polycyclic aromatic hydrocarbons in rat liver. Toxicol Lett. 2013 Jan 10;216(1):1-8.

20. Kim JK, Noh JH, Jung KH, Eun JW, Bae HJ, Kim MG, Chang YG, Shen Q, Park WS, Lee JY, Borlak J, Nam SW. Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b. Hepatology, 2013 Mar;57(3):1055-67.

21. Bae HJ, Chang YG, Noh JH, Kim JK, Eun JW, Jung KH, Kim MG, Shen Q, Ahn YM, Kwon SH, Park WS, Lee JY, Nam SW. DBC1 does not function as a negative regulator of SIRT1 in liver cancer. Oncol Lett. 2012 Nov;4(5):873-877.

22. Jung KH*, Kim JK*, Kim MG, Noh JH, Eun JW, Bae HJ, Chang YG, Shen Q, Park WS, Lee JY, Nam SW. Characteristic molecular signature for early detection and prediction of persistent organic pollutants in rat liver. Environ Sci Technol. 2012 Dec 4;46(23):12882-9. *Co-first authors.

23. Xie HJ, Noh JH, Kim JK, Jung KH, Eun JW, Bae HJ, Kim MG, Chang YG, Lee JY, Park H, Nam SW. HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer. PLoS One, 2012;7(4):e34265.

24. Jung KH, Noh JH, Kim JK, Eun JW, Bae HJ, Xie HJ, Chang YG, Kim MG, Park H, Lee JY, Nam SW. HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins. J Cell Biochem. 2012 Jun;113(6):2167-77.

25. Jung KH, Noh JH, Kim JK, Eun JW, Bae HJ, Chang YG, Kim MG, Park WS, Lee JY, Lee SY, Chu IS, Nam SW. Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer. Hepatology. 2012 Aug;56(2):644-57.

26. Noh JH, Jung KH, Kim JK, Eun JW, Bae HJ, Xie HJ, Chang YG, Kim MG, Park WS, Lee JY, Nam SW. Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins. PLoS One. 2011;6(11):e28103.

27. Jung KH, Noh JH, Eun JW, Kim JK, Bae HJ, Xie H, Jang JJ, Ryu JC, Park WS, Lee JY, Nam SW. Molecular signature for early detection and prediction of polycyclic aromatic hydrocarbons in peripheral blood. Environ Sci Technol. 2011 Jan 1;45(1):300-6.

28. Kim JK, Jung KH, Noh JH, Eun JW, Bae HJ, Xie HJ, Jang JJ, Ryu JC, Park WS, Lee JY, Nam SW. Identification of characteristic molecular signature for volatile organic compounds in peripheral blood of rat. Toxicol Appl Pharmacol. 2011 Jan 15;250(2):162-9.

29. Kim JK, Kim PJ, Jung KH, Noh JH, Eun JW, Bae HJ, Xie HJ, Shan JM, Ping WY, Park WS, Lee JY, Nam SW. Decreased expression of annexin A10 in gastric cancer and its overexpression in tumor cell growth suppression. Oncol Rep. 2010 Sep;24(3):607-12.

30. Jung KH, Kim JK, Noh JH, Eun JW, Bae HJ, Xie HJ, Ahn YM, Park WS, Lee JY, Nam SW. Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma. J Cell Biochem. 2010 Jun 1;110(3):687-96.

31. Eun JW, Kwack SJ, Noh JH, Jung KH, Kim JK, Bae HJ, Xie H, Ryu JC, Ahn YM, Park WS, Lee JY, Rhee GS, Nam SW. Identification of post-generation effect of 3,4-methylenedioxy-methamphetamine on the mouse brain by large-scale gene expression analysis. Toxicol Lett. 2010 May 19;195(1):60-7.

32. Kim JK, Jung KH, Noh JH, Eun JW, Bae HJ, Xie HJ, Ahn YM, Ryu JC, Park WS, Lee JY, Nam SW. Targeted disruption of S100P suppresses tumor cell growth by down-regulation of cyclin D1 and CDK2 in human hepatocellular carcinoma. Int J Oncol. 2009 Dec;35(6):1257-64.

33. Bae HJ, Eun JW, Noh JH, Kim JK, Jung KH, Xie HJ, Park WS, Lee JY, Nam SW. Down-regulation of transforming growth factor beta receptor type III in hepatocellular carcinoma is not directly associated with genetic alterations or loss of heterozygosity. Oncol Rep. 2009 Sep;22(3):475-80.

34. Noh JH, Song JH, Eun JW, Kim JK, Jung KH, Bae HJ, Xie HJ, Ryu JC, Ahn YM, Wee SJ, Park WS, Lee JY, Nam SW. Systemic cell-cycle suppression by Apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells. Int J Mol Med. 2009 Aug;24(2):205-26.

35. Bae HJ, Song JH, Noh JH, Kim JK, Jung KH, Eun JW, Xie HJ, Ryu JC, Ahn YM, Kim SY, Lee SH, Yoo NJ, Lee JY, Park WS, Nam SW. Low frequency mutation of the Ephrin receptor A3 gene in hepatocellular carcinoma. Neoplasma. 2009;56(4):331-4.

36. Eun JW, Kwack SJ, Noh JH, Jung KH, Kim JK, Bae HJ, Xie H, Ryu JC, Ahn YM, Min JH, Park WS, Lee JY, Rhee GS, Nam SW. Transcriptomic configuration of mouse brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine. Toxicol Appl Pharmacol. 2009 May 15;237(1):91-101.

37. Xie HJ, Bae HJ, Noh JH, Eun JW, Kim JK, Jung KH, Ryu JC, Ahn YM, Kim SY, Lee SH, Yoo NJ, Lee JY, Park WS, Nam SW. Mutational analysis of JAK1 gene in human hepatocellular carcinoma. Neoplasma. 2009;56(2):136-40.

38. Eun JW, Ryu SY, Noh JH, Lee MJ, Jang JJ, Ryu JC, Jung KH, Kim JK, Bae HJ, Xie H, Kim SY, Lee SH, Park WS, Yoo NJ, Lee JY, Nam SW. Discriminating the molecular basis of hepatotoxicity using the large-scale characteristic molecular signatures of toxicants by expression profiling analysis. Toxicology. 2008 Jul 30;249(2-3):176-83.