#co-correspondence, *equal contribution
2025
I. Ahn*, S. Chang*, J. Lee, S.-H. Choi, J. Han#, Y. Kim# “Exploration of Novel Biomarkers through a Precision Medicine Approach Using Multi-omics and Brain Organoids in Patients with Atypical Depression and Psychotic Symptoms” Advanced Science 2025.10.31; https://doi.org/10.1002/advs.202508383 (bioRxiv, 2025.04.23; doi:10.1101/2025.04.21.649748)
[bioRxiv] H. Do, D. Kim, R. Jappelli, H. Yang, Y. Jeon, G. Son, M. Ju, J.-H. Son, I. Ahn, C.K. Lim, J. Ji, J. Lee, Y.-K. Kim, J.-Y. An, S.-H. Lee, D. Lee, F.H. Gage, J. Han "AGO1 in neural progenitor cells orchestrates brain development and sociability via LIN28A-REELIN axis" doi: https://doi.org/10.1101/2025.10.01.679670
Y. An, J.-H. Lee, J. Lim, J. Youk, S. Park, J.-H. Park, K. Yi, T. Kim, C.H. Nam, W.H. Lee, S.A. Oh, Y.J. Bae, T.M. Klompstra, H. Lee, J. Han, J. Lee, J. W. Park, J.-H. Kim, H. Kim, H. Snippert, B.-K. Koo#, and Y.S. Ju# “APOBEC3A drives deaminase mutagenesis in human gastric epithelium” Genome Research 2025 Aug 26:gr.280338.124. doi: 10.1101/gr.280338.124
G.H. Baek*, D. Kim*, G. Son*, H. Do*, G.-B. Yeon, M.J. Lee, M. Ji, J.-H. Son, M. Ju, I. Ahn, C.S. Kang, H. Lee, S. Choi, J. M. Suh, J. Seo, F.H. Gage, M.-J. Paik, Y.K. Park, D.-S Kim and J. Han "Differential effects of lithium on metabolic dysfunctions in astrocytes derived from bipolar disorder patients" Molecular Psychiatry 2025.8.22; doi: https://doi.org/10.1038/s41380-025-03176-w
[bioRxiv] Dayeon Kim, Y. Koh, H.S. Jeong, J. Kim, H. Do, G. Son, Y. Kim, Donghyuk Kim, H.-H. Lim# , J.-E Park# , J. Han# " MEG3 Enhances Survival of Developing Human Neurons with CLCN4-Linked Autophagy Impairment" 2025.07.19; doi: https://doi.org/10.1101/2025.07.16.665078
S.M. Lee *, Y. Choi *, D. Kim, H.J. Jeong, Y.H. Do, S. Jung, B. Lee, H. J. Choi, S. Kim, J.-M. Oh, S. Jeon, J. Han#, Y. Kim# "Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model : Endophenotypic target for ASD" Translational Psychiatry, 2025 Jan 25;15(1):28. doi: 10.1038/s41398-024-03201-6
2024
G. Son, Y. Na, Y. Kim, J.-H Son, G. D. Clemenson, S. T. Schafer, J.-Y. Yoo, S. Parylak, A. Paquola, H. Do, D. Kim, I. Ahn, M. Ju, C.S. Kang, Y. Ju, E. Jung, A. McDonald, Y. Park, G. Kim, S.-B. Paik, J. Hur, J. Kim, Y.-M. Han, S.-H Lee, F. H. Gage, J.-S. Kim and J. Han “miR-124 coordinates metabolic regulators acting at early stages of human neurogenesis” Communications Biology 2024 Oct 25, DOI : 10.1038/s42003-024-07089-2.
Y.-K. Kim, J. Han "Nobel-winning microRNA, the micromaestro of gene silencing" Molecules and Cells, 2024, Volume 47, Issue 11, https://doi.org/10.1016/j.mocell.2024.100123
J. Ku, K. Lee, D. Ku, S. Kim, J. Lee, H. Bang, N. Kim, H. Do, H. Lee, C. Lim, J. Han , Y.S. Lee, Y. Kim "Alternative polyadenylation determines the functional landscape of inverted Alu repeats" Molecular Cell, 2024 Jan 30:S1097-2765(24)00009-1. doi: 10.1016/j.molcel.2024.01.008.
2023
E. Nam, A.Y. Lin, J. Park, H. Do, Jiyeon Han, B. Jeong, S. Park, D.Y. Lee, M. Kim, J. Han#, M.H. Baik#, Y.H. Lee#, M.H. Lim# "APP-C31: An Intracellular Promoter of Both Metal-Free and Metal-Bound Amyloid-β40 Aggregation and Toxicity in Alzheimer's Disease" Advanced Science, 2023 Nov 11. doi: 10.1002/advs.202307182
I. Ahn, C.S. Kang, and J. Han "Where should siRNAs go: applicable organs for siRNA drugs" Experimental & Molecular Medicine. 2023 July 10; https://doi.org/10.1038/s12276-023-00998-y
C.H. Nam, J. Youk, J.Y. Kim, J. Lim, J.W. Park, S.A. Oh, H.J. Lee, J. W. Park, H. Won, Y. Lee, S. Y. Jeong, D. S. Lee, J. W. Oh, J. Han, J. Lee, H. W. Kwon, M.J. Kim, Y.S. Ju "Widespread somatic L1 retrotransposition in normal colorectal epithelium" Nature. 2023 May 10. doi: 10.1038/s41586-023-06046-z.
M. Ju, D. Kim, G. Son, J. Han. "Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs" Molecules and Cells. 2023 Jan 31;46(1):33-40. doi: 10.14348/molcells.2023.2170.
2022
B. Kim, Y. Koh, H. Do, Y. Ju, J.B. Choi, G. Cho, H.-W. Yoo, B.H. Lee, J. Han, J.-E. Park#, and Y.-M. Han# (2022) "Aberrant Cortical Layer Development of Brain Organoids Derived from Noonan Syndrome-iPSCs" Int. J. Mol. Sci. 23(22), 13861
C.S. Park, S.H. Kim, H.Y. Yang, J.-H Kim, R. Schermuly, Y.S. Cho, H. Kang, J.-H. Park, E. Lee, H. Park, J.M. Yang, T.W. Noh, S.-P. Lee, S.S. Bae, J. Han, Y. S. Ju, J.-B. Park, and I. Kim (2022) "Sox17 deficiency promotes pulmonary arterial hypertension via HGF/c-Met signalling" Circulation Research 131(10):792-806
J.-H. Son, H. Do, and J. Han (2022) "Intragenic L1 Insertion: One Possibility of Brain Disorder" Life 12(9), 1425
2021
S.G. Kim*, S. Lee*, Y. Kim, J.E. Park, D. Woo, D. Kim, Y. Li, W. Shin, H. Kang, C. Yook, M. Lee, K. Kim, J.D. Roh, J. Ryu, H. Jung, S.M. Um, E. Yang, H. Kim, J. Han, W. D. Heo, and E. Kim (2021) "Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons" Nature communications
M. Bae*, J.D. Roh*, Y. Kim, S.S. Kim, H.M. Han, E. Yang, H. Kang, S. Lee, J.Y. Kim, R. Kang, H. Jung, T. Yoo, H. Kim, D. Kim, H. Oh, S. Han, D. Kim, J. Han, Y.C. Bae, H. Kim, S. Ahn, A.M. Chan, D. Lee, J. Kim, and E. Kim. (2021) "SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function" EMBO Mol Med
2020
M.B. Aldonza, J. Ku, J-.Y. Hong, D.Kim, S.J. Yu, M. Lee, M.C. Prayogo, S. Tan, D. Kim, J. Han, S.K. Lee, S.G. Im, H.S. Ryu, Y. Kim (2020) "Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms" Science Advances
2018
G. Son and J. Han (2018) "Roles of mitochondria in neuronal development" BMB Reports 51, 549-556
H.Y. Koh, S.H. Kim, J. Jang, H. Kim, S. Han, J.S. Lim, G.Son, J. Choi, B.O. Park, W.D. Heo, J.Han, H.J. Lee, D. Lee, H.C. Kang, M. Shong, S.B. Paik, D.S. Kim, J.H. Lee (2018) “BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors” Nature Medicine 24, 1662-1668
2003- 2016
J. Han# and F.H. Gage# (2016) “A role for miR-19 in the migration of adult-born neurons and schizophrenia” Neurogenesis doi:10.1080/23262133.2016.1251873
J. Han#, H.J. Kim*, S.T. Schafer*, A. Paquola, G.D. Clemenson, T. Toda, J. Oh, A.R. Pankonin, B.S. Lee, S.T. Johnston, A. Sarkar, A.M. Denli and F.H. Gage# (2016) “Functional implications of miR-19 in the migration of newborn neurons in the adult brain” Neuron 91, 79-89; doi: 10.1016/j.neuron.2016.05.034
J. Han, A. Sarkar and F.H. Gage (2015) “MIR137: big impacts from small changes” Nature Neuroscience 18, 931–933; doi:10.1038/nn.4045
S.T. Schafer, J. Han, M. Pena, O.V.B. Halbach, J. Peters, and F.H. Gage (2015) “The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis” The Journal of Neuroscience 35(12), 4983-4998; doi: 10.1523/JNEUROSCI.4130-14.2015
J. Han, A.M. Denli, and F.H. Gage (2012) “The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis” Genes & Development 26:6-10; doi: 10.1101/gad.184416.111.
H. Jin*, M.R. Suh*, J. Han, K.-H. Yeom, Y. Lee, I. Heo, M. Ha, S. Hyun and V. N. Kim (2009) " Human UPF1 participates in small RNA-induced mRNA downregulation” Molecular and Cellular Biology 29(21):5789-99; doi: 10.1128/MCB.00653-09
I. Heo*, C. Joo*, Y.-K. Kim*, M. Ha, M.-J. Yoon, J. Cho, K.-H. Yeom, J. Han and V. N. Kim (2009) "TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation" Cell 138:696–708; doi: 10.1016/j.cell.2009.08.002
V.N. Kim, J. Han, and M.C. Siomi (2009) "Biogenesis of small RNAs in animals" Nature Reviews: Molecular Cell Biology 10:126-139; doi: 10.1038/nrm2632
J. Han, J. S. Pedersen*, S. C. Kwon*, C. Belair*, Y. K. Kim, K. H. Yeom, W. Y. Yang, D. Haussler, R. Blelloch, and V. N. Kim (2009) " Posttranscriptional crossregulation between Drosha and DGCR8" Cell 136:75-84; doi: 10.1016/j.cell.2008.10.053
I. Heo*, C. Joo*, J. Cho, M. Ha, J. Han and V. N. Kim (2008) "Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA” Molecular Cell 32:1-9; doi: 10.1016/j.molcel.2008.09.014
Y. Lee, J. Han, K. H. Yeom, H. Jin and V.N. Kim (2006) "Drosha in primary microRNA processing" Cold Spring Harbor Symposia on Quantitative Biology 71:51-7
K. H. Yeom, Y. Lee, J. Han, M. R. Suh and V. N. Kim (2006) "Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing" Nucleic Acids Research 34(16):4622-9; doi: 10.1093/nar/gkl458
J. Han*, Y. Lee*, K. H. Yeom*, J. W. Nam, I. Heo, J. K. Rhee, S. Y. Sohn, Y. Cho, B. T. Zhang, and V. N. Kim (2006) "Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex" Cell 125(5):887-901; doi: 10.1016/j.cell.2006.03.043
J. W. Nam, K. R. Shin, J. Han, Y. Lee, and V. N. Kim, B. T. Zhang (2005) "Human microRNA prediction through a probabilistic co-learning model of sequence and structure" Nucleic Acids Research 33(11):3570-81; doi: 10.1093/nar/gki668
J. Han*, Y. Lee*, K. H. Yeom, Y. K. Kim, H. Jin and V. N. Kim (2004) "The Drosha-DGCR8 complex in primary microRNA processing" Genes & Development 18(24):3016-27; doi: 10.1101/gad.1262504
Y. Lee, M. Kim, J. Han, K. H. Yeom, S. Lee, S. H. Baek, and V. N. Kim (2004) "MicroRNA genes are transcribed by RNA polymerase II" EMBO Journal 23(20):4051-60; doi: 10.1038/sj.emboj.7600385
Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, J. Lee, P. Provost, O. Radmark, S. Kim, and V. N. Kim (2003) "The nuclear RNase III Drosha initiates microRNA processing" Nature 425(6956):415-9; doi:10.1038/nature01957