Research Areas

1. Activity-Based Probes & Covalent Chemical Biology

We develop activity-based probes (ABPs) that selectively target disease-associated enzymes and enable the functional interrogation of proteins in complex biological systems.

• Development of activity-based probes for selective targeting of disease-associated enzymes

• Discovery of novel covalent warheads and covalent inhibitors

• Chemoproteomics-based characterization of drug–protein interactions and identification of therapeutic targets

2. Covalent Medicinal Chemistry & Drug Discovery

We integrate synthetic chemistry, medicinal chemistry, and structure-guided/AI approaches to discover and optimize bioactive molecules and selective covalent inhibitors.

• Design and synthesis of novel bioactive molecules through organic and medicinal chemistry

• Development of covalent inhibitors using structure-based and computational/AI approaches

• Construction of focused covalent compound libraries and systematic structure–activity relationship (SAR) studies

3. Molecular Imaging & Chemical Probe Development

We develop chemical probes and molecular imaging agents that enable selective visualization of disease-associated biomarkers in cells and living systems.

• Development of fluorescent and molecular imaging probes for selective detection of disease-associated biomarkers

• Development of imaging/theranostic agents for the diagnosis/treatment of infectious diseases and cancer

• Characterization of probe activity, selectivity, and imaging performance in cellular and animal models