Publications at SKKU

25. Coming soon!

Publications before joining SKKU

24. Imaging of Staphylococcus aureus infections and biofilms using a selective covalent probe for the unique serine hydrolase FphE

Woods, E. C.†; Upadhyay, T.†; Park, K. W.; Su, S.-P.; Xiao, Z.; Rao, J.; Valdez, T. A.; Jo, J.*; Bogyo, M.*

Angew. Chem. Int. Ed. 2026, 65, e9575966. (Selected as a Hot Paper)

23. Unique structural and ligand binding properties of the Staphylococcus aureus serine hydrolase FphE

Jo, J.†; Upadhyay, T.; You, X.; Bennett, J. M.; Lee, H.; Bogyo, M.*; Fellner, M.†*

Proc. Natl. Acad. Sci. U. S. A. 2026, 123, e2532683123.

22. A pipeline for proteome-wide analysis of electrophile selectivity

Jo, J.*, Bogyo, M.*

Nat. Chem. 2025, 17, 1638–1640.

21. Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation

Upadhyay, T.; Woods, E. C.; Dela Ahator, S.; Julin, K.; Faucher, F. F.; Uddin, M. J.; Hollander, M. J.; Pedowitz, N. J.; Abegg, D.; Hammond, I.; Eke, I. E.; Wang, S.; Chen, S.; Bennett, J. M.; Jo, J.; Lentz, C. S.; Adibekian, A.; Fellner, M.; Bogyo, M.*

Nat. Commun. 2025, 16, 5046.

20. A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

Kim, M.-J.†; Kwak, J.†; Kim, H. S.; Han, J.; Kang, J. A.; Jo, J.; Kim, J.; Kim, D.-J.; Lee, H. S.; Yun, H.*; Jeong, J.-Y.*

Mol. Cancer Ther. 2025, 24, 1546–1560.

19. An mRNA Display Approach for Covalent Targeting of a Staphylococcus aureus Virulence Factor

Wang, S.; Woods, E. C.; Jo, J.; Zhu, J.; Hansel-Harris, A.; Holcomb, M.; Llanos, M.; Pedowitz, N. J.; Upadhyay, T.; Bennett, J.; Fellner, M.; Park, K. W.; Zhang, A.; Valdez, T. A.; Forli, S.; Chan, A. I.*; Cunningham, C. N.*; Bogyo, M.*

J. Am. Chem. Soc. 2025, 147, 8312–8325.

18. Discovery of N-Aryl-N′-[4-(aryloxy)cyclohexyl]squaramide-based Inhibitors of LXR/SREBP-1c Signaling Pathway Ameliorating Steatotic Liver Disease: Navigating the Role of SIRT6 Activation

Nguyen, L. H.†; Cho, Y. E.†; Kim, S.; Kim, Y.; Kwak, J.; Suh, J.-S.; Lee, J.; Son, K.; Kim, M.; Jang, E. S.; Song, N.; Choi, B.; Kim, J.; Tak, Y.; Hwang, T.; Jo, J.; Lee, E.-W.; Kim, S.-B.; Kim, S.; Kwon, O.-B.; Kim, S.; Lee, S. R.; Lee, H.; Kim, T.-J.*; Hwang, S.*; Yun, H.*

J. Med. Chem. 2024, 67, 17608–17628.

17. NRF2 Activation by AR-20007 Preserves Renal Tubular Epithelial Cells from Antimycin A-Induced Cell Death via Glutathione Metabolism Regulation

Yoo, J.†; Jo, J.†; Ha, S.; Kwak, J.; Kim, M.-J.; Kim, J.; Kim, J.; Lee, H.; Kim, D.; Kim, B. M.; Kim, J.; Yun, H.; Koh, M.*; Chung, K. W.*

Biol. Pharm. Bull. 2024, 47, 1557–1564.

16. AM-18002, a derivative of natural anmindenol A, enhances radiosensitivity in mouse breast cancer cells

Eum, D.-Y.†; Jeong, M.†; Park, S.-Y.†; Kim, J.; Jin, Y.; Jo, J.; Shim, J.-W.; Lee, S. R.; Park, S.-J.; Heo, K.; Yun, H.*; Choi, Y.-J.*

PLoS ONE 2024, 19, e0296989.

15. Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of Staphylococcus aureus Infections

Jo, J.†; Upadhyay, T.†; Woods, E. C.; Park, K. W.; Pedowitz, N. J.; Jaworek-Korjakowska, J.; Wang, S.; Valdez, T. A.; Fellner, M.; Bogyo, M.*

J. Am. Chem. Soc. 2024, 146, 6880–6892.

14. Synthesis of Benzo[a]fluorene, Benzo[c]fluorene, and Benzo[j]fluoranthene via a Lewis Acid-Catalyzed Prins-Type Cycloaromatization: Application to the Total Synthesis of Viridistratin A

Jeong, M.†; Yoon, M.†; Nguyen, L. H.†; Kim, S.; Han, J.; Tran, C. S.; Kim, J.; Jo, J.; Jung, Y.-S.; Yoo, J.-W.; Yun, H.*

Adv. Synth. Catal. 2024, 366, 390–395.

13. Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators

Jo, J.†; Kim, J.†; Ibrahim, L.; Kumar, M.; Iaconelli, J.; Tran, C. S.; Moon, H. R.; Jung, Y.; Wiseman, R. L.; Lairson, L. L.; Chatterjee, A. K.; Bollong, M. J.*; Yun, H.*

Bioorg. Med. Chem. Lett. 2023, 89, 129306.

12. A bioisosteric approach to the discovery of novel N-aryl-N′-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation

Kwak, J.†; Kim, M.-J.†; Kim, S.; Park, G.-B.; Jo, J.; Jeong, M.; Kang, S.; Moon, S.; Bang, S.; An, H.; Hwang, S.; Kim, M.-S.; Yoo, J.-W.; Moon, H. R.; Chang, W.; Chung, K. W.; Jeong, J.-Y.*; Yun, H.*

Eur. J. Med. Chem. 2022, 239, 114501.

11. Discovery and optimization of novel 3-benzyl-N-phenyl-1H-pyrazole-5-carboxamides as bifunctional antidiabetic agents stimulating both insulin secretion and glucose uptake

Jo, J.†; Lee, D.†; Park, Y. H.; Choi, H.; Han, J.; Park, D. H.; Choi, Y.-K.; Kwak, J.; Yang, M.-K.; Yoo, J.-W.; Moon, H. R.; Geum, D.; Kang, K. S.*; Yun, H.*

Eur. J. Med. Chem. 2021, 217, 113325.

10. Recent advances in development of hetero-bivalent kinase inhibitors

Lee, S.†; Kim, J.†; Jo, J.; Chang, J. W.; Sim, J.*; Yun, H.*

Eur. J. Med. Chem. 2021, 216, 113318.

9. Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators

Jo, J.†; Ibrahim, L.†; Iaconelli, J.; Kwak, J.; Kumar, M.; Jung, Y.; Lairson, L. L.; Chatterjee, A. K.; Schultz, P. G.; Bollong, M. J.*; Yun, H.*

Bioorg. Chem. 2021, 108, 104614.

8. SAR optimization studies on a novel series of 2-anilinopyrimidines as selective inhibitors against triple-negative breast cancer cell line MDA-MB-468

Jo, J.†; Kim, H.†; Oh, J. Y.†; Kim, S.; Park, Y. H.; Choi, H.; Jeong, J.-Y.; Jung, Y.-S.*; Yun, H.*

Bioorg. Med. Chem. Lett. 2019, 29, 126752.

7. Divergent Synthetic Route to Oxidized Benzofulvene Sesquiterpenoids: Protecting-Group-Free Total Synthesis of Nicotianasesterpenes A, B and a Polygonum Sesquiterpenoid

Jeong, M.; Lee, H.; Kim, G.; Jo, J.; Chang, J. W.; Jung, J. H.; Suh, Y.-G.; Yun, H.*

Eur. J. Org. Chem. 2019, 6714–6719.

6. Total Synthesis of Anmindenol A and Its Application to the Design, Synthesis, and Biological Evaluation of Derivatives Thereof

Jo, J.†; Jeong, M.†; Ahn, J.-S.; Akter, J.; Kim, H.-S.; Suh, Y.-G.; Yun, H.*

J. Org. Chem. 2019, 84, 10953–10961.

5. Dual effects of isoflavonoids from Pueraria lobata roots on estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells

Ahn, S.-Y.†; Jo, M. S.†; Lee, D.; Baek, S.-E.; Baek, J.; Yu, J. S.; Jo, J.; Yun, H.; Kang, K. S.; Yoo, J.-E.*; Kim, K. H.*

Bioorg. Chem. 2019, 83, 135–144.

4. Discovery and SAR studies of novel 2-anilinopyrimidine-based selective inhibitors against triple-negative breast cancer cell line MDA-MB-468

Jo, J.†; Kim, S. H.†; Kim, H.; Jeong, M.; Kwak, J.-H.; Han, Y. T.; Jeong, J.-Y.; Jung, Y.-S.*; Yun, H.*

Bioorg. Med. Chem. Lett. 2019, 29, 62–65.

3. Beneficial effects of Cirsium japonicum var. maackii on menopausal symptoms in ovariectomized rats

Park J. Y.†; Yun, H.†; Jo, J.; Baek, J. Y.; Lee, S. C.; Choi, Y. J.; Shim, J. S.; Choi, H. J.; Lee, S.*; Kang, K. S.*

Food Funct. 2018, 9, 2480–2489.

2. Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis

Jo, J.†; Kim, S.-H.†; Han, Y. T.; Kwak, J.-H.; Yun, H.*

Molecules 2017, 22, 1069.

1. Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis

Paek, S.-M.; Jeong, M.; Jo, J.; Heo, Y. M.; Han, Y. T.; Yun, H.*

Molecules 2016, 21, 951.