2024

Peter Obi, Jeevan B GC, Charles Mariasoosai, Ayobami Diyaolu, Senthil Natesan. Application of Generative Artificial Intelligence in Predicting Membrane Partitioning of Drugs: Combining Denoising Diffusion Probabilistic Models and MD Simulations Reduces the Computational Cost to One-Third. Journal of Chemical Theory and Computation, 2024,  https://pubs.acs.org/doi/abs/10.1021/acs.jctc.4c00315.

2023

Jeevan B. GC, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose & Senthil Natesan. Molecular basis for the recognition of 24‐(S)‐hydroxycholesterol by integrin αvβ3. Scientific Reports 13, Article number: 9166 (2023) https://www.nature.com/articles/s41598-023-36040-4

Jeevan B. GC,  Christopher T. Szlenk,  Ayobami Diyaolu,  Peter Obi, Haiyang Wei,  Xutong Shi,  K. Michael Gibson,  Senthil Natesan,  and Jean-Baptiste Roullet. Allosteric modulation of a1b3g2 GABAA receptors by farnesol through the neurosteroid sites. Biophysical Journal 122, 1–19, March 7, 2023 https://doi.org/10.1016/j.bpj.2023.01.032

2022

Marissa J. Stutzman, C.S. John Kim, David J. Tester, Samantha K. Hamrick, Steven M. Dotzler, John R. Giudicessi,  Marco C. Miotto, Jeevan B. GC, Joachim Frank, Andrew R. Marks, and Michael J. Ackerman, Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential; Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2022.07.002

Jonathan Shintaku, Wolfgang M. Pernice, Wafaa Eyaid, Jeevan B. GC, Zuben P. Brown, Marti Juanola-Falgarona, Javier Torres-Torronteras, Ewen W. Sommerville, Debby M.E.I. Hellebrekers, Emma L. Blakely, Alan Donaldson, Ingrid M.B.H. van de Laar, Cheng-Shiun Leu, Ramon Marti, Joachim Frank, Kurenai Tanji, David A. Koolen, Richard J. Rodenburg, Patrick F. Chinnery, H.J.M. Smeets, Gráinne S. Gorman, Penelope E. Bonnen, Robert W. Taylor, and Michio Hirano, "RRM1 variants cause a mitochondrial DNA maintenance disorder via impaired de novo nucleotide synthesis"; J Clin Invest. https://doi.org/10.1172/JCI145660

2021

Christopher T. Szlenk, Jeevan B. GC and Senthil Natesan, "Membrane-facilitated receptor access and binding mechanisms of long-acting β2-adrenergic receptor (β2-AR) agonists", Molecular Pharmacology, August 1, 2021, MOLPHARM-AR-2021-000285; DOI: https://doi.org/10.1124/molpharm.121.000285

2020

Michael J. Espiritu, Justin Chen, Jaydeep Yadav, Michael Larkin, Robert D. Pelletier, Jeannine M. Chan, Jeevan B. GC, Senthil Natesan, and John P. Harrelson, "Mechanisms of Herb-Drug Interactions Involving Cinnamon and Cytochrome P450 2A6: Focus on Time-dependent Inhibition by Cinnamaldehyde and 2- Methoxycinnamaldehyde",  Drug Metabolism and Disposition, July 15 2020, http://dmd.aspetjournals.org/content/early/2020/08/12/dmd.120.000087 (Editor's choice).

Jeevan B. GC, Christopher T. Szlenk, Jin Gao, Xinyue Dong, Zhenjia Wang, and Senthil Natesan, "Molecular Dynamics Simulations Provide Insight into the Loading Efficiency of Pro-Resolving Lipid Mediators Resolvin D1 and D2 in Cell Membrane-Derived Nanovesicles", Molecular Pharmaceutics, 2020, 17, 6, 2155–2164.

2019

Christopher Szlenk, Jeevan B. GC, and Senthil Natesan, "Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of GPCRs?", Molecular Pharmacology, November 2019,  96 (5) 527-541.

Swechha M. Pokharel, Niraj K. Shill, Jeevan B. GC, Zachary T. Colburn, Su-Yu Tsai, Jesus A. Segovia, Te-Hung Chang, Smarajit Bandyopadhyay, Senthil Natesan, Jonathan C. R. Jones & and Santanu Bose, '"Integrin activation by the lipid molecule 25-hydroxycholesterol induces a proinflammatory response",  Nature Communications, 10, 1482, 2019.

2018

Kathryn Del Vecchio, Cary T. Frick, Jeevan B. GC, Shun-ichiro Oda, Bernard S. Gerstman, Erica Ollmann Saphire, Prem P. Chapagain and Robert V. Stahelin, "A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine", Journal of Biological Chemistry, 2018, 293(9) 3335–3349.

2017

Jeevan B. GC, Rudra P. Pokhrel, Nisha Bhattarai, Bernard S. Gerstman, Kristen Johnson, Robert V. Stahelin, Prem P.Chapagain, "Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments", Biochemical Biophysical Research Communications (BBRC), 2017, 493(1), 176-181.

Jeevan B. GC, Bernard S. Gerstman, and Prem P. Chapagain, "Membrane Association and Localization Dynamics of the Ebola Virus Matrix Protein VP40", Biochimica et Biophysica Acta (BBA) – Biomembranes, 2017, 1859(10), 2012-2020.

Nisha Bhattarai, Jeevan B. GC, Bernard S. Gerstman, Robert V. Stahelin, Prem P. Chapagain, "Plasma Membrane Association Facilitates Conformational Changes in Marburg Virus Protein VP40 Dimer", RSC advances, 2017, 7, 22741-22748.

2016

Jeevan B. GC, Bernard S. Gerstman, Robert V. Stahelin and Prem P. Chapagain, "The Ebola virus protein VP40 hexamer enhances the clustering of PIP2 lipids in the Plasma membrane", Journal of Physical Chemistry Chemical Physics, 2016, 18, 28409-28417. (Cover Image Article)

Jeevan B. GC, Kristen A. Johnson, Monica L. Husby, Cary T. Frick, Bernard S. Gerstman, Robert V. Stahelin, and Prem P. Chapagain, "Interdomain salt-bridges in Ebola virus protein VP40 and their role on domain association and plasma membrane localization", Protein Science, 2016, 25(9), 1648–1658

2015

Jeevan B. GC, Bernard S. Gerstman, and Prem P. Chapagain, "The Role of the Interdomain interactions on RfaH dynamics and conformational transformation", Journal of Physical Chemistry B, 2015. 119 (40), pp 12750–12759.

2014

Jeevan B. GC, Yuba R. Bhandari, Bernard S. Gerstman, and Prem P. Chapagain, "Molecular dynamics investigations of the α-helix to β-barrel conformational transformation in the RfaH transcription factor", Journal of Physical Chemistry B, 2014. 118 (19), pp 5101–5108.

Book Chapter

Bernard S. Gerstman, Prem P. Chapagain, Jeevan B. GC and Timothy Steckman, "Molecular Dynamics Simulations of Conformational Conversions in Transformer Proteins", In: Kister A. (eds) Protein Supersecondary Structures. Methods in Molecular Biology, vol 1958. Humana Press, New York, NY

PhD Thesis

"Molecular Dynamics Investigations of Structural Conversions in Transformer Proteins", Jeevan B. GC,  ProQuest ETD Collection for FIU. AAI10744483.