We investigate the physiology and molecular mechanisms of energy metabolism from the organism to the molecule. We focus on metabolic aspects during obesity, adipose tissue biology, mitochondrial mechanisms and thermogenesis.
Five key publications:
Keipert, S., Lutter, D., Schroeder, B.O., Brandt, D., Ståhlman, M., Schwarzmayr, T., Graf, E., Fuchs, H., de Angelis, M.H., Tschöp, M.H., Rozman, J., Jastroch, M., 2020. Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice. Nat. Commun. 11, 624. https://doi.org/10.1038/s41467-019-14069-2
Walheim, E., Wiśniewski, J.R., Jastroch, M., 2018. Respiromics - An integrative analysis linking mitochondrial bioenergetics to molecular signatures. Mol. Metab. 9, 4–14. https://doi.org/10.1016/j.molmet.2018.01.002
Keipert, S., Kutschke, M., Ost, M., Schwarzmayr, T., van Schothorst, E.M., Lamp, D., Brachthäuser, L., Hamp, I., Mazibuko, S.E., Hartwig, S., Lehr, S., Graf, E., Plettenburg, O., Neff, F., Tschöp, M.H., Jastroch, M., 2017. Long-Term Cold Adaptation Does Not Require FGF21 or UCP1. Cell Metab. 26, 437-446.e5. https://doi.org/10.1016/j.cmet.2017.07.016
Kabra, U.D., Pfuhlmann, K., Migliorini, A., Keipert, S., Lamp, D., Korsgren, O., Gegg, M., Woods, S.C., Pfluger, P.T., Lickert, H., others, 2017. Direct substrate delivery into mitochondrial-fission deficient pancreatic islets rescues insulin secretion. Diabetes db161088. https://doi.org/10.2337/db16-1088
Keuper, M., Jastroch, M., Yi, C.-X., Fischer-Posovszky, P., Wabitsch, M., Tschop, M.H., Hofmann, S.M., 2014. Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions. FASEB J. 28, 761–770. https://doi.org/10.1096/fj.13-238725
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