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The Jang lab develops first-in-class chemical probes and best-in-class drug candidates that are utilized to study cellular processes related to cancer and other diseases, and to control specific target protein causing diseases such as various cancers, obesity, and infectious diseases by combining the tools of chemical biology, medicinal chemistry, computational approaches, molecular and cellular biology. In particular, our lab is focusing on development of novel kinase inhibitors based on new chemical scaffolds to target drug-resistant mutants of well-studied kinases, or orphan kinases. The development of a leading-edge platform of ‘proximity-based therapeutics’ which enables us to discover molecular glues and bifunctional molecules utilized in the targeted protein degradation approach is another main topic of our research. Additionally, we investigate novel synthetic methods that are capable of efficient synthesis of diverse chemical analogs, protein-drug conjugates, as well as complex natural products.
The Jang lab develops first-in-class chemical probes and best-in-class drug candidates that are utilized to study cellular processes related to cancer and other diseases, and to control specific target protein causing diseases such as various cancers, obesity, and infectious diseases by combining the tools of chemical biology, medicinal chemistry, computational approaches, molecular and cellular biology. In particular, our lab is focusing on development of novel kinase inhibitors based on new chemical scaffolds to target drug-resistant mutants of well-studied kinases, or orphan kinases. The development of a leading-edge platform of ‘proximity-based therapeutics’ which enables us to discover molecular glues and bifunctional molecules utilized in the targeted protein degradation approach is another main topic of our research. Additionally, we investigate novel synthetic methods that are capable of efficient synthesis of diverse chemical analogs, protein-drug conjugates, as well as complex natural products.
TARGETING KINASES
TARGETING KINASES
Since imatinib developed, a lot of kinase inhibitors have been developed especially in oncology field. And the tool-kits available for determination of potency or selectivity accelerate the development of new kinase inhibitors. Currently, our lab is working on developing new kinase inhibitors based on novel chemical scaffolds to target drug-resistant mutants of well-studied kinases or orphan kinases.
TARGETED PROTAIN DEGRADATION
TARGETED PROTAIN DEGRADATION
Targeted Protein Degradation is on one of the most innovative approaches in drug discovery since its mechanism of action is totally different with traditional small molecule drugs. We are developing leading-edge platforms that are capable of discovering molecular glues or bifunctional molecules enabling targeted degradation of disease-relevant proteins of interest.
TOTAL SYNTHESIS OF NATURAL PRODUCT
TOTAL SYNTHESIS OF NATURAL PRODUCT
The total synthesis of biologically active natural products is one of the dynamic area in the chemical synthesis. The development of novel synthetic route of a complex natural product provides an opportunity of finding novel synthetic methodology and obtaining a large scale of the natural product.
DEVELOPMENT OF NOVEL SYNTHETIC METHODOLOGY
DEVELOPMENT OF NOVEL SYNTHETIC METHODOLOGY
Synthetic methodology refers to the methods used for the synthesis of chemical compounds. Although countless synthetic methods have been developed, this field is still one of the highly competitive and fast-growing areas in organic chemistry.
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