PUBLICATION

Steric disruption of EGFR oligomerization overcomes therapy resistance in non–small cell lung cancer. D Song, J Jang, M Z Lin*, Y Jung* Science Advances (2025), 11, eady7032

Discovery of proteolysis-targeting chimera targeting undruggable proteins using a covalent ligand screening approach. H Lee, J Y Lee, H Jang, H Y Cho, M Kang, S H Bae, S Kim, E Kim, J Jang*, J Y Kim*, Y Ho Jeon* Eur. J. Med. Chem. (2024), 263, 115929

Risk of type 2 diabetes mellitus in adult patients with atopic dermatitis. S W Lee, J Park, H Kim, J Jang, K M Choi, Y S Baek, M G Kim, K Kim Diabetes Res. Clin.Pract. (2023) 204, 110883.

Identification of a novel class of cortisol biosynthesis inhibitors and its implications in a therapeutic strategy for hypercortisolism. S H Kim, G H Son, J Y Seok, S K Chun, H Yun, J Jang, Y-G Suh, K Kim, J-W Jung, S Chung Life Sciences (2023) 325, 121744

Synthesis and biological evaluation of flavonoid-based IP6K2 inhibitors. M Ahn, S E Park, J Choi, J Choi, D Choi, D An, H Jeon, S Oh, K Lee, J Kim, J Jang*, S Kim*, Y Byun*  J. Enzyme Inhib. Med. Chem. (2023) 38, 2193866.

Recent advances in the development of antidepressants targeting the purinergic P2X7 receptor. S Lee, H Ha, J Jang, Y Byun Curr. Med. Chem. (2023) 30, 164-177

Azumamides A-E: Isolation, Synthesis, Biological Activity, and Structure–Activity Relationship. S Jo, J-H Kim, J Lee, Y Park*, J Jang* Molecules (2022) 27, 8438.

Synthesis of 7,2`-Dihydroxy-4`,5`-Dimethoxyisoflavanone, a Phytoestrogen with Derma Papilla Cell Proliferative Activity. T Kim†, H S Kim†, J Jang†, D-J Kim, J Lee, D Lee, S-H Kim Molecules (2022) 27, 6660.

Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors. H Jang, Y Park*, J Jang* Front. Pharmacol. (2022) 13:1036844.

Prospect of ULK1 modulators in targeting regulatory T cells. Y Park*, J Jang* Bioorg. Chem. (2022) 129, 106141.

Cell extraction method coupled with LC-QTOF MS/MS analysis for predicting neuroprotective compounds from Polygonum tinctorium. H Shin, J Jang, M K Lee, K Y Lee J Pharm Biomed Anal (2022) 220, 114988.

Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. T S Beyett, C To, D E Heppner, J K Rana, A M Schmoker, J Jang, D J H De Clercq, G Gomez, D A Scott, N S Gray, P A Jänne, M J Eck Nat. Commun. (2022) 13, 2530

Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. T W Gero, D E Heppner, T S Beyett, C To, S C Azevedo, J Jang, T Bunnell, F Feru, Z Li, B H Shin, K M Soroko, P C Gokhale, N S Gray, P A Jänne, M J Eck, D A Scott B Bioorg. Med. Chem. Lett. (2022) 68, 128718

Allosteric Inhibition of Drug Resistant Forms of EGFR L858R mutant NSCLC. C To†, T S Beyett†, J Jang†, W W Feng, M Bahcall, H M Haikala, B H Shin, D E Heppner, J K Rana, B A Leeper, K M Soroko, M J Poitras, P C Gokhale, Y Kobayashi, K Wahid, K J Kurppa, T W Gero, M D Cameron, A Ogino, M Mushajiang, C Xu, Y Zhang, D A Scott, M J Eck, N S Gray, P A Jänne Nature Cancer (2022) 3, 402-417

A novel HER2-selective kinase inhibitor is effective in HER2 mutant and amplified non-small cell lung cancer. J Son, J Jang, T S Beyett, Y Eum, H M Haikala, A Verano, M Lin, J M Hatcher, N P Kwiatkowski, P Ö Eser, M J Poitras, S Wang, M Xu, P C Gokhale, M D Cameron, M J Eck, N S Gray, P A Jänne Cancer Res. (2022) 82, 1633-1645

Surveillance of avian influenza viruses from 2009 to 2013 in South Korea. J-H Nam, E Españo, E-J Song, S-M Shim, W Na, S-H Jeong, J Kim, J Jang, D Song, J-K Kim Sci. Rep. (2021) 11, 23991

Neural-Cadherin Influences the Homing of Terminally Differentiated Memory CD8 T Cells to the Lymph Nodes and Bone Marrow. K H Kim, A Choi, S H Kim, H Song, S Jin, K Kim, J Jang, H Choi, Y W Jung Mol. Cells (2021) 44, 795

A Review on Pharmacological Activities and Recent Synthetic Advances of γ-Butyrolactones. J Hur, J Jang*, J Sim*.  Int. J. Mol. Sci. (2021) 22, 2769

Inhibitors of prostate-specific membrane antigen in the diagnosis and therapy of metastatic prostate cancer - a review of patent literature. H Ha, H Kwon, T Lim, J Jang, S-K Park, Y Byun. Expert Opin. Ther. Pat. (2021) 31, 2525-2547

Structure-Activity Relationship Studies of Dipeptide-Based Hepsin Inhibitors with Arg Bioisosteres. H Kwon, H Ja, J Jeon, J Jang, S-H Son, K Lee, S-K Park, Y Byun. Bioorg. Chem. (2021) 107, 104521

Visible-Light-Induced Cysteine-Specific Bioconjugation: Biocompatible Thiol-Ene Click Chemistry. H Choi, M Kim, J Jang*, S. Hong*. Angewandte Chemie Int. Ed. (2020) 59, 22514-22522. *co-corresponding author 

Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations. J Jang†, C To† , D J H De Clercq, E Park, C M Ponthier, B H Shin, M Mushajiang, R P Nowak, E S Fischer, M J Eck, P A Jänne*, N S Gray*. Angewandte Chemie Int. Ed. (2020) 59, 14481-4489. †equal contribution

Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. D J H De Clercq, D E Heppner, C To, J Jang, E Park, C-H Yun, M Mushajiang, B H Shin, T W Gero, D A Scott, P A Jänne, M J Eck, N S Gray.  ACS Med. Chem. Lett. (2019) 10, 1549-1553.

Single and dual targeting of mutant EGFR with an allosteric inhibitor. C To†, J Jang†, T Chen, E Park, M Mushajiang, D J H De Clercq, M D Cameron, D E Heppner, A Yang, S E Dahlberg, K-K Wong, M J Eck, N S Gray, P A Jänne.  ‘ Cancer Discovery (2019) 9, 926-943. †equal contribution

 Identification of small molecule inhibitors targeting the Zika virus envelope protein. J Pitts, C-Y Hsia, W Lian, J Wang, M-P Pfeil, N Kwiatkowski, Z Li, J Jang, N S Gray, P L Yang. Antiviral Res. (2019) 164, 147-153.

Small molecules targeting the flavivirus E protein with broad-spectrum activity and antiviral efficacy in Vivo. P-C Li†, J Jang†, C-Y Hsia, P Groomes, W Lian, M de Wispelaere, J D Pitts, J Wang, N Kwaitkowski, N S Gray, P L Yang.  ACS Infectious Diseases (2019) 5, 460-472. †equal contribution

Discovery of fluorescent 3-heteroarylcoumarin derivatives as novel inhibitors of anaplastic lymphoma kinase. S Mah, J Jang, D Song, Y Shin, M Latif, Y Jung, S Hong. Org. Biomol. Chem. (2019) 17, 186-194.

Conversion of medium-sized lactams to α-vinyl or α-acetylenyl azacycles via N,O-acetal TMS ethers. M Kim†, J Jang†, G Choi, S Chung, C Lim, J Hur, J S Kim, Y Na, W S Son, Y-G Suh, J-W Jung, S-H Kim.  Molecules (2018) 23, 3023. †equal contribution'

Asymmetric synthesis of (-)-6-desmethyl-fluvirucinine A1 via conformationally-controlled diastereoselective lactam-ring expansions. H Moon, H Yoon, C Lim, J Jang, J-J Yi, J K Lee, J Lee, Y Na, W S Son, S-H Kim, Y-G Suh. Molecules (2018) 23, 2351.

Discovery of immunologically inspired small molecules that target the viral envelope protein. W Lian, J Jang, S Potisopon, P-C Li, A Rahmeh, J Wang, N P Kwiatkowski, N S Gray, P L Yang. ACS Infect. Dis. (2018) 4, 1395-1406.

 Discovery of a highly potent and broadly effective EGFR and HER2 exon 20 insertion mutant inhibitor. J Jang, J Son, E Park, T Kosaka, J A Saxon, D J H De Clercq, H G Choi, J Tanizaki, M J Eck, P A Jänne, N S Gray. Angewandte Chemie Int. Ed. (2018) 57, 11629-11633.

Inhibition of flaviviruses by targeting a conserved pocket on the viral envelope protein. M De Wispelaere, W Lian, S Potisopon, P-C Li, J Jang, S B Ficarro, M J Clark, X Zhu, J B Kaplan, J D Pitts, T E Wales, J Wang, J R Engen, J A Marto, N S Gray, P L Yang. Cell Chem. Biol. (2018), 25, 1-11.

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion. L H Chao, J Jang, A Johnson, A Nguyen, N S Gray, P L Yang, S C Harrison. eLife (2018); 7:e36461

The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. J Jang†, S Chung†, Y Choi, H Y Lim, Y Son, S K Chun, G H Son, K Kim, Y-G Suh, J-W Jung. Life Sciences (2018) 200, 49-55. †equal contribution

Conformation-enabled total syntheses of ohmyungsamycins A and B and structural revision of ohmyungsamycin B. J Hur, J Jang, J Sim, W S Son, H-C Ahn, T S Kim, Y-H Shin, C Lim, S Lee, H An, S-H Kim, D-C Oh, E-K Jo, J Jang, J Lee, Y-G Suh. Angew. Chem. Int. Ed. (2018) 57, 3069-3073.'

Asymmetric total synthesis of (+)-(3E)‑pinnatifidenyne via abnormally regioselective Pd(0)-catalyzed endocyclization. H S Kim, T Kim, J Ahn, H Yun, C Lim, J Jang, J Sim, H An, Y-J Surh, J Lee, Y-G Suh. J. Org. Chem. (2018) 83, 1997-2005.

A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader. H-T Huang, D Dobrovolsky, J Paulk, G Yang, E L Weisberg, Z M Doctor, D L Buckley, J-H Cho, E Ko, J Jang, K Shi, H G Choi, J D Griffin, Y Li, S P Treon, E S Fischer, J E Bradner, L Tan, N S Gray. Cell. Chem. Biol. (2018) 25, 88-99.

Total synthesis of (+)-brasilenyne via concise construction of an oxonane framework containing a 1,3-cis,cis-diene. C Lim, J Ahn, J Sim, H Yun, J Hur, H An, J Jang, S Lee, Y-G Suh. Chem. Commun. (2018) 54, 467-470.

Discovery of a potent dual ALK and EGFR T790M inhibitor. J. Jang†, J B Son†, C To, M Bahcall, S Y Kim, S Y Kang, M Mushajiang, Y Lee, P A Jänne, H G Choi, N S Gray.  European Journal of Medicinal Chemistry (2017) 136, 497-510. †equal contribution

Studies on the alkylation of phenolate in an organofluorine solvent and its application to the synthesis of myrsinoic acids A and E. M Ryu, M Kim, M Jeong, J Jang, M Lee, H-E. Jin, J-W. Jung. Syn. Commun. (2017) 47, 818-824.