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Chemical Biology I Targeted Protein Degradation I Proximity Drug I Covalent Drug
Chemical Biology I Targeted Protein Degradation I Proximity Drug I Covalent Drug
Grapical abstract of the paper, demonstrating a novel drug discovery platform via covalent-fragment screening and 2D NMR technology
Discovery of proteolysis-targeting chimera targeting undruggable proteins using a covalent ligand screening approach
Discovery of proteolysis-targeting chimera targeting undruggable proteins using a covalent ligand screening approach
Hyeonjun Lee1, Ju Yeon Lee1, Hyunsoo Jang1, Hye Young Cho1, Minhee Kang , Sang Hyun Bae , Suin Kim, Eunji Kim, Jaebong Jang*, Jin Young Kim*, Young Ho Jeon*
Eur. J. Med. Chem. (2024) 263, 115929.
Eur. J. Med. Chem. (2024) 263, 115929.
Co-crystal structure of EGFR bound to JBJ-09-063
An allosteric inhibitor against the therapy- resistant mutant forms of EGFR in non-small cell lung cancer
An allosteric inhibitor against the therapy- resistant mutant forms of EGFR in non-small cell lung cancer
C To†, T S Beyett†, J Jang†, W W Feng, M Bahcall, H M Haikala, B H Shin, D E Heppner, J K Rana, B A Leeper, K M Soroko, M J Poitras, P C Gokhale, Y Kobayashi, K Wahid, K J Kurppa, T W Gero, M D Cameron, A Ogino, M Mushajiang, C Xu, Y Zhang, D A Scott, M J Eck, N S Gray, P A Jänne
Nature Cancer (2022) 3, 401-417.
Nature Cancer (2022) 3, 401-417.
Grapical abstract of the paper, Visible‐Light‐Induced Cysteine‐Specific Bioconjugation: Biocompatible Thiol–Ene Click Chemistry
H Choi,† M Kim,† J Jang,* S Hong*
Angew. Chem. Int. Ed. (2020) 59, 22514-22522.
Angew. Chem. Int. Ed. (2020) 59, 22514-22522.
Grapical abstract of the paper, Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations
Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations.
Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations.
J Jang,† C To,† D J H De Clercq, E Park, C M Ponthier, B H Shin, M Mushajiang, R P Nowak, E S Fischer, M J Eck, P A Jänne,* N S Gray*
Angew. Chem. Int. Ed. (2020) 59, 14481–14489.
Angew. Chem. Int. Ed. (2020) 59, 14481–14489.
Grapical abstract of the paper, Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
C To,† J Jang,† T Chen, E Park, M Mushajiang, D J H De Clercq, M D Cameron, D E Heppner, A Yang, S E Dahlberg, K-K Wong, M J Eck, N S Gray,* P A Jänne*
Cancer Discov. (2019) 9, 926-943.
Cancer Discov. (2019) 9, 926-943.
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