35. Youngpyo Nam, Sehwan Kim, Jun-Yeong Lee, Jaekwang Kim, Sang Ryong Kim (2025) Enhancing the anti-aging potential of the nigrostriatal dopamine system to counteract age-related motor decline. Sig Transduct Target Ther 10, 153
34. Chang Jae Yoo, Youngtae Choi, Eugene Bok, Yuxi Lin, Mookyung Cheon, Young-Ho Lee, Jaekwang Kim* (2024) Complement receptor 4 mediates the clearance of extracellular tau fibrils by microglia. FEBS J. doi: 10.1111/febs.17150. Online ahead of print.
33. Eunju Leem, Sehwan Kim, Chanchal Sharma, Youngpyo Nam, Tae Yeon Kim, Minsang Shin, Seok-Geun Lee, Jaekwang Kim*, Sang Ryong Kim* (2024) Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy Biomolecules. 14(3):380. doi: 10.3390/biom14030380. *co-corresponding authors.
32. Yuxi Lin, So-Hyeon Park, Eugene Bok, Yunseok Heo, Seong-Bin Yang, Yoon-Sun Yi, Jun-Hyuck Lee, Donghyun Seo, Eunae Jo, Sungsu Lim, Yun Kyung Kim, József Kardos, Kyoung-Seok Ryu, Jaekwang Kim, Jooho Park, Young-Ho Lee (2023) An amphiphilic material arginine-arginine-bile acid promotes α-synuclein amyloid formation. Nanoscale. 15(21):9315-9328. doi: 10.1039/d3nr01468a.
31. Shristi Khanal, Eugene Bok, Jaekwang Kim, Gyu Hwan Park, Dong-Young Choi (2023) Dopaminergic neuroprotective effects of inosine in MPTP-induced parkinsonian mice via brain-derived neurotrophic factor upregulation. Neuropharmacology. 238:109652. doi: 10.1016/j.neuropharm.2023.109652.
30. Sehwan Kim, Chanchal Sharma, Minsang Shin, Hyung-Jun Kim, Jaekwang Kim, Sang Ryong Kim (2023) pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain Brain Behav Immun Health 28:100593. doi: 10.1016/j.bbih.2023.100593
29. Sehwan Kim*, Gyeong Joon Moon*, Hyung Jun Kim*, Do-Geun Kim*, Jaekwang Kim*, Youngpyo Nam, Chanchal Sharma, Eunju Leem, Shinrye Lee, Kyu-Sung Kim, Chang Man Ha, Catriona McLean, Byung Kwan Jin, Won-Ho Shin, Dong Woon Kim, Yong-Seok Oh, Chang-Won Hong, Sang Ryong Kim (2022) Control of hippocampal prothrombin kringle-2 (pKr-2) expression reduces neurotoxic symptoms in five familial Alzheimer's disease mice Br J Pharmacol. 79(5):998-1016. doi: 10.1111/bph.15681. Epub 2021 Oct 24. +equally contributed
28. Sunil Bhurtel, Eugene Bok, Nikita Katila, Jaekwang Kim*, Dong-Young Choi* (2021) Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP+ induced toxicity via ameliorating oxidative stress and mitochondrial dysfunction. Biochem Pharmacol. 192:114719. doi: 10.1016/j.bcp.2021.114719 *co-corresponding authors.
27. Eugene Bok, Eunju Leem, Bo-Ram Lee, Ji Min Lee, Chang Jae Yoo, Eun Mi Lee, Jaekwang Kim* (2021) Role of the Lipid Membrane and Membrane Proteins in Tau Pathology. Front Cell Dev Biol. 9:653815. doi: 10.3389/fcell.2021.653815.
26. Eun Seon Kim, Chang Geon Chung, Jeong Hyang Park, Byung Su Ko, Sung Soon Park, Yoon Ha Kim, In Jun Cha, Jaekwang Kim, Chang Man Ha, Hyung-Jun Kim, Sung Bae Lee (2021) C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons Hum Mol Genet. 30(12):1084-1100. doi: 10.1093/hmg/ddab089.
25. Minkyo Jung, Hyosun Choi, Jaekwang Kim, Ji Young Mun (2020) Correlative Light and Transmission Electron Microscopy Showed Details of Mitophagy by Mitochondria Quality Control in Propionic Acid Treated SH-SY5Y Cell. Materials (Basel). 13(19):4336. doi: 10.3390/ma13194336.
24. Jinhee Park, Hyerin Kim, Jaekwang Kim, Mookyung Cheon (2020) A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease. PLoS Comput Biol. 16(7):e1008099. doi: 10.1371/journal.pcbi.1008099.
23. Ha-Young Kang, Hyung-Jun Kim, Kiyoung Kim, Seung-Il Oh, Sunggyu Yoon, Jaekwang Kim, Sangwoo Park, Yeongmi Cheon, Song Her, Mihye Lee, Bingwei Lu, Seongsoo Lee (2020) Actin-microtubule crosslinker Pod-1 tunes PAR-1 signaling to control synaptic development and tau-mediated synaptic toxicity. Neurobiol Aging. 90:93-98. doi: 10.1016/j.neurobiolaging.2020.02.005.
22. Md Razaul Karim, Elly E Liao, Jaekwang Kim, Joyce Meints, Hector Martell Martinez, Olga Pletnikova, Juan C Troncoso, Michael K Lee (2020) α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment. Mol Neurodegener.15(1):27. doi: 10.1186/s13024-020-00364-w.
21. Shinrye Lee, Yu-Mi Jeon, Sun Joo Cha, Seyeon Kim, Younghwi Kwon, Myungjin Jo, You-Na Jang, Seongsoo Lee, Jaekwang Kim, Sang Ryong Kim, Kea Joo Lee, Sung Bae Lee, Kiyoung Kim, Hyung-Jun Kim (2020) PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies. Autophagy. 16(8):1396-1412. doi: 10.1080/15548627.2019.1686729.
20. Eugene Bok+, Myungjin Jo+, Shinrye Lee, Bo-Ram Lee, Jaekwang Kim*, Hyung-Jun Kim* (2019) Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link, Int J Mol Sci. 20(3) pii: E464. doi: 10.3390/ijms20030464. +equally contributed, *co-corresponding authors.
19. Jaekwang Kim*, Fabienne C. Fiesel, Krystal C Belmonte, Roman Hudec, Wang-Xia Wang, Chaeyoung Kim, Peter T. Nelson, Wolfdieter Springer, Jungsu Kim* (2016) miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1), Mol Neurodegener. 11(1):55. doi: 10.1186/s13024-016-0121-4. *co-corresponding authors.
18. Jaekwang Kim, Hyejin Yoon, Dah-eun Chung, Jennifer L. Brown, Krystal C Belmonte, Jungsu Kim (2016) miR-186 is decreased in aged brain and suppresses BACE1 expression, J Neurochem, 137 (3): 436-45. “Editorial highlight”
17. Jinkuk Choi*, Jie Gao*, Jaekwang Kim*, Cynthia Hong, Jungsu Kim, Peter Tontonoz (2015), The E3 ubiquitin ligase Idol controls brain LDL receptor levels, ApoE clearance and Aβ amyloidosis, Sci Transl Med. 7(314): 314ra184. *contributed equally to this work.
16. Jaekwang Kim, Hyejin Yoon, Takahiro Horie, Jack M. Burchett, Jessica L. Restivo, Noemi Rotllan, Cristina M. Ramírez, Philip B. Verghese, Masafumi Ihara, Hyang-Sook Hoe, Christine Esau, Carlos Fernández-Hernando, David M. Holtzman, John R. Cirrito, Koh Ono, Jungsu Kim (2015), microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain, J Neurosci. 35(44): 14717-26. “Featured Article”.
15. Gongbo Li, Chaeyoung Kim, Jaekwang Kim, Hyejin Yoon, Huadong Zhou, Jungsu Kim (2015) Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-beta Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer's Disease. J Alzheimers Dis 46:109-122.
14. Anuj K. Sharma, Jaekwang Kim, John T. Prior, Nicholas J. Hawco, Nigam P. Rath, Jungsu Kim, and Liviu M. Mirica (2014), Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity, Inorg Chem. 53(21): 11367-76.
13. Jaekwang Kim, Hyejin Yoon, Jacob Basak, Jungsu Kim (2014), Apolipoprotein E in synaptic plasticity and Alzheimer's disease: potential cellular and molecular mechanisms. Mol. Cells. 37: 767-776.
12. Jaekwang Kim, Hyejin Yoon, Jungsu Kim (2013), Role of Autophagy in Alzheimer’s Disease, Curr. Enz. Inhib. 9: 55-66.
11. Anuj K. Sharma, Stephanie T. Pavlova, Jaekwang Kim, Jungsu Kim, and Liviu M. Mirica (2013) The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity. Metallomics 5: 1529-1536.
10. Jungsu Kim, Adam E.M. Eltorai, Hong Jiang, Fan Liao, Philip B. Verghese, Jaekwang Kim, Floy R. Stewart, Jacob M. Basak, David M. Holtzman (2012) Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis. J. Exp. Med. 209: 2149-2156.
9. Jaekwang Kim, Hyejin Yoon, Cristina M. Ramírez, Sang-Mi Lee, Hyang-Sook Hoe, Carlos Fernández-Hernando, Jungsu Kim (2012) miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression. Exp. Neurol. 235, 476-483.
8. Anuj K. Sharma, Stephanie T. Pavlova, Jaekwang Kim, Darren Finkelstein, Nicholas J. Hawco, Nigam P. Rath, Jungsu Kim, and Liviu M. Mirica (2012) Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide. J. Am. Chem. Soc. 134: 6625-6636.
7. Kiyoung Kim, Song-Hee Kim, Jaekwang Kim, Heuijong Kim, Jeongbin Yim (2012) Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease. J. Biol. Chem. 287: 6628-6641.
6. Heuijong Kim, Kiyoung Kim, Jaekwang Kim, Song-Hee Kim, Jeongbin Yim (2012) Mutagenesis by imprecise excision of the piggyBac transposon in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 417: 335-339.
5. David Ramonet, João Paulo L. Daher, Brian M. Lin, Klodjan Stafa, Jaekwang Kim, Rebecca Banerjee, Marie Westerlund, Olga Pletnikova, Liliane Glauser, Lichuan Yang, Ying Liu, Deborah A. Swing, M. Flint Beal, Juan C. Troncoso, J. Michael McCaffery, Nancy A. Jenkins, Neal G. Copeland, Dagmar Galter, Bobby Thomas, Michael K. Lee, Ted M. Dawson, Valina L. Dawson, Darren J. Moore (2011) Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2. PLos One. 6: e18586.
4. Jaekwang Kim* and Sang Ick Park*, Chiyoung Ahn, Heuijong Kim, and Jeongbin Yim (2009) Guanine deaminase functions as dihydropterin deaminase in the biosynthesis of aurodrosopterin, a minor red eye pigment of Drosophila. J. Biol. Chem. 284: 23426-23435 *contributed equally to this work
3. Jaekwang Kim*, Hyunsuk Suh*, Songhee Kim, Kiyoung Kim, Chiyoung Ahn and Jeongbin Yim. (2006) Identification and characteristics of the structural gene for the Drosophila eye color mutant sepia, encoding PDA synthase, a member of the Omega class glutathione S-transferases. Biochemical J. 398: 451-460 *contributed equally to this work
2. Chiyoung Ahn, Mikyoeng Kim, Soojin Lee, Jaekwang Kim, Deogsu Hwang, Kyungmoon Park, Jeongbin Yim. (2006) Molecular Analysis of mps Operon Involved in Monapterin Synthesis in Escherichia Coli. Pteridines. 17:16-19
1. Yoontae Lee, Chiyoung Ahn, Jinju Han, Hyounjeong Choi, Jaekwang Kim, Jeongbin Yim, Junho Lee, Patrick Provost, Olof Rådmark, Sunyoung Kim and V. Narry Kim. (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature. 425: 415-419