論文

1. 磯崎 瑛宏, 菅 哲朗, “薄膜基板上に構成するテラヘルツMEMSメタマテリアル,” メタマテリアルの設計、作製と新材料、デバイス開発への応用, 株式会社技術情報協会, 第6章第5節, pp. 374-383, March 31, 2022.

2. 磯崎 瑛宏, “高性能細胞分取装置の開発,” 化学とマイクロ・ナノシステム学会誌, 第22巻 2号, pp. 17–18, October 1, 2021. (令和2年度化学とマイクロ・ナノシステム学会若手優秀賞に伴う寄稿)

3. 中川 悠太, 大貫 慎輔, 近藤 直子, 磯崎 瑛宏, 大矢 禎一, 合田 圭介, “液滴内の培養環境再評価：液滴サイズが細胞生理に与える影響,” 化学とマイクロ・ナノシステム学会誌, 第22巻 2号, pp. 48–49, October 1, 2021. (中川君の第43回研究会優秀発表賞受賞に伴う寄稿)

4. 磯崎 瑛宏, 新田 尚, 杉村 武昭, 合田 圭介, “画像活性セルソーター：画像情報に基づく生きた細胞の高速分取法” 実験医学増刊, 第39巻第12号, pp. 198–204, August 1, 2021.

5. 中川 敦寛，新田 尚，杉村 武昭，磯崎 瑛宏，小関 泰之，合田 圭介, “インテリジェント画像活性細胞選抜法 ー医療・生命科学分野への展開,” 医学のあゆみ, Vol. 273, No. 4, pp. 20524-20525, April 25, 2020.

6. 磯崎 瑛宏, “大規模単一細胞解析の普及へ向けた音響型細胞整列マイクロ流路プラットフォームの構築,” サウンド, 第35号, pp. 14–18, January 20, 2020.

7. 磯崎 瑛宏, 中川 悠太, Mun Hong Loo, 芝田 悠大, 田中 直樹, Dwi Larasati Setyaningrum, Jee-Woong Park, 白崎 善隆, 三上 秀治, 上村 想太郎, Dino Di Carlo, 合田 圭介, “電極アレイを用いた高速液滴分取,” 化学とマイクロ・ナノシステム学会誌, 第18巻 2号, pp. 33–36, October 1, 2019. (第39回研究会優秀研究賞受賞に伴う寄稿)

8. 磯崎 瑛宏, 三上 秀治, 平松 光太郎, 合田 圭介, “高速蛍光イメージング・ラマン分光法と生物学・医学への展開,” 月刊オプトロニクス, 第38巻第9号, pp. 72–79, October 1, 2019.

9. 磯崎 瑛宏, “次世代細胞分取装置,” 化学とマイクロ・ナノシステム学会誌, 第18巻 1号, pp. 7–9, March 1, 2019. 

†: corresponding author

1. Ayaka Matsumoto, Yu Toyoshima, Chenqi Zhang, Akihiro Isozaki, Keisuke Goda, and Yuichi Iino†, “Neuronal sensorimotor integration guiding salt concentration navigation in Caenorhabditis elegans,” Proceedings of the National Academy of Sciences, vol. 121, no. 5, e2310735121, 2024.
   [DOI: 10.1073/pnas.2310735121 ]
   [プレスリリース ]

2. Mika Hayashi, Shinsuke Ohnuki, Yating Tsai, Naoko Kondo, Yuqi Zhou, Hongqian Zhang, Natsumi Tiffany Ishii, Tianben Ding, Maik Herbig, Akihiro Isozaki†, Yoshikazu Ohya†, and Keisuke Goda†, “Is AI essential? Examining the need for deep learning in image-activated sorting of Saccharomyces cerevisiae,” Lab on a Chip, vol. 23, pp. 4232-4244, 2023.
   [DOI: 10.1039/D3LC00556A] 

3. Hiroki Matsumura*, Larina Tzu-Wei Shen*, Akihiro Isozaki†, Hideharu Mikami, Dan Yuan, Taichi Miura, Yuto Kondo, Tomoko Mori, Yoshika Kusumoto, Masako Nishikawa, Atsushi Yasumoto, Aya Ueda, Hiroko Bando, Hisato Hara, Yuhong Liu, Yunjie Deng, Masahiro Sonoshita, Yutaka Yatomi, Keisuke Goda†, Satoshi Matsusaka†,  “Virtual-freezing fluorescence imaging flow cytometry with 5-aminolevulinic acid stimulation and antibody labeling for detecting all forms of circulating tumor cells,” Lab on a Chip, vol. 23, pp. 1561-1575, 2023. (* co-first authors)
   [DOI: 10.1039/D2LC00856D] 

4. Julia Gala de Pablo, Matthew Lindley, Kotaro Hiramatsu, Akihiro Isozaki, and Keisuke Goda†, “Label-free live microalgal starch screening via Raman flow cytometry,” Algal Research, vol. 70, article number 102993, 2023.
   [DOI: 10.1016/j.algal.2023.102993] 

5. Yaqi Zhao*, Akihiro Isozaki*†, Maik Herbig†, Mika Hayashi, Kotaro Hiramatsu, Sota Yamazaki, Naoko Kondo, Shinsuke Ohnuki, Yoshikazu Ohya, Nao Nitta, and Keisuke Goda†, “Intelligent sort-timing prediction for image-activated cell sorting,” Cytometry Part A, vol. 103, pp. 88-97, 2023. (* co-first authors)
   [DOI: 10.1002/cyto.a.24664]

6. Jeffrey Harmon, Justin Findinier, Natsumi Tiffany Ishii, Maik Herbig†, Akihiro Isozaki†, Arthur R. Grossman, and Keisuke Goda†, “Intelligent image-activated sorting of Chlamydomonas reinhardtii by mitochondrial localization,” Cytometry Part A, vol. 101, issue 12, pp. 1027-1034, 2022.
   [DOI: 10.1002/cyto.a.24661] 

7. (Correspondence paper) Maik Herbig*, Akihiro Isozaki*, Dino Di Carlo, Jochen Guck, Nao Nitta, Robert Damoiseaux, Shogo Kamikawaji, Eigo Suyama, Hirofumi Shintaku, Angela Ruohao Wu, Itoshi Nikaido, and Keisuke Goda†, “Best practices for reporting throughput in biomedical research,” Nature Methods, vol. 19, pp. 633-634, 2022. (* co-first authors)
   [DOI: 10.1038/s41592-022-01483-6] 

8. Matthew Lindley, Julia Gala de Pablo, Jorgen Walker Peterson, Akihiro Isozaki, Kotaro Hiramatsu†, and Keisuke Goda†, “High-throughput Raman-activated cell sorting in the fingerprint region,” Advanced Materials Technologies, 2101567, 2022.
   [DOI: 10.1002/admt.202101567] 

9. Kangrui Huang, Hiroki Matsumura, Yaqi Zhao, Maik Herbig, Dan Yuan, Yohei Mineharu, Jeffrey Harmon, Justin Findinier, Mai Yamagishi, Shinsuke Ohnuki, Nao Nitta, Arthur R. Grossman, Yoshikazu Ohya, Hideharu Mikami, Akihiro Isozaki†, and Keisuke Goda†, “Deep imaging flow cytometry,” Lab on a Chip, vol. 22, pp. 876-889, 2022.
   [DOI: 10.1039/D1LC01043C] 

10. Mun Hong Loo*, Yuta Nakagawa*, Soo Hyeon Kim, Akihiro Isozaki†, and Keisuke Goda†, “High-throughput sorting of nanoliter droplets enabled by a sequentially addressable dielectrophoretic array,” Electrophoresis, vol. 43, issue 3, pp. 477-486, 2022. (* co-first authors)
    [DOI: 10.1002/elps.202100057] 

11. Yuta Nakagawa*, Shinsuke Ohnuki*, Naoko Kondo, Kaori Itto-Nakama, Farzan Ghanegolmohammadi, Akihiro Isozaki†, Yoshikazu Ohya†, and Keisuke Goda†, “Are droplets really suitable for single-cells analysis? A case study on yeast in droplets,” Lab on a Chip, vol 21, pp. 3793-3803, 2021. (* co-first authors)
    [DOI: 10.1039/D1LC00469G] 

12. Ting-Hui Xiao†, Zhenzhou Cheng, Zhenyi Luo, Akihiro Isozaki, Kotaro Hiramatsu, Tamitake Itoh, Masahiro Nomura, Satoshi Iwamoto, and Keisuke Goda†, “All-dielectric superchiral-field-enhanced Raman optical activity,” Nature Communications, vol. 12, article number 3062, 2021.
    [DOI: 10.1038/s41467-021-23364-w]
    [Press release from UTokyo (in Japanese)] 

13. Muzhen Xu, Jeffrey Harmon, Dan Yuan, Sheng Yan, Cheng Lei, Kotaro Hiramatsu, Yuqi Zhou, Mun Hong Loo, Tomohisa Hasunuma, Akihiro Isozaki†, and Keisuke Goda†, “Morphological indicator for directed evolution of Euglena gracilis with a high heavy metal removal efficiency,” Environmental Science and Technology, vol. 55, no. 12, pp. 7880-7889, 2021.
    [DOI: 10.1021/acs.est.0c05278]

14. (Perspective paper) Yuqi Zhou, Akihiro Isozaki, Atsushi Yasumoto, Ting-Hui Xiao, Yutaka Yatomi, Cheng Lei, and Keisuke Goda†, “Intelligent platelet morphometry,” Trends in Biotechnology, vol. 39, no. 10, pp. 978-989, 2021.
    [DOI: 10.1016/j.tibtech.2020.12.012]

15. Akihiro Isozaki†, Dunhou Huang, Yuta Nakagawa, and Keisuke Goda†, “Dual sequentially addressable dielectrophoretic array for high-throughput, scalable, multiplexed droplet sorting,” Microfluidics and Nanofluidics, vol. 15, article number 32, 2021.
    [DOI: 10.1007/s10404-021-02432-z]

16. (Review paper) Akihiro Isozaki, Jeffrey Harmon, Yuqi Zhou, Shuai Li, Yuta Nakagawa, Mika Hayashi, Hideharu Mikami, Cheng Lei, and Keisuke Goda†, “AI on a chip,” Lab on a Chip, vol. 20, pp. 3074-3090, 2020.
    [DOI: 10.1039/D0LC00521E]

17. Nao Nitta, Takanori Iino*, Akihiro Isozaki*, Mai Yamagishi*, Yasutaka Kitahama*, Shinya Sakuma*, Yuta Suzuki, Hiroshi Tezuka, Minoru Oikawa, Fumihito Arai, Takuya Asai, Dinghuan Deng, Hideya Fukuzawa, Misa Hase, Tomohisa Hasunuma, Takeshi Hayakawa, Kei Hiraki, Kotaro Hiramatsu, Yu Hoshino, Mary Inaba, Yuki Inoue, Takuro Ito, Masataka Kajikawa, Hiroshi Karakawa, Yusuke Kasai, Yuichi Kato, Hirofumi Kobayashi, Cheng Lei, Satoshi Matsusaka, Hideharu Mikami, Atsuhiro Nakagawa, Keiji Numata, Tadataka Ota, Takeichiro Sekiya, Kiyotaka Shiba, Yoshitaka Shirasaki, Nobutake Suzuki, Shunji Tanaka, Shunnosuke Ueno, Hiroshi Watarai, Takashi Yamano, Masayuki Yazawa, Yusuke Yonamine, Dino Di Carlo, Yoichiroh Hosokawa, Sotaro Uemura, Takeaki Sugimura, Yasuyuki Ozeki, and Keisuke Goda†, “Raman image-activated cell sorting,” Nature Communications, vol. 11, article number 3452, 2020. (*co-second authors)
    [DOI: 10.1038/s41467-020-17285-3]
    [Press release from UTokyo (in Japanese)]
    [日経新聞], [Bio Optics Japan], [Optronics online], [OPlusE], [大学ジャーナルonline], [Rakuten Infoseek News],  [exiteニュース], [Cube], [ZDNet Japan], [Best times]

18. Akihiro Isozaki, Hideharu Mikami, Hiroshi Tezuka, Hiroki Matsumura, Kangrui Huang, Marino Akamine, Kotaro Hiramatsu, Takanori Iino, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Yan Li, Yuta Nakagawa, Shinsuke Ohnuki, Tadataka Ota, Yong Qian, Shinya Sakuma, Takeichiro Sekiya, Yoshitaka Shirasaki, Nobutake Suzuki, Ehsen Tayyabi, Tsubasa Wakamiya, Muzhen Xu, Mai Yamagishi, Haochen Yan, Qiang Yu, Sheng Yan, Dan Yuan, Wei Zhang, Yaqi Zhao, Fumihito Arai, Robert E. Campbell, Christophe Danelon, Dino Di Carlo, Kei Hiraki, Yu Hoshino, Yoichiroh Hosokawa, Mary Inaba, Atsuhiro Nakagawa, Yoshikazu Ohya, Minoru Oikawa, Sotaro Uemura, Yasuyuki Ozeki, Takeaki Sugimura, Nao Nitta, and Keisuke Goda†, “Intelligent image-activated cell sorting 2.0,” Lab on a Chip, vol. 20, no. 13, pp. 2263-2273, 2020.
    [DOI: 10.1039/D0LC00080A]
    [Highlighted in one of Lab-on-a-Chip's best editorial]

19. Akihiro Isozaki†, Yuta Nakagawa, Mun Hong Loo, Yudai Shibata, Naoki Tanaka, Dwi Larasati Setyaningrum, Jee-Woong Park, Yoshitaka Shirasaki, Hideharu Mikami, Dunhou Huang, Hoilun Tsoi, Carson Tae Riche, Tadataka Ota, Hiromi Miwa, Yuko Kanda, Takuro Ito, Koji Yamada, Osamu Iwata, Kengo Suzuki, Shinsuke Ohnuki, Yoshikazu Ohya, Yuichi Kato, Tomohisa Hasunuma, Satoshi Matsusaka, Mai Yamagishi, Masayuki Yazawa, Sotaro Uemura, Kazumichi Nagasawa, Hiroshi Watarai, Dino Di Carlo, and Keisuke Goda†, “Sequentially addressable dielectrophoretic array for high-throughput sorting of large-volume biological compartments,” Science Advances, vol. 6, no. 22, eaba6712, 2020.
    [DOI: 10.1126/sciadv.aba6712]
    [UTokyo press release (in Japanese)]
    [UCLA press release]
    [日経新聞], [科学新聞, 2020/6/5], [化学工業日報, 2020/6/10], [中國新聞, 2020/7/12], [福井新聞, 2020/7/28], [中部経済新聞, 2020/8/31], [PHYS ORG]

20. Yuta Suzuki, Koya Kobayashi, Yoshifumi Wakisaka, Dinghuan Deng, Shunji Tanaka, Chun-Jung Huang, Cheng Lei, Chia-Wei Sun, Hanqin Liu, Yasuhiro Fujiwaki, Sangwook Lee, Akihiro Isozaki, Yusuke Kasai, Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai, Kenichi Koizumi, Hiroshi Tezuka, Mary Inaba, Kei Hiraki, Takuro Ito, Misa Hase, Satoshi Matsusaka, Kiyotaka Shiba, Kanako Suga, Masako Nishikawa, Masahiro Jona, Yutaka Yatomi, Yalikun Yaxiaer, Yo Tanaka, Takeaki Sugimura, Nao Nitta, Keisuke Goda, and Yasuyuki Ozeki†, “Label-free chemical imaging flow cytometry by high-speed multicolor stimulated Raman scattering,” Proceedings of the National Academy of Sciences, vol. 116, no. 32, pp. 15842-15848, 2019.
    [DOI: 10.1073/pnas.1902322116]
    [Utokyo press release (in Japanese)]

21. Akihiro Isozaki, Hideharu Mikami, Kotaro Hiramatsu, Shinya Sakuma, Yusuke Kasai, Takanori Iino, Takashi Yamano, Atsushi Yasumoto, Yusuke Oguchi, Nobutake Suzuki, Yoshitaka Shirasaki, Taichiro Endo, Takuro Ito, Kei Hiraki, Makoto Yamada, Satoshi Matsusaka, Takeshi Hayakawa, Hideya Fukuzawa, Yutaka Yatomi, Fumihito Arai, Dino Di Carlo, Atsuhiro Nakagawa, Yu Hoshino, Yoichiroh Hosokawa, Sotaro Uemura, Takeaki Sugimura, Yasuyuki Ozeki, Nao Nitta, and Keisuke Goda†, “A practical guide to intelligent image-activated cell sorting,” Nature Protocols, vol. 14, pp. 2370–2415, 2019.
    [DOI: 10.1038/s41596-019-0183-1]
    [Introduced in "Top 10 Technologies of 2019 that Biologists Should Know About"] [BIOS Show Daily]

22. Nao Nitta, Takeaki Sugimura, Akihiro Isozaki, Hideharu Mikami, Kei Hiraki, Shinya Sakuma, Takanori Iino, Fumihito Arai, Taichiro Endo, Yasuhiro Fujiwaki, Hideya Fukuzawa, Misa Hase, Takeshi Hayakawa, Kotaro Hiramatsu, Yu Hoshino, Mary Inaba, Takuro Ito, Hiroshi Karakawa, Yusuke Kasai, Kenichi Koizumi, SangWook Lee, Cheng Lei, Ming Li, Takanori Maeno, Satoshi Matsusaka, Daichi Murakami, Atsuhiro Nakagawa, Yusuke Oguchi, Minoru Oikawa, Tadataka Ota, Kiyotaka Shiba, Hirofumi Shintaku, Yoshitaka Shirasaki, Kanako Suga, Yuta Suzuki, Nobutake Suzuki, Yo Tanaka, Hiroshi Tezuka, Chihana Toyokawa, Yaxiaer Yalikun, Makoto Yamada, Mai Yamagishi, Takashi Yamano, Atsushi Yasumoto, Yutaka Yatomi, Masayuki Yazawa, Dino Di Carlo, Yoichiroh Hosokawa, Sotaro Uemura, Yasuyuki Ozeki, and Keisuke Goda†, “Intelligent image-activated cell sorting,” Cell, vol. 175, issue 1, pp. 266-276, 2018.
    [DOI: 10.1016/j.cell.2018.08.028]
    [UTokyo press release (in Japanese)]
    [Nature], [Cell Press], [日経バイオテク], [PHYS ORG], [Nature Methods], [Science Trends], [日経新聞]
    [YouTube]

23. Cheng Lei†, Hirofumi Kobayashi, Yi Wu, Ming Li, Akihiro Isozaki, Atsushi Yasumoto, Hideharu Mikami, Takuro Ito, Nao Nitta, Takeaki Sugimura, Makoto Yamada, Yutaka Yatomi, Dino Di Carlo, Yasuyuki Ozeki, and Keisuke Goda†, “High-throughput imaging flow cytometry by optofluidic time-stretch microscopy,” Nature Protocols, vol. 13, pp. 1603-1631, 2018.
    [DOI: 10.1038/s41596-018-0008-7]
    Click [HERE] to download a movie of microfluidic-chip fabrication.

24. 磯崎 瑛宏†, 菅 哲朗, 高橋 英俊, 松本 潔, 下山 勲†, “薄膜メタマテリアル実現に向けたフレーム構造のTHz応答解析,” 電気学会論文誌E, vol. 138, no.7, pp. 281-286, 2018.
    [DOI: 10.1541/ieejsmas.138.281]

25. Taichi Miura, Hideharu Mikami†, Akihiro Isozaki, Takuro Ito, Yasuyuki Ozeki, and Keisuke Goda†, “On-chip light-sheet fluorescence imaging flow cytometry at a high flow speed of 1 m/s,” Biomedical Optics Express, vol. 9, issue 7, pp. 3424-3433, 2018.
    [DOI: 10.1364/BOE.9.003424]

26. (Review paper) Baoshan Guo, Cheng Lei†, Yi Wu, Hirofumi Kobayashi, Takuro Ito, Yaxiaer Yalikun, Sangwook Lee, Akihiro Isozaki, Ming Li, Yiyue Jiang, Atsushi Yasumoto, Dino Di Carlo, Yo Tanaka, Yutaka Yatomi, Yasuyuki Ozeki, and Keisuke Goda†, “Optofluidic time-stretch quantitative phase microscopy,” Methods, vol. 136, no. 1, pp. 116-125, 2017.
    [DOI:10.1016/j.ymeth.2017.10.004]

27. Minako Hosono*, Akihiro Isozaki*, Koki Katoh, Yasumasa Ichikawa, Eiji Iwase, Kiyoshi Matsumoto, and Isao Shimoyama†, “Moisture sensor based on heat transfer possessing insusceptibility to coating materials on skin,” Sensors and Actuators: A. Physical, vol. 235, no. 1, pp. 265–272, 2015. (* co-first authors)
    [DOI:10.1016/j.sna.2015.10.012]

28. Tetsuo Kan, Akihiro Isozaki, Natsuki Kanda, Natsuki Nemoto, Kuniaki Konishi, Hidetoshi Takahashi, Makoto Kuwata-Gonokami†, Kiyoshi Matsumoto, and Isao Shimoyama†, “Enantiomeric switching of chiral metamaterial for terahertz polarization modulation employing vertically deformable MEMS spirals,” Nature Communications, vol. 6, article number 8422, 2015.
    [DOI:10.1038/ncomms9422]
    [Press release1] [Press release2] [News from UTokyo]
    [応用物理学会表紙]
    [movie]

29. Akihiro Isozaki†, Tetsuo Kan, Hidetoshi Takahashi, Kiyoshi Matsumoto, and Isao Shimoyama†, “Out-of-plane actuation with a sub-micron initial gap for reconfigurable terahertz micro-electro-mechanical systems metamaterials,” Optics Express, vol. 23, issue 20, pp. 26243-26251, 2015.
    [DOI: 10.1364/OE.23.026243]
    [movie]

30. Akihiro Isozaki†, Hidetoshi Takahashi, Hiroto Tamura, Tomoyuki Takahata, Kiyoshi Matsumoto, and Isao Shimoyama†, “Parallel Helmholtz resonators for a planar acoustic notch filter,” Applied Physics Letters, vol. 105, article number 241907, 2014.
    [DOI: 10.1063/1.4904509]

31. Hidetoshi Takahashi†, Yutaka Tomimatsu, Takeshi Kobayashi, Akihiro Isozaki, Toshihiro Itoh, Ryutaro Maeda, Kiyoshi Matsumoto, and Isao Shimoyama, “A smart, intermittent driven particle sensor with an airflow change trigger using a lead zirconate titanate (PZT) cantilever,” Measurement Science and Technology, vol. 25, no. 2, article number 025103, 2014.
    [DOI: 10.1088/0957-0233/25/2/025103]

32. Akihiro Isozaki†, Tetsuo Kan, Keisuke Takano, Masanori Hangyo, Kiyoshi Matsumoto, and Isao Shimoyama, “Batch fabrication of a double-layer metamaterial resonator using scalloping structure,” Journal of Micromechanics and Microengineering, vol. 23, no. 8, article number 085006, 2013.
    [DOI: 10.1088/0960-1317/23/8/085006]

33. Tetsuo Kan†, Akihiro Isozaki, Natsuki Kanda, Natsuki Nemoto, Kuniaki Konishi, Makoto Kuwata-Gonokami†, Kiyoshi Matsumoto, and Isao Shimoyama, “Spiral metamaterial for active tuning of optical activity,” Applied Physics Letters, vol. 102, no. 22, article number 221906, 2013.
    [DOI: 10.1063/1.4809533]

34. Akihiro Isozaki†, Tetsuo Kan, Yoshiharu Ajiki, Kiyoshi Matsumoto, and Isao Shimoyama, “Measurement method for light transmittance of layered metamaterials,” Optics Letters, vol. 38, issue 11, pp. 1811-1813, 2013.
    [DOI: 10.1364/OL.38.001811]