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In the present, the word "initial" commonly refers to the first letter of any word or name, the latter normally capitalized in English usage and is generally that of a first given name or a middle one or ones.

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In the very early history of printing, the typesetters would leave blank the necessary space, so that the initials could be added later by a scribe or miniature painter. Later initials were printed using separate blocks in woodcut or metalcut techniques.

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I was trying to run ab initio reconstruction for the stressosome data which the core has icosahedral symmetry, but I keep getting an wrong initial model from the reconstruction job which looks like an cakes.

the results of 2D classification looks like this:

2D1919591 293 KB

Thanks for reporting. For these highly symmetric particles (at least the core in your case) the squashed result can occur due to the fact that all projections look quite similar at low resolutions, so that the beginning, ab-initio reconstruction will rather assign all particles to the same viewing direction, when the initial model is very far from correct.

Along with the minibatch size, increasing the

Initial resolution (A): to 15 or 20 A and

Final resolution (A): to 8 or 6 A

will generaly help a lot when the only alignable signal is at higher resolutions. The job will run slower but give a better result. This also works for C1 reconstructions of apofettitin.

I encountered similar problem for my particles (Oh global symmetry). But neither increasing batch size to 1000 or 2000, nor resolution limits gave me correct initial model. My question is what would be now more sensible to change further: batch size or resolution? I need to admit that models generated now are better, but still far away from being correct.

I'm not sure why the second method you used (from the article) didn't work - as far as the simulator is concerned, the data it sees is the same, so there must have been a difference in the initial condition file being read, or there was a mistake in your setup.

I have a problem with the initial conditions in the capacitor. The initial condition seems to be ignored when the capacitor value is greater than 1 mF.

What could be the problem? Kindly help me find a solution to this issue.

Your problem is not the large capacitor value but the small resistor value. Quoting from the Spectre User Guide (support.cadence.com/.../cos;src=pubs;releaseName=;DocumentType=manuals;q=/spectreuser/spectreuser15.1/chap17.html#297523):

The Spectre simulator sets initial conditions on a node by attaching a voltage source through a resistor. The default value of this resistor is 1, but you can control the value through the options parameter rforce. You can lower the value of rforce to bring the voltage values into agreement in one of the following ways:

Notice from spectre during IC analysis, during transient analysis `tran'.

C0: Initial condition computed for node out is in error by 9.52381 mV

(95.2381 %).

Decrease `rforce' to reduce error in computed initial conditions.

However, setting rforce too small may result in convergence

difficulties or in the matrix becoming singular.

Initial conditions are met by applying a voltage source in series with a resistor, rforce which defaults to 1ohm. So with a 5 ohm resistor, you'd expect to get the initial condition of approx 5/6*10mV - which is 8.333mV which is pretty much what you see. With a 50mOhm resistor, you're going to get a tiny proportion of the initial condition - hence the message above. If I set the option rforce=1m then you get closer to the initial condition (I would be wary of setting it too much lower than this though - generally speaking tiny resistors are bad for convergence). This rforce can be set on Simulation->Options->Analog or by adding:

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