Publications

2025

· Proliferation and weak aerotaxis changes the cancer cell distribution in oxygen gradients at physiological level
Satoshi Aratake, Naoto Kawahara, Kenichi Funamoto
Microfluidics and Nanofluidics, Vol. 29, (2025), 21-1-13. DOI: 10.1007/s10404-025-02797-5

· Aneurysm wall enhancement can predict rupture point in intracranial aneurysms with multiple blebs
Shunsuke Omodaka, Shin-ichiro Sugiyama, Hiroyuki Sakata, Kenichi Funamoto, Yamaguchi Takuhiro, Kuniyasu Niizuma Hidenori Endo
Neurosurgery, Vol. 96, Issue 3, (2025), 593-599. DOI: 10.1227/neu.0000000000003134/s10404-024-02768-2

2024

· pH-dependent migratory behaviors of neutrophil-like cells in a microfluidic device with controllability of dissolved gas concentrations
Masashi Tomita, Satomi Hirose, Taishi Nakam4/10 (木) 13：30～ ura, Kenichi Funamoto
Scientific Reports, Vol. 14, (2024), 28730-1-14. DOI: 10.1038/s41598-024-79625-3

· Physiological hypoxia promotes cancer cell migration and attenuates angiogenesis in co-culture using a microfluidic device
Satoshi Aratake, Kenichi Funamoto
Microfluidics and Nanofluidics, Vol. 28, (2024), 72-1-13. DOI: 10.1007/s10404-024-02768-2

· Hypoxia suppresses glucose-induced increases in collective cell migration in vascular endothelial cell monolayers
Kazuki Sone, Yuka Sakamaki, Satomi Hirose, Mai Inagaki, Masanori Tachikawa, Daisuke Yoshino, Kenichi Funamoto
Scientific Reports, Vol. 14, (2024), 5164-1-12. DOI: 10.1038/s41598-024-55706-1

· Biological characterization of breast cancer spheroid formed by fast fabrication method
Yuta Iijima, Norino Uenaka, Mayu Morimoto, Daiki Sato, Satomi Hirose, Naoyoshi Sakitani, Masahiro Shinohara, Kenichi Funamoto, Gen Hayase, Daisuke Yoshino
In Vitro Models, Vol. 3, (2024), 19-32. DOI: 10.1007/s44164-024-00066-3

2023

· The aerotaxis of Dictyostelium discoideum is independent of mitochondria, nitric oxide and oxidative stress
Satomi Hirose, Julie Hesnard, Nasser Ghazi, Damien Roussel, Yann Voituron, Olivier Cochet-Escartin, Jean-Paul Rieu, Christophe Anjard, Kenichi Funamoto
Frontiers in Cell and Developmental Biology, Vol .11, (2023), 1134011-1-14. DOI: 10.3389/fcell.2023.113401

· Interstitial-fluid shear stresses induced by vertically oscillating head motion lower blood pressure in hypertensive rats and humans
Shuhei Murase, Naoyoshi Sakitani, Takahiro Maekawa, Daisuke Yoshino, Kouji Takano, Ayumu Konno, Hirokazu Hirai, Taku Saito, Sakae Tanaka, Keisuke Shinohara, Takuya Kishi, Yuki Yoshikawa, Takamasa Sakai, Makoto Ayaori, Hirohiko Inanami, Koji Tomiyasu, Atsushi Takashima, Toru Ogata, Hirotsugu Tsuchimochi, Shinya Sato, Shigeyoshi Saito, Kohzoh Yoshino, Yuiko Matsuura, Kenichi Funamoto, Hiroki Ochi, Masahiro Shinohara, Motoshi Nagao, Yasuhiro Sawada
Nature Biomedical Engineering, Vol. 7, No. 11, (2023), 1350-1373. DOI: 10.1038/s41551-023-01061-x

· Numerical analysis of hemodynamic changes and blood stagnation in the left ventricle by internal structures and torsional motion
Suguru Miyauchi, Koichi Hosoi, Shingo Tsuda, Toshiyuki Hayase, Kenichi Funamoto
AIP Advances, Vol. 13, Issue 4, (2023), 045105-1-7. DOI: 10.1063/5.0143833

· Microfluidic platform for the reproduction of hypoxic vascular microenvironments
Naoyuki Takahashi, Daisuke Yoshino, Ryuji Sugahara, Satomi Hirose, Kazuki Sone, Jean-Paul Rieu, Kenichi Funamoto
Scientific Reports, Vol. 13, (2023), 5428-1-13. DOI: 10.1038/s41598-023-32334-9

· Development of ultrasound phantom made of transparent material: Feasibility of optical particle image velocimetry
Muhammad Shiddiq Sayyid Hashuro, Simon Tupin, Narendra Kurnia Putra, Kotaro Daibo, Kosuke Inoue, Takuro Ishii, Hiroyuki Kosukegawa, Kenichi Funamoto, Toshiyuki Hayase, Makoto Ohta
Ultrasound in Medicine & Biology, (2023). DOI: 10.1016/j.ultrasmedbio.2022.12.020

· Region-based SVD processing of high-frequency ultrafast ultrasound to visualize cutaneous vascular networks
Anam Bhatti, Takuro Ishii, Naoya Kanno, Hayato Ikeda, Kenichi Funamoto, Yoshifumi Saijo
Ultrasonics, Vol. 129, (2023), 106907-1-8. DOI: 10.1016/j.ultras.2022.106907

2022

· Stiffness of primordial germ cells is required for their extravasation in avian embryos
Daisuke Saito, Ryosuke Tadokoro, Arata Nagasaka, Daisuke Yoshino, Takayuki Teramoto, Kanta Mizumoto, Kenichi Funamoto, Hinako Kidokoro, Takaki Miyata, Koji Tamura, Yoshiko Takahashi
iScience, Vol. 25, Issue 12, (2022), 105629-1-16. DOI: 10.1016/j.isci.2022.105629

· A review of functional analysis of endothelial cells in flow chambers
Makoto Ohta, Naoya Sakamoto, Kenichi Funamoto, Zi Wang, Yukiko Kojima, Hitomi Anzai
Journal of Functional Biomaterials, Vol. 13, Issue 3, (2022), 92-1-19. Doi.org/10.3390/jfb13030092

· Model?based estimation of QT intervals of mouse fetal electrocardiogram
Namareq Widatalla, Kiyoe Funamoto, Motoyoshi Kawataki, Chihiro Yoshida, Kenichi Funamoto, Masatoshi Saito, Yoshiyuki Kasahara, Ahsan Khandoker, Yoshitaka Kimura
BioMedical Engineering OnLine, Vol. 21, (2022), 45-1-9. DOI: 10.1186/s12938-022-01015-5

· The oxygen gradient in hypoxic conditions enhances and guides Dictyostelium discoideum migration
Satomi Hirose, Jean-Paul Rieu, Olivier Cochet-Escartin, Christophe Anjard, Kenichi Funamoto
Processes, Vol. 10, No. 2, (2022), 318-1-16. DOI: 10.3390/pr10020318

2021

· P21-activated kinase regulates oxygen-dependent migration of vascular endothelial cells in monolayers
Satomi Hirose, Yugo Tabata, Kazuki Sone, Naoyuki Takahashi, Daisuke Yoshino, Kenichi Funamoto
Cell Adhesion & Migration, Vol. 15, Issue 1, (2021), 272-284. DOI: 10.1080/19336918.2021.1978368

· Hypoxia triggers collective aerotactic migration in Dictyostelium discoideum
Olivier Cochet-Escartin, Mete Demircigil, Satomi Hirose, Blandine Allais, Philippe Gonzalo, Ivan Mikaelian, Kenichi Funamoto, Christophe Anjard, Vincent Calvez, Jean-Paul Rieu
eLife, Vol. 10, (2021), e64731-1-34. DOI: 10.7554/eLife.64731

2020

· Cancer cell migration and cancer drug screening in oxygen tension gradient chip
Hyeono Nam, Kenichi Funamoto, Jessie S Jeon
Biomicrofluidics, Vol. 14, Issue 4, (2020), 044107-1-10. DOI: 10.1063/5.0011216

· Mechanism driving hydrostatic pressure-promoted endothelial tube formation
Daisuke Yoshino, Kenichi Funamoto, Kakeru Sato, Kenry, Masaaki Sato, Chwee Teck Lim
Communications Biology, Vol. 3, 152 (2020). DOI: 10.1038/s42003-020-0881-9

· Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension
Rei Koens, Yugo Tabata, Jean C. Serrano, Satoshi Aratake, Daisuke Yoshino, Roger D. Kamm, Kenichi Funamoto
APL Bioengineering, Vol. 4, Issue 1, (2020), 016106-1-11. DOI: 10.1063/1.5127069

· Real-Time Estimation of Molten Steel Flow in Continuous Casting Mold
Yoshinari Hashimoto, Akitoshi Matsui, Toshiyuki Hayase, Manabu Kano
METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE, Vol. 51 No. 2, (2020-4), 581-588.

· Blood pressure estimation based on pulse rate variation in a certain period
Toshiyuki Hayase
Scientific Reports, Vol. 10 No. 1, (2020-1), 1410.

2019

· Numerical analysis of the blood flow in the left ventricle with internal structures: Effect of trabeculae carneae models and atrial fibrillation
Suguru Miyauchi, Tomomi Yamada, Koichi Hosoi, Toshiyuki Hayase, Kenichi Funamoto
AIP Advances, Vol. 9 No. 10, (2019-10), 105209.

· Viscosity estimation of a suspension with rigid spheres in circular microchannels using particle tracking velocimetry
Misa Kawaguchi, Tomohiro Fukui, Kenichi Funamoto, Miho Tanaka, Mitsuru Tanaka, Shigeru Murata, Suguru Miyauchi, Toshiyuki Hayase
Micromachines, Vol. 10 No. 10, (2019-10), 675.

· Influence on Measurement Signal by Pressure and Viscosity Changes of Fluid and Installation Condition of FBG Sensor Using Blood Flow Simulation Model
Shouhei Koyama, Toshiyuki Hayase, Suguru Miyauchi, Atsushi Shirai, Shun Chino, Yuki Haseda, Hiroaki Ishizawa
IEEE Sensors Journal, Vol. 19 No. 24, (2019-8), 11946-11954.

· Oxygen-dependent contraction and degradation of the extracellular matrix mediated by interaction between tumor and endothelial cells
Daisuke Yoshino, Kenichi Funamoto
AIP Advances, Vol. 9 No. 4, (2019-4), 045215.

· Migration of vascular endothelial cells in monolayers under hypoxic exposure
Yugo Tabata, Daisuke Yoshino, Kiyoe Funamoto, Rei Koens, Roger D. Kamm, Kenichi Funamoto
Integrative Biology, Vol. 11 No. 1, (2019-3), 26-35.

· Dissipation scaling in the transition region of turbulent mixing layer
Kotaro Takamure, Yasuhiko Sakai, Yasuaki Ito, Koji Iwano, Toshiyuki Hayase
International Journal of Heat and Fluid Flow, Vol. 75, (2019-2), 77-85.

2018

· Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
Tomomi Yamada, Toshiyuki Hayase, Suguru Miyauchi, Kenichi Funamoto
Journal of Biomechanical Science and Engineering, Vol. 13, No. 2, (2018), 17-00597-1-14.

· Differentiation of neutrophil-like HL-60 cells strongly impacts their rolling on surfaces with various adhesive properties under a pressing force
Atsushi Shirai，Yoshiro Sugiyama，Jean-Paul Rieu
Technology and Health Care, Vol. 26 No. 1, (2018), 93-108.

2017

· Endothelial monolayer permeability under controlled oxygen tension
Kenichi Funamoto, Daisuke Yoshino, Kento Matsubara, Ioannis K. Zervantonakis, Kiyoe Funamoto, Masafumi Nakayama, Jun Masamune, Yoshitaka Kimura, Roger D. Kamm
Integrative Biology, Vol. 9, Issue 6, (2017), 529-538. DOI 10.1039/c7ib00068e.

· Ultrasound imaging of mouse fetal intracranial hemorrhage due to ischemia/reperfusion
Kenichi Funamoto, Takuya Ito, Kiyoe Funamoto, Clarissa L. Velayo, Yoshitaka Kimura
Frontiers in Physiology, Vol. 8, Article 340, (2017), 1-6. DOI 10.3389/fphys.2017.00340.

· Numerical analysis of the effect of trabeculae carneae models on blood flow in a left ventricle model constructed from magnetic resonance images
Suguru Miyauchi, Toshiyuki Hayase, Arash Alizad Banaei, Jean-Christophe Loiseau, Luca Brandt, Fredrik Lundell
Journal of Fluid Science and Technology, Vol. 12 No. 2, (2017-8), JFST0015.

· Effects of upstream bifurcation and bend on the blood flow in a cerebral aneurysm
Daichi SUZUKI, Kenichi FUNAMOTO, Shin-ichiro SUGIYAMA, Toshiyuki HAYASE, Suguru MIYAUCHI and Teiji TOMINAGA
Journal of Biomechanical Science and Engineering, Vol. 12 No. 4, (2017-8), 17-00189.

· A numerical method for interaction problems between fluid and membranes with arbitrary permeability for fluid
Suguru Miyauchi, Shintaro Takeuchi, Takeo Kajishima
Journal of Computational Physics, Vol. 345 No. , (2017-5), 33-57.

2016

· Daughter sac formation related to blood inflow jet in an intracranial aneurysm: A case study
Shin-ichiro Sugiyama, Hidenori Endo, Shunsuke Omodaka, Toshiki Endo, Kuniyasu Niizuma, Sherif Rashad, Toshio Nakayama, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga
World Neurosurgery, Vol. 96, (2016), 396-402.

· Computational hemodynamic analysis for the diagnosis of atherosclerotic changes in intracranial aneurysms: A proof-of-concept study using 3 cases harboring atherosclerotic and non-atherosclerotic aneurysms simultaneously
Shin-ichiro Sugiyama, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga
Computational and Mathematical Methods in Medicine, Vol. 2016, (2016), ID 2386031.

· Reduced uterine perfusion pressure (RUPP) model of preeclampsia in mice
Tomofumi Fushima, Akiyo Sekimoto, Takahiro Minato, Takuya Ito, Yuji Oe, Kiyomi Kisu, Emiko Sato, Kenichi Funamoto, Toshiyuki Hayase, Yoshitaka Kimura, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi
PLoS ONE, Vol. 11, No. 5, (2016), e0155426.

· Properties of convective delivery in spinal cord gray matter: Laboratory investigation and computational simulations
Toshiki Endo, Yushi Fujii, Shin-ichiro Sugiyama, Rong Zhang, Shogo Ogita, Kenichi Funamoto, Ryuta Saito, Teiji Tominaga
Journal of Neurosurgery: Spine, Vol. 24, No. 2, (2016), 359-366.

· Computational investigation toward selective collection of water particles containing odorous molecules by electrostatic spraying
Jin Muraoka, Kenichi Funamoto, Mariko Seno, Satoshi Arimoto, Ken Shimono, Satoshi Suzuki, Yoshio Mitsutake, Tetsuya Maekawa, Toshihiko Yoshioka, Toshiyuki Hayase
Journal of Electrostatics, Vol. 83 , (2016-7), 35-41.

· Study of Estimation Method for Unsteady Inflow Velocity in Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Simulation
Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, and Nobuyuki Taniguchi
IEEE Transactions on Biomedical Engineering, Vol. 63 No. 2, (2016-2), 403-414.

· Systematical experiment for optimal design of vibrating flow pump with jelly-fish valve
Satoyuki Kawano, Saki Miyagawa, Atsushi Shirai
Bionic Engineering, Vol. 13 No. 1, (2016), 166-179.

· Numerical analysis for elucidation of mechanical interaction between an erythrocyte moving in medium subject to inclined centrifugal force and endothelial cells on a plate
Akira YATSUYANAGI, Toshiyuki HAYASE, Suguru MIYAUCHI, Kenichi FUNAMOTO, Kosuke INOUE, Atsushi SHIRAI and Luca BRANDT
Journal of Fluid Science and Technology, Vol. 11 No. 4, (2016-12), 1-10.

· Photoplethysmography and ultrasonic?measurement?integrated simulation to clarify the relation between two-dimensional unsteady blood flow field and forward and backward waves in a carotid artery
Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai
Medical & Biological Engineering & Computing, (2016-7), DOI 10.1007/s11517-016-1543-4.

· Grid Convergence Property of Three-Dimensional Measurement-Integrated Simulation for Unsteady Flow Behind a Square Cylinder with Karman Vortex Street
Takayuki Yamagata, Toshiyuki Hayase
Journal of Flow Control, Measurement & Visualization, (2016-7)

· Photoplethysmography and Ultrasonic-Measurement-Integrated Simulation to Clarify the Relation between Two-Dimensional Unsteady Blood Flow Field and Forward and Backward Waves in a Carotid Artery
Shusaku Sone, Toshiyuki Hayase, Kenichi Funamoto, Atsushi Shirai
Medical & Biological Engineering & Computing, Vol. to be published , (2016-7)

· Computational investigation toward selective collection of water particles containing odorous molecules by electrostatic spraying
Jin Muraoka, Kenichi Funamoto, Mariko Seno, Satoshi Arimoto, Ken Shimono, Satoshi Suzuki, Yoshio Mitsutake, Tetsuya Maekawa, Toshihiko Yoshioka, Toshiyuki Hayase
Journal of Electrostatics, Vol. 83 , (2016-7), 35-41.

· Study of Estimation Method for Unsteady Inflow Velocity in Two-Dimensional Ultrasonic-Measurement-Integrated Blood Flow Simulation
Hiroko Kadowaki, Toshiyuki Hayase, Kenichi Funamoto, and Nobuyuki Taniguchi
IEEE Transactions on Biomedical Engineering, Vol. 63 No. 2, (2016-2), 403-414.

· Systematical experiment for optimal design of vibrating flow pump with jelly-fish valve
Satoyuki Kawano, Saki Miyagawa, Atsushi Shirai
Bionic Engineering, Vol. 13 No. 1, (2016), 166-179.