Pedro Pais
Education
• PhD in Biotechnology and Biosciences, IST-ULisboa, 2019
• MSc in Biotechnology, IST-ULisboa, 2014
• BSc in Molecular and Cellular Biology, FCT-NOVA, 2012
Research Activities
• Mechanisms of antifungal drug resistance in Candida glabrata
• Genomics, transcriptomics and proteomics
• Systems biology tools for the study of transcriptional regulatory networks
Selected Publications
Pais, P.*, Galocha, M.*, Takahashi-Nakaguchi, A., Chibana, H., Teixeira, M.C., “Multiple genome analysis of Candida glabrata clinical isolates renders new insights into genetic diversity and drug resistance determinants”, Microbial Cell, 9(11): 174-189, 2022.
Pais, P., Galocha, M., California, R., Viana, R., Ola, M., Okamoto, M., Chibana, H., Butler, G., Teixeira, M.C., “Characterization of the Candida glabrata transcription factor CgMar1: role in azole susceptibility”, Journal of Fungi, 8: 61, 2022.
Pais, P.*, Oliveira, J.*, Almeida, V., Yilmaz M., Monteiro P.T.**, Teixeira, M.C.**, “Transcriptome-wide differences between Saccharomyces cerevisiae and Saccharomyces cerevisiae var. boulardii: clues on host adaptation and probiotic activity based on promoter sequence variability”, Genomics, 113: 530-539, 2021.
Pais, P., Vagueiro, S., Mil-Homens, D., Pimenta, A.I., Viana, R., Okamoto, M., Chibana, H., Fialho, A.M., Teixeira, M.C., “A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: the transcription factor CgTog1”, Virulence, 11(1):1522-1538, 2020.
Pais, P., California, R., Galocha, M., Viana, R., Ola, M., Cavalheiro, M., Takahashi-Nakaguchi, A., Chibana, H., Butler, G., Teixeira, M.C., “Candida glabrata transcription factor Rpn4 mediates fluconazole resistance through regulation of ergosterol biosynthesis and plasma membrane permeability”, Antimicrobial Agents and Chemotherapy, 64: e00554-20, 2020.
Pais, P., Galocha, M., Miranda, I.M., Rodrigues, A.G., Teixeira, M.C., “Draft genome sequences from three clinical isolates of the pathogenic yeast Candida glabrata”, Microbial Resource Announcements, 8(35). pii: e00278-19, 2019.
Pais, P., Galocha, M., Viana, R., Cavalheiro, M., Pereira, D., Teixeira, M.C., “Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection”, Microbial Cell, 6(3): 142 – 159, 2019.
Pais, P., Costa, C., Pires, C., Shimizu, K., Chibana, H., Teixeira, M.C., “Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2”, Molecular and Cellular Proteomics, 15(1):57-72, 2016.
Pais, P., Pires, C., Costa, C., Okamoto, M., Chibana, H., Teixeira, M.C., “Membrane proteomics analysis of the Candida glabrata response to 5-flucytosine: unveiling the role and regulation of the drug efflux transporters CgFlr1 and CgFlr2”, Frontiers in Microbiology, 7:2045, 2016.
Pais, P., Costa, C., Cavalheiro, M., Romão, D., Teixeira, M.C., "Transcriptional control of drug resistance, virulence and immune system evasion in pathogenic fungi: a cross-species comparison", Frontiers in Cellular and Infection Microbiology, 6:131, 2016.
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