Miguel Cacho Teixeira

Education

• Habilitation in Biotechnology and Biosciences, IST-ULisboa, 2017

• PhD in Biotechnology, IST-UTL, 2004

• Degree in Chemical Engineering (Biotech track), IST-UTL, 2000

Research Activities

• Mechanisms of antifungal drug resistance in Candida glabrata

• Fungal pathogenesis

• Yeast physiology and Molecular Biology

• Genomics, transcriptomics and proteomics

• Systems biology tools for the study of transcriptional regulatory networks

Selected Publications

Zolotareva, M., Cascalheira, F., Caneiras, C., Bárbara, C., Caetano, D.M.**, Teixeira, M.C.**, "In the flow of molecular miniaturized fungal diagnosis", Trends in Biotechnology, 42(12): 1628-1643, 2024.

Teixeira, M.C.**, Viana, R., Palma, M., Oliveira, J., Galocha, M., Mota, M.N., Couceiro, D., Pereira, M.G., Antunes, M., Costa, I.V., Pais, P., Parada, C., Chaouiya, C., Sá-Correia, I.**, Monteiro, P.T.**, “YEASTRACT+: a portal for the exploitation of global transcription regulation and metabolic model data in yeast biotechnology and pathogenesis”, Nucleic Acids Research, gkac1041, 2023. 

Galocha, M., Viana, R., Pais, P., Silva-Dias, A., Cavalheiro, M., Miranda, I.M., Van Ende, M., Souza, C.S., Costa, C., Branco, J., Soares, C.M., Van Dijck, P., Rodrigues, A.G.**, Teixeira, M.C.**, “Genomic evolution towards azole resistance in Candida glabrata clinical isolates unveils the importance of CgHxt4/6/7 in azole accumulation”, Communications Biology, 5: 1118, 2022. 

Cavalheiro, M., Pereira, D., Formosa-Dague, C., Leitão, C., Pais, P., Ndlovu, E., Viana, R., Pimenta, A.I., Santos, R., Takahashi-Nakaguchi, A., Michiyo Okamoto , Mihaela Ola , Chibana, H., Fialho, A.M., Butler, G., Dague, E.**, Teixeira, M.C.**, “From the first touch to biofilm establishment by the human pathogen Candida glabrata: a genome-wide to nanoscale view”, Communications Biology, 4: 886, 2021.

Pais, P.*, Oliveira, J.*, Almeida, V., Yilmaz M., Monteiro P.T.**, Teixeira, M.C.**, “Transcriptome-wide differences between Saccharomyces cerevisiae and Saccharomyces cerevisiae var. boulardii: clues on host adaptation and probiotic activity based on promoter sequence variability”, Genomics, 113: 530-539, 2021.

Pais, P., Vagueiro, S., Mil-Homens, D., Pimenta, A.I., Viana, R., Okamoto, M., Chibana, H., Fialho, A.M., Teixeira, M.C., “A new regulator in the crossroads of oxidative stress resistance and virulence in Candida glabrata: the transcription factor CgTog1”, Virulence, 11(1):1522-1538, 2020.

Viana, R., Dias, O., Lagoa, D., Galocha, M., Rocha, I., Teixeira, M.C., “Genome-scale metabolic model of the human pathogen Candida albicans: a platform for drug target prediction”, Journal of Fungi, 6: 171, 2020.

Cavalheiro, M., Costa, C., Silva-Dias, A., Miranda, I.M., Wang, C., Pais, P., Pinto, S.N., Mil-Homens, D., Sato-Okamoto, M., Takahashi-Nakaguchi, A., Silva, R.M., Mira, N.P., Fialho, A.M., Chibana, H., Rodrigues, A.G., Butler, G., Teixeira, M.C., “Unveiling the mechanisms of in vitro evolution towards fluconazole resistance of a Candida glabrata clinical isolate: a transcriptomics approach”, Antimicrobial Agents and Chemotherapy, 63: e00995-18, 2019. 

Monteiro, P.T., Pais, P., Costa, C., Manna, S., Sá-Correia, I., Teixeira, M.C., 2017, "The PathoYeastract database: an information system for the analysis of gene and genomic transcription regulation in pathogenic yeasts", Nucleic Acids Research, 45(D1):D597-D603, 2017.

Pais, P., Costa, C., Pires, C., Shimizu, K., Chibana, H., Teixeira, M.C., “Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the Drug:H+ Antiporters CgTpo1_1 and CgTpo1_2”, Molecular and Cellular Proteomics, 15(1):57-72, 2016.

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