Mafalda Cavalheiro

Education

• PhD in Biotechnology and Biosciences, IST-ULisboa, 2020

• MSc in Biotechnology, IST-ULisboa, 2015

• BSc in Biochemistry, FCUL, 2013

Research Activities

• Mechanisms of antifungal drug resistance in Candida glabrata

• Cell adhesion and biofilm formation

• Single-Cell Force Spectroscopy

• Transcriptional regulatory networks controlling biofilm formation

Selected Publications

Cavalheiro, M., Pereira, D., Formosa-Dague, C., Leitão, C., Pais, P., Ndlovu, E., Viana, R., Pimenta, A.I., Santos, R., Takahashi-Nakaguchi, A., Michiyo Okamoto , Mihaela Ola , Chibana, H., Fialho, A.M., Butler, G., Dague, E., Teixeira, M.C., “From the first touch to biofilm establishment by the human pathogen Candida glabrata: a genome-wide to nanoscale view”, Communications Biology, 4: 886, 2021.

Cavalheiro, M., Romão, D., Santos, R., Mil-Homens, D., Pais, P., Costa, C., Galocha, M., Pereira, D., Takahashi-Nakaguchi, A., Chibana, H., Fialho, A.M., Teixeira, M.C., “Role of CgTpo4 in polyamine and antimicrobial peptide resistance: determining virulence in Candida glabrata”, International Journal of Molecular Sciences, 22: 1376, 2021.

Santos, R.*, Cavalheiro, M.*, Costa, C., Takahashi-Nakaguchi, A., Okamoto, M., Chibana, H., Teixeira, M.C., “Screening the Drug:H⁺ Antiporter family for a role in biofilm formation in Candida glabrata”, Frontiers in Cellular and Infection Microbiology, 10: 29, 2020.

Cavalheiro, M., Costa, C., Silva-Dias, A., Miranda, I.M., Wang, C., Pais, P., Pinto, S.N., Mil-Homens, D., Sato-Okamoto, M., Takahashi-Nakaguchi, A., Silva, R.M., Mira, N.P., Fialho, A.M., Chibana, H., Rodrigues, A.G., Butler, G., Teixeira, M.C., “Unveiling the mechanisms of in vitro evolution towards fluconazole resistance of a Candida glabrata clinical isolate: a transcriptomics approach”, Antimicrobial Agents and Chemotherapy, 63: e00995-18, 2019.

Cavalheiro, M., Pais, P., Galocha, M., Teixeira, M.C., “Host-pathogen interactions mediated by MDR transporters in fungi: as pleiotropic as it gets!”, Genes, 9: 332, 2018.

Cavalheiro, M., Teixeira, M.C., “Candida biofilms: threats, challenges and promising strategies", Frontiers in Medicine, 5: 28, 2018.

Romão, D.*, Cavalheiro, M.*, Mil-Homens, D., Santos, R., Pais, P., Costa, C., Takahashi-Nakaguchi, A., Fialho, A.M., Hiroji Chibana, H.**, Teixeira, M.C.**, 2017, “A new determinant of Candida glabrata virulence: the acetate exporter CgDtr1", Frontiers in Cellular and Infection Microbiology, 7: 473.

E-mail (click on)

Alternative webpages