Ethics review is now an accepted and standard requirement in clinical research. Conduct of such research has improved research after the current system was institutionalized in the early 1970s. There are, however, still unresolved, tough ethical issues, and often a need for high level expertise in research ethics. The mission of I-REC is to train individuals who are capable of providing useful and sound advice to researchers doing cutting-edge clinical research, who are faced with unresolved ethical issues.