• Research Field

Gene transcriptional regulation

Cancer Biology

Pulmonary and Cancer development

• Education

Ph.D.
- Department of Molecular Genetics, University of Illinois at Chicago, USA.

M.S.
- Department of Life Science, College of Life Science, National Tsing Hua University, Taiwan

B.S.
- Department of Biology, Tunghai University, Taiwan

• Experiences

Associate Professor
- Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan

Assistant Professor
- Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan

Research Associate
- Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Ohio, USA

Research  Professional Associate
- Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Illinois, USA

Postdoctoral Research Associate
- Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Illinois, USA

Research Assistant
- Institute of Biomedical Sciences, Academia Sinica, Taiwan

• Publications

Yang MC, Huang WL, Chen HY, Lin SH, Chang YS, Tseng KY, Lo HJ, Wang IC, Lin CJ, and Lan CY*. Deletion of RAP1 affects iron homeostasis, azole resistance and virulence in Candida albicans. mSphere. 2025 May 27;10(5):e0015525. DOI: 10.1128/msphere.00155-25

Hsu CC, Yao X, Chen SY, Tsuo TC,  Wang IC*. The Conformation of FOXM1 Homodimers in vivo is Crucial for Regulating Transcriptional Activities. Nucleic Acids Research. DOI: 10.1093/nar/gkae988

Li PC, Dai SY, Lin YS, Chang YT, Liu CC, Wang IC* and Lee MF*. Forkhead box M1 mediates metabolic reprogramming in human colorectal cancer cells. Am J Physiol Gastrointest Liver Physiol. 2024 Aug 1;327(2):G284-G294. DOI:10.1152/ajpgi.00032.2024

Lee CH*, Tsao YH, Weng YP, Wang IC, Chen YP, Hung PF. Therapeutic Effects of Perilla Phenols in Oral Squamous Cell Carcinoma. Int J Mol Sci. 2023 Oct 5;24(19):14931-14944.  DOI: 10.3390/ijms241914931 

Chuang CK*, Chen SF, Su YH, Chen WH, Lin WM, Wang IC, Shyue SK. The Role of SCL Isoforms in Embryonic Hematopoiesis. Int. J. Mol. Sci. 2023 Mar 29;24(7):6427-6438. DOI: 10.3390/ijms24076427

Liang SK, Hsu CC, Song HL, Huang YC, Kuo CW, Yao X, Li CC, Yang HC, Hung YL, Chao SY, Wu SC, Tsai FR, Chen JK, Liao WN, Cheng SC, Tsou TC, Wang IC*. (2021 Jul). FOXM1 is required for small cell lung cancer tumorigenesis and associated with poor clinical prognosis. Oncogene. 40(30):4847-4858. DOI: 10.1038/s41388-021-01895-2 

Chen WT, Tseng HY, Jiang CL, Lee CY, Chi P, Chen LY, Lo KY, Wang IC, Lin FJ*. Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation. J Biomed Sci. 2021 Nov 24;28(1):81. DOI: 10.1186/s12929-021-00773-z  

Kurahashi T, Yoshida Y, Ogura S, Egawa M, Furuta K, Hikita H, Kodama T, Sakamori R, Kiso S, Kamada Y, Wang IC, Eguchi H, Morii E, Doki Y, Mori M, Kalinichenko VV, Tatsumi T, Takehara T*. Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice. Cell Mol Gastroenterol Hepatol. 2020 Oct; 9 (3):425-446. DOI: 10.1016/j.jcmgh.2019.10.008 

Hsieh NT, Huang CY, Li CC, Wang IC, Lee MF*. MED28 and forkhead box M1 (FOXM1) mediate matrix metalloproteinase 2 (MMP2)-dependent cellular migration in human non-small cell lung cancer (NSCLC) cells. J Cell Physiol. 2019 Jul; 234(7): 11265-11275. DOI: 10.1002/jcp.27784

Sun L, Ren X, Wang IC, Pradhan A, Zhang Y, Flood HM, Han B, Whitsett JA, Kalin TV, Kalinichenko VV*. The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. Science Signaling. 2017 Apr 18;10(475) pii: eaai8583. DOI:10.1126/scisignal.aai8583 

Wang IC, Ustiyan V, Zhang Y, Cai Y, Kalin TV, Kalinichenko VV*. Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic KrasG12D. Oncogene. 2014 Nov 13;33(46):5391-6. DOI: 10.1038/onc.2013.475

Balli D, Ustiyan V, Zhang Y, Wang IC, Masino AJ, Ren X, Whitsett JA, Kalinichenko VV, Kalin TV*. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J. 2013 Jan 4;32(2):231-44. DOI: 10.1038/emboj.2012.336 

Wang IC*, Snyder J, Zhang Y, Lander J, Nakafuku Y, Lin J, Chen G, Kalin TV, Whitsett JA, Kalinichenko VV*. Foxm1 Mediates a Cross-talk between Kras/MAPK and Canonical Wnt Signaling Pathways during Development of Respiratory Epithelium. Mol Cell Biol. 2012 Oct;32(19):3838-50.  DOI: 10.1128/MCB.00355-12 

Usityan V, Wert S, Ikegami M, Wang IC, Kalin TV, Whitsett JA and Kalinichenko VV*. Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways. Dev Biol. 2012 Oct 15;370(2):198-212. DOI: 10.1016/j.ydbio.2012.07.028

Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV*. Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development. PLoS One. 2011;6(7):e22217. DOI: 10.1371/journal.pone.0022217 

Wang IC*, Zhang Y, Snyder J, Sutherland M, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV*. Increased Expression of Foxm1 Transcription Factor in Respiratory Epithelium Inhibits Lung Sacculation and Causes Clara Cell Hyperplasia. Dev. Biol. 2010 Nov 15; 347(2):301-314. DOI: 10.1016/j.ydbio.2010.08.027 

Ustiyan V, Wang IC, Ren X, Zhang Y, Snyder J, Xu Y, Wert SE, Lessard JL, Kalin TV, Kalinichenko VV*. Forkhead Box M1 transcription factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus. Dev. Biol. 2009 Dec 15; 336(2):266-279. DOI: 10.1016/j.ydbio.2009.10.007 

Wang IC, Meliton L, Ren X, Zhang Y, Balli D, Snyder J, Whitsett JA, Kalinichenoko VV, Kalin TV*. Deletion of FoxM1 Transcription Factor from Lung Epithelial Cells Inhibits Pulmonary Tumorigenesis. PLoS One 2009 Aug 12; 4(8):e6609. DOI: 10.1371/journal.pone.0006609 

Kalin TV, Wang IC, Meliton L, Zhang Y, Wert SE, Ren X, Snyder J, Bell SM, Graf L Jr, Whitsett JA, Kalinichenko VV*. Forkhead Box m1 transcription factor is required for perinatal lung function. Proc. Natl. Acad. Sci. USA. 2008 Dec 9; 105(49):19329-19334. DOI: 10.1073/pnas.0806748105 

Wang IC, Chen YJ, Hughes DE, Ackerson T, Major ML, Costa RH*, Tyner AL*, Raychaudhuri P* and Lau LF*. FOXM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem. 2008 Jul 25; 283(30):20770-8. DOI: 10.1074/jbc.M709892200 

Wang IC, Meliton L, Tretiakova M, Costa RH, Kalinichenko VV and Kalin TV*. Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors. Oncogene 2008 Jul 10; 27(30):4137-49. DOI: 10.1038/onc.2008.60

Yoshida Y, Wang IC, Yoder HM, Davidson NO and Costa RH*. The Forkhead Box M1 Transcription Factor is Required for Development and Growth of Mouse Colorectal Cancer. Gastroenterology 2007 Apr; 132(4): 1420-31. DOI: 10.1053/j.gastro.2007.01.036

Ramakrishna S, Kim IM, Petrovic V, Malin D, Wang IC, Kalin TV, Meliton L, Zhao YY, Qin Y, Malik AB, Costa RH, and Kalinichenko VV*. Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box m1 transcription factor. Dev Dyn. 2007 Mar 15; 236(4):1000-1013. DOI: 10.1002/dvdy.21113 

Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Ackerson T, Petrovic V, and Costa RH*. A Cell Penetrating ARF Peptide Inhibitor of the Foxm1 Transcription Factor Is an Effective Treatment for Hepatocellular Carcinoma In Vivo. J Clin Invest. 2007 Jan; 117(1):99-111.  DOI: 10.1172/JCI27527

Radhakrishnan SK, Bhat UG, Hughes DE, Wang IC, Costa RH and Gartel AL*. Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Cancer Res. 2006 Oct 1; 66(19):9731-5. DOI: 10.1158/0008-5472.CAN-06-1576

Zhao YY, Gao X, Vogel S, Kalinichenko VV, Wang IC, Costa RH, and Malik AB*. Endothelial Proliferation and Vascular Re-annealing Following Injury Induced by LPS. J Clin Invest. 2006 Sep; 116(9):2333-43. DOI: 10.1172/JCI27154 

Kim IM, Ackerson T, Ramakrishna S, Tretiakova M, Wang IC, Gusarova GA, Yoder HM, Costa RH, and Kalinichenko VV*. The Forkhead Box m1 Transcription Factor Is Essential for Proliferation of Tumor Cells during Development of Lung Cancer. Cancer Res. 2006 Feb; 66(4):2153-2161. DOI: 10.1158/0008-5472.CAN-05-3003

Kalin TV, Wang IC, Ackerson T, Major ML, Detrisac C, Kalinichenko VV, Lyubimov A and Costa RH*. Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Proliferation of Prostate Adenocarcinomas in both TRAMP and LADY Transgenic Mice. Cancer Res. 2006 Feb; 66(3):1712-1720. DOI: 10.1158/0008-5472.CAN-05-3138

Wang IC, Chen YJ, Hughes DE, Petrovic V, Major ML, Park HJ, Tan Y, Ackerson T, and Costa RH*. Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase. Mol Cell Biol. 2005 Dec; 25(24):10875-94. DOI: 10.1128/MCB.25.24.10875-10894.2005

Costa RH*, Kalinichenko VV, Tan Y, and Wang IC. The CAR Nuclear Receptor and Hepatocyte Proliferation. Hepatology, 2005 Nov; 42(5):1004-1008. DOI: 10.1002/hep.20953

Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH, Costa RH*. The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol. 2004 Dec; 276(1):74-88. DOI: 10.1016/j.ydbio.2004.08.022

Kalinichenko VV, Gusarova GA, Tan Y, Wang IC, Major ML, Wang X, Yoder HM, Costa RH*. Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury. J Biol Chem. 2003 Sep; 278(39):37888-94. DOI: 10.1074/jbc.M305555200

Chuang SM, Wang IC, Hwua YS, Yang JL*. Short-term depletion of catalase suppresses cadmium-elicited c-Jun N-terminal kinase activation and apoptosis: role of protein phosphatases. Carcinogenesis. 2003 Jan; 24(1):7-15. DOI: 10.1093/carcin/24.1.7

Chuang SM, Wang IC, Yang JL*. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis. 2000 Jul; 21(7):1423-32.