Purpose of review:  Hypertensive disorders of pregnancy (HDP)-gestational hypertension, preeclampsia, and eclampsia-are a leading cause of adverse maternal and perinatal outcomes internationally. Prevention, timely diagnosis, and prompt management can reduce associated morbidity. The purpose of this review is to compare international guidelines pertaining to HDP.

Recent findings:  Fourteen HDP guidelines were compared relative to guidelines for the United States (US) where the authors practice. Aspirin is universally recommended for high-risk women to reduce preeclampsia risk. Recommended dose and gestational age at initiation vary. Diagnoses of chronic hypertension, gestational hypertension, and preeclampsia in pregnant women are similar, although blood pressure (BP) thresholds for antihypertensive medication initiation and treatment targets vary due to the limitations in high-quality evidence. There are differences among international HDP guidelines related to dose and timing of aspirin initiation, thresholds for antihypertensive medication initiation, and BP targets. However, all guidelines acknowledge the significant morbidity associated with HDP and advocate for timely diagnosis and management to reduce associated morbidity and mortality. More research is needed to understand optimal BP thresholds at which to initiate antihypertensive medication regimens and BP targets in pregnancy.


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Pulmonary hypertension (PH) is a rare and devastating disease characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance, which eventually leads to right ventric-ular failure and death. Pulmonary arterial hypertension (PAH) (World Health Organization Group I), a subset of PH, and may be idiopathic in nature or associated with other systemic conditions and is thought to most commonly effect women, the majority of whom are of childbearing age. However, PAH in the elderly population is being increasingly diagnosed creating clinical considerations that had once not been considered. Often in an elderly population the diagnosis of PAH may be delayed due to chronic comorbid conditions such as coronary artery disease or other dyspneic conditions. Though survival and clinical outcomes have improved, the elderly population continues to have disproportionately lower survival rates. High clinical suspicion of PAH warrants a complete diagnostic workup with right heart catheterization. Upon diagnosis, PAH specific therapy should be initiated with possible drug interactions in mind. Adjuvant pulmonary rehabilitation should be considered as a conservative measure with definitive results. Finally, psychosomatic aspects of the disease should also be considered in elderly populations.

The staff includes certified specialists in non-invasive risk assessment, preventive cardiology, treatment of hypertensive and atherosclerotic disorders, diagnostic cardiac catheterization and intervention (angioplasty, stents), clinical cardiac electrophysiology, pacemaker and automatic cardiac defibrillator implant and follow-up.

The Arrythmia Diagnosis and Treatment program provides the full spectrum of diagnostic and therapeutic cardiovascular services. Diagnostic cardiac electrophysiologic studies are performed, as well as therapeutic cardiac electrophysiologic procedures, including radiofrequency transcatheter ablation, insertion of temporary and permanent pacemakers, and implantation of automatic defibrillators.

The Cardiac Catheterization and Catheter-Based Interventions program provides the full spectrum of diagnostic and therapeutic cardiovascular services. Diagnostic procedures are performed, including right-heart catheterization, left-heart catheterization, angioscopy, intravascular ultrasound and Doppler wire evaluations. Interventional procedures are performed, including percutaneous transluminal balloon angioplasty, directional coronary atherectomy, rotoblater therapy, laser angioplasty, TEC procedures, intercoronary stent deployment, laser percutaneous transmyocardial revascularization, pericardiocentesis and balloon pericardial window procedures.

The Cardiovascular Research Program performs the full spectrum of basic, translational and clinical research on inpatients and outpatients with cardiovascular diseases and hypertension. Cardiovascular clinical trials, clinical pharmacology studies and outcomes research are three major areas of research activity.

The full spectrum of diagnostic evaluations and state-of-the-art surgical and medical therapies is provided for patients prior to, during and following heart transplantation. This comprehensive program includes infectious disease, immunology, psychiatry and social services support.

The full spectrum of diagnostic cardiac ultrasound services is provided. Two-dimensional and Doppler transthoracic echocardiography with and without contrast for adult and pediatric patients. Stress echocardiography, including bicycle and treadmill exercise, as well as adenosine, dobutamine and dipyridamole adjunctive pharmacotherapy. Transesophageal echocardiography, including outpatient, inpatient and intraoperative procedures with and without contrast. 

The full spectrum of diagnostic services, with and without adjunctive radionuclide imaging, is provided. Exercise stress testing using treadmill or bicycle. Stress testing using atrial pacing. Pharmacological stress testing using adenosine, dobutamine or dipyridamole. Metabolic stress testing. 

The Cardiac MRI Laboratory provides the full spectrum of diagnostic cardiac magnetic resonance imaging services. Anatomic/morphologic assessment. Functional studies. Stress wall motion and perfusion studies. Cardiac MRI research (especially angiography and plaque characterization). 

Pulmonary hypertension (PH) can be difficult to diagnose in a routine medical exam because the most common symptoms of PH, such as breathlessness, fatigue and dizziness, are also associated with many other conditions. If your doctor suspects that you have PH, he or she will want to review your medical and family history, perform a physical exam and perform one or more diagnostic tests.

This diagnostic tool tests for blood clots in the lungs by producing a picture of air and blood flow to the lungs. A small dose of radioactive material is breathed in and another small dose is injected via a blood vessel into the lungs. The doctor will review the images that are produced to evaluate the health of the lungs.

We specialize in diagnosing and treating a wide range of conditions that affect your lungs and breathing, like asthma, chronic obstructive pulmonary disease (COPD) and pulmonary hypertension. Using the latest diagnostic tests and treatments, we create the best possible care plan to manage your symptoms and improve your quality of life.

Echocardiography is a diagnostic tool physicians can use to evaluate the structures and functions of the heart. Information about heart wall motion, heart attack damage or scarring, ejection fraction, valve function, congenital (present at birth) heart defects, and pericardial disease (the membrane surrounding the heart) can all be evaluated by an echocardiogram.

Echocardiography is a diagnostic tool that physicians use to evaluate the structures and functions of the heart (see Echocardiography). When combined with a stress test, it can be a powerful method to detect cardiac ischemia, that is, insufficient blood supply to the heart muscle. Physicians often use stress echocardiography to diagnose cardiac ischemia when a patient complains of chest pain.

Cardiac Catheterization and Angiography are techniques that can be used to diagnose many types of heart disease, but most commonly, it is used to diagnose the presence of coronary artery disease (CAD). Blockages or narrowings of the heart arteries can be seen by injecting a fluid through them that can be seen under x-ray (contrast). Contrast can also be used to fill the left ventricle (the main pumping chamber) to evaluate its function. Cardiac catheterization can also be used to diagnose certain types of valve disease, pulmonary hypertension, or congenital (present from birth) heart disease.


The program has established distinction and dedication in state-of-the-art care advanced therapies for patients with a diagnosis of pulmonary hypertension. In existence for close to 30 years the program currently sees over 600 patients with a diagnosis of pulmonary hypertension. The program received the highest designation as a referral center by the Pulmonary Hypertension Association (PHA) in 2015. The program has a multidisciplinary approach with a team of pulmonologists, cardiologists, radiologist, rheumatologists, nurse specialists, pharmacists and respiratory therapist all working together to provide the highest level care to patients with pulmonary hypertension. Our program emphasis is on a patient centered approach with a primary aim to support and educate patients and their families about their disease.

Our multi-disciplinary team, which includes physicians, nurses, respiratory therapists, pharmacists and clinical research coordinators, provide multidisciplinary comprehensive advanced therapy for conditions within the full spectrum of pulmonary vascular disease. Patients will have access to highest level diagnostics and advanced therapies for pulmonary vascular disease. The program is recognized by the PHA as a destination center for comprehensive care of patients with pulmonary hypertension. In addition to access to advanced therapies, patients will have opportunities to participate in a broad range of clinical trials and translational investigation and basic science research.

Our multidisciplinary team comprises board-certified specialists in pulmonology and rheumatology, with extensive expertise in pulmonary vascular disease, including longstanding experience in the diagnosis and management of pulmonary hypertension. Our team engages in weekly multi-disciplinary conferences and maintains close ties with referring pulmonologists to ensure seamless care for our patients. 17dc91bb1f

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