Publications
2024
Kelly-Castro, E.C., Shear, R., Dindigal, A., Bhagwat, M., and Zhang, H. MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo. Experimental Neurology. 2024 376:114752. doi: 10.1016/j.expneurol.2024.114752.
2023
Huang, C, Voglewede MM, Ozsen EN, Wang H. and Zhang H. SHANK3 mutations associated with autism and schizophrenia lead to shared and distinct changes in dendritic spine dynamics in the developing mouse brain. Neuroscience. 2023; 528:1-11. doi: 10.1016/j.neuroscience.2023.07.024.
2022
Voglewede, M.M. and Zhang, H. Polarity proteins: shaping dendritic spines and memory. Developmental Biology, 2022;488:68-73.
2021
Liu Y, Gokhale S, Jung J, Zhu S, Luo C, Saha D, Guo JY, Zhang H, Kyin S, Zong WX, White E, Xie P. Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes. Front Immunol. 2021; 12:670338.
DiBona VL, Shah MK, Krause K, Zhu W, Voglewede, MM, Smith D, Crockett DP, and Zhang H. Metformin reduces neuroinflammation and improves cognitive functions after traumatic brain injury. Neuroscience Research. 2021; S0168-0102(21)00105-X. doi: 10.1016/j.neures.2021.05.007.
2020
Zhang, H. Synaptic dysregulation in autism spectrum disorders. J. Neurosci. Res., 2020, 98(11):2111-2114. doi: 10.1002/jnr.24711.
Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR. Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development. Nature Communications. 2020; 11(1), 1674.
Norton SA, Gifford JJ, Pawlak AP, Derbaly A, Sherman SL, Zhang H, Wagner GC, Kusnecov AW. Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment. Neuroscience. 2020; 434:8-21.
2019
Yu W., Zhang H., Shin M.R., Sesti F. Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment. Biochem Biophys Res Commun. 2019; 512(4):665-669.
Sun, M., Huang, C., Wang, H. and Zhang, H. Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons. Neurobiology of Aging, 2019; 77:87-93.
DiBona, V.L., Zhu, W., Shah, M., Rafalia, A., Ben Cheikh, H., Crockett, D.P., and Zhang, H. Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury. Journal of Neuroinflammation, 2019; 16(1):11.
2018
Winckler, B., Faundez V., Maday, S., Cai, Q. Guimas Almeida, C. and Zhang, H. The endolysosomal system and proteostasis: from development to degeneration. Journal of Neuroscience 2018; 38(44):9364-9374.
Zhang L.*, Zhang, P.*, Wang G.*, Zhang H.*, Zhang, Y. Yu Y., Zhang M., Xiao, J., Crespo, P., Hell JW, Lin, L., Huganir RL. and Zhu J.J. Ras and Rap signal bidirectional synaptic plasticity via distinct subcellular microdomains. Neuron, 2018; 98:1-18. *Equal contribution.
Zhang H., Winckler B., Cai Q. Introduction to the special issue on membrane trafficking in neurons. Dev Neurobiol. 2018 Mar;78(3):167-169.
Eyo, U.B., Bispo, A., Liu, J., Sabu, S., Wu, R., DiBona, V.L., Zhang, H., Tang, Y. and Wu, L.J. The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions. Scientific Reports, 2018; 8(1):828.
2017
Sun, M. and Zhang, H. Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1. Neurobiology of Aging, 2017; 60:129-140.
Wu, Q., Sun, M., Bernard, L.P. and Zhang, H. Postsynapse Density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity. Journal of Biological Chemistry, 2017; 292(39) 16150–16160.
Lim C.S., Wen C., Sheng Y., Wang G., Zhou Z., Wang S., Zhang H., Ye A. and Zhu J.J. Analysis of Ras-BRaf signal transduction with single-molecule force spectroscopy. Small, 2017 doi: 10.1002/smll.201701972.
Lim, C.S., Kang, X., Mirabella, V., Zhang, H., Bu, Q., Araki, Y., Hoang, E.T., Wang, S., Shen, Y., Choi, S., Kaang, B.S., Chang, Q., Pang, Z.P., Huganir, R.L. and Zhu J.J. BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method. Genes and Development, 2017, 31(6):537-552.
2016
Sun, M., Asghar, S.Z. and Zhang, H. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb. Neurobiology of Disease, 2016, Sep;93:1-11. doi: 10.1016/j.nbd.2016.03.022.
Zhang, H. Polarity determinants in dendritic spine development and plasticity. Neural Plasticity, 2016; 2016:3145019. doi: 10.1155/2016/3145019.
2015
Bernard, L.P. and Zhang, H. MARK/Par1 kinase is activated downstream of NMDA receptors through a PKA-dependent mechanism. PLoS One 2015; 10(5):e0124816. doi: 10.1371 /journal.pone.0124816.
Lee, S., Zhang, H. and Webb, D.J. Dendritic Spine Morphology and Dynamics in Health and Disease. Cell Health and Cytoskeleton, 2015:7 121-131.
2013
Yasuda, K., Zhang, H., Loiselle, D. Haystead, T., Macara, I.G. and Mili, S. The RNA-binding protein Fus directs translation of localized mRNAs in APC-ribonucleoprotein granules. Journal of Cell Biology 2013; 203(5), 737-746.
Sun, M.*, Bernard, L.P.*, DiBona V.L., Wu, Q. and Zhang, H. Calcium phosphate transfection of primary hippocampal neurons. Journal of Visualized Experiments, 2013; 81, e50808, doi:10.3791/50808. *equal contribution.
2012
Wu, Q.*, DiBona V.L.*, Bernard, L.P. and Zhang, H. The polarity protein PAR-1 regulates dendritic spine morphogenesis through phosphorylating PSD-95. Journal of Biological Chemistry 2012; 287(36):30781-30788. *equal contribution.
2011
Kim, J.-Y. Oh, M.H., Bernard, L.P., Macara, I.G. and Zhang, H. The RhoG/ELMO1/Dock180 signaling module is required for dendritic spine morphogenesis in hippocampal neurons. Journal of Biological Chemistry 2011; 286(43): 37615-24.
2001-2010
Zhang, H. Rho GTPases and spines. In: Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford, 2009; 8: 357-364.
Zhang, H. and Macara, I.G. The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190RhoGAP and the Rho GTPase. Developmental Cell 2008; 14(2): 216-226.
Webb D.J., Zhang, H., Majumdar, D. and Horwitz, A.F. alpha 5 integrin signaling regulates the formation of spines and synapses in hippocampal neurons. Journal of Biological Chemistry 2007; 282: 6929-6935.
Zhang, H. and Macara, I.G. The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis. Nature Cell Biology 2006; 8(3): 227-237.
Zhang, H., Webb, D.J., Asmussen, H., Niu, S. and Horwitz, A.F. A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC, Journal of Neuroscience 2005; 25(13):3379-88.
Webb, D.J., Zhang, H. and Horwitz, A.F. Cell migration: An overview. Methods in Molecular Biology 2004; 294: 3-11.
Zhang, H., Webb, D.J., Asmussen, H. and Horwitz, A.F. Synapse formation is regulated by the signaling adaptor GIT1. Journal of Cell Biology 2003; 161(1):131-42.
West, K.A., Zhang, H., Brown, M.C., Nikolopoulos, S.N., Riedy, M.C., Horwitz, A.F. and Turner, C.E. The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). Journal of Cell Biology 2001; 54(1):161-76.