worked on research composed in this article from Nov. 2025.  Gene therapy (SPAST-AAV9) prevents manifestation of symptoms in a mouse model of SPG4 hereditary spastic paraplegia.  They used micro RNA to stop the expression from the SPAST gene and cDNA to express healthy human M1 and M87.  Treatment replaced endogenous spastin with healthy spastin preventing onset and progression of corticospinal degeneration and gait defects.

is furthering research with Dr. Ozdinler on AKV-9 (which was formally called NU-9s).  The FDA cleared AKV-9 for clinical trials. Dr. Silverman created AKAVA Therapeutics, a drug company, for AKV-9 to be mass produced.  AKV-9 has proven successful for ALS and Alzheimers Disease.  But that's not all...

AKV9 works by targeting the accumulation of misfolded proteins, a core issue in neurodegenerative diseases like ALS and Alzheimer's, helping cells clear these toxic protein clumps, improving neuron health, and restoring cellular machinery like the ER and mitochondria, though the exact binding site is still being explored. It helps the cell's recycling system (lysosomes) break down harmful protein aggregates, rather than just preventing folding, by facilitating their removal and improving cellular structure.  It may also work for other diseases, so our fingers are crossed.

They have lots of resources in the Tecnology section.

The National Library of Medicine and the National Center for Biotechnology Information compose research studies here.  Look up studies, or If you want to find a trial to take part in.

is a leader at Spastic Paraplegia - Centers for Excellence Research Network  (SP-CERN).  They have eleven locations across America to research and assist those living with spastic paraplegia.  Of these eleven, sadly, none are in California!   SP-CERN received $8.4 million for 5 years of research so we can expect great things to be coming.  Hopefully they can set up a California clinic.  This site has a ton of great links. 

recently updated their website with lots of information including ways to get involved, resources, research, funding, media etc. 

teaches life skills such as centering which we may all need reminders about, or perhaps you never learned this way.  Here is an avenue to strengthening your wellbeing.