Publications

Peer-Reviewed Journal Articles

43. 6-Isoprenylindole-3-carboxylic Acid with an Anti-Melanogenic Activity from a Marine-Derived Streptomyces sp. APA-053

M. Kim; E.-Y. Lee; G.-E. Shin; J. Chin; H. An; S.-J. Nam*; K.-M. Lim* 

Mar. Drugs 2025, 23, 448 (https://doi.org/10.3390/md23120448) 

42. Expedited access to novel hypoxia-inducible factor 1α (HIF-1α) inhibitory benzyl aryl ketones via a decarboxylative Claisen condensation or tandem decarboxylative Claisen condensation-alkylation

S. Lee; M. J. Heo; E. Kim; J. M. Lee; S. G. Kim; I. Kim, Y.-G. Suh; H. An*

New J. Chem. 2025, 49, 19515-19522 (https://doi.org/10.1039/D5NJ00600G)

41. RA-PR058, a novel ramalin derivative, reduces BACE1 expression and phosphorylation of tau in Alzheimer’s disease mouse models

Y. Cho; J. Lee; J.-S. Kim; Y. Jeon; S. Han; H. Cho; Y. Lee; T. K. Kim; J.-M. Hong; Y. Lee; Y. Byun; M. Chae; S. Park; L. F. Palomera; S. Y. Park; H. Kim; S. Kim; S. Kang; J.-G. Jee; H. An; J. H. Yim*; S. H. Kim*; D.-G. Jo* 

Anim. Cells Syst. 2025, 29, 122-134 (https://doi.org/10.1080/19768354.2025.2459649)

40. Trifluoromethylative and Pentafluoroethylative Heterofunctionalization (C–O, C–S, and C–N) of Alkenes Using Visible Light Photocatalysis

Y. R. Choi; S. Kang; J. Hwang; H. An*; K. B. Hong*

ACS Omega 2024, 9, 47500-47505 (https://pubs.acs.org/doi/10.1021/acsomega.4c06017)

39. Semaxanib, a VEGF inhibitor, suppresses melanogenesis by modulating CRTC3 independently of VEGF signaling 

H. Kwon; J. H. Lee; J. M. Yoo; H. Nguyen; H. An*; S. E. Chang*; Y. Song*

J. Dermatol. Sci. 2024, 115, 121-129 (https://doi.org/10.1016/j.jdermsci.2024.07.004)

38. Engineering small-molecule analogues of altiratinib via CREB-regulated transcription co-activator 3-target screening for the development of potent and safe topical therapeutics against skin hyperpigmentary diseases

J. H. Lee#; H. An#; H. Kwon#; S.-J. Lee; Y. H. Park; J. S. Hwang; M. Y. Kim; H. Hwang; J. Y. Kim; S. J. Lee; S. E. Chang*; Y. Song* (# Equal contribution)

Clin. Transl. Med. 2024, 14, e1625 (https://doi.org/10.1002/ctm2.1625)

37. Photocatalytic intermolecular bromonitroalkylation of styrenes: synthesis of cyclopropylamine derivatives and their evaluation as LSD1 inhibitors

D. Kim; H.-J. Jeon; Y. Kwak; S. J. Lee; T.-G. Nam; J. H. Yu; H. An; K. B. Hong*

RSC Adv. 2024, 14, 831-835 (https://doi.org/10.1039/D3RA07830B)

36. Thio(seleno)cyano-difluoroalkylation of Alkenes Using Visible-Light Photocatalysis

Y. R. Choi; S. B. Lee; J. K. Lee; Y. Kwak; H. An*; S. Choi*; K. B. Hong*

Org. Lett. 2023, 25, 3564-3567 (https://doi.org/10.1021/acs.orglett.3c01206)

35. Degrader–Antibody Conjugates: Emerging New Modality

K. B. Hong*; H. An*

J. Med. Chem. 2023, 66, 140-148 (https://doi.org/10.1021/acs.jmedchem.2c01791)

34. BCI-215, a dual-specificity phosphatase inhibitor, reduces UVB-induced pigmentation in human skin by activating mitogen-activated protein kinase pathways

J. H. Lee; M. E. Choi; H. An; J. W. Moon; H. J. Yeo; Y. Song*; S. E. Chang*

Molecules 2022, 27, 5449 (https://doi.org/10.3390/molecules27175449)

33. A bioisosteric approach to the discovery of novel N-aryl-N′-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation

J. Kwak; M.-J. Kim; S. Kim; G.-B. Park; J. Jo; M. Jeong; S. Kang; S. Moon; S. Bang; H. An; S. Hwang; M.-S. Kim; J.-W. Yoo; H. R. Moon; W. Chang; K. W. Chung; J.-Y. Jeong*; H. Yun*

Eur. J. Med. Chem. 2022, 239, 114501 (https://doi.org/10.1016/j.ejmech.2022.114501)

32. Targeting the nuclear receptor-binding set domain family of histone lysine methyltransferases for cancer therapy: Recent progress and perspectives

A. Shrestha; N. Kim; S.-J. Lee; Y. H. Jeon; J.-J. Song; H. An*; S. J. Cho*; T. M. Kadayat*; J. Chin*

J. Med. Chem. 2021, 64, 14913-14929 (https://doi.org/10.1021/acs.jmedchem.1c01116)

31. Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents

T. M. Kadayat; D. E. Kim; S. B. Lee; K. Jung; S. E. Park; J.-Y. Hong; J. Kim; A. Shrestha; D.-S. Kim; H. An; N. Kim; S.-J. Lee; S. Kwon; S. Kim; J. Y. Hwang; S. Kim; D. Hahn; H. Choi; S.-J. Nam; Y. H. Jeon; J. J. Hwang*; S. J. Cho*; J. Chin*

Bioorg. Chem. 2021, 113, 105027 (https://doi.org/10.1016/j.bioorg.2021.105027)

30. Physical and functional analysis of the putative Rpn13 inhibitor RA190

P. Dickson; D. Abegg; E. Vinogradova; J. Takaya; H. An; S. Simanski; B. F. Cravatt; A. Adibekian; T. Kodadek*

Cell Chem. Biol. 2020, 27, 1371-1382.e6 (https://doi.org/10.1016/j.chembiol.2020.08.007)

29. An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer

J. Kim; H. Hwang; H. Yoon; J.-E. Lee; J. M. Oh; H. An; H. D. Ji; S. Lee; E. Cha; M. J. Ma; D.-S. Kim; S.-J. Lee; T. M. Kadayat; J. Song; S. W. Lee; J.-H. Jeon; K.-G. Park; I.-K. Lee; Y. H. Jeon*; J. Chin*; S. J. Cho*

Eur. J. Med. Chem. 2020, 205, 112501 (https://doi.org/10.1016/j.ejmech.2020.112501)

28. Targeting peroxisome proliferator-activated receptor delta (PPARδ): A medicinal chemistry perspective

T. M. Kadayat; A. Shrestha; Y. H. Jeon; H. An; J. Kim; S. J. Cho*; J. Chin*

 J. Med. Chem. 2020, 63, 10109-10134 (https://doi.org/10.1021/acs.jmedchem.9b01882)

27. Novel hypoxia-inducible factor 1α (HIF-1α) inhibitors for angiogenesis-related ocular diseases: Discovery of a novel scaffold via ring-truncation strategy

H. An; S. Lee; J. M. Lee; D. H. Jo; J. Kim; Y.-S. Jeong; M. J. Heo; C. S. Cho; H. Choi; J. H. Seo; S. Hwang; J. Lim; T. Kim; H. O. Jun; J. Sim; C. Lim; J. Hur; J. Ahn; H. S. Kim; S.-Y. Seo; Y. Na; S.-H. Kim; J. Lee; J. Lee; S.-J. Chung; Y.-M. Kim; K.-W. Kim; S. G. Kim; J. H. Kim* and Y.-G. Suh*

J. Med. Chem. 2018, 61, 9266-9286 (https://doi.org/10.1021/acs.jmedchem.8b00971)

26. Conformation-enabled total syntheses of ohmyungsamycins A and B and structural revision of ohmyungsamycin B

J. Hur; J. Jang; J. Sim; W. S. Son; H.-C. Ahn; T. S. Kim; Y.-H. Shin; C. Lim; S. Lee; H. An; S.-H. Kim; D.-C. Oh; E.-K. Jo; J. Jang; J. Lee and Y.-G. Suh*

Angew. Chem. Int. Ed. 2018, 57, 3069-3073 (https://doi.org/10.1002/anie.201711286)

25. Stereoselective synthesis of 1,4,5-tri-cis-guaiane sesquiterpene: First total synthesis of (−)-dendroside C aglycon

 J. Sim; H. Park; J. Lim; I. Yoon; C. Lim; H. An; H. Yun; H. J. Choi and Y.-G. Suh*

Org. Lett. 2018, 20, 586-589 (https://doi.org/10.1021/acs.orglett.7b03701)

24. Asymmetric total synthesis of (+)-(3E)-pinnatifidenyne via abnormally regioselective Pd(0)-catalyzed endocyclization

H. S. Kim; T. Kim; J. Ahn; H. Yun; C. Lim; J. Jang; J. Sim; H. An; Y.-J. Surh; J. Lee and Y.-G. Suh*

J. Org. Chem. 2018, 83, 1997-2005 (https://doi.org/10.1021/acs.joc.7b02937)

23. DNA-compatible solid-phase combinatorial synthesis of β-cyanoacrylamides and related electrophiles

K. Pels; P. Dickson; H. An and T. Kodadek*

ACS Comb. Sci. 2018, 20, 61-69 (https://doi.org/10.1021/acscombsci.7b00169)

22. Total synthesis of (+)-brasilenyne via concise construction of an oxonane framework containing a 1,3-cis,cis-diene

C. Lim; J. Ahn; J. Sim; H. Yun; J. Hur; H. An; J. Jang; S. Lee and Y.-G. Suh*

Chem. Commun. 2018, 54, 467-470 (https://doi.org/10.1039/C7CC08329G)

21. Asymmetric total synthesis of (+)-Intricenyne via an endocyclization route to oxocane skeleton

J. Ahn; C. Lim; H. Yun; H. S. Kim; S. Kwon; J. Lee; S. Lee; H. An; H.-g. Park and Y.-G. Suh*

Org. Lett. 2017, 19, 6642-6645 (https://doi.org/10.1021/acs.orglett.7b03370)

20. Asymmetric synthesis of vinylogous beta-amino acids and their incorporation into mixed backbone oligomers

H. Wu#; H. An#; S. Mo and T. Kodadek* (# Equal contribution)

Org. Biomol. Chem. 2017, 15, 3255-3264 (https://doi.org/10.1039/C7OB00333A)

19. Identification and structural analysis of new Nrf2 activators by mechanism-based chemical transformation of 15-Deoxy-∆12,14 -PGJ2

K. Kim; J.-M. Park; N.-J. Kim; S.-J. Kim; H. Moon; H. An; J. Lee; H.-J. Park; Y.-J. Surh* and Y.-G. Suh*

ChemBioChem 2016, 17, 1900-1904 (https://doi.org/10.1002/cbic.201600165)

18. Identification of a novel circadian clock modulator controlling BMAL1 expression through a ROR/REV-ERB-response element-dependent mechanism

J. Lee; S. Lee; S. Chung; N. Park; G. H. Son; H. An; J. Jang; D.-J. Chang; Y.-G. Suh* and K. Kim*

Biochem. Biophys. Res. Commun. 2016, 469, 580-586 (https://doi.org/10.1016/j.bbrc.2015.12.030)

17. Deguelin analogue SH-1242 inhibits Hsp90 activity and exerts potent anticancer efficacy with limited neurotoxicity

S.-C. Lee; H.-Y. Min; H. Choi; S. Y. Bae; K. H. Park; S. Y. Hyun; H. J. Lee; J. Moon; S.-H. Park; J. Y. Kim; H. An; S.-J. Park; J. H. Seo; S. Lee; Y.-M. Kim; H.-J. Park; S. K. Lee; J. Lee; J. Lee; K.-W. Kim; Y.-G. Suh and H.-Y. Lee*

Cancer Res. 2016, 76, 686-699 (https://doi.org/10.1158/0008-5472.CAN-15-1492)

16. Divergent synthetic route to new cyclopenta[c]pyran iridoids: Syntheses of jatamanin A, F, G and J, gastrolactone and nepetalactone

J. Sim; I. Yoon; H. Yun; H. An and Y.-G. Suh*

Org. Biomol. Chem. 2016, 14, 1244-1251 (https://doi.org/10.1039/C5OB02147B)

15. Diastereoselective total synthesis of (-)-galiellalactone

T. Kim; Y. T. Han; H. An; K. Kim; J. Lee and Y.-G. Suh*

J. Org. Chem. 2015, 80, 12193-12200 (https://doi.org/10.1021/acs.joc.5b02121)

14. Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action

K. Kim; S.-J. Kim; Y. T. Han; S.-J. Hong; H. An; D.-J. Chang; T. Kim; B. Lim; J. Lee; Y.-J. Surh* and Y.-G. Suh*

Bioorg. Med. Chem. Lett. 2015, 25, 5444-5448 (https://doi.org/10.1016/j.bmcl.2015.07.063)

13. Synthesis and biological evaluation of novel homoisoflavonoids for retinal neovascularization

H. D. Basavarajappa; B. Lee; H. Lee; R. S. Sulaiman; H. An; C. Magana; M. Shadmand; A. Vayl; G. Rajashekhar; E.-Y. Kim; Y.-G. Suh; K. Lee; S.-Y. Seo* and T. W. Corson*

J. Med. Chem. 2015, 58, 5015-5027 (https://doi.org/10.1021/acs.jmedchem.5b00449)

12. Total synthesis of (-)-deguelin via an iterative pyran-ring formation strategy

S. Lee; H. An; D.-J. Chang; J. Jang; K. Kim; J. Sim; J. Lee and Y.-G. Suh*

Chem. Commun. 2015, 51, 9026-9029 (https://doi.org/10.1039/C5CC02215K)

11. Synthesis and synthesis-based structural elucidation of (‒)-Macrosphelides J and K

H. An; S.-H. Kim; H. Kim; K. Kim; J. Sim; J. Jang; S.-M. Paek; Y.-G. Suh and H. Yun*

Heterocycles 2015, 91, 970-988 (https://doi.org/10.3987/COM-15-13195)

10. Fine tuning of 4,6-bisphenyl-2-(3-alkoxyanilino)pyrimidine focusing on the activity-sensitive aminoalkoxy moiety for a therapeutically useful inhibitor of receptor for advanced glycation end products (RAGE)

Y. T. Han; K. Kim; D. Son; H. An; H. Kim; J. Lee; H.-J. Park; J. Lee and Y.-G. Suh*

Bioorg. Med. Chem. 2015, 23, 579-587 (https://doi.org/10.1016/j.bmc.2014.12.003)

9. Efficient strategy for the stereoselective synthesis of 2,3-disubstituted benzo[α]quinolizidine alkaloids: concise synthesis of (−)-protoemetinol

H. Moon; H. An; J. Sim; K. Kim; S.-M. Paek and Y.-G. Suh*

Tetrahedron Lett. 2015, 56, 608-611 (https://doi.org/10.1016/j.tetlet.2014.12.030)

8. Design and synthesis of a macrosphelide A-biotin chimera

H. Yun; J. Sim; H. An; J. Lee; H. S. Lee; Y. K. Shin; S.-M. Paek* and Y.-G. Suh*

Org. Biomol. Chem. 2014, 12, 7127-7135 (https://doi.org/10.1039/C4OB01028K)

7. Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors

D. H. Jo; H. An; D.-J. Chang; Y.-Y. Baek; C. S. Cho; H. O. Jun; S.-J. Park; J. H. Kim; H.-Y. Lee; K.-W. Kim; J. Lee; H.-J. Park; Y.-M. Kim; Y.-G. Suh* and J. H. Kim*

J. Mol. Med. 2014, 92, 1083-1092 (https://doi.org/10.1007/s00109-014-1168-8)

6. Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE)

Y. T. Han; K. Kim; G.-I. Choi; H. An; D. Son; H. Kim; H.-J. Ha; J.-H. Son; S.-J. Chung; H.-J. Park; J. Lee and Y.-G. Suh*

Eur. J. Med. Chem. 2014, 79, 128-142 (https://doi.org/10.1016/j.ejmech.2014.03.072)

5. Glucal-conjugated sterols as novel vascular leakage blocker: Structure–activity relationship focusing on the C17-side chain

K. Kim; S. Maharjan; C. Lim; N.-J. Kim; V. Agrawal; Y. T. Han; S. Lee; H. An; H. Yun; H.-J. Choi; Y.-G. Kwon* and Y.-G. Suh*

Eur. J. Med. Chem. 2014, 75, 184-194 (https://doi.org/10.1016/j.ejmech.2014.01.027)

4. Microwave-assisted synthesis of 3-substituted indoles via intramolecular arene–alkene coupling of o-iodoanilino enamines

W.-I. Lee; J.-W. Jung; J. Sim; H. An and Y.-G. Suh*

Tetrahedron 2013, 69, 7211-7219 (https://doi.org/10.1016/j.tet.2013.06.101)

3. Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis

D.-J. Chang; H. An; K.-s. Kim; H. H. Kim; J. Jung; J. M. Lee; N.-J. Kim; Y. T. Han; H. Yun; S. Lee; G. Lee; S. Lee; J. S. Lee; J.-H. Cha; J.-H. Park; J. W. Park; S.-C. Lee; S. G. Kim; J. H. Kim; H.-Y. Lee; K.-W. Kim and Y.-G. Suh*

J. Med. Chem. 2012, 55, 10863-10884 (https://doi.org/10.1021/jm301488q)

2. Design, synthesis and insight into the structure–activity relationship of 1, 3-disubstituted indazoles as novel HIF-1 inhibitors

H. An; N.-J. Kim; J.-W. Jung; H. Jang; J.-W. Park and Y.-G. Suh*

Bioorg. Med. Chem. Lett. 2011, 21, 6297-6300 (https://doi.org/10.1016/j.bmcl.2011.08.120)

1. Design, synthesis and identification of novel colchicine-derived immunosuppressant

D.-J. Chang; E.-Y. Yoon; G.-B. Lee; S.-O. Kim; W.-J. Kim; Y.-M. Kim; J.-W. Jung; H. An and Y.-G. Suh*

Bioorg. Med. Chem. Lett. 2009, 19, 4416-4420  (https://doi.org/10.1016/j.bmcl.2009.05.054)

Book Chapters

1. Synthesis and screening of bead-displayed combinatorial libraries

T. M. Doran, P. Dickson, J. M. Ndungu, P. Ge, I. Suponitsky-Kroyter, H. An and T. Kodadek*

in Methods in Enzymology, ed. A. K. Shukla, Academic Press, 2019, vol. 622, pp. 91-127 (https://doi.org/10.1016/bs.mie.2019.02.005)