RESEARCH

Design and development of innovative and functional artificial nucleic acid-based nanostructure as a carrier to enhace the safety and efficacy of drug delivery and diagnostic imaging. 

Design, synthesis, and biomedical applications of nucleic acid-based hydrogels for wound healing, biosensing, and skin care products (cosmetics).

Investigation and advancement of nucleic acid nanotechnology across a wide range of biomedical applications.

Design of a novel non-viral and vector delivery system to safely transport target genes into cells for the treatment of hereditary diseases.

Investigation of gene therapies based on siRNA-mediated RNA interference (RNAi) and the CRISPR/Cas9 system for potential clinical applications.

Utilization of diverse biomaterials (e.g., inorganic nanoparticles, peptides, aptamers, polymers, lipids, and proteins) to enhace the efficacy of gene therapy.

Development of molecular sensing platforms for the simple, rapid, specific, and sensitive detection of infectious pathogens and genetic alternations. 

Design of biosensors based on hairpin DNA probes, quantum dots, DNA structures, and gold nanoparticles utilizing fluorescence resonance energy transfer (FRET) assay and colorimetric assays. 

Development of user-friendly and cost-effective diagnostic tests (e.g., lateral flow assay kits and ELISA kits) for parcitcal clinical diagnosis.