Ogawa M, Fujisawa T, Takenaka S, Yano M, Kuroda M, Taniguchi D, Wang Z, Hiratsuka T, Kanai A, Suzuki Y, Sato S, Miyagi Y, Takano A, Daigo Y, Nita A, Moroishi T, Naguro I, Ichijo H. FGF21 suppresses hepatocellular carcinoma by driving competitive cell-cell interactions. Cell Rep. 2026 Jun 23;45(6):117410. https://doi.org/10.1016/j.celrep.2026.117410
Hiratsuka T, Peng D. Multiplex live imaging approaches to interrogate the interplay of multiple signaling pathways. Cell Structure and Function. 2026;51(1):109-119. https://doi.org/10.1247/csf.25129
Zijl S, Hiratsuka T, Mobasseri A, Ebrahimkutty M, Börmel M, Garcia-Manyes S, Watt FM. Cell volume regulates terminal differentiation of cultured human epidermal keratinocytes. Journal of Cell Science. 2025 July 29;jcs.264242. https://doi.org/10.1242/jcs.264242
Hiratsuka T, Rognoni E. Protocol for detecting 3D dermal fibroblast cellular dynamics in mice using an intravital imaging technique. STAR Protocols. 2025 June 20;6(2):103801. https://doi.org/10.1016/j.xpro.2025.103801
Tsukamoto S, Huaze Y, Weisheng Z, Machinaga A, Kakiuchi N, Ogawa S, Seno H, Higashiyama S, Matsuda M, Hiratsuka T. Quantitative Live Imaging Reveals Phase Dependency of PDAC Patient-Derived Organoids on ERK and AMPK Activity. Cancer Sci. 2025 Mar;116(3):724–35. https://doi.org/10.1111/cas.16439
Weisheng Z, Nakayama J, Inomata Y, Higashiyama S, Hiratsuka T. A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription. Cell Structure and Function. 2025;50(1):15–24. https://doi.org/10.1247/csf.24070
Bernabé-Rubio M, Ali S, Bhosale PG, Goss G, Mobasseri SA, Tapia-Rojo R, Zhu T, Hiratsuka T, Battilocchi M, Tomás IM, Ganier C, Garcia-Manyes S, Watt FM. Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation. Nat Cell Biol. 2023 Oct;25(10):1426–38. https://doi.org/10.1038/s41556-023-01234-5
Harada Y, Mizote Y, Suzuki T, Hirayama A, Ikeda S, Nishida M, Hiratsuka T, Ueda A, Imagawa Y, Maeda K, Ohkawa Y, Murai J, Freeze HH, Miyoshi E, Higashiyama S, Udono H, Dohmae N, Tahara H, Taniguchi N. Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells. Elife. 2023 July;12:e83870. https://doi.org/10.7554/elife.83870
Rognoni E, Goss G, Hiratsuka T, Sipilä KH, Kirk T, Kober KI, Lui PP, Tsang VS, Hawkshaw NJ, Pilkington SM, Cho I, Ali N, Rhodes LE, Watt FM. Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage. Elife. 2021 Dec;10:e71052. https://doi.org/10.7554/eLife.71052
Hiratsuka T, Bordeu I, Pruessner G, Watt FM. Regulation of ERK basal and pulsatile activity control proliferation and exit from the stem cell compartment in mammalian epidermis. Proc Natl Acad Sci USA. 2020 July;117(30):17796–807. https://doi.org/10.1073/pnas.2006965117
Brayford S, Kenny FN, Hiratsuka T, Serna-Morales E, Yolland L, Luchici A, Luchici A, Stramer BM. Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations. J Cell Sci. 2019 June 1;132(11):jcs223974. https://doi.org/10.1242/jcs.223974
Hiratsuka T, Komatsu N. Single-Cell Live Imaging. In: Proserpio V, editor. Single Cell Methods [Internet]. New York, NY: Springer New York; 2019 [cited 2023 Aug 13]. p. 409–21. (Methods in Molecular Biology; vol. 1979). Available from: http://link.springer.com/10.1007/978-1-4939-9240-9_24
Rognoni E, Pisco AO, Hiratsuka T, Sipilä KH, Belmonte JM, Mobasseri SA, Philippeos C, Dilão R, Watt FM. Fibroblast state switching orchestrates dermal maturation and wound healing. Molecular Systems Biology. 2018 Aug;14(8):e8174. https://doi.org/10.15252/msb.20178174
Aoki K, Kondo Y, Naoki H, Hiratsuka T, Itoh RE, Matsuda M. Propagating Wave of ERK Activation Orients Collective Cell Migration. Dev Cell. 2017 Nov;43(3):305-317.e5. https://doi.org/10.1016/j.devcel.2017.10.016
Sakaue-Sawano A, Yo M, Komatsu N, Hiratsuka T, Kogure T, Hoshida T, Goshima N, Matsuda M, Miyoshi H, Miyawaki A. Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle. Mol Cell. 2017 Nov;68(3):626-640.e5. https://doi.org/10.1016/j.molcel.2017.10.001
Donati G, Rognoni E, Hiratsuka T, Liakath-Ali K, Hoste E, Kar G, Kayikci M, Russell R, Kretzschmar K, Mulder KW, Teichmann SA, Watt FM. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties. Nat Cell Biol. 2017 June;19(6):603–13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610974
Hiratsuka T, Fujita Y, Naoki H, Aoki K, Kamioka Y, Matsuda M. Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin. Elife. 2015 Feb;4:e05178. https://doi.org/10.7554/eLife.05178
Matsuzaki S, Hiratsuka T, Taniguchi M, Shingaki K, Kubo T, Kiya K, Fujiwara T, Kanazawa S, Kanematsu R, Maeda T, Takamura H, Yamada K, Miyoshi K, Hosokawa K, Tohyama M, Katayama T. Physiological ER Stress Mediates the Differentiation of Fibroblasts. PLoS One. 2015;10(4):e0123578. https://doi.org/10.1371/journal.pone.0123578
Koyama Y, Hiratsuka T, Matsuzaki S, Yamagishi S, Kato S, Katayama T, Tohyama M. Familial amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS. Neurochem Int. 2010 Dec;57(7):838–43. https://doi.org/10.1016/j.neuint.2010.08.023
Hiratsuka T, Matsuzaki S, Miyata S, Kinoshita M, Kakehi K, Nishida S, Katayama T, Tohyama M. Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response. PLoS One. 2010 Oct;5(10):e13280. https://doi.org/10.1371/journal.pone.0013280
Matsuzaki S, Hiratsuka T, Kuwahara R, Katayama T, Tohyama M. Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress. Neurochem Int. 2010 Jan;56(2):352–6. https://doi.org/10.1016/j.neuint.2009.11.007