Research Keywords
・Human Genome
・Microprotein
・Noncoding RNA
・Retrotransposon
・Proteomics
Academic Membership
・The Genetics Society of Japan
・The Society for the Study of the Origin and Evolution of Life Japan
・The Molecular Biology Society of Japan
Research
①Recent studies have revealed that regions of the human genome previously considered non-coding can express small proteins of fewer than 100 amino acids. However, the full extent of which regions produce these proteins and their specific functions remains largely unknown. My research focuses on the characteristics and physiological roles of these small proteins within human cells.
②LINE1, a type of retrotransposon, constitutes approximately 17% of the human genome. While many LINE1 elements have suppressed transpositional activity, certain loci or conditions can lead to active transposition. Currently, I am utilizing genome-wide identification methods to pinpoint highly active LINE1 elements and studying their expression dynamics across various cell types.
Publications
Award Announcements
Exploration of determinants for intracellular stability of upstream open reading frame-derived proteins, The Genetics Society of Japan 96th Annual Meeting, Best Papers Award Link
Oral Presentations
Mass spectrometry-based exploration of upstream ORF-encoded protein, 2021 Japanese Proteomics Society, Online, July, 2021.
Exploration of microproteins in human cells, ISAS Astrobiology Exploration Symposium 2022, Online, March, 2022.
Intracellular Stability is the Key Toward Functional Expression of Human Microproteins, Keystone Symposia Micropeptides: Biogenesis and Function, USA, Apr 2022.
Intracellular stability-based screening for functional human proteins encoded in noncoding regions, The Genetics Society of Japan 94th Annual Meeting, Hokkaido, Japan, September, 2022.
Exploration of determinants for intracellular stability of upstream open reading frame-derived proteins, The Genetics Society of Japan 96th Annual Meeting, Kochi, Japan, September, 2024.
Identifying Factors Determining the Intracellular Stability of Proteins Encoded by the Human Upstream ORF, The Genetics Society of Japan 97th Annual Meeting, Hyogo, Japan, September, 2025.
Poster Presentations
Intracellular Stability is the Key Toward Functional Expression of Human Microproteins, Keystone Symposia Micropeptides: Biogenesis and Function, No.1006, USA, Apr 2022.
Transcriptional dynamics of L1 antisense promoters during differentiation of human iPS cells into β-cells, Cold Spring Harbor Laboratory Meetings TRANSPOSABLE ELEMENTS,USA, Oct 2024.
Evaluation of intracellular stability of human microproteins encoded in 5’UTRs, The 47th Annual Meeting of the Molecular Biology Society of Japan, Fukuoka, Japan, November, 2024.
Construction of a Landing Pad for Useful Substance Production in Yeast and Optimization of the Expressed Gene Cluster, GteX Biomanufacturing Area Meeting, Hyogo, Japan, 2025.
Development of an Experimental Automation Device Utilizing 3D Printers, The 65th Summer School of Life Sciences, Tokyo, Japan, 2025.
Awards
Tokyo Tech Life Science and Technology Alumni Association Outstanding Undergraduate Research Presentation Award (2021)
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT (NICHD) SCHOLARSHIP(2022)
The Genetics Society of Japan 96th Annual Meeting Best Papers Award（2024）
Grants
JSPS Fellows, Establishment of a screening method for functional microproteins independent of amino acid sequence conservation 2023-2026
Leave a Nest, The 63th incu-be award, Investigating the helical phyllotaxy of Spiranthes sinensis through citizen science data and computational modeling. 2024-2025