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What is epigenetic regulators?
What is epigenetic regulators?
Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. Epigenetic regulation is mainly carried out by three types of modification: Histone modification at the protein level, DNA methylation at the DNA level, and ncRNA at the RNA level.
Epigenetic regulators are modifying enzymes that can affect gene expression.
Epigenetic regulators as a switch of disease progression
Epigenetic regulators as a switch of disease progression
Epigenetic change can have more damaging effects that can result in diseases like cancer. Even if twins possess same genetic information at birth, the difference in the activity of the epigenetic regulator will cause one person to develop a disease and the other to be healthy.
Aim I. Construction of DSER database
Aim I. Construction of DSER database
We will discover and verify disease-specific epigenetic regulators(DSER), and finally build a database of various human disease-specific epigenetic regulators.
Aim II. Therapeutic application of DSER database
Aim II. Therapeutic application of DSER database
Ultimately, We will share the DSER database for application to disease treatment. We believe that inhibiting disease development by controlling the expression of various target genes at once through the epigenetic regulator will be more fundamental and beyond the limits of antibody therapy. In addition, We think that effective clinical application will be possible by using the DSER database.
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