I hold a B.S. in Medical Physics (2008) and an M.S./Ph.D. in Physics Applied to Medicine and Biology (2011/2016) from the University of São Paulo, Brazil. During my graduate studies, I conducted research in therapeutic ultrasound and imaging at Mayo Clinic (2010) and Columbia University (2014) through student exchange programs. Following this, I pursued postdoctoral research at CEA, France, and Columbia University, where I was later promoted to Associate Research Scientist.
At CEA, I developed a feedback control system for MRI-guided targeted blood-brain barrier (BBB) disruption using focused ultrasound, aimed at drug delivery to the brain. This work was validated in non-human primates and earned me the Best Presentation Award at the 2017 6th Winter School on Therapeutic Ultrasound, France. During my time at Columbia University, I investigated the safety aspects of focused ultrasound stimulation of human peripheral nerves, focusing on thermal measurements, simulations, and cavitation mapping.
Since joining InSightec in 2021, I have led clinical applications in neurosurgery, helping train neurosurgeons to utilize our device for FDA-approved indications such as Essential Tremor and Parkinson's disease. I also collaborate closely with top neurosurgeons across the US Northeast to translate research into clinical practice. My research interests focus on therapeutic ultrasound, including ultrasound ablation, neuromodulation, and BBB disruption for targeted drug delivery in the central nervous system. I also specialize in MR- and ultrasound imaging-based monitoring techniques.
My technical expertise includes developing systems for signal acquisition and data processing using Matlab, LabVIEW, and Python. I have extensive experience with ultrasound devices, such as the IGT (Image Guided Therapy, France) and Verasonics Vantage systems, and I have worked with ultrasound imaging techniques such as vibro-acoustography, B-mode, passive cavitation imaging, displacement imaging, and thermal strain imaging.
I actively serve as a reviewer for 15 scientific journals and have been a topic editor for Frontiers in Physics and Frontiers in Physiology. I am a member of the IEEE and its Ultrasonics, Ferroelectrics, and Frequency Control Society, the Acoustical Society of America, the Brazilian Physical Society, and the Brazilian Society of Biomedical Engineering.
My contributions to the field have been recognized with several honors, including the Outstanding Reviewer Award from Physics in Medicine and Biology (IOP Publishing) in 2018 and the Best Ph.D. Dissertation Award in Medical Physics from the Brazilian Physical Society in 2016.
2011 – 2016 Ph.D. in Physics Applied to Medicine and Biology
University of São Paulo, Brazil
Collaborative project with Columbia University, New York, USA (04/2014 – 03/2015)
Thesis Title: Multifrequency excitation and safety for transcranial sonothrombolysis
Brief Synopsis: Methods of multifrequency ultrasonic excitation were developed and validated in vitro and in vivo to improve targeting in transcranial focused ultrasound for sonothrombolysis, ultrasound neuromodulation, and blood-brain barrier opening.
Supervisor in Brazil: Antonio A. O. Carneiro, Ph.D.
Supervisor in the USA: Elisa E. Konofagou, Ph.D.
2009 – 2011 M.S. in Physics Applied to Medicine and Biology
University of São Paulo, Brazil
Collaborative project with Mayo Clinic, USA (07/2010 – 12/2010)
Dissertation title: Vibro-acoustography in the tridimensional evaluation of total hip arthroplasty.
Brief Synopsis: Techniques of 3D reconstruction of vibro-acoustography images were presented to evaluate bone-implant positioning. In addition, numerical simulations of vibro-acoustography demonstrated the capability of reconfigurable array transducers in performing electronic beam steering while maintaining high spatial resolution.
Supervisor in Brazil: Antonio A. O. Carneiro, Ph.D.
Supervisor in the USA: Mostafa Fatemi, Ph.D. and Matthew W. Urban, Ph.D.
2004 – 2008 B.S. in Medical Physics
University of São Paulo, Brazil
2000 – 2003 Technologist in Mechatronics
2021 Front cover in IEEE Transaction on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 68, no. 1, Jan 2021.
"Real-time passive acoustic mapping using sparse matrix multiplication," vol. 68, no. 1, Jan. 2021.
Front cover link: https://doi.org/10.1109/TUFFC.2020.3042289
Paper link: https://doi.org/10.1109/TUFFC.2020.3001848
2019 Student Paper Competition Award - IEEE Int Ultrasonics Symposium, 6-9 Oct. 2019, Glasgow, Scotland, UK, IEEE.
“Nerve displacement mapping for human peripheral neuromodulation”, by Lee, Stephen.A., Kamimura HAS, Konofagou E
2019 2018 Outstanding Reviewer Award winner for Physics in Medicine and Biology, IOP Publishing
2018 Best Ph.D. dissertation in the field of Medical Physics (2016)
2017 Best presentation (oral)
2015 Best Student Poster Award in the field of Medical Physics
2014 Best poster
São Paulo Research Foundation. Scholarship - Doctorate: FAPESP 11/10809-6 (BRA R$ 131,375.79; 09/01/2011 - 11/30/2015, http://www.bv.fapesp.br/25326).
São Paulo Research Foundation. Scholarship Abroad: FAPESP 13/08116-8 (US$ 32,480.00; 04/01/2014 - 03/31/2015, http://www.bv.fapesp.br/25325)
National Council for Scientific and Technological Development. Scholarship – M.S.: CNPq 130320/2009-9 (BRA R$ 28,800.00; 03/01/2009 a 02/28/2011)
National Council for Scientific and Technological Development. Scholarship - B.S.
Fundação de Apoio às Ciências: Humanas, Exatas e Naturais. Scholarship - B.S