Research Period as a PI (2008 - present)

Co-first author*

Co-corresponding author#

2024

Bobae Hyeon, Jaehyun Shin, Heeyoung Lee, Dae-gun Kim, Choong Yeon Kim, Jea Kwon, C. Justin Lee, Jae-Woong Jeong, Kwang-soo Kim, Daesoo Kim#, Won Do Heo#

Nature Communications. 2024. Under Review.  

Heeyoung Lee, Sangkyu Lee, Yeji Seo, Dongsan Kim, Yohan Oh, Juae Jin, Bobae Hyeon, Younghyun Han, Hyunjun Kim, Homin Kim, Gabsang Lee#, Kwang-Hyun Cho#, 

Won Do Heo#

Nature Communications. 2024. Under Review.  

Jihwan Yu, Juae Jin, Eury Kwon, Hyunsoo Jang, Donggyun Kim, Sang-kun Choi, Seungkyu Son, Ki-Jun Yoon, and Won Do Heo

Nature Chemical Biology. 2024. Under Revision.

Jinsu Lee, Yeonji Jeong, Seehyung Park, Sungsoo Kim, Hyunsik Oh, Jong-Woo Sohn, Daesoo Kim, Hee-Sup Shin, Won Do Heo 

Science Advances. 2024. Accepted.

Jeonghye Yu, Jongpil Shin, Jihwan Yu, Jihye Kim, Daseuli Yu and, Won Do Heo

Programmable RNA base editing with photoactivatable CRISPR-Cas13.

Nature Communications. Jan 22 2024. 10.1038/s41467-024-44867-2 

Seungkyu Son*, Kenichiro Nagahama*, Jinsu Lee*, Kanghoon Jung*, Chuljung Kwak, Jihoon Kim, Young Woo Noh, Eunjoon Kim, Sangkyu Lee#, Hyung-Bae Kwon#, 

Won Do Heo#

Real-time visualization of structural dynamics of synapses in live cells in vivo. 

Nature Methods. Jan 08 2024. doi: 10.1038/s41592-023-02122-4

2023

Yeon Hee Kook, Hyoin Lee, Jinsu Lee, Yeonji Jeong, Jaerang Rho, Won Do Heo# and Sangkyu Lee#

AAV‑compatible optogenetic tools for activating endogenous calcium channels in vivo.                   

Molecular Brain. Oct 17 2023. doi: 10.1186/s13041-023-01061-7

Bobae Hyeon, Heeyoung Lee, Nury Kim and Won Do Heo#

Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons.

Molecular Brain. 04 July 2023. doi: 10.1186/s13041-023-01046-6

Daseuli Yu*, Hee-Jeong Han*, Jeonghye Yu*, Jihye Kim*, Gun-Hee Lee, Ju-Hee Yang, Dongseob Tark, Byeong-Sun Choi, Sang-Min Kang#, and Won Do Heo# 

Pseudoknot-targeting Cas13b combats SARS-CoV-2 infection by suppressing viral replication.

Molecular Therapy. 21 March 2023. doi: 10.1016/j.ymthe.2023.03.018

Jieun Choi*, Eunji Shin*, Jinsu Lee*, Somayadineshraj D., Dongkyu Kim, Jennifer H. Shin, Jin-Ho Choi, Won Do Heo#, Yong-Mahn Han# 

Light-stimulated insulin secretion from pancreatic islet-like organoids derived from human pluripotent stem cells.

Molecular Therapy. 16 March 2023. doi: 10.1016/j.ymthe.2023.03.013

2022

Jongryul Hong, Yeonji Jeong, Won Do Heo# 

The neurotrophic receptor tyrosine kinase in MEC-mPFC neurons contributes to remote memory consolidation.

Journal of Neuroscience. 2022 July 21. doi:10.1523/JNEUROSCI.2433-21.2022 .

Daseuli Yu , Won Do Heo# 

Optogenetic Activation of Intracellular Nanobodies.

Methods Mol Biol. 2022;2446:595-606. doi: 10.1007/978-1-0716-2075-5_31.

Yang Shen, Miou Zhou#, Denise Cai, Daniel Almeida Filho, Giselle Fernandes, Ying Cai, André F. de Sousa, Min Tian, Nury Kim, Jinsu Lee, Deanna Necula, Chengbin Zhou, Shuoyi Li, Shelbi Salinas, Andy Liu, Xiaoman Kang, Masakazu Kamata, Ayal Lavi, Shan Huang, Tawnie Silva, Won Do Heo, Alcino J. Silva# 

CCR5 closes the temporal window for memory linking.

Nature. 2022 May 25;606(7912). doi: 10.1038/s41586-022-04783-1.

Yang Shen*, Alessandro Luchetti*, Giselle Fernandes, Won Do Heo, Alcino J. Silva#

The emergence of molecular systems neuroscience.

MOLECULAR BRAIN. 2022 Jan 04;15(1). doi: 10.1186/s13041-021-00885-5.

2021

YoungJu Jo*, Hyungjoo Cho*, Wei Sun Park*, Geon Kim, DongHun Ryu, Young Seo Kim, Moosung Lee, Sangwoo Park, Mahn Jae Lee, Hosung Joo, HangHun Jo, Seongsoo Lee, Sumin Lee, Hyun-seok Min#, Won Do Heo#, and YongKeun Park#

Label-free multiplexed microtomography of endogenous subcellular dynamics using generalizable deep learning.

Nature Cell Biology. 2021 Dec 07. https://doi.org/10.1038/s41556-021-00802-x 

Joungha Won, Yuriy Pankratov, Minwoo WendyJang, Sunpil Kim, Yeon HaJu, Sangkyu Lee, Seung EunLee, Arie Kim, Soowon Park, C. Justin Lee# and Won Do Heo#.

Opto-vTrap, an optogenetic probe for reversible inhibition of vesicular release, synaptic transmission, and behavior.

Neuron. 2021 Nov 30. https://doi.org/10.1016/j.neuron.2021.11.003 

Yuchao Li, Heeyoung Lee, Won Do Heo, Zhike Zi#

Revisiting the Role of TGF beta Receptor Internalization for Smad Signaling: It is Not Required in Optogenetic TGF beta Signaling Systems .

ADVANCED BIOLOGY. 2021 Oct;5(10). https://doi.org/10.1002/adbi.202101008 

Hae-Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Ozlem Altintas, Sangsoon Park, Heehwa G. Son, Yujin Lee, Dongyeop Lee, Won Do Heo, Seung-Jae V. Lee#

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.

Nature Communications. 2021 Sep 24. https://doi.org/10.1038/s41467-021-25920-w 

Mariana De Niz, Reto Caldelari, Gesine Kaiser, Benoit Zuber, Won Do Heo, Volker T. Heussler, Carolina Agop-Nersesian#

Hijacking of the host cell Golgi by Plasmodium berghei liver stage parasites.

Journal of Cell Science. 2021 May 20. https://doi.org/10.1242/jcs.252213 

Sun-Gyun Kim*, Suho Lee*, Yangsik Kim, Jieun Park, Doyeon Woo, Dayeon Kim, Yan Li, Wangyong Shin, Hyunjeong Kang, Chaehyun Yook, Minji Lee, Kyungdeok Kim, Junyeop Daniel Roh, Jeseung Ryu, Hwajin Jung, Seung Min Um, Esther Yang, Hyun Kim, Jinju Han, Won Do Heo, Eunjoon Kim#

Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. 

Nature Communications. 2021 May 11;12(1):2695. https://doi.org/10.1038/s41467-021-22908-4

Prashanta Silwal*, Jin Kyung Kim*, Sang Min Jeon, June-Young Lee, Young Jae Kim, Yi Sak Kim, Yeji Seo, Jihye Kim, Soo Yeon Kim, Min Joung Lee, Jun Young Heo, Mi-Ja Jung, Hyun Sik Kim, Dong-Wook Hyun, Jeong Eun Han, Jake Whang, Yang Hoon Huh, Sang-Hee Lee, Won Do Heo, Jin-Man Kim, Jin-Woo Bae , Eun-Kyeong Jo

Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice.

Communications Biology. 2021 May 10;4(1)1-17. https://doi.org/10.1038/s42003-021-02073-6

Joungha Won, Hasan Hüseyin Kazan, Jea Kwon, Myungsun Park, Mehmet Ali Ergun, Sureyya Ozcan, Byung Yoon Choi, Won Do Heo#, C. Justin Lee#

Ultimate COVID-19 Detection Protocol Based on Saliva Sampling and qRT-PCR with Risk Probability Assessment. 

Exp Neurobiol. 2021 Feb 28;30(1):13-31. https://doi.org/10.5607/en20063

Jung Eun Kim, Sujin Chae, Sungsoo Kim, Yeon-Joo Jung, Myoung-Goo Kang, Won Do Heo, Daesoo Kim#

Cerebellar 5HT-2A receptor mediates stress-induced onset of dystonia.

SCIENCE ADVANCES. 2021 Mar 03. https://doi.org/10.1126/sciadv.abb5735

In Young Choi* , HoTae Lim*, Alex Huynh, James Schofield, Hyeon Jin Cho, Hosuk Lee, Peter Andersen, Joo Heon Shin , Won Do Heo, Sang-Hwan Hyun, Yong Jun Kim, Yohan Oh#, Hyesoo Kim#, Gabsang Lee#.

Novel culture system via wirelessly controllable optical stimulation of the FGF signaling pathway for human and pig pluripotency.

Biomaterials. 2021 Feb. https://doi.org/10.1016/j.biomaterials.2020.120222

Jisu Park, Hyunwoo Choi, Young Doo Kim, Seo-Hyun Kim, Youbin Kim, Youngdae Gwon, Dong Young Lee, Sung-Hye Park, Won Do Heo, Yong-Keun Jung#

Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.

MOLECULAR PSYCHIATRY.  2021 Jan 15. https://doi.org/10.1038/s41380-020-01003-y

2020

Davis B, Backus K, Winter G, Chica R, Li D, Lee SY, He C, Weeks A, Overall C, Hagihara S, Thuronyi B, Kamat S, Chen LL, Guerrero RH, Yao S, Mahal LK, Voigt C, Woo C, Strauss E, Kikuchi K, Dore T, Radford S, Li XD, Heo WD, Superti-Furga G, Deans T, Belousov V, Matthews M, Jackson C, Malek S, Waldmann H, Rising A, Jewett M, Stamou D, Parker E, Murakami M, Polizzi K, Hamachi I, Erb T, Joo C, Uesugi M, Prinjha R, Rechavi G, Solano R, Schulman B, David Y, Oslund, R.

Voices of chemical biology

NATURE CHEMICAL BIOLOGY. 2020 Dec 16. https://doi.org/10.1038/s41589-020-00714-1

Doyeon Kim, Sangwon Jang, Jeongah Kim, Inah Park, Kyojin Ku, Mijung Choi, Sukwon Lee, Won Do Heo, Gi Hoon Son, Han Kyoung Choe, Kyungjin Kim#.

Kisspeptin Neuron-Specific and Self-Sustained Calcium Oscillation in the Hypothalamic Arcuate Nucleus of Neonatal Mice: Regulatory Factors of its Synchronization.

Neuroendocrinology. 2020 Jan 15. https://doi.org/10.1159/000505922

Lee YR, Khan K, Armfield-Uhas K, Srikanth S, Thompson NA, Pardo M, Yu L, Norris JW, Peng Y, Gripp KW,

Aleck KA, Li C, Spence E, Choi TI, Kwon SJ, Park HM, Yu D, Heo WD, Mooney MR, Baig SM, Wentzensen IM, Telegrafi A, McWalter K, Moreland T, Roadhouse C, Ramsey K, Lyons MJ, Skinner C, Alexov E, Katsanis N. Stevenson RE, Choudhary JS, Adams DJ, Kim CH#, Davis EE#, Schwartz CE#.

Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy .

Nature  Communications. 2020 Jul 23;11(1):3698. doi: 10.1038/s41467-020-17452-6.

Seokhwi Kim, Nury Kim, Jinsu Lee, Sungsoo Kim, Jongryul Hong, Seungkyu Son and Won Do Heo#.

Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement.

Science Advances. 2020 Apr 22.  Vol. 6, no. 17, eaaz9691.  https://doi.org/10.1126/sciadv.aaz9691

Byoungsan Choi* , Minkwon Cha* , Gee Sung Eun, Dae Hee Lee, Seul Lee, Muhammad Ehsan, Pil Seok Chae, Won Do Heo, YongKeun Park, Tae-Young Yoon#

Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers.

ELIFE. 2020 Apr 8. https://doi.org/10.7554/eLife.53934

Na Yeon Kim*, Sangkyu Lee*#,  Jeonghye Yu, Nury Kim, Seong Su Won,  Hyerim Park and Won Do Heo#.

Optogenetic control of mRNA localization and translation in live cells.

Nature Cell Biology. 2020 Feb 17.  https://doi.org/10.1038/s41556-020-0468-1

This article was highlighted by Nature Reviews Genetics.

This article was highlighted by Nature Methods.

Jongryul Hong, Won Do Heo#.

Optogenetic modulation of TrkB signaling in the mouse brain.

Journal of Molecular Biology. 2020 Feb 14. https://doi.org/10.1016/j.jmb.2020.01.010

Eury Kwon, Won Do Heo#.

Optogenetic tools for dissecting complex intracellular signaling pathways.

Biochem Biophys Res Commun. 2020 Jun 25. https://doi.org/10.1016/j.bbrc.2019.12.132

Sungsoo Kim*, Taeyoon Kyung*, Jae-Hee Chung, Nury Kim, Sehoon Keum, Jinsu Lee, Hyerim Park, Ho Min Kim, Sangkyu Lee#, Hee-Sup Shin#, Won Do Heo#.

Non-invasive optical control of endogenous Ca2+ channels in awake mice.

Nature Communications. 2020 Jan 10;11(1):210. https://doi.org/10.1038/s41467-019-14005-4

This article was introduced in Commentary of Cell Calcium.

Kim S, Shin J, Oh H, Ahn S, Kim N, Won Do Heo#.

An inducible system for in vitro and in vivo Fas activation using FKBP-FRB-rapamycin complex.

Biochem Biophys Res Commun. 2020 Mar. doi: 10.1016/j.bbrc.2019.12.072. [Epub ahead of print 2019 Dec 25].

2019

Doyeon Woo, Yeji Seo, Nury Kim, Hyeonjin Jung, Sang-Min Park, Sangkyu Lee, Heeyoung Lee, Kwang-Hyun Cho#, Won Do Heo#.

Local activation of BDNF-TrkB receptor generates actin waves and initiates to acquire axonal characteristics.

Cell Chemical Biology (Cover Article). 2019 Oct 24. doi: 10.1016/j.chembiol.2019.10.006

This article was introduced in the preview of Cell Chemical Biology.

Yu D, Lee H, Hong J, Jung H, Jo Y, Oh BH, Park BO#, Won Do Heo#.

Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins.

Nature Methods. 2019 Oct 14. doi: 10.1038/s41592-019-0592-7.

This article was highlighted by Nature Methods.

Won Do Heo was selected as the month author of Nature Methods.

Hyunjin Jung, Seong-Wook Kim, Minsoo Kim, Jongryul Hong, Ji Hye Kim, Sungsoo Kim, Yunju Lee, Daseuli Yu, Jihoon Kim, Doyeon Woo, Hee-Sup Shin, Byung Ouk Park#, Won Do Heo#.

Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions.

Nature Communications. 2019 Jan 18;10(1):314. doi: 10.1038/s41467-018-08282-8.

This article was highlighted by Nature Communications.

Jihoon Kim, Sangkyu Lee, Kanghoon Jung, Won Chan Oh, Nury Kim, Seungkyu Son, YoungJu Jo, Hyung-Bae Kwon# & Won Do Heo#.

Intensiometric biosensors visualize the activity of multiple small GTPases in vivo.

Nature Communications. 2019 Jan 14;10:211. doi: 10.1038/s41467-018-08217-3.

Lee JH*, Kim J*, Park JH, Won Do Heo#, Lee GM#.

Analysis of Golgi pH in CHO cells using ratiometric pH-sensitive fluorescent proteins.

Biotechnol Bioeng. 2019 Jan 13. doi: 10.1002/bit.26920. [Epub ahead of print].

2018

Hyun Yong Koh, Se Hoon Kim, Jaeson Jang, Hyungguk Kim, Sungwook Han, Jae Seok Lim, Geurim Son, Junjeong Choi, Byung Ouk Park, Won Do Heo, Jinju Han, Hyunjoo Jenny Lee, Daeyoup Lee, Hoon-Chul Kang, Minho Shong, Se-Bum Paik, Dong Seok Kim, Jeong Ho Lee.

BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors.

Nature Medicine. 2018 Sep 17. doi.org/10.1038/s41591-018-0172-x. [Epub ahead of print]

Sang H Lee#, Seung Min Shin, Peng Zhong, Hyun-Taek Kim, Dong-Il Kim, June Myoung Kim, Won Do Heo, Dae-Won Kim, Chang-Yeol Yeo, Cheol-Hee Kim, Qing-song Liu.

Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes.

Nature Communications. 2018.Aug 24;9(1):3434. doi.org/10.1038/s41467-018-05858-2.

Dorothy Truong, Kirsten C. Boddy, Veronica Canadien, Danielle Brabant, Gregory D. Fairn, Vanessa M. D’Costa, Etienne Coyaud, Brian Raught, Dolores Pérez-Sala, Wei Sun Park, Won Do Heo, Sergio Grinstein, John H. Brumel.

Salmonella exploits host Rho GTPase signalling pathways throughthe phosphatase activity of SopB.

Cell Microbiol. 2018 Oct;20(10):e12938. doi.org/10.1111/cmi.12938. Epub 2018 Aug 3.

Jihoon Kim, and Won Do Heo.

Synergistic Ensemble of Optogenetic Actuators and DynamicIndicators in Cell Biology.

Mol Cells. 2018 Aug 29;41(9):809~917. doi.org/10.14348/molcells.2018.0295. [Epub ahead of print].

2017

Li Y*, Lee M*, Kim N, Wu G, Deng D, Kim JM, Liu X, Heo WD#, Zi Z#.

Spatiotemporal Control of TGF-β Signaling with Light.

ACS Synth Biol. 2017 Dec 14. doi: 10.1021/acssynbio.7b00225. [Epub ahead of print].

This article was recommended by the faculty of 1000.

Won SY*, Kim CY*, Kim D, Ko J, Um JW, Lee SB, Buck M, Kim E, Heo WD#, Lee JO#, Kim HM#.

LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate.

Front Mol Neurosci. 2017 Oct 13;10:327. doi: 10.3389/fnmol.2017.00327. eCollection 2017.

Park H*, Kim NY*, Lee S, Kim N, Kim JH, Heo WD.

Optogenetic protein clustering through fluorescent protein tagging andextension of CRY2.

Nature Communications. 2017 Jun 23. doi: 10.1038/s41467-017-00060-2.

Qin X*, Park BO*, Liu J, Chen B, Cadamuro V, Belguise K, Heo WD#, Wang X#.

Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation.

Nature Communications. 2017 Apr 13;8:14708. doi: 10.1038/ncomms14708.

2016

Nguyen TT*, Park WS*, Park BO, Kim CY, Oh Y, Kim JM, Choi H, Kyung T, Kim CH, Lee G, Hahn KM, Meyer T, Heo WD.

PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.

PNAS. 2016 Sep 6;113(36):10091-6. doi: 10.1073/pnas.1604720113. Epub 2016 Aug 23.

This article was recommended by the faculty of 1000.

Yim N, Ryu SW, Choi K, Lee KR, Lee S, Choi H, Kim J, Shaker MR, Sun W, Park JH, Kim D, Heo WD, Choi C.

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module.

Nature Communications. 2016 Jul 22;7:12277. doi: 10.1038/ncomms12277.

Lee S, Kim MG, Kim N, Heo WD, Lee GM.

Heparan sulfate proteoglycan synthesis in CHO DG44 and HEK293 Cells.

Biotechnol. Bioproc. Eng. 2016 July 22. doi:10.1007/s12257-015-0688-6.

Mankouri J, Walter C, Stewart H, Bentham M, Park WS, Heo WD, Fukuda M, Griffin S, Harris M.

Release of infectious hepatitis C virus from Huh7 cells occurs via a trans-Golgi network to endosome pathway independent of VLDL.

J Virol. 2016 May 25. pii: JVI.00826-16. [Epub ahead of print].

Kim JM*, Lee M*, Kim N, Heo WD.

Optogenetic toolkit reveals the role of Ca2+ sparklets in coordinated cell migration.

PNAS. 2016 May 24;113(21):5952-7. doi: 10.1073/pnas.1518412113. Epub 2016 May 17.

Han KA, Woo D, Kim S, Choii G, Jeon S, Won SY, Kim HM, Heo WD, Um JW#, Ko J#.

Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTPσ Synaptic Adhesion and Intracellular Signaling Pathways.

J Neurosci. 2016 Apr 27;36(17):4816-31. doi: 10.1523/JNEUROSCI.4024-15.2016.

Nguyen MK, Kim CY, Kim JM, Park BO, Lee S, Park H, Heo WD.

Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking.

Nature Chemical Biology. 2016 Apr 11. doi: 10.1038/nchembio.2064. [Epub ahead of print].

This article was recommended by the faculty of 1000. 

Park H, Lee S, Heo WD.

Protein Inactivation by Optogenetic Trapping in Living Cells.

Methods Mol Biol. 2016;1408:363-76. doi: 10.1007/978-1-4939-3512-3_25.

Kim N, Kim JM, Heo WD.

Optogenetic Control of Fibroblast Growth Factor Receptor Signaling.

Methods Mol Biol. 2016;1408:345-62. doi: 10.1007/978-1-4939-3512-3_24.

Hong SH, Lee WJ, Kim YD, Kim H, Jeon YJ, Lim B, Cho DH, Heo WD, Yang DH, Kim CY, Yang HK, Yang JK, Jung YK.

APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.

Oncotarget. 2016 Mar 1. doi: 10.18632/oncotarget.7802. [Epub ahead of print].

Kim HY, Lee JJ, Kim N, Heo WD#, Kim HS#.

Tracking protein-protein interaction and localization in living cells using a high-affinity molecular binder.

Biochem Biophys Res Commun. 2016 Feb 19;470(4):857-63. doi: 10.1016/j.bbrc.2016.01.129. Epub 2016 Jan 26.

Ryou JH, Sohn YK, Hwang DE, Park WY, Kim N, Heo WD, Kim MY, Kim HS.

Engineering of bacterial exotoxins for highly efficient and receptor-specific intracellular delivery of diverse cargos.

Biotechnol Bioeng. 2016 Jan 16. doi: 10.1002/bit.25935. [Epub ahead of print].

2015

 Kyung T*, Lee S*, Kim JE, Cho T, Park H, Jeong YM, Kim D, Shin A, Kim S, Baek J, Kim J, Kim NY, Woo D, Chae S, Kim CH, Shin HS, Han YM#, Kim D#, Heo WD#.

Optogenetic control of endogenous Ca(2+) channels in vivo.

Nature Biotechnology (Cover Article). 2015 Sep 14. doi: 10.1038/nbt.3350.

This article was recommended by the faculty of 1000. 

Yoon J*, Lee M*, Lee K, Kim N, Kim JM, Park J, Yu H, Choi C, Heo WD#, Park Y#.

Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping.

Scientific Reports. 2015 Aug 21;5:13289. doi: 10.1038/srep13289.

Kim J, Jo H, Hong H, Kim MH, Kim JM, Lee JK, Heo WD, Kim J.

Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.

Nature Communications. 2015 Apr 7;6:6781. doi: 10.1038/ncomms7781.

Sohn YS, Shin HC, Park WS, Ge J, Kim CH, Lee BL, Heo WD, Jung JU, Rigden DJ, Oh BH.

Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22.

PLoS One. 2015 Mar 30;10(3):e0118683. doi: 10.1371/journal.pone.0118683. eCollection 2015.

Choi YA, Keem JO, Kim CY, Yoon HR, Heo WD, Chung BH, Jung Y.

A novel copper-chelating strategy for fluorescent proteins to image dynamic copperfluctuations on live cell surfaces.

Chemical Science. 2015;6 (2),1301-1307. doi: 10.1039/C4SC03027C.

2014

 Um JW, Kim KH, Park BS, Choi Y, Kim D, Kim CY, Kim SJ, Kim M, Ko JS, Lee SG, Choii G, Nam J, Heo WD, Kim E, Lee JO, Ko J*, Kim HM*.

Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.

Nature Communications. 2014 Nov 14;5:5423. doi: 10.1038/ncomms6423.

Kim N*, Kim JM*, Lee M, Kim CY, Chang KY, Heo WD.

Spatiotemporal control of fibroblast growth factor receptor signals by blue light.

Chemisty & Biology (Cover Article). 2014 Jul 17;21(7):903-12. doi: 10.1016/j.chembiol.2014.05.013. Epub 2014 Jun 26.

This article was recommended by the faculty of 1000. 

Chang KY*, Woo D*, Jung H, Lee S, Kim S, Won J, Kyung T, Park H, Kim N, Yang HW, Park JY, Hwang EM, Kim D, Heo WD.

Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling.

Nature Communications. 2014 Jun 4;5:4057. doi: 10.1038/ncomms5057. 

Lee S*, Park H*, Kyung T, Kim NY, Kim S, Kim J, Heo WD.

Reversible protein inactivation by optogenetic trapping in cells.

Nature Methods. 2014 Jun;11(6):633-6. doi: 10.1038/nmeth.2940. Epub 2014 May 4.

This article was highlighted by Nature Methods.

Manjare ST, Kim S, Heo WD, Churchill DG.

Selective and sensitive superoxide detection with a new diselenide-based molecular probe in living breast cancer cells.

Organic Letters. 2014 Jan 17;16(2).410-2.  

Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park JS, Park I, Jung J, Kataoka H, Lee D, Heo WD, Kim I, Jon S, Adams RH, Nishikawa S, Uemura A*, Koh GY*.

Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.

Cancer Cell. 2014 Jan 13;25(1).102-17. 

2013

 Truong D, Brabant D, Bashkurov M, Wan LC, Braun V, Heo WD, Meyer T, Pelletier L, Copeland J, Brumell JH.

Formin-mediated actin polymerization promotes Salmonella invasion.

Cell Microbiol. 2013 Dec;15(12).2051-63. Epub 2013 Aug 13.

Lee HW, Kyung T, Yoo J, Kim T, Chung C, Ryu JY, Lee H, Park K, Lee S, Jones WD, Lim DS, Hyeon C, Heo WD*, Yoon TY*.

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics.

Nature Communications. 2013;4:1505. doi: 10.1038/ncomms2507.

Cho S, Jang J, Song C, Lee H, Ganesan P, Yoon TY, Kim MW, Choi MC, Ihee H*, Heo WD*, Park Y*.

Simple super-resolution live-cell imaging based on diffusion-assisted Förster resonance energy transfer.

Scientific Reports. 2013;3:1208. doi: 10.1038/srep01208. Epub 2013 Feb 4.

Na HK, Kim MH, Lee J, Kim YK, Jang H, Lee KE, Park H, Heo WD, Jeon H, Choi IS, Lee Y, Min DH.

Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials.

Nanoscale. 2013 Feb 21;5(4):1669-77. doi: 10.1039/c2nr33800a.

2012

 Ku B, Lee KH, Park WS, Yang CS, Ge J, Lee SG, Cha SS, Shao F, Heo WD, Jung JU, Oh BH.

VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages.

PLoS Pathog. 2012;8(12):e1003082. doi: 10.1371/journal.ppat.1003082. Epub 2012 Dec 13.

Gil JE, Kim E, Kim IS, Ku B, Park WS, Oh BH, Ryu SH, Cho W*, Heo WD*.

Phosphoinositides differentially regulate protrudin localization through the FYVE domain.

J Biol Chem. 2012 Nov 30;287(49):41268-76. doi: 10.1074/jbc.M112.419127. Epub 2012 Oct 5.

Shin YC, Yoon JH, Jang TH, Kim SY, Heo WD, So I, Jeon JH, Park HH.

Crystal structure of Rab6A'(Q72L) mutant reveals unexpected GDP/Mg²⁺ binding with opened GTP-binding domain.

Biochem Biophys Res Commun. 2012 Jul 27;424(2):269-73. doi: 10.1016/j.bbrc.2012.06.102. Epub 2012 Jun 27.

Park MH, Lee HS, Lee CS, You ST, Kim DJ, Park BH, Kang MJ, Heo WD, Shin EY, Schwartz MA, Kim EG.

p21-Activated kinase 4 promotes prostate cancer progression through CREB.

Oncogene. 2013 May 9;32(19):2475-82. doi: 10.1038/onc.2012.255. Epub 2012 Jun 18.

Yang HW, Shin MG, Lee S, Kim JR, Park WS, Cho KH, Meyer T*, Heo WD*.

Cooperative activation of PI3K by Ras and Rho family small GTPases.

Molecular Cell. 2012 Jul 27;47(2):281-90. doi: 10.1016/j.molcel.2012.05.007. Epub 2012 Jun 7.

This article was recommended by the faculty of 1000.

Won JK, Yang HW, Shin SY, Lee JH, Heo WD*, Cho KH*.

The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor.

J Mol Cell Biol (Cover Article). 2012 Jun;4(3):153-63. doi: 10.1093/jmcb/mjs021. Epub 2012 May 4.

Mun JY, Lee KJ, Kim YJ, Kwon O, Kim SJ, Lee SG, Park WS, Heo WD, Oh DB.

Development of fluorescent probes for the detection of fucosylated N-glycans using an Aspergillus oryzae lectin.

Appl Microbiol Biotechnol. 2012 Jan;93(1):251-60. doi: 10.1007/s00253-011-3549-z. Epub 2011 Sep 3.

2011

 Kaniuk NA, Canadien V, Bagshaw RD, Bakowski M, Braun V, Landekic M, Mitra S, Huang J, Heo WD, Meyer T, Pelletier L, Andrews-Polymenis H, McClelland M, Pawson T, Grinstein S, Brumell JH.

Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.

Cell Microbiol. 2011 Nov;13(11):1812-23. doi: 10.1111/j.1462-5822.2011.01663.x. Epub 2011 Sep 14.

Jeon H, Zheng LT, Lee S, Lee WH, Park N, Park JY, Heo WD, Lee MS, Suk K.

Comparative analysis of the role of small G proteins in cell migration and cell death: cytoprotective and promigratory effects of RalA.

Exp Cell Res. 2011 Aug 15;317(14):2007-18. doi: 10.1016/j.yexcr.2011.05.021. Epub 2011 May 27.

Shin SY, Yang HW, Kim JR, Heo WD*, Cho KH*.

A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network.

J Cell Sci (Cover Article). 2011 Jan 1;124(Pt 1):82-90. doi: 10.1242/jcs.076034.

Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH.

Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.

Autophagy. 2011 Jan;7(1):17-26. Epub 2011 Jan 1.

2010

 Bakowski MA, Braun V, Lam GY, Yeung T, Heo WD, Meyer T, Finlay BB, Grinstein S, Brumell JH.

The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole.

Cell Host Microbe. 2010 Jun 25;7(6):453-62. doi: 10.1016/j.chom.2010.05.011.

Lee KH, Lee S, Lee WY, Yang HW, Heo WD.

Visualizing dynamic interaction between calmodulin and calmodulin-related kinases via a monitoring method in live mammalian cells.

PNAS. 2010 Feb 23;107(8):3412-7. doi: 10.1073/pnas.0911262107. Epub 2010 Feb 3.

Manna D, Aligo J, Xu C, Park WS, Koc H, Heo WD, Konan KV.

Endocytic Rab proteins are required for hepatitis C virus replication complex formation.

Virology. 2010 Mar 1;398(1):21-37. doi: 10.1016/j.virol.2009.11.034. Epub 2009 Dec 16.

2009

 Han K, Kim MH, Seeburg D, Seo J, Verpelli C, Han S, Chung HS, Ko J, Lee HW, Kim K, Heo WD, Meyer T, Kim H, Sala C, Choi SY, Sheng M, Kim E.

Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD.

PLoS Biol. 2009 Sep;7(9):e1000187. doi: 10.1371/journal.pbio.1000187. Epub 2009 Sep 8.

Yang  HM, Lee HJ, Jang KS, Park CW, Yang HW, Heo WD, Kim, JD.

Poly(amino acid)-coated iron oxidenanoparticles as ultra-small magnetic resonance probes.

J. Mater. Chem. 19(26). 4566-4574.

2008

 Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, Meyer T, Suh PG, Ryu SH.

Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.

Mol Biol Cell. 2008 Jul;19(7):3111-23. doi: 10.1091/mbc.E07-04-0337. Epub 2008 May 14.

Park WS, Heo WD, Whalen JH, O'Rourke NA, Bryan HM, Meyer T, Teruel MN.

Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging.

Molecular Cell (Cover Article). 2008 May 9;30(3):381-92. doi: 10.1016/j.molcel.2008.04.008.

This article was recommended by the faculty of 1000.

Post-doctoral Period at Stanford (2000 - 2008)

Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T.

siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake.

Genome Biology. 2007;8(7):R142.

Stone M, Jia S, Heo WD, Meyer T, Konan KV.

Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery. 

J Virol. 2007 May;81(9):4551-63. Epub 2007 Feb 14.

Smith AC, Heo WD, Braun V, Jiang X, Macrae C, Casanova JE, Scidmore MA, Grinstein S, Meyer T, Brumell JH.

A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium.

J Cell Biol. 2007 Jan 29;176(3):263-8.

Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, Meyer T. 

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.

Science. 2006 Dec 1;314(5804):1458-61. Epub 2006 Nov 9.

This article was recommended by the faculty of 1000.

            A.        This paper has been introduced in several journals in special introductory articles.

            B.        Science (Perspectives) Tools to Tamper with Phosphoinositides. Stuart McLaughlin. 2006 314 (5804).

            C.        Nature Methods (Research Highlights) Lipids under scrutiny.2007 4 (7).

            D.        Science STKE (Editors' Choice) Turn on the PIPs. Peter Stern. 2006 (364).

Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr, Meyer T.

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.  

Current Biology. 2005 Jul 12;15(13):1235-41.

Inoue T, Heo WD, Grimley JS, Wandless TJ, Meyer T.

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.  

Nature Methods. 2005 Jun;2(6):415-8.

Yoo JH, Park CY, Kim JC, Heo WD, Cheong MS, Park HC, Kim MC, Moon BC, Choi MS, Kang YH, Lee JH, Kim HS, Lee SM, Yoon HW, Lim CO, Yun DJ, Lee SY, Chung WS, Cho MJ.

Direct interaction of a divergent CaM isoform and the transcription factor, MYB2, enhances salt tolerance in arabidopsis.

J Biol Chem. 2005 Feb 4;280(5):3697-706. Epub 2004 Nov 29.

Yoo JH, Park CY, Kim JC, Heo WD, Cheong MS, Park HC, Kim MC, Moon BC, Choi MS, Kang YH, Lee JH, Kim HS, Lee SM, Yoon HW, Lim CO, Yun DJ, Lee SY, Chung WS, Cho MJ.

Pathogenesis-related gene expression by specific calmodulin isoforms is dependent on NIM1, a key regulator of systemic acquired resistance. 

Molecules and Cells. 2004 Oct 31;18(2):207-13.

Eom CY, Heo WD, Craske ML, Meyer T, Lehman IR.

The neural F-box protein NFB42 mediates the nuclear export of the herpes simplex virus type 1 replication initiator protein (UL9 protein) after viral infection.  

PNAS. 2004 Mar 23;101(12):4036-40. Epub 2004 Mar 9.

Heo WD, Meyer T.

Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases.  

Cell (Cover Article). 2003 May 2;113(3):315-28.

This article was recommended by the faculty of 1000.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.

Overview of the Alliance for Cellular Signaling.

Nature. 2002 Dec 12;420(6916):703-6.

PhD. Course Period (1994 - 1999)

Choi JY, Lee SH, Park CY, Heo WD, Kim JC, Kim MC, Chung WS, Moon BC, Cheong YH, Kim CY, Yoo JH, Koo JC, Ok HM, Chi SW, Ryu SE, Lee SY, Lim CO, Cho MJ. 

Identification of calmodulin isoform-specific binding peptides from a phage-displayed random 22-mer peptide library.  

J Biol Chem. 2002 Jun 14;277(24):21630-8. Epub 2002 Mar 18.

Chung WS, Lee SH, Kim JC, Heo WD, Kim MC, Park CY, Park HC, Lim CO, Kim WB, Harper JF, Cho MJ. 

Identification of a calmodulin-regulated soybean Ca(2+)-ATPase (SCA1) that is located in the plasma membrane.  

Plant Cell. 2000 Aug;12(8):1393-407.

Lee SH, Kim MC, Heo WD, Kim JC, Chung WS, Park CY, Park HC, Cheong YH, Kim CY, Lee KJ, Bahk JD, Lee SY, Cho MJ.

Competitive binding of calmodulin isoforms to calmodulin-binding proteins: implication for the function of calmodulin isoforms in plants.    

Biochim Biophys Acta. 1999 Aug 17;1433(1-2):56-67.

Heo WD, Lee SH, Kim MC, Kim JC, Chung WS, Chun HJ, Lee KJ, Park CY, Park HC, Choi JY, Cho MJ. 

Involvement of specific calmodulin isoforms in salicylic acid-independent activation of plant disease resistance responses.

PNAS. 1999 Jan 19;96(2):766-71.

Cho MJ, Vaghy PL, Kondo R, Lee SH, Davis JP, Rehl R, Heo WD, Johnson JD. 

Reciprocal regulation of mammalian nitric oxide synthase and calcineurin by plant calmodulin isoforms.

Biochemistry. 1998 Nov 10;37(45):15593-7.

Lee SH, Seo HY, Kim JC, Heo WD, Chung WS, Lee KJ, Kim MC, Cheong YH, Choi JY, Lim CO, Cho MJ. 

Differential activation of NAD kinase by plant calmodulin isoforms. The critical role of domain I.

J Biol Chem. 1997 Apr 4;272(14):9252-9.

Lee SH, Kim JC, Lee MS, Heo WD, Seo HY, Yoon HW, Hong JC, Lee SY, Bahk JD, Hwang I, Cho MJ.

Identification of a novel divergent calmodulin isoform from soybean which has differential ability to activate calmodulin-dependent enzymes. 

J Biol Chem. 1995 Sep 15;270(37):21806-12.