Publications
Co-first author*
Co-corresponding author#
Research Period as a PI (2008 - present)
2024
Shin J, Oh H, Park JH, Bae HS, Lee M, Kim S, Heo WD
Molecular Psychiatry. 2024. Under Review.
Hyeon B, Shin J, Lee H, Kim D-G, Kim CY, Kwon J, Lee CJ, Jeong J-W, Kim K-S, Kim D#, Heo WD#
Nature Communications. 2024. Under Review.
Lee H, Lee S, Seo Y, Kim D, Oh Y, Jin J, Hyeon B, Han Y, Kim H, Kim H, Lee G#, Cho K-H#, Heo WD#
Nature Communications. 2024. Under Revision.
Yu J, Jin J, Kwon E, Jang H, Kim D, Choi S-K, Son S, Yoon K-J, and Heo WD
Nature Chemical Biology. 2024. Under Revision.
S Krüssel, I Deb, S Son, G Ewall, M Chang, HK Lee, Heo WD#, HB Kwon#
iScience. 2024 July 17, doi: 10.1016/j.isci.2024.110535
W ElGrawani #, G Sun, FP Kliem, S Sennhauser, S Pierre-Ferrer, A Rosi-Andersen, Ida Boccalaro, Philipp Bethge, Heo WD, Fritjof Helmchen, Antoine R. Adamantidis#, Daniel B. Forger#, Maria S. Robles# and Steven A. Brown
BDNF-TrkB signaling orchestrates the buildup process of local sleep
Cell Reports. 2024 July 15, doi: 10.1016/j.celrep.2024.114500
J Lee, Y Jeong, S Park, S Kim, H Oh, JA Jin, JW Sohn, D Kim, HS Shin, Heo WD
Science Advances. 2024 Jul 3, doi: 10.1126/sciadv.adj4433
Yu J, Shin J, Yu J, Kim J, Yu D, Heo WD
Programmable RNA base editing with photoactivatable CRISPR-Cas13.
Nature Communications. 2024 Jan 22, doi: 10.1038/s41467-024-44867-2
Son S*, Nagahama K*, Lee J*, Jung K*, Kwak C, Kim J, Noh YW, Kim E, Lee S#, Kwon HB#, Heo WD#
Real-time visualization of structural dynamics of synapses in live cells in vivo.
Nature Methods. 2024 Jan 08, doi: 10.1038/s41592-023-02122-4
2023
Kook YH, Lee H, Lee J, Jeong Y, Rho J, Heo WD# , Lee S#
AAV‑compatible optogenetic tools for activating endogenous calcium channels in vivo.
Molecular Brain. 2023 Oct 17, doi: 10.1186/s13041-023-01061-7
Hyeon B, Lee H, Kim N, Heo WD#
Optogenetic dissection of RET signaling reveals robust activation of ERK and enhanced filopodia-like protrusions of regenerating axons.
Molecular Brain. 2023 July 04, doi: 10.1186/s13041-023-01046-6
Yu D*, Han HJ*, Yu J*, Kim J*, Lee GH, Yang JH, Song BM, Tark D, Choi BS, Kang SM#, Heo WD#
Pseudoknot-targeting Cas13b combats SARS-CoV-2 infection by suppressing viral replication.
Molecular Therapy. 2023 Mar 21, doi: 10.1016/j.ymthe.2023.03.018
Choi J*, Shin E*, Lee J*, Devarasou S, Kim D, Shin JH, Choi JH, Heo WD#, Han YM#
Molecular Therapy. 2023 Mar 16, doi: 10.1016/j.ymthe.2023.03.013
2022
Hong J, Jeong Y, Heo WD
The neurotrophic receptor tyrosine kinase in MEC-mPFC neurons contributes to remote memory consolidation.
Journal of Neuroscience. 2022 July 21, doi:10.1523/JNEUROSCI.2433-21.2022.
Hyeon B, Nguyen MK, Heo WD
Membrane Trafficking, 2022 July 13, doi: 10.1007/978-1-0716-2209-4_20
Shen Y, Zhou M, Cai D, Filho DA, Fernandes G, Cai Y, de Sousa AF, Tian M, Kim N, Lee J, Necula D, Zhou C, Li S, Salinas S, Liu A, Kang X, Kamata M, Lavi A, Huang S, Silva T, Heo WD, Silva AJ
CCR5 closes the temporal window for memory linking.
Nature. 2022 May 25, doi: 10.1038/s41586-022-04783-1.
Yu D, Heo WD
Optogenetic Activation of Intracellular Nanobodies.
Methods Mol Biol. 2022. doi: 10.1007/978-1-0716-2075-5_31.
Shen Y, Luchetti A, Fernandes G, Heo WD, Silva AJ
The emergence of molecular systems neuroscience.
Mol Brain. 2022 Jan 4, doi: 10.1186/s13041-021-00885-5.
2021
Jo Y*, Cho H*, Park WS*, Kim G, Ryu D, Kim YS, Lee M, Park S, Lee MJ, Joo H, Jo H, Lee S, Lee S, Min HS, Heo WD#, Park Y#
Label-free multiplexed microtomography of subcellular dynamics using generalizable deep learning.
Nature Cell Biology. 2021 Dec 07, doi: 10.1038/s41556-021-00802-x.
Won J, Pankratov Y, Jang MW, Kim S, Ju YH, Lee S, Lee SE, Kim A, Park S, Lee CJ#, Heo WD#
Opto-vTrap, an optogenetic probe for reversible inhibition of vesicular release, synaptic transmission and behavior.
Neuron. 2021 Nov 30, doi: 10.1016/j.neuron.2021.11.003.
Li Y, Lee H, Heo WD, Zi Z
Revisiting the Role of TGF beta Receptor Internalization for Smad Signaling: It is Not Required in Optogenetic TGF beta Signaling Systems.
ADVANCED BIOLOGY. 2021 Oct, doi: 10.1002/adbi.202101008.
Park HH, Hwang W, Ham S, Kim E, Altintas O, Park S, Son HG, Lee Y, Lee D, Heo WD, Lee SV
A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.
Nature Communications. 2021 Sep 24, doi: 10.1038/s41467-021-25920-w.
De Niz M, Caldelari R, Kaiser G, Zuber B, Heo WD, Heussler VT, Agop-Nersesian C
Hijacking of the host cell Golgi by Plasmodium berghei liver stage parasites.
Journal of Cell Science. 2021 May 20, doi: 10.1242/jcs.252213.
Kim SG*, Lee S*, Kim Y, Park J, Woo D, Kim D, Li Y, Shin W, Kang H, Yook C, Lee M, Kim K, Roh JD, Ryu J, Jung H, Um SM, Yang E, Kim H, Han J, Heo WD, Kim E
Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
Nature Communications. 2021 May 11, doi: 10.1038/s41467-021-22908-4.
Silwal P*, Kim JK*, Jeon SM, Lee JY, Kim YJ, Kim YS, Seo Y, Kim J, Kim SY, Lee MJ, Heo JY, Jung MJ, Kim HS, Hyun DW, Han JE, Whang J, Huh YH, Lee SH, Heo WD, Kim JM, Bae JW, Jo EK
Mitofusin-2 boosts innate immunity through maintenance of aerobic glycolysis and activation of xenophagy.
Communications Biology. 2021 May 10, doi: 10.1038/s42003-021-02073-6.
Kim JE, Chae S, Kim S, Jung YJ, Kang MG, Heo WD, Kim D
Cerebellar 5HT-2A receptor mediates stress-induced onset of dystonia.
SCIENCE ADVANCES. 2021 Mar 03, doi: 10.1126/sciadv.abb5735.
Won J, Kazan HH, Kwon J, Park M, Ergun MA, Ozcan S, Choi BY, Heo WD#, Lee CJ#
Ultimate COVID-19 Detection Protocol Based on Saliva Sampling and qRT-PCR with Risk Probability Assessment.
Exp Neurobiol. 2021 Feb 28, doi: 10.5607/en20063.
Choi IY*, Lim H*, Huynh A, Schofield J, Cho HJ, Lee H, Andersen P, Shin JH, Heo WD, Hyun SH, Kim YJ, Oh Y#, Kim H#, Lee G#
Novel culture system via wirelessly controllable optical stimulation of the FGF signaling for human and pig pluripotency.
Biomaterials. 2021 Feb, doi: 10.1016/j.biomaterials.2020.120222.
Park J*, Choi H*, Kim YD, Kim SH, Kim Y, Gwon Y, Lee DY, Park SH, Heo WD, Jung YK
Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.
MOLECULAR PSYCHIATRY. 2021 Jan 15 doi: 10.1038/s41380-020-01003-y.
2020
Davis B, Backus K, Winter G, Chica R, Li D, Lee SY, He C, Weeks A, Overall C, Hagihara S, Thuronyi B, Kamat S, Chen LL, Guerrero RH, Yao S, Mahal LK, Voigt C, Woo C, Strauss E, Kikuchi K, Dore T, Radford S, Li XD, Heo WD, Superti-Furga G, Deans T, Belousov V, Matthews M, Jackson C, Malek S, Waldmann H, Rising A, Jewett M, Stamou D, Parker E, Murakami M, Polizzi K, Hamachi I, Erb T, Joo C, Uesugi M, Prinjha R, Rechavi G, Solano R, Schulman B, David Y, Oslund, R
Voices of chemical biology
Nature Chemical Biology. 2020 Dec 16, doi: 10.1038/s41589-020-00714-1
Lee YR, Khan K, Armfield-Uhas K, Srikanth S, Thompson NA, Pardo M, Yu L, Norris JW, Peng Y, Gripp KW, Aleck KA, Li C, Spence E, Choi TI, Kwon SJ, Park HM, Yu D, Heo WD, Mooney MR, Baig SM, Wentzensen IM, Telegrafi A, McWalter K, Moreland T, Roadhouse C, Ramsey K, Lyons MJ, Skinner C, Alexov E, Katsanis N, Stevenson RE, Choudhary JS, Adams DJ, Kim CH#, Davis EE#, Schwartz CE#
Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy.
Nature Communications. 2020 Jul 23, doi: 10.1038/s41467-020-17452-6.
Kim S, Kim N, Lee J, Kim S, Hong J, Son S, Heo WD#
Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement.
Sci Adv. 2020 Apr 22, doi: 10.1126/sciadv.aaz9691. eCollection 2020 Apr.
Choi B*, Cha M*, Eun GS, Lee DH, Lee S, Ehsan M, Chae PS, Heo WD, Park Y, Yoon TY#
Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers.
Elife. 2020 Apr 8, doi: 10.7554/eLife.53934.
Kim S, Shin J, Oh H, Ahn S, Kim N, Heo WD#
An inducible system for in vitro and in vivo Fas activation using FKBP-FRB-rapamycin complex.
Biochem Biophys Res Commun. 2020 Mar 5. doi: 10.1016/j.bbrc.2019.12.072.
Kim NY, Lee S*#, Yu J, Kim N, Won SS, Park H, Heo WD#
Optogenetic control of mRNA localization and translation in live cells.
Nature Cell Biology. 2020 Feb 17, doi: 10.1038/s41556-020-0468-1.
This article was highlighted by Nature Reviews Genetics.
This article was highlighted by Nature Methods.
Hong J, Heo WD#
Optogenetic modulation of TrkB signaling in the mouse brain.
Journal of Molecular Biology. 2020 Jan 18, doi: 10.1016/j.jmb.2020.01.010.
This article was recommended by the faculty of 1000.
Kim D, Jang S, Kim J, Park I, Ku K, Choi M, Lee S, Heo WD, Son GH, Choe HK, Kim K#
Kisspeptin Neuron-Specific and Self-Sustained Calcium Oscillation in the Hypothalamic Arcuate Nucleus of Neonatal Mice: Regulatory Factors of its Synchronization.
Neuroendocrinology. 2020 Jan 15, doi:10.1159/000505922.
Kwon E, Heo WD#
Optogenetic tools for dissecting complex intracellular signaling pathways.
Biochem Biophys Res Commun. 2020 Jan 14. Doi: 10.1016/j.bbrc.2019.12.132.
Kim S*, Kyung T*, Chung JH, Kim N, Keum S, Lee J, Park H, Kim HM, Lee S#, Shin HS#, Heo WD#
Non-invasive optical control of endogenous Ca2+ channels in awake mice.
Nature Communications. 2020 Jan 10, doi: 10.1038/s41467-019-14005-4.
This article was introduced in Commentary of Cell Calcium.
2019
Woo D, Seo Y, Jung H, Kim S, Kim N, Park SM, Lee H, Lee S, Cho KH#, Heo WD#
Locally Activating TrkB Receptor Generates Actin Waves and Specifies Axonal Fate
Cell Chemical Biology (Cover Article). 2019 Oct 24. doi: 10.1016/j.chembiol.2019.10.006.
This article was introduced in the preview of Cell Chemical Biology.
Yu D, Lee H, Hong J, Jung H, Jo Y, Oh BH, Park BO#, Heo WD#
Optogenetic activation of intracellular antibodies for direct modulation of endogenous proteins.
Nature Methods. 2019 Oct 14, doi: 10.1038/s41592-019-0592-7.
This article was highlighted by Nature Methods.
Heo WD was selected as the month author of Nature Methods.
Jung H, Kim SW, Kim M, Hong J, Yu D, Kim JH, Lee Y, Kim S, Woo D, Shin HS, Park BO#, Heo WD#
Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions.
Nature Communications. 2019 Jan 18, doi: 10.1038/s41467-018-08282-8.
This article was highlighted by Nature Communications.
Kim J, Lee S, Jung K, Oh WC, Kim N, Son S, Jo Y, Kwon HB#, Heo WD#
Intensiometric biosensors visualize the activity of multiple small GTPases in vivo.
Nature Communications. 2019 Jan 14, doi: 10.1038/s41467-018-08217-3.
Lee JH*, Kim J*, Park JH, Heo WD#, Lee GM#
Analysis of Golgi pH in CHO cells using ratiometric pH-sensitive fluorescent proteins.
Biotechnol Bioeng. 2019 Jan 13, doi: 10.1002/bit.26920.
2018
Koh HY, Kim SH, Jang J, Kim H, Han S, Lim JS, Son G, Choi J, Park BO, Heo WD, Han J, Lee HJ, Lee D, Kang HC, Shong M, Paik SB, Kim DS, Lee JH#
BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors.
Nature Medicine. 2018 Sep 17, doi: 10.1038/s41591-018-0172-x.
Kim J, Heo WD#
Synergistic Ensemble of Optogenetic Actuators and Dynamic Indicators in Cell Biology.
Mol Cells. 2018 Aug 29, doi: 10.14348/molcells.2018.0295.
Lee SH#, Shin SM, Zhong P, Kim HT, Kim DI, Kim JM, Heo WD, Kim DW, Yeo CY, Kim CH, Liu QS
Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes.
Nature Communications. 2018 Aug 24, doi: 10.1038/s41467-018-05858-2.
Truong D, Boddy KC, Canadien V, Brabant D, Fairn GD, D'Costa VM, Coyaud E, Raught B, Pérez-Sala D, Park WS, Heo WD, Grinstein S, Brumell JH
Salmonella exploits host Rho GTPase signalling pathways through the phosphatase activity of SopB.
Cell Microbiol. 2018 Aug 3, doi: 10.1111/cmi.12938.
Li Y*, Lee M*, Kim N, Wu G, Deng D, Liu X, Heo WD#, Zi Z#
Spatiotemporal Control of TGF-β Signaling with Light.
ACS Synth Biol. 2018 Jan 12, doi: 10.1021/acssynbio.7b00225.
This article was recommended by the faculty of 1000.
2017
Li Y*, Lee M*, Kim N, Wu G, Deng D, Liu X, Heo WD#, Zi Z#
Spatiotemporal Control of TGF-β Signaling with Light.
ACS Synth Biol. 2017 Dec 14, doi: 10.1021/acssynbio.7b00225.
This article was recommended by the faculty of 1000.
Kim K, Park WS, Na S, Kim S, Kim T, Heo WD, Park Y
BIOMEDICAL OPTICS EXPRESS. 2017 Dec 1, doi: 10.1364/BOE.8.005688
Won SY*, Kim CY*, Kim D, Ko J, Um JW, Lee SB, Buck M, Kim E, Heo WD#, Lee JO#, Kim HM#
Front Mol Neurosci. 2017 Oct 13, doi: 10.3389/fnmol.2017.00327. eCollection 2017.
Park H*, Kim NY*, Lee S, Kim N, Heo WD#
Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2.
Nature Communications. 2017 Jun 23, doi: 10.1038/s41467-017-00060-2.
Qin X*, Park BO*, Liu J, Chen B, Cadamuro V, Belguise K, Heo WD#, Wang X#
Cell-matrix adhesion and cell-cell adhesion control basal myosin oscillation and Drosophila egg chamber elongation.
Nature Communications. 2017 Apr 13, doi: 10.1038/ncomms14708.
2016
Nguyen TT*, Park WS*, Park BO, Kim CY, Oh Y, Kim JM, Choi H, Kyung T, Kim CH, Lee G, Hahn KM, Meyer T, Heo WD
PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.
PNAS. 2016 Aug 23, doi: 10.1073/pnas.1604720113.
This article was recommended by the faculty of 1000.
Yim N, Ryu SW, Choi K, Lee KR, Lee S, Choi H, Kim J, Shaker MR, Sun W, Park J, Kim D, Heo WD, Choi C
Nature Communications. 2016 Jul 22, doi: 10.1038/ncomms12277.
Lee S, Kim MG, Kim N, Heo WD, Lee GM
Heparan sulfate proteoglycan synthesis in CHO DG44 and HEK293 Cells.
Biotechnol. Bioproc. Eng. 2016 July 22, doi:10.1007/s12257-015-0688-6.
Mankouri J, Walter C, Stewart H, Bentham M, Park WS, Heo WD, Fukuda M, Griffin S, Harris M
J Virol. 2016 May 25, doi: 10.1128/JVI.00826-16.
Kim JM*, Lee M*, Kim N, Heo WD
Optogenetic toolkit reveals the role of Ca2+ sparklets in coordinated cell migration.
PNAS. 2016 May 17, doi: 10.1073/pnas.1518412113.
Han KA, Woo D, Kim S, Choii G, Jeon S, Won SY, Kim HM, Heo WD, Um JW#, Ko J#
J Neurosci. 2016 Apr 27, doi: 10.1523/JNEUROSCI.4024-15.2016.
Nguyen MK, Kim CY, Kim JM, Park BO, Lee S, Park H, Heo WD#
Optogenetic oligomerization of Rab GTPases regulates intracellular membrane trafficking.
Nature Chemical Biology. 2016 Apr 11, doi: 10.1038/nchembio.2064.
This article was recommended by the faculty of 1000.
Park H, Lee S, Heo WD
Protein Inactivation by Optogenetic Trapping in Living Cells.
Methods Mol Biol. 2016, doi: 10.1007/978-1-4939-3512-3_25.
Kim N, Kim JM, Heo WD
Optogenetic Control of Fibroblast Growth Factor Receptor Signaling.
Methods Mol Biol. 2016, doi: 10.1007/978-1-4939-3512-3_24.
Hong SH, Lee WJ, Kim YD, Kim H, Jeon YJ, Lim B, Cho DH, Heo WD, Yang DH, Kim CY, Yang HK, Yang JK, Jung YK
APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis.
Oncotarget. 2016 Mar 1, doi: 10.18632/oncotarget.7802.
Kim HY, Lee JJ, Kim N, Heo WD#, Kim HS#.
Biochem Biophys Res Commun. 2016 Feb 19, doi: 10.1016/j.bbrc.2016.01.129.
Ryou JH, Sohn YK, Hwang DE, Park WY, Kim N, Heo WD, Kim MY, Kim HS
Biotechnol Bioeng. 2016 Jan 16, doi: 10.1002/bit.25935.
2015
Kyung T*, Lee S*, Kim JE, Cho T, Park H, Jeong Y-M, Kim D, Shin A, Kim S, Baek J, Kim J, Kim NY, Woo D, Chae S, Kim C-H, Shin H-S, Han Y-M#, Kim D#, Heo WD#
Optogenetic control of endogenous Ca2+ channels in vivo.
Nature Biotechnology (Cover Article). 2015 Sep 14, doi: 10.1038/nbt.3350. Epub 2015 Sep 14.
This article was recommended by the faculty of 1000.
Yoon J*, Lee M*, Lee K, Kim N, Kim JM, Park J, Yu H, Choi C, Heo WD#, Park Y#
Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping.
Scientific Reports. 2015 Aug 21, doi: 10.1038/srep13289.
Kim J, Jo H, Hong H, Kim MH, Kim JM, Lee JK, Heo WD, Kim J
Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
Nature Communications. 2015 Apr 7, doi: 10.1038/ncomms7781.
Sohn YS, Shin HC, Park WS, Ge J, Kim CH, Lee BL, Heo WD, Jung JU, Rigden DJ, Oh BH
Lpg0393 of Legionella pneumophila is a guanine-nucleotide exchange factor for Rab5, Rab21 and Rab22.
PLoS One. 2015 Mar 30, doi: 10.1371/journal.pone.0118683. eCollection 2015.
Choi YA, Keem JO, Kim CY, Yoon HR, Heo WD, Chung BH, Jung Y
A novel copper-chelating strategy for fluorescent proteins to image dynamic copper fluctuations on live cell surfaces.
Chemical Science. 2015, doi: 10.1039/C4SC03027C.
2014
Um JW, Kim KH, Park BS, Choi Y, Kim D, Kim CY, Kim SJ, Lee SG, Choii G, Nam J, Heo WD, Kim E, Lee JO, Ko J, Kim HM
Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion.
Nature Communications. 2014 Nov 14, doi: 10.1038/ncomms6423.
Kim N*, Kim JM*, Lee M, Kim CY, Chang KY, Heo WD
Spatiotemporal control of fibroblast growth factor receptor signals by blue light.
Chemistry & Biology (Cover Article). 2014 Jun 26, doi: 10.1016/j.chembiol.2014.05.013.
This article was recommended by the faculty of 1000.
Chang KY*, Woo D*, Jung H, Lee S, Kim S, Won J, Kyung T, Park H, Kim N, Yang HW, Park JY, Hwang EM, Kim D, Heo WD
Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling.
Nature Communications. 2014 Jun 4, doi: 10.1038/ncomms5057.
Lee S*, Park H*, Kyung T, Kim NY, Kim S, Kim J, Heo WD
Reversible protein inactivation by optogenetic trapping in cells.
Nature Methods. 2014 May 4, doi: 10.1038/nmeth.2940.
This article was highlighted by Nature Methods.
Kim C, Yang H, Fukushima Y, Saw PE, Lee J, Park JS, Park I, Jung J, Kataoka H, Lee D, Heo WD, Kim I, Jon S, Adams RH, Nishikawa S, Uemura A, Koh GY.
Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.
Cancer Cell. 2014 Jan 13, doi: 10.1016/j.ccr.2013.12.010.
2013
Manjare ST, Kim S, Heo WD, Churchill DG.
Selective and sensitive superoxide detection with a new diselenide-based molecular probe in living breast cancer cells.
Organic Letters. 2013 Dec 26, doi: 10.1021/ol4033013.
Truong D, Brabant D, Bashkurov M, Wan LC, Braun V, Heo WD, Meyer T, Pelletier L, Copeland J, Brumell JH
Formin-mediated actin polymerization promotes Salmonella invasion.
Cell Microbiol. 2013 Aug 13, doi: 10.1111/cmi.12173.
Lee HW*, Kyung T*, Yoo J, Kim T, Chung C, Ryu JY, Lee H, Park K, Lee S, Jones WD, Lim DS, Hyeon C, Heo WD*, Yoon TY*
Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics.
Nature Communications. 2013, doi: 10.1038/ncomms2507.
Na HK, Kim MH, Lee J, Kim YK, Jang H, Lee KE, Park H, Heo WD, Jeon H, Choi IS, Lee Y, Min DH
Cytoprotective effects of graphene oxide for mammalian cells against internalization of exogenous materials.
Nanoscale. 2013 Feb 21, doi: 10.1039/c2nr33800a.
Cho S*, Jang J*, Song C, Lee H, Ganesan P, Yoon TY, Kim MW, Choi MC, Ihee H#, Heo WD#, Park Y#
Simple super-resolution live-cell imaging based on diffusion-assisted Förster resonance energy transfer.
Scientific Reports. 2013 Feb 4, doi: 10.1038/srep01208.
2012
Ku B, Lee KH, Park WS, Yang CS, Ge J, Lee SG, Cha SS, Shao F, Heo WD, Jung JU, Oh BH.
VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking.
PLoS Pathog. 2012, doi: 10.1371/journal.ppat.1003082.
Gil JE, Kim E, Kim IS, Ku B, Park WS, Oh BH, Ryu SH, Cho W#, Heo WD#
Phosphoinositides differentially regulate protrudin localization through the FYVE domain.
J Biol Chem. 2012 Nov 30, doi: 10.1074/jbc.M112.419127.
Shin YC, Yoon JH, Jang TH, Kim SY, Heo WD, So I, Jeon JH, Park HH
Crystal structure of Rab6A'(Q72L) mutant reveals unexpected GDP/Mg²⁺ binding with opened GTP-binding domain.
Biochem Biophys Res Commun. 2012 Jul 27, doi: 10.1016/j.bbrc.2012.06.102.
Park MH, Lee HS, Lee CS, You ST, Kim DJ, Park BH, Kang MJ, Heo WD, Shin EY, Schwartz MA, Kim EG.
p21-Activated kinase 4 promotes prostate cancer progression through CREB.
Oncogene. 2012 Jun 18, doi: 10.1038/onc.2012.255.
Yang HW, Shin MG, Lee S, Kim JR, Park WS, Cho KH, Meyer T#, Heo WD#
Cooperative activation of PI3K by Ras and Rho family small GTPases.
Molecular Cell. 2012 Jul 2, doi: 10.1016/j.molcel.2012.05.007.
This article was recommended by the faculty of 1000.
Won JK*, Yang HW*, Shin SY*, Lee JH, Heo WD#, Cho KH#
The crossregulation between ERK and PI3K pathways determines the tumoricidal efficacy of MEK inhibitor.
J Mol Cell Biol (Cover Article). 2012 May 4, doi: 10.1093/jmcb/mjs021.
2011
Mun JY, Lee KJ, Kim YJ, Kwon O, Kim SJ, Lee SG, Park WS, Heo WD, Oh DB
Development of fluorescent probes for the detection of fucosylated N-glycans using an Aspergillus oryzae lectin.
Appl Microbiol Biotechnol. 2011 Sep 3, doi: 10.1007/s00253-011-3549-z.
Kaniuk NA, Canadien V, Bagshaw RD, Bakowski M, Braun V, Landekic M, Mitra S, Huang J, Heo WD, Meyer T, Pelletier L, Andrews-Polymenis H, McClelland M, Pawson T, Grinstein S, Brumell JH
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Cell Microbiol. 2011 Sep 14, doi: 10.1111/j.1462-5822.2011.01663.x.
Jeon H, Zheng LT, Lee S, Lee WH, Park N, Park JY, Heo WD, Lee MS, Suk K
Comparative analysis of small G proteins in cell migration and cell death: promigratory effects of RalA.
Exp Cell Res. 2011 May 27, doi: 10.1016/j.yexcr.2011.05.021.
Shin SY*, Yang HW*, Kim JR, Heo WD#, Cho KH#
A hidden incoherent switch regulates RCAN1 in the calcineurin-NFAT signaling network.
J Cell Sci (Cover Article). 2011 Jan 1, doi: 10.1242/jcs.076034.
Huang J, Birmingham CL, Shahnazari S, Shiu J, Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, Brumell JH
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase.
Autophagy. 2011 Jan 1, doi: 10.4161/auto.7.1.13840
2010
Bakowski MA, Braun V, Lam GY, Yeung T, Heo WD, Meyer T, Finlay BB, Grinstein S, Brumell JH
The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole.
Cell Host Microbe. 2010 Jun 25, doi: 10.1016/j.chom.2010.05.011.
Lee KH, Lee S, Lee WY, Yang HW, Heo WD
Visualizing dynamic interaction between calmodulin and calmodulin-related kinases in live mammalian cells.
PNAS. 2010 Feb 3, doi: 10.1073/pnas.0911262107.
2009
Manna D, Aligo J, Xu C, Park WS, Koc H, Heo WD, Konan KV
Endocytic Rab proteins are required for hepatitis C virus replication complex formation.
Virology. 2009 Dec 16, doi: 10.1016/j.virol.2009.11.034.
Han K, Kim MH, Seeburg D, Seo J, Verpelli C, Han S, Chung HS, Ko J, Lee HW, Kim K, Heo WD, Meyer T, Kim H, Sala C, Choi SY, Sheng M, Kim E
Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD.
PLoS Biology. 2009 Sep 8, doi: 10.1371/journal.pbio.1000187.
Yang HM , Lee HJ, Jang KS, Park CW, Yang HW, Heo WD, Kim, JD.
Poly(amino acid)-coated iron oxide nanoparticles as ultra-small magnetic resonance probes.
J. Mater. Chem. 2009 May 19, doi: 10.1039/B820139K
2008
Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, Meyer T, Suh PG, Ryu SH
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.
Mol Biol Cell. 2008 May 14, doi: 10.1091/mbc.E07-04-0337.
Park WS*, Heo WD*, Whalen JH, O'Rourke NA, Bryan HM, Meyer T, Teruel MN
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by live imaging.
Molecular Cell (Cover Article). 2008 May 9, doi: 10.1016/j.molcel.2008.04.008.
This article was recommended by the faculty of 1000.
Post-doctoral Period at Stanford (2000 - 2008)
Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T
Genome Biology. 2007;8(7):R142.
Stone M, Jia S, Heo WD, Meyer T, Konan KV
Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery.
J Virol. 2007 May;81(9):4551-63. Epub 2007 Feb 14.
Smith AC, Heo WD, Braun V, Jiang X, Macrae C, Casanova JE, Scidmore MA, Grinstein S, Meyer T, Brumell JH
J Cell Biol. 2007 Jan 29;176(3):263-8.
Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, Meyer T
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane.
Science. 2006 Dec 1;314(5804):1458-61. Epub 2006 Nov 9.
This article was recommended by the faculty of 1000.
A. This paper has been introduced in several journals in special introductory articles.
B. Science (Perspectives) Tools to Tamper with Phosphoinositides. Stuart McLaughlin. 2006 314 (5804).
C. Nature Methods (Research Highlights) Lipids under scrutiny.2007 4 (7).
D. Science STKE (Editors' Choice) Turn on the PIPs. Peter Stern. 2006 (364).
Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr, Meyer T
STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.
Current Biology. 2005 Jul 12;15(13):1235-41.
Inoue T, Heo WD, Grimley JS, Wandless TJ, Meyer T
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways.
Nature Methods. 2005 Jun;2(6):415-8.
Yoo JH, Park CY, Kim JC, Heo WD, Cheong MS, Park HC, Kim MC, Moon BC, Choi MS, Kang YH, Lee JH, Kim HS, Lee SM, Yoon HW, Lim CO, Yun DJ, Lee SY, Chung WS, Cho MJ
J Biol Chem. 2005 Feb 4;280(5):3697-706. Epub 2004 Nov 29.
Yoo JH, Park CY, Kim JC, Heo WD, Cheong MS, Park HC, Kim MC, Moon BC, Choi MS, Kang YH, Lee JH, Kim HS, Lee SM, Yoon HW, Lim CO, Yun DJ, Lee SY, Chung WS, Cho MJ
Molecules and Cells. 2004 Oct 31;18(2):207-13.
Eom CY, Heo WD, Craske ML, Meyer T, Lehman IR
PNAS. 2004 Mar 23;101(12):4036-40. Epub 2004 Mar 9.
Heo WD, Meyer T
Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases.
Cell (Cover Article). 2003 May 2;113(3):315-28.
This article was recommended by the faculty of 1000.
Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.
Overview of the Alliance for Cellular Signaling.
Nature. 2002 Dec 12;420(6916):703-6.
PhD. Course Period (1994 - 1999)
Choi JY, Lee SH, Park CY, Heo WD, Kim JC, Kim MC, Chung WS, Moon BC, Cheong YH, Kim CY, Yoo JH, Koo JC, Ok HM, Chi SW, Ryu SE, Lee SY, Lim CO, Cho MJ
J Biol Chem. 2002 Jun 14;277(24):21630-8. Epub 2002 Mar 18.
Chung WS, Lee SH, Kim JC, Heo WD, Kim MC, Park CY, Park HC, Lim CO, Kim WB, Harper JF, Cho MJ
Plant Cell. 2000 Aug;12(8):1393-407.
Lee SH, Kim MC, Heo WD, Kim JC, Chung WS, Park CY, Park HC, Cheong YH, Kim CY, Lee KJ, Bahk JD, Lee SY, Cho MJ
Biochim Biophys Acta. 1999 Aug 17;1433(1-2):56-67.
Heo WD, Lee SH, Kim MC, Kim JC, Chung WS, Chun HJ, Lee KJ, Park CY, Park HC, Choi JY, Cho MJ
PNAS. 1999 Jan 19;96(2):766-71.
Cho MJ, Vaghy PL, Kondo R, Lee SH, Davis JP, Rehl R, Heo WD, Johnson JD
Biochemistry. 1998 Nov 10;37(45):15593-7.
Lee SH, Seo HY, Kim JC, Heo WD, Chung WS, Lee KJ, Kim MC, Cheong YH, Choi JY, Lim CO, Cho MJ
Differential activation of NAD kinase by plant calmodulin isoforms. The critical role of domain I.
J Biol Chem. 1997 Apr 4;272(14):9252-9.
Lee SH, Kim JC, Lee MS, Heo WD, Seo HY, Yoon HW, Hong JC, Lee SY, Bahk JD, Hwang I, Cho MJ
J Biol Chem. 1995 Sep 15;270(37):21806-12.
Kim et al., Chemistry & Biology. 2014.
Won et al., Journal of Molecular Cell Biology. 2012.
Shin et al., Journal of Cell Science. 2011.
Heo & Meyer. Cell. 2003.