昭和医科大学 薬学部
社会健康薬学講座
衛生薬学部門
Division of Health Chemistry,
Department of Healthcare and Regulatory Sciences,
School of Pharmacy, Showa Medical University
昭和医科大学 薬学部
社会健康薬学講座
衛生薬学部門
Division of Health Chemistry,
Department of Healthcare and Regulatory Sciences,
School of Pharmacy, Showa Medical University
【原著論文】
Dynamic intra-renal changes in cadmium distribution detected by LA-ICP-MS in mice administered cadmium-metallothionein.
Fujishiro H, Matsumoto K, Umemoto H, Tsuneyama K, Matsukawa T, Kubota A, Himeno S, Sumi D
Metallomics (2025) 17: in press.
Combined effects of arsenic and bisphenol-A on locomotor activity and oxidative stress mediated neurotoxicity in mice.
Beauty SA, Hossain J, Sarder SJ, Uddin N, Goni O, Abedin F, Rossi KN, Rimi RK, Himeno S, Hossain K, Saud ZA
Biol Trace Elem Res (2025) 203: 4694-4706.
Concomitant exposure to lower doses of arsenic, lead, and manganese induces greater synergistic neurotoxicity than individual metals in mice.
Kabir T, Shila TT, Islam J, Beauty SA, Islam F, Hossain S, Nikkon F, Himeno S, Hossain K, Saud ZA
Biol Trace Elem Res (2025) 203: 1571-1581.
Novel evidence of arsenic-related excess adiposity and its implication in the risk of cardiometabolic diseases.
Jubayar AM, Khan S, Sadi J, Uddin N, Goni O, Khatun M, Siddique AE, Kabir E, Rimi RK, Beauty SA, Rossi KN, Abedin F, Sarder SJ, Islam MS, Sarker MK, Hossain S, Sumi D, Saud ZA, Barchowsky A, Wahed AS, Himeno S, Hossain K
Environ Res (2025) 271: 121059.
【原著論文】
Prostacyclin synthase deficiency exacerbates systemic inflammatory responses in lipopolysaccharide-induced septic shock in mice.
Ochiai T, Honsawa T, Yamaguchi K, Sasaki Y, Yokoyama C, Kuwata H, Hara S
Inflamm Res (2024) 73: 1349-1358.
Knockdown of iPLA2γ enhances cisplatin-induced apoptosis by increasing ROS-dependent peroxidation of mitochondrial phospholipids in bladder cancer cells.
Nakayama S, Yoda E, Yamashita S, Takamatsu Y, Suzuki Y, Kondo Y, Hara S
Free Radic Biol Med (2024) 220: 301-311.
Arsenic exposure-related hypertension in Bangladesh and reduced circulating nitric oxide bioavailability.
Khatun M, Haque N, Siddique AE, Wahed AS, Islam MS, Khan S, Jubayar AM, Sadi J, Kabir E, Shila TT, Islam Z, Sarker MK, Banna HU, Hossain S, Sumi D, Saud ZA, Barchowsky A, Himeno S, Hossain K
Environ Health Perspect (2024) 132: 47003.
【原著論文】
Deficiency of long-chain acyl-CoA synthetase 4 leads to lipopolysaccharide-induced mortality in a mouse model of septic shock.
Kuwata H, Nakatani E, Tomitsuka Y, Ochiai T, Sasaki Y, Yoda E, Hara S
FASEB J (2023) 37: e23330.
Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation.
Tomitsuka Y, Imaeda H, Ito H, Asou I, Ohbayashi M, Ishikawa F, Kuwata H, Hara S.
Redox Biol (2023) 66: 102850.
Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
Hirabayashi T, Kawaguchi M, Harada S, Mouri M, Takamiya R, Miki Y, Sato H, Taketomi Y, Yokoyama K, Kobayashi T, Tokuoka SM, Kita Y, Yoda E, Hara S, Mikami K, Nishito Y, Kikuchi N, Nakata R, Kaneko M, Kiyonari H, Kasahara K, Aiba T, Ikeda K, Soga T, Kurano M, Yatomi Y, Murakami M.
Cell Rep (2023) 42: 111940.
Association between serum periostin levels and the severity of arsenic-induced skin lesions.
Khatun M, Siddique AE, Wahed AS, Haque N, Tony SR, Islam J, Alam S, Sarker MK, Kabir I, Hossain S, Sumi D, Saud ZA, Barchowsky A, Himeno S, Hossain K.
PLoS One (2023) 18: e0279893.
【原著論文】
Role of ACSL4 in the chemical-induced cell death in human proximal tubule epithelial HK-2 cells
Kuwata H, Tomitsuka Y, Yoda E, Hara S.
Biosci Rep (2022) 42: BSR20212433.
Spatial localization of cadmium and metallothionein in the kidneys of mice at the early phase of cadmium accumulation.
Fujishiro H, Sumino M, Sumi D, Umemoto H, Tsuneyama K, Matsukawa T, Yokoyama K, Himeno S.
J Toxicol Sci (2022) 47: 507-517.
Elevated serum periostin levels among arsenic-exposed individuals and their associations with the features of asthma
Tony SR, Haque N, Siddique AE, Khatun M, Rahman M, Islam Z, Islam MS, Islam J, Hossain S, Hoque MA, Saud ZA, Sumi D, Wahed AS, Barchowsky A, Himeno S, Hossain K.
Chemosphere (2022) 298: 134277.
Effects of individual amino acid mutations of zinc transporter ZIP8 on manganese- and cadmium-transporting activity.
Fujishiro H, Miyamoto S, Sumi D, Himeno S
Biochem Biophys Res Commun (2022) 616, 26-32.
PAI-1 is a potential transcriptional silencer that supports bladder cancer cell activity.
Furuya H, Sasaki Y, Chen R, Peres R, Hokutan K, Murakami K, Kim N, Chan OTM, Pagano I, Dyrskjøt L, Jensen JB, Malmstrom PU, Segersten U, Sun Y, Arab A, Goodarzi H, Goodison S, Rosser CJ.
Sci Rep (2022) 12, 12186.
【総説】
Foreword (to “Emerging roles of lipid mediators in health sciences).
Hara S.
Biol Pharm Bull (2022) 45: 978.
Prostacyclin synthase as an ambivalent regulator of inflammatory reactions.
Ochiai T, Honsawa T, Sasaki Y, Hara S
Biol Pharm Bull (2022) 45: 979-984
【原著論文】
Substrate specificity of human long-chain acyl-CoA synthetase ACSL6 variants.
Kurotaki A, Kuwata H, Hara S.
Biol Pharm Bull (2021) 44: 1571-1575.
Absence of prostacyclin greatly relieves cyclophosphamide-induced cystitis and bladder pain in mice.
Ochiai T, Sasaki Y, Yokoyama C, Kuwata H, Hara S.
FASEB J (2021) 35: e21952.
Involvement of prostacyclin synthase in high-fat-diet-induced obesity.
Sasaki Y, Kuwata H, Akatsu M, Yamakawa Y, Ochiai T, Yoda E, Nakatani Y, Yokoyama C, Hara S.
Prostaglandins Other Lipid Mediat (2021) 153: 106523.
Gene deletion of microsomal prostaglandin E synthase-1 suppresses chemically induced skin carcinogenesis.
Sasaki Y, Kuwata H, Aida E, Ochiai T, Kamei D, Nakatani Y, Hara S.
Anticancer Res (2021) 41: 1307-1314.
Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Ochiai T, Sasaki Y, Kuwata H, Nakatani Y, Yokoyama C, Hara S.
Biochem Biophys Res Commun (2021) 546: 124-129.
Arsenic secondary methylation capacity is inversely associated with arsenic exposure-related muscle mass reduction.
Sarker MK, Tony SR, Siddique AE, Karim MR, Haque N, Islam Z, Islam MS, Khatun M, Islam J, Hossain S, Alam Saud Z, Miyataka H, Sumi D, Barchowsky A, Himeno S, Hossain K.
Int J Environ Res Public Health (2021) 18: 9730.
Comparisons of segment-specific toxicity of platinum-based agents and cadmium using S1, S2, and S3 cells derived from mouse kidney proximal tubules.
Fujishiro H, Taguchi H, Hamao S, Sumi D, Himeno S.
Toxicol In Vitro (2021) 75: 105179.
T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma.
Rahman A, Islam MS, Tony SR, Siddique AE, Mondal V, Hosen Z, Islam Z, Hossain MI, Rahman M, Anjum A, Paul SK, Hossen F, Sarker MK, Hossain S, Salam KA, Haque A, Hoque MA, Saud ZA, Xin L, Sumi D, Himeno S, Hossain K.
Toxicol Appl Pharmacol (2021) 420: 115532.
Arsenite suppresses IL-2-dependent tumoricidal activities of natural killer cells.
Sumi D, Tsuyama H, Ogawa T, Ogawa M, Himeno S.
Toxicol Appl Pharmacol (2021) 412: 115353.
【総説】
Non-malignant diseases associated with environmental arsenic exposure in Taiwan, Chile, and Bangladesh
Himeno S, Hossain K.
Metallomics Res (2021) 1: rev31-rev46.
【原著論文】
Gene deletion of calcium-independent phospholipase A2γ (iPLA2γ) suppresses adipogenic differentiation of mouse embryonic fibroblasts.
Yoda E, Hachisu K, Kuwata H, Nakatani Y, Hara S.
Biol Pharm Bull (2020) 43: 1375-1381.
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure。
Yamada N, Karasawa T, Kimura H, Watanabe S, Komada T, Kamata R, Sampilvanjil A, Ito J, Nakagawa K, Kuwata H, Hara S, Mizuta K, Sakuma Y, Sata N, Takahashi M.
Cell Death Dis (2020) 11: 144.
Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass.
Mondal V, Hosen Z, Hossen F, Siddique AE, Tony SR, Islam Z, Islam MS, Hossain S, Islam K, Sarker MK, Hasibuzzaman MM, Liu LZ, Jiang BH, Hoque MM, Saud ZA, Xin L, Himeno S, Hossain K.
Environ Int (2020) 143: 105890.
Differential role of liver X receptor (LXR) α and LXRβ in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice.
Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH.
Drug Metab Dispos (2020) 48: 255-263.
【原著論文】
Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages.
Kuwata H, Nakatani E, Shimbara-Matsubayashi S, Ishikawa F, Shibanuma M, Sasaki Y, Yoda E, Nakatani Y, Hara S.
Biochim Biophys Acta Mol Cell Biol Lipids (2019) 1864: 1606-1618.
Analysis on the substrate specificity of recombinant human acyl-CoA synthetase ACSL4 variants.
Shimbara-Matsubayashi S, Kuwata H, Tanaka N, Kato M, Hara S.
Biol Pharm Bull (2019) 42: 850-855.
【総説】
Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism.
Kuwata H, Hara S.
Prostaglandins Other Lipid Mediat (2019) 144: 106363.
Calcium-independent phospholipase A2γ (iPLA2γ) and its roles in cellular functions and diseases.
Hara S, Yoda E, Sasaki Y, Nakatani Y, Kuwata H.
Biochim Biophys Acta Mol Cell Biol Lipids (2019) 1864: 861-868.
【原著論文】
The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts。
Kuwata H, Yuzurihara C, Kinoshita N, Taki Y, Ikegami Y, Washio S, Hirakawa Y, Yoda E, Aiuchi T, Itabe H, Nakatani Y, Hara S.
FEBS J (2018) 285: 2056-2070.
【原著論文】
Cytosolic prostaglandin E synthase is involved in c-Fos expression in rat fibroblastic 3Y1 cells.
Nakatani Y, Miyazaki Y, Hara S.
Biol Pharm Bull (2017) 40: 963-967.
Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.
Yoda E, Paszek M, Konopnicki C, Fujiwara R, Chen S, Tukey RH.
Sci Rep (2017) 7: 46489.
【総説】
Role of prostacyclin synthase in carcinogenesis.
Sasaki Y, Ochiai T, Takamura M, Kondo Y, Yokoyama C, Hara S.
Prostaglandins Other Lipid Mediat (2017) 133: 49-52.
Prostaglandin terminal synthases as novel therapeutic targets.
Hara S.
Proc Jpn Acad Ser B-Phys Biol Sci (2017) 93: 703-23.
Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans.
Fujiwara R, Yoda E, Tukey RH.
Drug Metab Pharmacokinet (2017) 33: 9-16.
【原著論文】
Inhibition of amyloid fibril formation and cytotoxicity by caffeic acid-conjugated amyloid-β C-terminal peptides.
Arai T, Ohno A, Mori K, Kuwata H, Mizuno M, Imai K, Hara S, Shibanuma M, Kurihara M, Miyata N, Nakagawa H, Fukuhara K.
Bioorg Med Chem Lett (2016) 26: 5468-5471.
Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer's disease.
Arai T, Ohno A, Mori K, Kakizawa T, Kuwata H, Ozawa T, Shibanuma M, Hara S, Ishida S, Kurihara M, Miyata N, Nakagawa H, Fukuhara K.
Bioorg Med Chem (2016) 24: 4138-4143.
【原著論文】
Genetic-deletion of cyclooxygenase-2 downstream prostacyclin synthase suppresses inflammatory reactions but facilitates carcinogenesis, unlike deletion of microsomal prostaglandin E synthase-1.
Sasaki Y, Kamiyama S, Kamiyama A, Matsumoto K, Akatsu M, Nakatani Y, Kuwata H, Ishikawa Y, Ishii T, Yokoyama C, Hara S.
Sci Rep (2015) 5: 17376.
Inhibition of long-chain acyl-coenzyme A synthetase 4 facilitates production of 5,11-dihydroxyeicosatetraenoic acid via the cyclooxygenase-2 pathway.
Kuwata H, Hara, S.
Biochem Biophys Res Commun (2015) 465: 525-533.
【総説】
Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis.
Sasaki Y, Nakatani Y, Hara S.
Prostaglandins Other Lipid Mediat (2015) 121: 42-45.
Prostaglandin terminal synthases as novel drug targets.
Hara S.
Bioactive Lipid Mediators: Current Reviews and Protocols (eds. T. Yokomizo & M. Murakami ) Springer (2015) 43-57.
桑田浩、原俊太郎
アラキドン酸代謝物産生反応におけるリン脂質リモデリング経路の役割
昭和学士会雑誌 (2015) 75: 130-137.
【原著論文】
Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice.
Yoda E, Rai K, Ogawa M, Takakura Y, Kuwata H, Suzuki H, Nakatani Y, Murakami M, Hara S.
PLoS One (2014) 9: e109409.
The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M.
Cell Metab (2014) 20: 119-32.
Time course-changes in phosphatidylcholine profile during oxidative modification of low-density lipoprotein.
Sasabe N, Keyamura Y, Obama T, Inoue N, Masuko K, Igarashi Y, Aiuchi T, Kato R, Yamaguchi T, Kuwata H, Iwamoto S, Miyazaki A, Hara S, Yoshikawa T, Itabe H.
Lipids Health Dis (2014) 13: 48.
Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts.
Kuwata H, Yoshimura M, Sasaki Y, Yoda E, Nakatani Y, Kudo I, Hara, S.
Biochim Biophys Acta Mol Cell Biol Lipids (2014) 1841: 44-53.
【紀要】
五十嵐良明、原俊太郎
化粧品の機能性と安全性を支える科学
薬学雑誌 (2014) 134: 25-26.
【原著論文】
Acetylcholine esterase is a regulator of GFAP expression and a target of dichlorvos in astrocytic differentiation of rat glioma C6 cells.
Ozawa A, Kadowaki E, Haga Y, Sekiguchi H, Hemmi N, Kaneko T, Maki T, Sakabe K, Hara S, Yamamoto M, Arishima K, Sakaue M.
Brain Res (2013) 1537: 37-45.
Crucial role of perilipin-3 (TIP47) in formation of lipid droplets and PGE2 production in HL-60-derived neutrophils.
Nose F, Yamaguchi T, Kato R, Aiuchi T, Obama T, Hara S, Yamamoto M, Itabe H.
PLoS One (2013) 8: e71542.
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.
Miki Y, Yamamoto K, Taketomi Y, Sato H, Shimo K, Kobayashi T, Ishikawa Y, Ishii T, Nakanishi H, Ikeda K, Taguchi R, Kabashima K, Arita M, Arai H, Lambeau G, Bollinger JM, Hara S, Gelb MH, Murakami M.
J Exp Med (2013) 210: 1217-34.
Mast cell maturation is driven via a novel group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M.
Nat Immunol (2013) 14: 554-563.
Microsomal prostaglandin E synthase-1 is induced in Alzheimer's disease and its deletion mitigates Alzheimer's disease-like pathology in a mouse model.
Akitake Y, Nakatani Y, Kamei D, Hosokawa M, Akatsu H, Uematsu S, Akira S, Kudo I, Hara S, Takahashi M.
J Neurosci Res (2013) 91: 909-919.
【総説】
創薬の標的としてのプロスタグランジン最終合成酵素群
佐々木由香、原俊太郎
横溝岳彦 監修 遺伝子医学MOOK24号「最新生理活性脂質研究?実験手法，基礎的研究とその応用」 メディカルドゥ 146-153.
【原著論文】
Metallothionein deficiency exacerbates chronic inflammation associated with carcinogenesis in stomach of mice infected with Helicobacter pylori.
Mita M, Satoh M, Shimada A, Azuma S, Himeno S, Hara S.
J Toxicol Sci (2012) 37: 1261-1265.
Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35.
Kuroki Y, Sasaki Y, Kamei D, Akitake Y, Takahashi M, Uematsu S, Akira S, Nakatani Y, Kudo I, Hara S.
Biochem Biophys Res Commun (2012) 424: 409-413.
Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.
Yoshioka W, Aida-Yasuoka K, Fujisawa N, Kawaguchi T, Ohsako S, Hara S, Uematsu S, Akira S, Tohyama C.
Toxicol Sci (2012) 127: 547-554.
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Sasaki Y, Kamei D, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Hara S.
Oncogene (2012) 31: 2943-2952.
【総説】
中谷良人
細胞質型プロスタグランジンE2合成酵素
昭和大学薬学雑誌 (2012) 3: 27-34.
【原著論文】
Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH.
Nakatani Y, Hokonohara Y, Tajima Y, Kudo I, Hara S.
Prostaglandins Other Lipid Mediat (2011) 94: 112-117.
Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
Sato H, Isogai Y, Masuda S, Taketomi Y, Miki Y, Kamei D, Hara S, Kobayashi T, Ishikawa Y, Ishii T, Ikeda K, Taguchi R, Ishimoto Y, Suzuki N, Yokota Y, Hanasaki K, Suzuki-Yamamoto T, Yamamoto K, Murakami M.
J Biol Chem (2011) 286(13): 11632-48.
Hair follicular expression and function of group x secreted phospholipase A2 in mouse skin.
Yamamoto K, Taketomi Y, Isogai Y, Miki Y, Sato H, Masuda S, Nishito Y, Morioka K, Ishimoto Y, Suzuki N, Yokota Y, Hanasaki K, Ishikawa Y, Ishii T, Kobayashi T, Fukami K, Ikeda K, Nakanishi H, Taguchi R, Murakami M.
J Biol Chem (2011) 286(13): 11616-31.
【総説】
原俊太郎
新たなNSAIDsの標的としてのプロスタグランジン最終合成酵素
昭和大学薬学雑誌 (2011) 2: 115-126.
原俊太郎、近藤幸尋
腫瘍進展を抑える内在性低酸素応答抑制因子HIF-3a
生化学 (2011) 83: 50-55.
【原著論文】
Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2γ-deficient mice.
Yoda E, Hachisu K, Taketomi Y, Yoshida K, Nakamura M, Ikeda K, Taguchi R, Nakatani Y, Kuwata H, Murakami M, Kudo I, Hara S.
J Lipid Res (2010) 51: 3003-3015.
Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.
Escoffier J, Jemel I, Tanemoto A, Taketomi Y, Payre C, Coatrieux C, Sato H, Yamamoto K, Masuda S, Pernet-Gallay K, Pierre V, Hara S, Murakami M, De Waard M, Lambeau G, Arnoult C.
J Clin Invest (2010) 120: 1415-1428.
Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.
Sato H, Taketomi Y, Isogai Y, Miki Y, Yamamoto K, Masuda S, Hosono T, Arata S, Ishikawa Y, Ishii T, Kobayashi T, Nakanishi H, Ikeda K, Taguchi R, Hara S, Kudo I, Murakami M.
J Clin Invest (2010) 120: 1400-1414.
Effect of the hsp90 inhibitor geldanamycin on androgen response of prostate cancer under hypoxic conditions.
Suzuki Y, Kondo Y, Hara S, Kimata R, Nishimura T.
Int J Urol (2010) 17: 281-285.
Microsomal prostaglandin E synthase-1 in both cancer cells and host contributes to tumour growth, invasion and metastasis.
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I.
Biochem J (2010) 425: 361-371.
Differential contribution of protein kinase C isoforms in the regulation of group IIA secreted phospholipase A2 expression in cytokine-stimulated rat fibroblasts.
Sugita M, Kuwata H, Kudo I, Hara S.
Biochim Biophys Acta (2010) 1801: 70-76.
【総説】
Prostaglandin E synthases: understanding their pathophysiological roles through mouse genetic models.
Hara S, Kamei D, Sasaki Y, Tanemoto A, Nakatani Y, Murakami M.
Biochimie (2010) 92: 651-659.
原俊太郎
新たなNSAIDsの標的を求めて
ファルマシア (2010) 46: 517-519.
【原著論文】
Hypoxia-inducible factor-3α functions as an accelerator of 3T3-L1 adipose differentiation.
Hatanaka M, Shimba S, Sakaue M, Kondo Y, Kagechika H, Kokame K, Miyata T, Hara, S.
Biol Pharm Bull (2009) 72:1166-1172.
Acceleration of methylmercury-induced cell death of rat cerebellar neurons by brain-derived neurotrophic factor in vitro.
Sakaue M, Mori N, Makita M, Fujishima K, Hara S, Arishima K, Yamamoto M.
Brain Res (2009) 1273: 155-162.
Suppression of mutant androgen receptors by flutamide.
Ishioka J, Hara S, Isaacs JT, Tomura A, Nishikawa K, Kageyama Y.
Int J Urol (2009) 16: 516-521.
Hypoxia downregulates farnesoid X receptor via a hypoxia-inducible factor-independent but p38 mitogen-activated protein kinase-dependent pathway.
Fujino T, Murakami K, Ozawa I, Minegishi Y, Kashimura R, Akita T, Saitou S, Atsumi T, Sato T, Ando K, Hara S, Kikugawa K, Hayakawa M.
FEBS J (2010) 276: 1319-1332.