Publications
1. Lensmire, J.M., Wischer, M.R., Sosinski, L.M., Ensink, E., Dodson, J.P., Shook, J.C., Delekta, P. C., Copper, C.C., Havlichek, D., Jr., Mulks, M.H., Lunt, S.Y., Ravi, J., and Hammer, Neal D. (2023) The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition. PLoS Genetics, Jul 7;19 (7):e1010834. doi:10.1371/journal.pgen.1010834. PMID:37418503
2. Burtchett, T.A., Shook, J.C., Hesse, L.E., Delekta, P.C., Brzozowski, R.S., Nouri, A., Calas, A.J., Spanoudis, C.M., Eswara, P.J., and Hammer, Neal D. (2023) Crucial role for lipoteichoic acid assembly in the metabolic versatility and antibiotic resistance of Staphylococcus aureus. Infect. Immun. Jul 18;91(7):e0055022. doi: 10.1128/iai.00550-22. PMID 37347167
3. Pajares-Chamorro, N., Hammer, Neal D., and Chatzistavrou, X. (2022) Unraveling the mechanisms of inhibition of silver-doped bioactive glass-ceramic particles. J Biomed Mater Res A. Dec 30. doi:10.1002/jbm.a.37482 PMID:36583930
4. Hammer, Neal D. and Waters, Chris M. (2022) The 27th Annual Midwest Microbial Pathogenesis Conference in the Age of COVID. J. Bacteriol. Jun 21; 204 (6) doi:10.1128/jb.00136-22 PMID: 35506693 PMCID: PMC9210972
*co-corresponding authors
5. Pajares-Chamorro, N., Hammer, Neal D., and Chatzistavrou, X. (2022) Materials for Restoring Lost Activity: Old Drugs for New Bugs. Advanced Drug Delivery Reviews; Jul; 186:114302 PMID35461913
6. Kies, P.J. and Hammer, Neal D. (2022) A resourceful race: bacterial scavenging of host sulfur metabolism during colonization. Infect Immun. May 19; 90(5):e0057921 PMID: 35315692 DOI: 10.1128/iai.00579-21 PMID: 35315692 PMCID: PMC9119060
7. Boumegouas, M., Raju, M., Gardiner, J., Hammer, Neal, Saleh, Y., Al-Abcha, A., Kalra, A., and Abela, George, S. (2022) Interaction between bacteria and cholesterol crystals: implications for endocarditis and atherosclerosis. PLoS One; 17(2):e0263847. Doi: 10.1371/journal.pone.0263847 PMID: 35180238 PMCID: PMC8856546
8. Pajares-Chamorro, N., Wagley, Y., Hammer, Neal D., and Chatzistavrou, X. (2021) Bioactive glass particles as multi-functional therapeutic carriers against antibiotic-resistant bacteria. J. Am. Ceram. Soc.; 00:1-12. https://doi.org/10.1111/jace.17923
9. Marsh, A.C., Mellott, N., Crimp, M., Wren, A., Hammer, Neal D., M., Chatzistavrou, X. (2021) Ag-Doped Bioactive Glass-ceramic 3D Scaffolds: A Microstructural Study to Antibacterial and Biological Performance. J. Euro. Ceram. Soc. 41:3713-30. https://doi.org/10.1016/j.jeurceramsoc.2021.01.011
10. Marsh, A.C., Zhang, Y., Poli, L., Hammer, Neal D., Roch, A., Crimp, M., Chatzistavrou, X. (2021) 3D printed bioactive and antibacterial silicate glass-ceramic scaffold by fused filament fabrication. Mater. Sci. Eng. C. 111516, doi:10.1016/j.msec.2020.111516. PMID: 33255072
11. Pajares-Chamorro, N., Wagley, Y., Maduka, C.V., Youngstrom, D.W., Yeger, A, Badylak, S.F., Hammer, Neal D., Hankenson, K.D., Chatzistavrou, X. (2021) Silver-doped bioactive glass particles for in vivo bone tissue regeneration and enhanced methicillin-resistant Staphylococcus aureus (MRSA) inhibition, Mater Sci Eng C Mater Biol Appl. 111693, ISSN 0928-4931, https://doi.org/10.1016/j.msec.2020.111693. PMID: 33545854 PMCID: PMC8168684
12. Hammer, Neal D. mSphere of Influence: A Controlled Burn-Pathogen Manipulation of the Dynamic Chemistry That Results from Inflammation. (2020) mSphere 5 (1):e00110-20. doi: 10.1128/mSphere.00110-20. PMID: 32102940 PMCID: PMC7045386
13. Soule, L.D., Pajares-Chomorro, N., Chuong, K., Mellott, N., Hammer, Neal D., Hankenson, K.D., Chatzistavrou, X. (2020) Sol–Gel-Derived Bioactive and Antibacterial Multi-Component Thin Films by the Spin-Coating Technique. ACS Biomater. Sci. & Eng. 6, 10, 5549-5562 PMID 33320549
14. Lensmire, J.M., Dodson, J.P., Hsueh, B.Y., Wischer, M.R., Delekta, P.C., Shook, J.C., Ottosen, E.N., Kies, P.J., Ravi, J., and Hammer, Neal D. (2020) The Staphylococcus aureus cystine transporters, TcyABC and TcyP, facilitate nutrient sulfur acquisition during infection. Infection and Immunity, PMID: 31843961 PMCID:PMC7035926
15. Pajares-Chamorro, N., Shook, J.C., Hammer, Neal D., and Chatzistavrou, X. (2019) Resurrection of Antibiotics that MRA Resists by Silver-Doped Bioactive Glass-Ceramic Microparticles. Acta Biomaterialia, PMID: 31302297
16. Marsh, A.C., Mellott, N., Pajares-Chamorro, N., Crimp, M., Wren, A., Hammer, Neal D., Chatzistavrou, X. (2019) Fabrication and multiscale characterization of 3D silver-containing bioactive glass-ceramic scaffolds. Bioactive Materials, 4:215-223. PMID: 31236524 PMCID:PMC6580235
17. Delekta, P.C., Lydic, T.A. and Hammer, Neal D. (2019) Isolation of lipoprotein particles from chicken egg yolk for the study of bacterial pathogen fatty acid incorporation into membrane phospholipids. Journal of Visualized Experiments, 147 doi: 10.3791/59538. PMID: 31157784 PMCID: PMC5952394
18. Lensmire, J.M. and Hammer, Neal D. (2018) Nutrient sulfur acquisition strategies employed by bacterial pathogens. Current Opinion in Microbiology, 47:52-58. PMID: 30530037
19. Delekta, P.C., Shook, J.C., Lydic, T.A. and Hammer, Neal D. (2018) Staphylococcus aureus utilizes host lipoprotein particles as a source of fatty acids. Journal of Bacteriology, doi: 10.1128/JB.00728-17. PMID: 29581406 PMCID: PMC5952394
** Press release: https://msutoday.msu.edu/news/2018/using-mrsas-strength-against-it/
20. Coulson, G.B., Johnson, B.K., Colvin, C.J., Fillinger, R.J., Zheng, H., Haiderer, E.R., Hammer, Neal D., Abramovitch, R.B. (2017) Targeting Mycobacterium tuberculosis sensitivity to thiol stress at acidic pH kills the bacterium and potentiates antibiotics. Cell Chemical Biology, 24:993-1004. PMID: 28781126 PMCID: PMC5562523
21. Hammer, Neal D., Schurig-Briccio, L.A., Gerdes, S.Y., Gennis, R.B., and Eric P. Skaar. (2016) CtaM is required for menaquinol oxidase aa3 function in Staphylococcus aureus. MBio, 7(4): pii: e00823-16. PMID: 27406563 PMCID: PMC4958251
22. Hendrix, A.S., Spoonmore, T.J., Wilde, A.D., Putnam, N.E., Hammer, Neal D., Snyder, D.J., Guelcher, S.A., Skaar, E.P., and Cassat, J. E. (2016) Repurposing the nonsteroidal anti-inflammatory drug diflunisal as an osteoprotective, anti-virulence therapy for Staphylococcus aureus osteomyelitis. Antimicrobial agents and chemotherapy. Jun 20.PMID: 27324764 PMCID: PMC4997817
23. Wilde, A.D., Snyder, D.J., Putnam, N.E., Valentino, M.D., Hammer, Neal D., Lonergan, Z.R., Hinger, S.A., Aysanoa, E.E., Blanchard, C., Dunman, P.M., Wasserman, G.A, Chen, J., Shopsin, B., Gilmore, M.S., Skaar, Eric P., and James E. Cassat (2015) Bacterial Hypoxic Response Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection. PLoS Pathogens, 11:e1005341 PMID:26684646 PMCID: PMC4684308
24. Spraggins, J.M., Rizzo, D., Moore, J.L., Rose, K.L., Hammer, Neal D., Skaar, Eric P., and Richard M. Caprioli. (2015) MALDI FTICR IMS of intact proteins: Using mass accuracy to link protein images with proteomic data. Journal of the American Society of Mass Spectrometry, 26: 974-85 PMID 25904064 PMCID: PMC4442642
25. Hammer, Neal D., Cassat, J.E., Noto, M.J., Lojek, L.J., Chadha, A.D., Schmitz, J.E., Creech, C. Buddy, and Eric P. Skaar. (2014) Inter- and intraspecies metabolite exchange promotes virulence of antibiotic-resistant Staphylococcus aureus. Cell Host & Microbe, 16: 531-7 PMID: 25299336 PMCID: PMC4197139
26. Thompson, M.K., Goodman, M., Keithly, M. E., Hammer, Neal. D., Cook, P., Jagessar, K.L., Harp, J., Skaar, Eric P., and Richard N. Armstrong. (2014) Structure and function of the genomically-encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus. Biochemistry, 53:755-6. PMID: 24447055 PMCID: PMC3985756
27. Hammer, Neal D., Reniere, M.L., Cassat, J.E., Zhang, Y., Hirsch, A.O., Hood, M. Indriati, and Eric P. Skaar. (2013) Two heme-dependent terminal oxidases power Staphylococcus aureus organ specific colonization of the vertebrate host. MBio, 4(4): pii: e00241-13. PMID: 23900169 PMCID: PMC3735196
28. Cassat, J.E., Hammer, Neal D., Campbell J.P., Benson M.A., Perrien D.S., Mrak L.N., Smeltzer M.S., Torres V.J., and Eric P. Skaar. (2013) A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host & Microbe. 13:759-72 PMID: 23768499 PMCID: PMC3721972
29. Mayfield, J.A., Hammer, Neal D., Kurker R.C., Chen T.K., Ojha S., Skaar, Eric P., and Jennifer L. Dubois. (2013) The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype. Journal of Biological Chemistry. 288:23488-504 PMID: 23737523 PMCID: PMC5395028
30. Hammer, Neal D. and Eric P. Skaar. (2013) Powerful genetic resource for the study of methicillin-resistant Staphylococcus aureus. MBio. 4 (2) PMID: 23549918 PMCID: PMC3622929
31. Wakeman Catherine.A., Hammer, Neal D., Stauff D.L., Attia A.S., Anzaldi L.L., Dikalov S.I., Calcutt M.W., and Eric P. Skaar. (2012) Menaquinone biosynthesis potentiates haem toxicity in Staphylococcus aureus. Molecular Microbiology. 86:1376-92. PMID: 23043465 PMCID: PMC3524387
32. Attia, A.S., Schroeder, K.A., Wilson, K.J., Seeley, E.H., Hammer, Neal D., Colvin, D.C., Gore, J.C., Caprioli, R.M., and Eric P. Skaar. (2012) Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI. Cell Host & Microbe, 11:664-73. PMID:22704626 PMCID: PMC3377982
33. Hammer, Neal, D., McGuffie, B.A., Zhou, Y., Badtke, M.P., Reinke, A.A., Brännström, K., Gestwicki, J.E., Olofsson, A., Almqvist, F., and Matthew R. Chapman. (2012) The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation. Journal of Molecular Biology, 422:376-89. PMID:22684146 PMCID: PMC3423549
34. Hammer, Neal D. and Eric P. Skaar. (2012) The impact of metal sequestration on Staphylococcus aureus metabolism. Invited Review: Current Opinions in Microbiology, 15:10-14. PMID: 22153710 PMCID: PMC3265625
35. Hammer, Neal D. and Eric P. Skaar. (2011) Molecular Mechanisms of Staphylococcus aureus Iron Acquisition. Invited Review: Annual Review of Microbiology, 65: 129-47. PMID: 21639791 PMCID: PMC3807827
36. Nenninger, A.A., Robinson, L.S., Hammer, Neal D., Ashman Epstein, E.M., Badtke, M.P., Hultgren, S.J., and Matthew R. Chapman. (2011) CsgE is a curli specificity factor that prevents amyloid fiber polymerization. Molecular Microbiology, 81: 486-99. PMID: 21645131 PMCID: PMC3134098
37. Wang, X., Zhou, Y., Ren, J.J., Hammer, Neal D., and Matthew R. Chapman. (2010) Gatekeeper residues modulate bacterial amyloid aggregation. Proceedings of the National Academy of Sciences, 107: 163-8. PMID: 19966296 PMCID: PMC2806774
38. Cegelske, L., Pinkner, J.S., Hammer, Neal D., Cusumano, C.K., Hund, C.S., Chorell, E., Aberg, V., Walker, J.N., Seed, P.C., Almqvist, F., Chapman, Matthew R., and Scott J. Hultgren. (2009) Small- molecule inhibitors target E. coli amyloid biogenesis and biofilm formation. Nature Chemical Biology, 5: 913-9. PMID: 19915538 PMCID: PMC2838449
39. Badtke, M.P., Hammer, Neal D., and Matthew R. Chapman. (2009) Functional amyloids signal their arrival Science Signaling, 2 pe43. Review. PMID: 19622831 PMCID: PMC2838484
40. Wang, X., Hammer, Neal D., and Matthew R. Chapman. (2008) The molecular basis of functional bacterial amyloid polymerization and nucleation. Journal of Biological Chemistry, 283: 21530-21539. PMID: 18508760 PMCID: PMC2490784
41. Hammer, Neal D., Wang, Xuan., McGuffie B. A., and Matthew R. Chapman. (2008) Amyloids: Friend or Foe?. Journal of Alzheimer’s Disease, 13: 407-419. Review. PMID:18487849 PMCID: PMC2674399
42. Hammer, Neal D., Schmidt, J.C., and Matthew R. Chapman. (2007) The curli nucleator protein, CsgB, contains an amyloidogenic domain that directs the polymerization of CsgA. Proceedings of the National Academy of Sciences, 104: 12494-12499. PMID: 17636121 PMCID: PMC1941497
43. Bentz, B.G., Hammer, Neal D., Milash, B., Klein, S., Burnett, D.M., Radosevich, James A., and G. Kenneth Haines 3rd. (2007) The kinetics and redox state of nitric oxide determine the biological consequences in lung adenocarcinoma. Tumour Biology. 28: 301-11. PMID: 18253068
44. Altman, K.W., Chhaya, V., Hammer, Neal D., Pavlova, S., Vesper, B.J., Tao, L., and James A. Radosevich. (2008) Effect of proton pump inhibitor pantoprazole on growth and morpholgy or oral Lactobacillus strains. Laryngoscope. 118: 599-604. PMID: 18176340
45. Lee, S., Vesper, B.J., Zong, H., Hammer, Neal D., Elseth, K.M., Barrett, A.G., Hoffman, B.M., and James A. Radosevich. (2008) Synthesis and biological analysis of thiotetra(ethylene glycol) monomethyl ether-functionalized porphyrazines: cellular uptake and light-dependent toxicity studies. Metal-Based Drugs. 2008:391418. PMID: 18274661 PMCID: PMC2225588
46. Vesper, B.J., Lee, S., Hammer, Neal D., Elseth, K.M., Barrett, A.G., Hoffman, B.M., and James A. Radosevich. (2006) Developing a structure-function relationship for anionic porphyrazines exhibiting selective anti-tumor activity. Journal of Photochemical Photobiology. 82: 180-6. PMID: 16388964
47. Hammer, Neal D,, Lee, S., Vesper, B.J., Elseth, K.M., Hoffman, B.M., Barrett, A.G.M., and James A. Radosevich. (2005) Charge dependence of cellular uptake and selective anti-tumor activity of porphyrazines. Journal of Medicinal Chemistry, 48: 8125-33. PMID: 16366594
48. Altman, K.W., Waltonen, J.D., Hammer, Neal D., Radosevich, James A., and G. Kenneth Haines 3rd. (2005) Proton pump (H+/K+-ATPase) expression in human laryngeal seromucinous glands. Otolaryngology and Head Neck Surgery. 133: 718-24. PMID: 16274799
49. Bentz, B.G., Hammer, Neal D., Radosevich, James A., and G. Kenneth Haines 3rd. (2004) Nitrosative stress induces DNA strand breaks but not caspase mediated apoptosis in a lung cancer cell line. Journal of Carcinogenesis. 3:16. PMCID: PMC544845
50. Altman, K.W., Haines, G.K. 3rd, Hammer, Neal D., and James A. Radosevich. (2003) The H+/K+-ATPase (proton) pump is expressed in human laryngeal submucosal glands. Laryngoscope. 113: 1927-30. PMID: 14603049