Dr. Mirzajani was the PI of this project, supported by Scientific and Technological Research Council of Türkiye through a TUBITAK 1001 grant, with a funding amount of €60k.
Cardiovascular disease remains the world’s leading killer, causing 19.8 million deaths in 2022. More than 300 million surgical procedures are performed globally each year, and over 10 million patients experience major cardiac complications within 30 days after non-cardiac surgery. Many perioperative myocardial injuries are clinically silent and can be missed without troponin-based monitoring, especially after hospital discharge. WACHCARDIO addresses this global monitoring gap through a wearable, wirelessly connected microneedle biosensing patch designed for real-time cardiac biomarker surveillance in out-of-hospital settings. The platform targets cTnI and NT-proBNP to enable early detection of myocardial injury and heart-failure risk after surgery, before complications progress. By combining minimally invasive biomarker access, in situ sensing, and remote data transmission, WACHCARDIO aims to shift postoperative cardiac care from episodic hospital testing to continuous, patient-centered surveillance.
Introducing WACHCARDIO, a) conceptual operation mechanism of the WACHCARDIO which includes attachment to the skin where microneedles penetrate to the dermis layer and become connected to the ISF. Real-time cardiac biomarker measurement and wireless transmission of test results to a smartphone and then healthcare providers, b) an exploded view of the WACHCARDIO including different layers and components used inside of it, c) structure of the interdigitated electrode integrated microneedle array used for cTnI and NT-proBNP measurement.