Hadi Mirzajani

Scientist

École Polytechnique Fédérale de Lausanne (EPFL), Switzerland 

My work bridges fundamental sensor science and practical diagnostic technology. 

My diverse work background has allowed me to engineer a versatile biosensing portfolio capable of supporting sensitive detection, reliable characterization, and translational development across wearable/implantable, point-of-care, minimally invasive, and biomedical monitoring platforms.

My research spans a broad, highly interdisciplinary biosensing and bioelectronics portfolio, linking enabling technologies with high-impact biomedical applications. I have developed microneedle biosensors, sweat-based wearable patches, smart contact lens platforms, implantable and biodegradable biosensors, and portable point-of-care devices for cardiac biomarker monitoring, female hormone sensing, glucose and metabolite tracking, tear-fluid diagnostics, and Alzheimer’s disease biomarker detection. My work transforms fundamental sensor science into practical biomedical systems through microfabrication, surface functionalization, biointerface engineering, electrochemical and capacitive transduction, wireless electronics, and real-time signal analysis. Across these platforms, I address key limitations of conventional diagnostics by enabling minimally invasive access to clinically rich biofluids, detecting biomarkers earlier and closer to the patient, and shifting healthcare from centralized testing toward continuous, personalized, point-of-care monitoring. This research reflects a system-level approach in which materials, devices, biological interfaces, electronics, and data acquisition are engineered together to create next-generation technologies for precision diagnostics, wearable health monitoring, and translational biomedical innovation. A visual overview of my research area is provided in the figure below; details are available in the corresponding publications.

My research experience spans the full biosensor development pipeline, from molecular recognition and biointerface engineering to electrochemical transduction, signal characterization, and quantitative biomarker analysis. I have developed and optimized multiple classes of biosensors, including electrochemical aptamer-based sensors, aptamer-based recognition platforms, antibody-based immunosensors, enzymatic biosensors, and sensors for the direct detection and quantification of electroactive biomarkers. Across these systems, I have worked with diverse biorecognition strategies to convert specific molecular interactions into measurable electrical signals, enabling sensitive, selective, and application-driven biosensing for clinically relevant analytes.

A major focus of my work has been the integration of recognition chemistry with advanced electrochemical and interfacial characterization techniques. I have used cyclic voltammetry, square-wave voltammetry, differential pulse voltammetry, chronoamperometry, and electrochemical impedance-based methods to evaluate sensor performance, quantify biomarker concentrations, and understand the underlying electron-transfer and mass-transport processes. In parallel, I have characterized key interfacial parameters such as charge-transfer resistance and electrical double-layer capacitance to probe electrode–biointerface behavior, surface functionalization quality, binding events, and sensing mechanisms.

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