Publications

PUBLICATIONS

1. Measuring the Molecular Charge of Nucleosomes Using Solid-State Nanopores. G.V.Soni et.al. (In Preparation)

2. Multiplexed single molecule flow-force calibration using Optical tweezers. Punit et.al. (In preparation)

3. Reversible DNA Translocation as a molecular caliper to probe the nanoscale asymmetry of glass nanopores. Sukanya Sadhu, Gautam V Soni BioRxiv

4. Nanopore Assay for Fingerprinting DNA Binding and Quantifying Real-Time Cleavage by Catalytically Active Cas9 Enzyme. Punitkumar Nagpure, Sarangi Suresh, Divya Shet and Gautam V. Soni BioRxiv

5. High-throughput and label-free screening of red blood cell stiffness: A study of sickle cell disease. Saurabh Kaushik, Arkabrata Mishra, Roshan Ross, Sweta Srivastava, Cecil R. Ross, Gautam V. Soni Biosensors and Bioelectronics: X (2025) Volume 24, 100616 LINK PDF1 PDF2

Press Coverage: DDNewsX, DD News Live X, Deccan Herald (online), Times of India, DH Post, NeoSciencehub

6. Nanopore Sensing of DNA–Histone Complexes on Nucleosome Arrays. Sumanth K. Maheshwaram, Divya Shet, Serene R. David, Mahesh B. Lakshminarayana, and Gautam V. Soni ACS Sensors (2022) 7(12), 3876-3884 LINK PDF

Press Coverage: DST Media

7. Temperature dependent in vitro binding and release of target DNA by Cas9 enzyme. Serene Rose David*, Sumanth Kumar Maheshwaram*, Divya Shet, Mahesh B. Lakshminarayana & Gautam V. Soni Scientific Reports (2022) 12, 15243 LINK PDF (* = equal contribution)

Press Coverage: DST Media, Times of India,

8. Customized low-cost high-throughput amplifier for electro-fluidic detection of cell volume changes in point-of-care applications. Kaushik Saurabh*, Selvanathan P*, Soni GV PLoS ONE (2022), 17(4): e0267207 LINK PDF  (* = equal contribution)

9. Fingerprinting branches on supercoiled plasmid DNA using quartz nanocapillaries. Sumanth Kumar Maheshwaram, Koushik Sreenivasa and Gautam Vivek Soni Nanoscale (2021), 13, 320-331 LINK PDF

Press Coverage: DST Media, PharmaBiz

10. Measurement of Alcohol-Dependent Physiological Changes in Red Blood Cells Using Resistive Pulse Sensing. Saurabh Kaushik, Manohara Mahadeva, Kandhasamy Durai Murugan, Varadharajan Sundaramurthy, and Gautam Vivek Soni ACS Sensors (2020), 5(12): 3892–3901 LINK PDF

Press Coverage: DST Media, Times of India, Bangalore Mirror

11. Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. Yael Nechemia-Arbely, Daniele Fachinetti, Karen H. Miga, Nikolina Sekulic, Gautam Soni, Dong Hyun Kim, Adeline K. Wong, Ah Young Lee, Kristen Nguyen, Cees Dekker, Bing Ren, Ben Black, and Don Cleveland J Cell Biol (2017), 216(3):607-621 LINK PDF

12. Fabrication of Low Noise Borosilicate Glass Nanopores for Single Molecule Sensing. J.Bafna and G.V. Soni PLoS ONE (2016), 11(6):e0157399 LINK PDF

13. Periodic Modulations of Optical Tweezers Near Solid-state Membranes. G.V. Soni, M. Jonsson & Cees Dekker, Small (2013) 9(5):679-684. PDF

14. Rapid manufacturing of low-noise membranes for nanopore sensors by trans-chip illumination lithography. X. Janssen, M. Jonsson, C. Plesa, G.V. Soni, N.H. Dekker & C. Dekker Nanotechnology (2012)23:475302. PDF

15. Detection of Nucleosomal Substructures Using Solid-State Nanopores. G.V. Soni & Cees Dekker. Nanoletters (2012) 12:3180-6. PDF

16. Synchronous Optical and Electrical Detection of Biomolecules Traversing Through Solid-State Nanopores. G.V.Soni, A. Singer, Y. Sun, Z. Yu & A. Meller. Rev.Sci. Instrum. (2010) 81: 014301 PDF

17. Probing Structural Stability of Chromatin Assembly Sorted From Living Cells. F.M. Hameed, G.V. Soni, H. Krishnamurthy & G.V. Shivashankar, Biochem. Biophys. Res. Comm.(2009) 385:518-522. PDF

18. The Potential and Challenges of Nanopore Sequencing. D. Branton,…, G.V. Soni, et.al.  Nature Biotechnology. (2008) 26: 1146-1153. PDF

19. Progress Towards Ultrafast DNA Sequencing Using Solid-State Nanopores. G.V.Soni & Amit Meller, Clin. Chem. (2007) 53:1996-2001 PDF

20. Distinct Levels In Nanoscale Organization Of DNA-Histone Complex Revealed By Its Mechanical Unfolding. G.V. Soni, Lovelleen Brar, Feroz Meeran Hamid & G.V. Shivashankar,Appl. Phys. Lett. (2007) 90:193904. PDF

21. Nanopore Sensors for Ultra-Fast DNA Analysis. Min Jun Kim, Meni Wanunu, Gautam Soni, Amit Meller, Proc. ASME. IMECE2006 (2006), Fluids Engineering, 201-205. LINK, DOI

22. Probing Collective Dynamics Of Active Particles Using Modulation Force Spectroscopy. G.V.Soni, G.Ananthakrishna & G.V. Shivashankar, Appl.Phys. Lett., (2004) 85:2414-16. PDF

23. Single Particle Tracking Of Correlated Bacterial Dynamics, G.V.Soni, B.M. Jaffar Ali, Y.Hatwalne & G.V. Shivashankar, Biophys J., (2003) 84:2634-2637. PDF

24. Development Of An Optical Tweezer Combined With Micromanipulation For DNA & Protein Nanobioscience. G.V.Soni, Feroz Meeran, T.Roopa & G.V.Shivashankar, Curr. Sc.(2002) 83:1464-1470. PDF

BOOK CHAPTERS

1. Cellular and Nuclear Forces: An Overview. B. Sinha, A. Biswas, A. Kaushik & G.V. Soni. in Molecular Motors 3e, 2881:3-39 (Invited Chapter in Methods in Mol. Biol. Vol 2881, Eds. C. Lavelle &  A. Gall), Springer (2025) LINK

2. Cellular and Nuclear Forces: An Overview. B. Sinha, A. Biswas & G.V. Soni. Molecular Motors 2e, 1805:1-29 (Invited Chapter in Methods Mol Biol. Vol 1805, Ed. C. Lavelle) Springer (2018) LINK

3. Analyzing Individual Biomolecules using Nanopores. M. Wanunu, G.V. Soni & A. Meller. In Handbook of Nanophysics: Nanomedicine and Nanorobotics (Ed. K.D. Sattler), CRC Press (2010) LINK

4. Single Molecule Studies Of Nucleic Acids Interactions using Nanopores. M. Wanunu, G.V. Soni & A. Meller. In Handbook of Single Molecule Biophysics. (Eds. P. Hinterdorfer & A. Oijen) Springer Verlag (2009) LINK

PATENTS 

1. G.V. Soni and A. Meller: Method For Imaging on Thin Solid-State Interface Between Two Fluids. (PCT/US2010/028845)

2. G.V. Soni and S. Kaushik: A system and method for studying mechanical and morphological properties of soft materials. (Submitted Application 202341066337)

TALKS & CONFERENCE PRESENTATIONS

1. Aditi Simha Memorial Soft and Biological Matter symposium 2025, 07 Jan 2025, IIT Madras.

2. Talk at "Interdisciplinary aspects of chromatin organization and gene regulation", 09-20 Sept 2024, ICTS Bangalore

3. Distinguished speaker at the National Physicists’ Conclave 2024 (NPC 2024), 7-10 Feb 2024, SRM Inst. of Science and Tech, Chennai

4. Invited Talk at DNA Nanotech Conference 2020

5. Presentation at Grand Challenge Annual Meeting 2020

6. Didactic talk at Bangalore Microscopy Course 2019

7. Invited talk at “Microfluidics Techniques & Applications” C-CAMP and RRI 2019

8. Plenary Talk at Annual Symposium Molecular Biophysics Unit (MBU), IISc, 08 Sept 2018 Title: Measuring Molecular and Cellular Structures and The Forces That Control it.

9. Invited Talk at Founder’s Day Celebration of Poornaprajna Institute of Scientific Research (PPISR), 05-06 July 2018 Title: Role of Nanotechnology in Structure-Function Relationship in Biology 

10. Presented in Ramalingaswami Fellowship Conclave in NIPGR Delhi; 15 - 17th Feb 2018; Title: Nanopore and AFM Platform to study Chromatin Structure

11. Presented at Grand Challenge Exploration (GCE-India); 14 June 2017; Title: Electrical Detection of Malaria Infection in Single Red Blood Cells (RBCs) for High Throughput Low Parasite Density Profiling.

12. Invited talk at Conference on DNA Physics at BITS Pilani, Rajasthan; 09 Mar 2017 – 11 Mar 2017; Title: Nucleotide and Nucleo-protein Complexes detection using Nanopore platform

13. Presentation at 61st Biophysical Society meeting at New Orleans, Louisiana, USA; 11 Feb 2017 – 15th Feb 2017; Title: Measuring Whole Cell Stiffness Using Microfluidic Platform

14. Presentation at 2017 Physical Science of Cancer Conference (GRC) at Galveston, TX USA; 05 Feb 2017-10 Feb 2017; Title: Measuring Whole Cell Stiffness Using Novel Microfluidic Platform

15. Presented in Ramalingaswami Fellowship Conclave in IISER Pune; 04 Jan 2017 – 06 Jan 2017; Title: Epigenetic Gene Silencing by Chromatin Using Nano-Devices

16. Invited talk at OWLS-2016 at TIFR Mumbai and IIT-B - Mar 2016

17. Presentation at 60th Biophysical Society meeting, LA USA - Feb-Mar 2016

18. Attended RLF conclave at RCB, Delhi - Jan 2015

19. Invited talk at IABS, Kolkata, Feb 2015

20. Ramalingaswami Fellowship Conclave, Bhuvaneswar Jan-Feb 2015

21. Talk at JNCASR, Srikanth Sastry group, Jan 2015

22. Invited Talk at FCS - 2014 , IISER Pune Dec 2014

23. Invited talk in "3rd international Single Molecule Biology, Genome Engineering & Genome Editing Europe – 2014 Meeting", Peterhouse College,  University of Cambridge, Cambridge, United Kingdom. Nov. 2014

24. Invited talk at GANIT Labs, IBAB, Biotech Park, Bangalore. Oct. 2014

25. RRI General Council Meeting Sept 2014

26. 57th Biophysical Society Meeting, Philadelphia PA, USA (2013).

27. 56th Biophysical Society Meeting, San Diego CA, USA (2012).

28. Nanofluidics in Biology: Protein and Toxin Translocation through nanopores, Bremen (2011).

29. Meeting on Molecular and Cellular Biophysics, Veldhoven, The Netherlands (2011).

30. Meeting on Molecular and Cellular Biophysics, Veldhoven, The Netherlands (2010).

31. 53rd Biophysical Society Meeting, Boston MA (2009).

32. NHGRI (National Human Genome Research Institute) Advanced DNA Sequencing Technology Development Meeting, La Jolla CA (2009).

33. NHGRI (National Human Genome Research Institute) Meeting on Advanced DNA Sequencing Technology Development Grantee Meeting, La Jolla CA (2008).

34. 51st Biophysical Society Meeting, Baltimore (2007).

35. National Conference in Disorder, complexity and Biology (DISCOMB-04), Varanasi, July(2004).

36. 48th Biophysical Society Annual Meeting, Baltimore, USA, Feb 2004.

37. “International Symposium on Molecules, Machines and Networks” NCBS, India Jan (2004).

38. International workshop on Single Molecule Biophysics, NCBS, India, Jan (2004).

39. “India and Abroad: A Conference on Condensed Matter Physics”,JNCASR, India, Jan (2002).

40. National Symposium on Biophysics, Univ. of Madras conference [Best poster award], Jan (2002).

41. L.A. Meera Memorial Meeting on Soft Condensed Matter Physics, Mysore, India Jan (2000).

AWARDS

1. Awarded prestigious Ramalingaswami Re-entry Fellowship of the Department of Biotechnology for the year 2012-2013.

2. Press highlight on my Research is published in Nanotechweb magazine (2012) under the title “Nanopores detect nucleosome substructures” http://nanotechweb.org/cws/article/tech/49858

3. Presented progress reports in NHGRI (National Human Genome Research Institute, USA) meeting for the $1000 genome project, San Diego, USA (2008-2009).

4. Travel Grant from Molecular Imaging Corp (2004), to attend Biophysical Society meeting.

5. Awarded TIFR Alumni Association (TAA) career development fellowship (2001-2004).

6. Awarded Kanwal Rekhi fellowship for career development (2001-2004).

7. Best poster award at National Symposium on Biophysics, Dept. of Biophysics and Crystallography, Univ. of Madras, (2002).

8. National Eligibility Test (NET), Govt. of India, Junior Research Fellowship, (1999).

9. Selected for summer school at IUCAA, Pune (1998).

10. Gold Medal for securing highest marks in Hindi language in BSc.(Univ. of Madras) (1997).