Publications
23 - Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles toTarget a Conserved His Residue of the Bacterial Sliding Clamp
Guillaume Compain, Clément Monsarrat, Julie Blagojevic, Karl Brillet, Philippe Dumas, Philippe Hammann, Lauriane Kuhn, Isabelle Martiel, Sylvain Engilberge, Vincent Oliéric, Philippe Wolff, Dominique Y. Burnouf, Jérôme Wagner, and Gilles Guichard
JACS Au, 2024, doi: 10.1021/jacsau.3c00572, link
22 - In Situ Generated DBU·HF Acts as a Fluorinating Agent in a Hexafluoroisobutylation Tandem Reaction: An Effective Route to 5,5,5,5’,5’,5’-Hexafluoroleucine
Guillaume Naulet, Aline Delamare, Gilles Guichard, Guillaume Compain
Eur. J. Org. Chem. 2023, 26, e202201148 (1 of 6), link
21 - Cell-free synthesis of amyloid fibrils with infectious properties and amenable to sub-milligram magic-angle spinning NMR analysis
Alons Lends, Asen Daskalov, Ansis Maleckis, Aline Delamare, Mélanie Berbon, Axelle Grélard, Estelle Morvan, Jayakrishna Shenoy, Antoine Dutour, James Tolchard, Abdelmajid Noubhani, Marie-France Giraud, Corinne Sanchez, Birgit Habenstein, Gilles Guichard, Guillaume Compain, Kristaps Jaudzems, Sven J. Saupe & Antoine Loquet
Comm. Biol. 2022, 5:1202, link
20 - Hexafluoroisobutylation of Enolates Through a Tandem Elimination/Allylic Shift/Hydrofluorination Reaction
Aline Delamare, Guillaume Naulet, Brice Kauffmann, Gilles Guichard and Guillaume Compain
Chem. Sci. 2022, 13, 9507–9514, link
19 - Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp
C. Monsarrat, G. Compain, C. André, S. Engilberge, I. Martiel, V. Oliéric, P. Wolff, K. Brillet, M. Landolfo, C. Silva da Veiga, J. Wagner, G. Guichard and D. Y. Burnouf
J. Med. Chem. 2021, 64, 23, 17063-17078 , link
18 - Antibacterial Activity of a Dual Peptide Targeting the Escherichia Coli Sliding Clamp and the Ribosome
C. André, F. Veillard, P. Wolff, A.-M. Lobstein, G. Compain, C. Monsarrat, J.-M. Reichhart, C. Noûs, D. Y. Burnouf, G. Guichard and J. E. Wagner
RSC Chem. Biol. 2020, 1, 137-147, link
17 - Monitoring Glycosidase Activity for Clustered Sugar Substrates, A Study on β-Glucuronidase
Y. Brissonnet, G. Compain, B. Renoux, E.-M. Krammer, F. Daligault, D. Deniaud, S. Papot and S. G. Gouin
RSC Adv. 2019, 9, 40263-40267, link
16 - A ß-Glucuronidase-Responsive Albumin-Binding Prodrug for Selective Kinase Inhibitor-Based Cancer Chemotherapy
G. Compain, N. Nessoumata, J. Clarhaut, E. Péraudeau, B. Renoux, H. Galons, S. Papot
Eur. J. Med. Chem. 2018, 158, 1-6, link
15 - Cationic Polycyclization of Ynamides: Building up Molecular Complexity
C. Theunissen, B. Métayer, M. Lecomte, N. Henry, H.-C. Chan, G. Compain, P. Gérard, C. Bachmann, N. Mokhtari, J. Marrot,
A. Martin-Mingot, S. Thibaudeau, G. Evano
Org. Biomol. Chem. 2017, 15, 4399-4416, link
14 - Bond Strength and Reactivity Scales for Lewis Superacid Adducts: A Comparative Study with In(OTf)3 and Al(OTf)3
G. Compain, L. Sikk, L. Massi, J.-F. Gal, E. Duñach
ChemPhysChem 2017, 18, 683-691, link
13 - Influence of Alcohol β-Fluorination on Hydrogen-Bond Acidity of Conformationally Flexible Substrates
J. Graton, G. Compain, F. Besseau, E. Bogdan, J. M. Watts, L. Mtashobya, Z. Wang, A. Weymouth-Wilson, N. Galland, J.-Y. Le Questel, B. Linclau
Chem. Eur. J. 2017, 23, 2811 (hot paper/inside back cover), link
12 - α-Fluoro-o-cresols: The Key Role of Intramolecular Hydrogen Bonding in Conformational Preference and Hydrogen Bond Acidity
E. Bogdan, A. Quarré de Verneuil, F. Besseau, G. Compain, B. Linclau, J.-Y. Le Questel, J. Graton
ChemPhysChem 2016, 17, 2702-2709, link
11 - A Journey in the Chemistry of Ynamides: From Synthesis to Applications
G. Evano, N. Blanchard, G. Compain, A. Coste, C. S. Demmer, W. Gati, C. Guissart, J. Heimburger, N. Henry, K. Jouvin, K. Ganesan, A. Laouiti, M. Lecomte, A. Martin-Mingot, B. Métayer, B. Michelet, A. Nitelet, C. Theunissen, S. Thibaudeau, J. Wang, M. Zarca, C. Zhang
Chem. Lett. 2016, 45, 574-585, link
10 - Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New logP Determination Method
B. Linclau, Z. Wang, G. Compain, V. Paumelle, C. Q. Fontenelle, N. Wells, A. Weymouth-Wilson
Angew. Chem. Int. Ed. 2016, 55, 674-678 (VIP), link
9 - Intramolecular OH···Fluorine Hydrogen Bonding in Saturated, Acyclic Fluorohydrins: The γ-Fluoropropanol Motif
B. Linclau, F. Peron, E. Bogdan, N. Wells, Z. Wang, G. Compain, C. Q. Fontenelle, N. Galland, J.-Y. Le Questel, J. Graton
Chem. Eur. J. 2015, 21, 17808-17816, link
8 - Influence of Fluorination on the Conformational and Hydrogen-Bond Acidity Poperties of Benzyl Alcohol Derivatives
E. Bogdan, G. Compain, L. Mtashobya, J.-Y. Le Questel, F. Besseau, N. Galland, B. Linclau, J. Graton
Chem. Eur. J. 2015, 21, 11462-11474, link
7 - Chemo- and Stereoselective Synthesis of Fluorinated Enamides from Ynamides in HF/Pyridine: Second-Generation Approach to Potent Ureas Bioisosters
B. Métayer, G. Compain, K. Jouvin, A. Martin-Mingot, C. Bachmann, J. Marrot, G. Evano, S. Thibaudeau
J. Org. Chem. 2015, 80, 3397-3410 (cover), link
6 - Keteniminium Ion-Initiated Cascade Cationic Polycyclization
C. Theunissen, B. Métayer, N. Henry, G. Compain, J. Marrot, A. Martin-Mingot, S. Thibaudeau, G. Evano
J. Am. Chem. Soc. 2014, 136, 36, 12528-12531 (cover/spotlight), link
5 - Selective Anti-Markovnikov Cyclization and Hydrofluorination Reaction in Superacid HF/SbF5: A Tool in the Design of Nitrogen Containing (Fluorinated) Polycyclic Systems
G. Compain, C. Bonneau, A. Martin-Mingot, S. Thibaudeau
J. Org. Chem. 2013, 78, 4463-4472, link
4 - Superacid Synthesis of Halogen Containing N-Substituted-4-Aminobenzene Sulfonamides: New Selective Tumor-Associated Carbonic Anhydrase Inhibitors
G. Compain, A. Martin-Mingot, A. Maresca, S. Thibaudeau, C. Supuran
Bioorg. Med. Chem. 2013, 21, 1555-1563, link
3 - Anti-Markovnikov Addition on N-Allylic Derivatives Involving Ammonium-Carbenium Superelectrophiles
G. Compain, A. Martin-Mingot, G. Frapper, C. Bachmann, M.-P. Jouannetaud, S. Thibaudeau
Chem. Commun. 2012, 48, 5877-5879, link
2 - Stereoselective Hydrofluorination of Ynamides: A Straightforward Synthesis of Novel α-Fluoroenamides
G. Compain, K. Jouvin, A. Martin-Mingot, G. Evano, J. Marrot, S. Thibaudeau
Chem. Commun. 2012, 48, 5196-5198, link
1 - Dications in Superacid HF/SbF5: When Superelectrophilic Activation Makes Possible Fluorination and/or C–H Bond Activation
A. Martin-Mingot, G. Compain, F. Liu, M.-P. Jouannetaud, C. Bachmann, G. Frapper, S. Thibaudeau
J. Fluorine Chem. 2012, 134, 56-62, link