Selected Publications

Zhou, D., Chen, Y., Liu, P., Zhu, K., Holder-Haynes, J., Lloyd, S. J., La, C. M., Astapova, I. I., Choa, S., Xiong, Y., Bae, H., Aguilar, M., Yang, H., An, Y. A., Sun, Z., Herman, M. A., Gao, X., Pei, L., Jang, C., Rabinowitz, J. D., … Guan, D. (2025). Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism. Cell metabolism, 37(10), 1961–1979.e7. https://doi.org/10.1016/j.cmet.2025.07.010

Zhou, D., López-Valiente, R. E., Mattar, S. G., & Guan, D. (2025). Noncanonical clock regulators control stress responses in digestive diseases. Trends in endocrinology and metabolism: TEM, S1043-2760(25)00148-1. Advance online publication. https://doi.org/10.1016/j.tem.2025.07.002

Chen, Y., Liu, P., Sabo, A., & Guan, D. (2025). Human genetic variation determines 24-hour rhythmic gene expression and disease risk. Nature communications, 16(1), 4270. https://doi.org/10.1038/s41467-025-59524-5

Han, Y., Xia, G., Harris, L., Liu, P., Guan, D., & Wu, Q. (2024). Reversal of Obesity by Enhancing Slow-wave Sleep via a Prokineticin Receptor Neural Circuit. bioRxiv : the preprint server for biology, 2024.04.30.591948. https://doi.org/10.1101/2024.04.30.591948

Mukhi, D., Li, L., Liu, H., Doke, T., Kolligundla, L. P., Ha, E., Kloetzer, K., Abedini, A., Mukherjee, S., Wu, J., Dhillon, P., Hu, H., Guan, D., Funai, K., Uehara, K., Titchenell, P. M., Baur, J. A., Wellen, K. E., & Susztak, K. (2023). ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules. The Journal of clinical investigation, 134(4), e172963. https://doi.org/10.1172/JCI172963

Guan, D., Bae, H., Zhou, D., Chen, Y., Jiang, C., La, C. M., Xiao, Y., Zhu, K., Hu, W., Trinh, T. M., Liu, P., Xiong, Y., Cai, B., Jang, C., & Lazar, M. A. (2023). Hepatocyte SREBP signaling mediates clock communication within the liver. The Journal of clinical investigation, 133(8), e163018. https://doi.org/10.1172/JCI163018

Xiao, Y., Batmanov, K., Hu, W., Zhu, K., Tom, A. Y., Guan, D., Jiang, C., Cheng, L., McCright, S. J., Yang, E. C., Lanza, M. R., Liu, Y., Hill, D. A., & Lazar, M. A. (2023). Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. Science translational medicine, 15(682), eadc9653. https://doi.org/10.1126/scitranslmed.adc9653

Zhu, K., Celwyn, I. J., Guan, D., Xiao, Y., Wang, X., Hu, W., Jiang, C., Cheng, L., Casellas, R., & Lazar, M. A. (2023). An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver. Molecular cell, 83(19), 3457–3469.e7. https://doi.org/10.1016/j.molcel.2023.09.010

Jiang, C., Liu, P., La, C. M., & Guan, D. (2022). In silico integrative analysis of multi-omics reveals regulatory layers for diurnal gene expression in mouse liver. Frontiers in endocrinology, 13, 955070. https://doi.org/10.3389/fendo.2022.955070

Guan, D., & Lazar, M. A. (2022). Circadian Regulation of Gene Expression and Metabolism in the Liver. Seminars in liver disease, 42(2), 113–121. https://doi.org/10.1055/a-1792-4240

Hu, W., Jiang, C., Kim, M., Xiao, Y., Richter, H. J., Guan, D., Zhu, K., Krusen, B. M., Roberts, A. N., Miller, J., Steger, D. J., & Lazar, M. A. (2022). Isoform-specific functions of PPARγ in gene regulation and metabolism. Genes & development, 36(5-6), 300–312. https://doi.org/10.1101/gad.349232.121

Hu, W., Jiang, C., Kim, M., Yang, W., Zhu, K., Guan, D., Lv, W., Xiao, Y., Wilson, J. R., Rader, D. J., Pui, C. H., Relling, M. V., & Lazar, M. A. (2021). Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids. Cell metabolism, 33(8), 1592–1609.e7. https://doi.org/10.1016/j.cmet.2021.06.004

Guan, D., & Lazar, M. A. (2021). Interconnections between circadian clocks and metabolism. The Journal of clinical investigation, 131(15), e148278. https://doi.org/10.1172/JCI148278

Fang, B., Guan, D., & Lazar, M. A. (2021). Using GRO-Seq to Measure Circadian Transcription and Discover Circadian Enhancers. Methods in molecular biology (Clifton, N.J.), 2130, 127–148. https://doi.org/10.1007/978-1-0716-0381-9_10

Guan, D., Xiong, Y., Trinh, T. M., Xiao, Y., Hu, W., Jiang, C., Dierickx, P., Jang, C., Rabinowitz, J. D., & Lazar, M. A. (2020). The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science (New York, N.Y.), 369(6509), 1388–1394. https://doi.org/10.1126/science.aba8984

Guan, D., & Lazar, M. A. (2019). Shining light on dark matter in the genome. Proceedings of the National Academy of Sciences of the United States of America, 116(50), 24919–24921. https://doi.org/10.1073/pnas.1918894116

Hu, W., Jiang, C., Guan, D., Dierickx, P., Zhang, R., Moscati, A., Nadkarni, G. N., Steger, D. J., Loos, R. J. F., Hu, C., Jia, W., Soccio, R. E., & Lazar, M. A. (2019). Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell stem cell, 24(2), 299–308.e6. https://doi.org/10.1016/j.stem.2018.11.018

Guan, D., Xiong, Y., Borck, P. C., Jang, C., Doulias, P. T., Papazyan, R., Fang, B., Jiang, C., Zhang, Y., Briggs, E. R., Hu, W., Steger, D., Ischiropoulos, H., Rabinowitz, J. D., & Lazar, M. A. (2018). Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell, 174(4), 831–842.e12. https://doi.org/10.1016/j.cell.2018.06.031