Published papers:
AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network.
Majumder P, Edmison D, Rodger C, Patel S, Reid E, and Gowrishankar S
Mol Biol Cell. 2022 Aug 17:mbcE21090473. doi: 10.1091/mbc.E21-09-0473. Epub ahead of print. PMID: 35976706. Article link
Loss of MAPK8IP3 Affects Endocytosis in Neurons.
Snead AM, and Gowrishankar S.
Front Cell Neurosci. 2022 May 27;16:828071. doi: 10.3389/fncel.2022.828071. PMID: 35711470; PMCID: PMC9196590. Article link
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC- derived neurons.
Swetha Gowrishankar, Lila Lyons, Nisha Rafiq, Agnes Roczniak-Ferguson, Pietro De Camilli, and Shawn Ferguson.
Mol. Biol. Cell. 2021 mbc.E20-06-0382. doi:10.1091/mbc.E20-06-0382. Article link
Lysosome Function and Dysfunction in Hereditary Spastic Paraplegias.
Daisy Edmison, Judy Wang, and Sweth Gowrishankar.
Brain Sci. 11:152. 2021 doi:10.3390/brainsci11020152 PMID: 33498913 Article link
The inositol 5-phosphatase INPP5K participates in the fine control of ER organization.
Dong R, Zhu T, Benedetti L, Swetha Gowrishankar, Deng H, Cai Y, Wang X, Shen K and Pietro De Camilli.
J Cell Biol. 2018 Aug 7. pii: jcb.201802125. PMID:30087126. Article link
Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology
Swetha Gowrishankar, Yumei Wu and Shawn Ferguson.
J Cell Biol. 2017 Aug 7. pii: jcb.201612148. PMID:28784610 Pubmed link
Lysosomes relax in the cellular suburbs.
Swetha Gowrishankar and Shawn Ferguson.
J Cell Biol. 2016 Mar 14;212(6):617-9. PMID: 26975848. Pubmed link
Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.
Swetha Gowrishankar, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P,Ferguson SM.
Proc Natl Acad SciU S A. 2015 Jul 14;112(28):E3699-708. PMID: 26124111. Pubmed link