Rho GTPase Signaling: A Molecular Switchboard for Regulating the Actin Cytoskeleton in Axon Guidance
Madhavi Gorla*, Digvijay Singh Guleria
Journal of Cellular Physiology, 2025
Madhavi Gorla, Karina Chaudhari, Maya Hale, Chloe Potter, Greg J. Bashaw
Journal of Neuroscience, 2022
Anusruti Sabui, Mitali Biswas, Pramod Rajaram Somvanshi, Preethi Kandagiri,
Madhavi Gorla, Fareed Mohammed, Prasad Tammineni
Frontiers in Molecular Neuroscience, 2022
Karina Chaudhari, Madhavi Gorla, Chao Chang, Artur Kania, Greg J Bashaw
Elife, 2021
Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins
Boris Simonetti, Blessy Paul, Karina Chaudhari, Saroja Weeratunga, Florian Steinberg, Madhavi Gorla, Kate J Heesom, Greg J Bashaw, Brett M Collins, Peter J Cullen
Nature Cell Biology, 2020
Madhavi Gorla, Celine Santiago, Karina Chaudhari, Awo Akosua Kesewa Layman, Paula M Oliver, Greg J Bashaw
Cell Reports, 2019
Madhavi Gorla, Greg J Bashaw
Developmental Biology, 2020
1. Gorla M* and Guleria DS (2025) Rho GTPase signaling: A Molecular Switchboard for regulating the Actin Cytoskeleton in Axon Guidance. Journal of Cellular Physiology, 240, e70005 DOI: https://doi.org/10.1002/jcp.70005 (* Corresponding Author)
2. Aeri, A., Gorla, M. & Sharma, G.T. Veterinary Regenerative Medicine: The Evolving Role of Stem Cell-Based Therapies. Stem Cell Reviews and Reports 21, 2484–2510 (2025). https://doi.org/10.1007/s12015-025-10963-z
3. Lohitaksha K, Kumari D, Shukla M, Byagari L, Ashireddygari VR, Tammineni P, Reddanna P*, Gorla M* (2024) Eicosanoid Signaling in Neuroinflammation Associated with Alzheimer’s Disease. European Journal of Pharmacology 976 (2024) https://doi.org/10.1016/j.ejphar.2024.176694. (* Corresponding Author)
4. Sabui A, Biswas M, Somvanshi PR, Kandagiri P, Gorla M, Mohammed F, Tammineni P. Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons. Frontiers in Molecular Neuroscience 2022 Sep 30;15:927195. doi: 10.3389/fnmol.2022.927195.
5. Gorla M, Chaudhari K, Hale M, Potter C, Bashaw GJ. A Nedd4 E3 Ubiquitin ligase pathway inhibits Robo1 repulsion and promotes commissural axon guidance across the midline. Journal of Neuroscience. 2022 Aug 22;42(40):7547–61. doi: 10.1523/JNEUROSCI.2491-21.2022. PMID: 36002265
6. Chaudhari K, Gorla M, Chang C, Kania A and Bashaw GJ. Robo recruitment of the WAVE regulatory complex plays an essential and conserved role in midline repulsion. eLife 2021;10:e64474 10.7554/eLife.64474.
7. Gorla M, Bashaw GJ. Molecular mechanisms regulating axon responsiveness at the midline. Developmental Biology 2020 Oct 1;466(1-2):12-21. doi: 10.1016/j.ydbio.2020.08.006. Epub 2020 Aug 17. PMID: 32818516; PMCID: PMC8447865.
8. Mohammed F, Gorla M, Tammineni P, Sepuri NB. Reactive Oxygen Species generated by complex I inhibition signals the recruitment of STAT3 to mitochondria. FEBS letters 2020 Jan 25. doi: 10.1002/1873- 3468.13741
9. Gorla, M., Santiago, C., Chaudhari K, Layman, AAK., Oliver, PM., and Bashaw, G.J. (2019) Functional conservation of axon guidance receptor sorting: Ndfip proteins negatively regulate mammalian Robo receptors and control midline guidance in the spinal cord. Cell Reports 2019 Mar 19;26(12):3298-3312.e4.
10. Simonetti B§, Paul B§, Chaudhari K, Weeratunga S, Steinberg F, Gorla M, Heesom KJ, Bashaw GJ, Collins BM, Cullen PJ (2019) Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins. Nature Cell Biology, 2019. 21(10): p. 1219-1233.
11. Gorla M, Sepuri NB. (2014) Perturbation of apoptosis upon binding of tRNA to the heme domain of cytochrome c. Apoptosis 19, 259–268.
12. Murari A, Thiriveedi VR, Mohammad F, Vengaldas V, Gorla M, Tammineni P, Krishnamoorthy T, Sepuri NB (2015) Human mitochondrial MIA40 (CHCHD4) is a component of the Fe-S cluster export machinery. Biochem J 15, 471, 231-24.
13. M. Saikia, R. Jobava, M. Parisien, A. Putnam, D. Krokowski, X.H. Gao, B.J. Guan, Y. Yuan, E. Jankowsky, Z. Feng, G.F. Hu, M. Pusztai-Carey, M. Gorla, N.B. Sepuri, T. Pan, M. Hatzoglou. (2014) Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress. Molecular and Cellular Biology 34, 2450–2463.
14. Sepuri N. B, Gorla M, King M. P. (2012) Mitochondrial lysyl-tRNA synthetase independent import of tRNA lysine into yeast mitochondria. PLoS One 7, e35321 doi: 10.1371/journal.pone.0035321.
Book Chapters
1. Mankuzhy DP, Aeri A, Gorla M, Chandra V, Thirupathi Y, GT Sharma* (2023) Translational Potential and Therapeutic Strategies of Stem Cells in Livestock and Companion Animals: An Update and Way Forward. Stem Cells and their Therapeutic Applications: The Indian Prospective (World Scientific Publishing)https://doi.org/10.1142/13891