Research
Our group is broadly focused in new method development and Total synthesis. Our main research focus is to develop new synthetic strategies using catalysis as the main tool with special focus on visible light photoredox catalysis, metal catalysis & dual catalysis. These new synthetic methods will be used for applications in total synthesis of natural products, drugs & bioactive compounds to either improvise the synthesis of existing drugs/natural products or to construct new natural products/bioactive molecules in a novel fashion. Our other area of interest is prebiotic chemistry wherein we try to understand the origin of essential life components on the primitive earth such as amino acids, sugars, nucleosides/nucleotides, RNA etc. using biomimetic chemistry as the tool.
Our group is broadly focused in new method development and Total synthesis. Our main research focus is to develop new synthetic strategies using catalysis as the main tool with special focus on visible light photoredox catalysis, metal catalysis & dual catalysis. These new synthetic methods will be used for applications in total synthesis of natural products, drugs & bioactive compounds to either improvise the synthesis of existing drugs/natural products or to construct new natural products/bioactive molecules in a novel fashion. Our other area of interest is prebiotic chemistry wherein we try to understand the origin of essential life components on the primitive earth such as amino acids, sugars, nucleosides/nucleotides, RNA etc. using biomimetic chemistry as the tool.
1. Photoredox catalysis
1. Photoredox catalysis
One of the major research focus of our group is to use visible light photoredox catalysis for useful organic transformations. In this direction, we have already achieved chemoselective C-H arylation of free phenylureas under mild conditions. We are further exploring the use of photoredox catalysis for other functionalization reactions and for the synthesis of useful heterocycles, natural products & drug derivatives.
One of the major research focus of our group is to use visible light photoredox catalysis for useful organic transformations. In this direction, we have already achieved chemoselective C-H arylation of free phenylureas under mild conditions. We are further exploring the use of photoredox catalysis for other functionalization reactions and for the synthesis of useful heterocycles, natural products & drug derivatives.
- Photoredox catalyzed cascade CF3 addition/chemodivergent annulations of ortho-alkenyl aryl ureas. Sakamuri Sarath Babu, A Anagha Varma, Purushothaman Gopinath.* Chem. Commun. 2022, 58, 1990-1903.
- Dual palladium-photoredox catalyzed chemoselective C-H arylation of phenylureas. Sakamuri Sarath Babu, M. Shahid, and Purushothaman Gopinath.* Chem. Commun. 2020, 56, 5985-5988.
- Photomediated Tandem Sulfonyl Addition-Chemoselective N-Cyclization of O-Alkenyl Aryl Ureas: Direct Assembly of Functionalized Dihydroquinazolinones. Sakamuri Sarath Babu, Purushothaman Gopinath.* J. Org. Chem. 2022, 87, 9414–9418.
2. Dual catalysis
2. Dual catalysis
Dual catalysis is another area of focus wherein we use photoredox catalysis with other types of catalysis, such as transition metal catalysis for achieving transformations that are previously considered elusive. The combined synergistic effects of both the catalyst systems make these transformations plausible.
Dual catalysis is another area of focus wherein we use photoredox catalysis with other types of catalysis, such as transition metal catalysis for achieving transformations that are previously considered elusive. The combined synergistic effects of both the catalyst systems make these transformations plausible.
- Dual palladium-photoredox catalyzed chemoselective C-H arylation of phenylureas. Sakamuri Sarath Babu, M. Shahid, and Purushothaman Gopinath.* Chem. Commun. 2020, 56, 5985-5988.
- Dual Palladium-Photoredox catalyzed C-H functionalization. Partha Sarathi Saha, Purushothaman Gopinath.* Eur. J. Org. Chem. 2022 (35), e202200733.
3. Transition metal catalysis
3. Transition metal catalysis
Our group is also interested in the applications of transition metal catalysis for achieving remote C-H functionalizations and annulation-type reactions using sulfoxonium ylides.
Our group is also interested in the applications of transition metal catalysis for achieving remote C-H functionalizations and annulation-type reactions using sulfoxonium ylides.
- Controlled meta-selective C-H Mono- and Di-Olefination of Mandelic Acid Derivatives. Perumal Muthuraja, Rahamdil Usman Revathy Sajeev, Purushothaman Gopinath.* Org. Lett. 2021, 23, 6014-6018.
- Hydrazine-Directed Rh(III) Catalyzed (4+2) Annulation with Sulfoxonium Ylides: Synthesis and Photophysical Properties of Dihydrocinnolines, Pothapragada S. K. Prabhakar Ganesh, Perumal Muthuraja, Purushothaman Gopinath*, Chem. Commun. 2022, 58, 4211-4214.
