Research

Biological membranes surrounding cells and their organelles are dynamic platforms that enable cells to sense, respond to, and adapt to diverse stimuli. Our lab explores how these membranes remodel and how such transformations shape cellular behavior and function.

• Using cutting-edge imaging technologies — including super-resolution live-cell microscopy, electron microscopy, and in vitro reconstitution — we visualize membrane architecture and dynamics at unprecedented resolution.

• By integrating cell biology with membrane biophysics, we investigate membrane trafficking and organelle dynamics to reveal fundamental principles that govern cellular homeostasis and aging.

• References 

Various organelles within the cell regulate cellular states through a tightly interconnected network. Our lab seeks to understand how organellar dynamics and networks are linked to aging and neurodevelopment, and to translate this knowledge into new therapeutic strategies.

• We study the structure and dynamics of the organelle network involved in the Golgi, endoplasmic reticulum, mitochondria, and lysosomes. 

• We develop approaches to suppress aging and restore cellular function through Golgi remodeling. In addition, we investigate how intracellular dynamics influence brain development and neurological disorders.

Sugars are not merely sources of energy, but also important biological information that helps define cellular states and disease processes. Our lab aims to understand the mechanisms underlying disease-associated changes in glycosylation and to leverage this knowledge to develop innovative technologies for diagnosis and therapy.

• We identify cancer-specific glycan biomarkers to open new possibilities for disease diagnosis.

• We develope next-generation biopharmaceutical production technologies using SPARE (Secretory PAthway REmodeling).

Our research is supported by