Publications

*, equal contribution; †, correspondence 

2026

• COPI vesicle and tubule formation at the Golgi complex

Park K, Yang JS, Hsu WV†, Park SY†

Subcell Biochem. 2026;111:37-47.

2025

• EGFR activation requires cholesterol interaction at the inner leaflet of the plasma membrane 

Kim DH, Hong MT, Bocharov EV, Park S, Bershatsky YV, Volynsky PE, Kim E, Efremov RG, Cho W, Park SY, Ryu SH†

Sci Adv. 2025 Dec 19;11(51):eadx2398.

• PITPß promotes COPI vesicle fission through lipid transfer and membrane contact formation 

Park K, Ju S, Choi H, Gao P, Bang G, Choi JH, Jang J, Morris A, Kang BH, Hsu VW†, Park SY†

J Cell Biol 2025 May 5;224(5):e202407166.

• Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission 

Pang X*, Zhang Y*, Park K*, Liao Z, Li J, Xu J, Hong MT, Yin G, Zhang T, Wang Y, Egelman EH, Fan J†, Hsu VW†, Park SY†, Sun F†

Proc Natl Acad Sci USA. 2025 Mar 25;122(12):e2417820122.

• Fucosylated haptoglobin promotes inflammation by interacting with Mincle during sepsis

Roh T*, Ju S*, Park SY*, Ahn Y, Chung J, Nakano M, Ryu G, Kim YJ, Kim G, Choi H, Lee SG, Kim IS, Lee SI, Chung C, Shimizu T, Miyoshi E, Jung SS, Park C, Yamasaki  S,  Park SY†, Jo EK†

Nat Commun. 2025 Feb 4;16(1):1342.

• Noncanonical role of Golgi-associated macrophage TAZ in chronic inflammation and tumorigenesis 

Park SY, Ju S, Lee J, Park DJ, Park S, Sub Y, Kang HG, Kim HR, Shin JE, Kim DH, Cho SC, Park JE, Shim H, Kim YJ, Roe JS, Gee HY, Guan KL, Chun KH, Ha SJ, Lee HW, Park SY, Park HW†

Sci Adv. 2025 Jan 24;11(4):eadq2395.

2024

• ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification

Yang S*, Golkaram M*, Oh S, Oh Y, Cho Y, Yoe J, Lalli MA, Park SY, Lee Y, Jang J†

Nat Cell Biol, 2024 May 3; 26(6):903-916

2023

• Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport

Kim N†, Kim TH, Kim C, Lee JE, Kang MG, Shin S, Jung M, Kim JS, Mun JY, Rhee HW, Park SY, Shin Y, Yoo JY†

Dev Cell, 2023 Oct 9;58(19):1950-1966.

• Differences in the clinical and molecular profiles of subungual melanoma and acral melanoma in Asian patients

Ahn SY, Bae GE, Park SY†, Yeo MK†

Cancers, 2023 Sep 4;15(17):4417.

• Homotypic SCOTIN assemblies form ER-endosome membrane contacts and regulate endosome dynamics

Yun H, Jung MK, Lee H, Jung S, Kim T, Kim N, Park SY, Kim WJ, Mun JY, Yoo JY†

EMBO Rep, 2023 Jun 28:e56538.

• Terminal fucosylation of haptoglobin in cancer-derived exosomes during cholangiocarcinoma progression

Choi H, Ju S, Kang K, Seo MH, Kim JM, Miyoshi E, Yeo MK†, Park SY†

Front Oncol, 2023 Apr 24;13:1183442.

• Editorial: Drug-Resistance in Cancer Cells: A New Wine in an old Bottle

Fonseca LM, Tatsuta T†, Park SY†, Freire-de-Lima L†

Front Oncol, 2023 Feb 22;13:1161008.

• Gcap14 is a novel microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment

Mun DJ, Goo BS, Suh BK, Hong JH, Woo Y, Kim SJ, Kim S, Lee SB, Won Y, Yoo JY, Cho E, Jang EJ, Nhung TTM, Triet HM, An H, Lee H, Nguyen MD, Park SY, Baek ST, Park SK†

Proc Natl Acad Sci USA, 2023 Feb 21;120(8):e2214507120.

• Studying the role of lipid geometry in COPI vesicle formation

Choi H, Park K, Hsu VW†, Park SY†

Methods in Mol Biol, 2023;2557:519-528.

• Schizophrenia-associated Mitotic Arrest Deficient-1 (MAD1) regulates the polarity of migrating neurons in the developing neocortex

Goo BS, Mun DJ, Kim S, Nhung TTM, Lee SB, Woo Y, Kim SJ, Suh BK, Park SJ, Lee HE, Park K, Jang H, Rah JC, Yoon KJ, Baek ST, Park SY†, Park SK†

Molecular Psychiatry, 2023 Feb;28(2):856-870.

2022

• ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth

Park J, Park GY, Lee J, Park J, Kim S, Kim E, Park SY, Yoon JH, Lee Y†

Front Mol Biosci, 2022 Dec 22;9:1030725.

• Dimerization of β2–adrenergic Receptor Is Responsible for the constitutive Activity Subjected to Inverse Agonism

Kwon Y*, Kim DH*, Jeong MG*, Hong MT, Park S, Chang Y, Zhou K, Park SY, Zhang J, Ryu SH†

Cell Chem Biol, 2022 Oct 20;29(10):1532-1540.e5.

• Multiple isogenic GNE-myopathy modeling with mutation specific phenotypes from human pluripotent stem cells by vase editors

Park JC*, Kee J*, Kang HK, Lee SY, Kim KT, Kwon EJ, Park S, Lee HS, Choi H, Park SY, Choi HJ, Park, SJ, Moon SH, Bae S, Cha HJ†

Biomaterials, 2022 Feb 17;282:121419

• MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications

Artan M, Sohn J, Lee C†, Park SY†, Lee SJV†

Autophagy, 2022 Feb 19:1-3

• Trafficking defective mutant PROKR2 cycles between endoplasmic reticulum (ER) and Golgi to attenuate ER stress

Song YB, Park SY, Park K, Hwang H, Carrol RS, Hsu VW, Kaiser UB†

Proc Natl Acad Sci USA, 2022 Feb 22;119(8)

2021

• MON-2, a Golgi protein, mediates autophagy-dependent longevity in Caenorhabditis elegans

Jung Y*, Artan M*, Kim N*, Yeom J, Hwang AB, Jeong DE, Altintas Z, Seo K, Seo M, Lee D, Hwang W, Lee Y, Sohn J, Kim EJ, Ju S, Han SK, Nam H, Adams L, Ryu Y, Mun DJ, Kang C, Yoo JY, Park SK, Ha CM, Hansen M, Kim S, Lee C†, Park SY†, Lee SJV†

Sci Adv, 2021 Dec 3:7(49)

• The Golgi complex: a hub of the secretory pathway

Park K, Ju S, Kim N, Park SY†

BMB Rep, 2021;54(5):246-252

• Combined immunodeficiency due to a mutation in the g subunit of the Coat Protein I complex

Bainter W*, Platt CD*, Park SY*, Stafstrom K, Wallace JG, Peters ZT, Massaad MJ, Becuwe M, Salinas SA, Jones J, Beaussant-Cohen S, Jaber F, Yang JS, Walther TC, Orange JS, Rao C, Rakoff-Nahoum S, Tsokos M, Naseem SUR, Al-Tamemi S, Chou J, Hsu VW, Geha RS†

J Clin Invest, 2021;131(3):e140494

2020

• Self-organization of Fibroblast-Laden 3D collagen microstructures from inkjet-printed cell patterns

Park JA, Lee HR†, Park SY, Jung SJ†

Adv Biosys, 2020 May 17;1900280

2019

• ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis

Yang JS†, Hsu JW, Park SY, Lee S, Li J, Bai M, Alves C, Tseng W, Michelet X, Ho IC, Hsu VW†

Nat Commun, 2019 Sep 6;10(1):40682

• The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol

Park SY, Yang JS, Li Z, Deng P, Zhu X, Young D, Ericsson M, Andringa RLH, Minnaard AJ, Zhu C, Sun F, Moody DB, Morris AJ, Fan J, Hsu VW†

Nat Commun, 2019 Jul 30;10(1):3409

~2018

• GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis 

Yang JS, Hsu JW, Park SY, Li J, Oldham WM, Beznoussenko GV, Mironov AA, Loscalzo J, Hsu VW

Nature, 2018; 561(7722): 263-267

• Inhibition of poly-LacNAc biosynthesis with release of CMP-Neu5Ac feedback inhibition increases the sialylation of recombinant EPO produced in CHO cells

Lee CG, Oh MJ, Park SY, An HJ, Kim JH

Sci Rep, 2018 May 8;8(1):7273

• Bcl-xL mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophages

Zhao X, Khan N, Gan H, Tezalapis F, Nishimura T, Park SY, Divangahi M, Remold HG

Mucosal immunol, 2017 Nov;10(6):1553-1568   

• Enhancing the sialylation of recombinant EPO produced in CHO cells via the inhibition of glycosphingolipid biosynthesis

Kwak CY*, Park SY*,†, Lee CG, Okino N, Ito M, Kim JH†

Sci Rep, 2017, Oct 12;7(1):13059

• Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

Nishita M, Park SY, Nishio T, Kamizaki K, Wang Z, Tamada K, Takumi T, Hashimoto R, Otani H, Pazour G, Hsu VH, Minami Y

Sci Rep, 2017 Jan 26;7(1):1

• Glycomic profiling of targeted serum haptoglobin for gastric cancer using nano LC/MS and LC/MS/MS

Lee SH, Jeong S, Lee J, Yeo IS, Oh MJ, Kim U, Kim S, Kim S, Park SY, Kim JH, Park SH, Kim JH, An HJ

Mol Biosyst, 2016 Nov 15; 12(12):3611-3621

• Reconstitution of COPI vesicle and tubule formation

Park SY, Yang JS, Hsu VW

Methods Mol Biol, 2016; 1496:63-74

• Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42 

Park SY, Yang JS, Schmider AB, Soberman RJ, Hsu VW

Nature, 2015; 521(7553): 529-532

• Globoside (Gb4) promotes activation of MAPK-induced cell proliferation by interaction with the epidermal growth factor receptor

Park SY, Kwak CY, Shayman JA, Kim JH

Biochim Biophys Acta, 2012; 1820(7): 1141-8

• α1-3/4 fucosylation at Asn 241 of β-haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers

Park SY, Lee SH, Kawasaki N, Itoh S, Kang K, Ryu SH, Hashii N, Kim JM, Kim JY, Kim JH

Int J Cancer, 2012; 130(10): 2366-76

• Transcriptional changes of secreted Wnt antagonist in hindlimb skeletal muscle during the lifetime of the C57BL/6J mouse

Ryu SH, Yoo T, Kang K, Park SY, Joe CO, Chung JH

Mech Ageing Dev, 2011; 132(10): 511-4

• Enhanced sialylation of recombinant human EPO in Chinese hamster ovary cells by combinatorial engineering of selected genes

Son YD, Jeong YT, Park SY, Kim JH

Glycobiology, 2011; 21(8): 1019-28

• A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses

Sun D, Lee G, Lee JH, Kim HY, Rhee HW, Park SY, Kim KJ, Kim Y, Kim BY, Hong JI, Park C, Choy HE, Kim JH, Jeon YH, Chung J

Nat Struct Mol Biol, 2010; 17(10): 1188-94

• Dimeric Le(a) (Le(a)-on-Le(a)) status of beta-haptoglobin in sera of colon cancer, chronic inflammatory disease and normal subjects

Park SY, Yoon SJ, Hakomori SI, Kim JM, Kim JY, Bernert B, Ullman T, Itzkowitz SH, Kim JH

Int J Oncol, 2010; 36(5): 1291-7

• N-glycosylation status of beta-haptoglobin in sera of patients with prostate cancer vs. benign prostate diseases

Yoon SJ, Park SY, Pang PC, Gallagher J, Gottesman JE, Dell A, Kim JH, Hakomori SI

Int J Oncol, 2010; 36(1): 193-203

• N-glycosylation status of β-haptoglobin in sera of patients with colon cancer vs. normal subjects

Park SY, Yoon SJ, Jeong YT, Kim JM, Kim JY, Bernert B, Ullman T, Itzkowitz SH, Kim JH, Hakomori SI

Int J Cancer, 2010; 126(1): 142-55

• Control of cell growth and motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 vs. KB epithelial cells

Park SY*, Yoon SJ*, Freire-de-Lima L, Kim JH, Hakomori SI

Carbohydr Res. 2009; 344(12): 1479-86

• Enhanced sialylation of recombinant erythropoietin in genetically engineered CHO cells

Jeong YT, Choi O, Son YD, Park SY, Kim JH

Biotechnol Appl Biochem, 2009; 52(4), 283-291.