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Soluble lectins recognize sugar structures on pathogens and host-glycoproteins as a part of immune recognition during host-pathogen interaction.
Soluble lectins in mammals are specialized proteins that bind to carbohydrates and play a crucial role in defending the body against pathogens. These proteins recognize unique sugar structures on viruses, bacteria, and fungi, and help the immune system respond effectively.
The soluble lectins often interact with host mucins- the highly glycosylated proteins at the mucosal barrier and help trap and neutralize harmful microorganisms.
Despite their key role in host defense, the glycan-binding properties of many soluble lectins remain unclear. Our lab explores their function in mucosal immunity using glycobiology approaches.
We develop soluble lectin-based probes to track evolving glycosylation patterns, rapid compositional changes, and site-specific heterogeneity on viral glycoproteins that drive zoonotic transmission and immune evasion.
We develop soluble lectin-based probes to track evolving glycosylation patterns, rapid compositional changes, and site-specific heterogeneity on viral glycoproteins that drive zoonotic transmission and immune evasion.
Lectin-based probes to study virus binding and neutralization
Lectin-based probes for understanding the importance of viral sugars in zoonotic transmission
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