PHIP and SABRE
PHIP and SABRE
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PHIP and SABRE are hyperpolarization techniques using parahydrogen as a source of polarization.
Radicals for high field MAS DNP
Radicals for high field MAS DNP
A fundamental parameter to achieve a good DNP is the choice of the radical. I studied mono- and bis-nitroxides to maximize the cross-effect DNP mechanism at very high magnetic-fields (21.1 T) and 100 K. We optimized radical design and magnetic parameters in order to achieve the best performance.Â
In addition, I investigated Gd-complexes as polarizing agents for high-field DNP. Gd(tpatcn) has been shown to double the enhancement of the so-far state-of-the-art Gd(dota). We correlated the better performance of Gd(tpatcn) with reduced Zero Field Splitting parameters. These type of MAS DNP probes hold promise as a valid alternative to commonly used nitroxide radicals in applications under reducing conditions as for example in-cell DNP.
Long-lived nuclear spin states
Long-lived nuclear spin states
LLS are nuclear spin configurations that can survive the longitudinal relaxation time T1. LLS can be present in two- or multi-spin chemical environments. IN multi-spin systems the presence of an inversion geometry has been demonstrated as a crucial ingredient for LLS. The extended lifetime has been used to achieve tremendous contrast in protein ligand-binding interactions.
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