Functional Genomics Lab

Dissecting the functional potential of genomes

Our group develops and deploys omics technologies to measure Biological phenomena with High Resolution (single cell), High Precision (Isoforms), and High throughput (100s-1,000,000 samples simultaneously). We apply Big Data algorithms on the generated data to dissect the biological complexity in the context of Evolution and Disease.

Currently hiring Postdocs ( NPDF, DBT-RA), PhDs (GATE, NET, JRF) , MS(Research) Students (GATE qualified), and Long-term Interns (12m+).

Drop a mail with subject "App-Degree-Position-FirstName-Interest" along with a description of interest and your CV to fungel.iitd@gmail.com
For example: if you are Mr. Virat Kohli seeking a PhD to work on Covid-19, email subject should be "App-B.E.CompScience-MSR-Virat-Covid19"

Current Research Areas

Mapping functional consequences of Genetic Diversity in India

Cellular heterogeneity in
Host-Pathogen interaction

Molecular dissection of Cancer persistence and Immunotherapy

Custom Genomics solutions for
Low-cost point-of-care Diagnostics

Fresh off the press

Completion of Sequencing of 10,000 Genomes of Indian Population (February 27, 2024)
GenomeIndia, a national Pan-India initiative by the Department of Biotechnology (DBT), focussed on whole genome sequencing of representative populations across India — crucial in mapping the vast genetic blueprint of India from healthy individuals. Our lab is excited to contribute towards de novo assembly of the mitochondrial genome for generating the first Indian mitochondrial genome reference. A majority of this work, was executed by Mr. Nirmal Singh Mahar, a PhD student in the lab, in collaboration with Prof. Sundar at IIT Delhi and Prof. Shweta Ramdass at the Centre for Brain Research, Indian Institute of Science.

DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages

Amit Subudhi et al 2023. Nature Microbiology
Extending our work on the first scRNA-Seq dataset from India

Caution towards spurious off-target signal in 10X Visium spatial transcriptomics assay from potential lncRNAs

Prakrithi et al 2023, Breifings in Bioinformatics
FIRST SPATIAL TRANSCRIPTOMICS DATASET FROM INDIA

A systematic comparison of human mitochondrial genome assembly tools

Nirmal Singh Mahar et al 2023, BMC Genomics
Benchmarking tools for the GenomeIndia project

Highlights of past work

Single-cell RNA sequencing reveals cellular heterogeneity and stage transition under temperature stress in synchronized Plasmodium falciparum cells

First single-cell RNA-SEQ dataset from India

Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

One of the Largest tissue collections in the world with RNA-seq data from COVID-19 patients

Genomics and new tools to better understand Cancer for enhancing patient care

Applications of precision genomics to diagnostics, Roel of Intronless genes, Using Single-cell methylation profiling in Cancers

Dissecting the mechanism of gene expression homeostasis in yeast

Gupta et al 2014; Gupta & Villanyi et al 2016

Development of single-cell Isoform sequencing for Proteogenomics

First protocol for single-cell sequencing that captures the entire transcript (isoform)

Machine Learning to understand genetic and non-genetic factors in disease

Raj et al 2018; Kapoor et al 2019; Bhatia & Makhija et al 2022

How to reach us:

Department of Biochemical Engineering and BiotechnologyBlock I, Indian Institute of Technology DelhiHauz Khas, New Delhi 110 016Tel: +91-11-26591008

Follow our work on:

Twitter @FungeLab